{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T08:25:14Z","timestamp":1787127914566,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.xphs.2018.08.013","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T12:33:15Z","timestamp":1535545995000},"page":"3089-3097","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["In Situ Gel Formulation for Enhanced Ocular Delivery of Nepafenac"],"prefix":"10.1016","volume":"107","author":[{"given":"Haley","family":"Shelley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanne M.","family":"Rodriguez-Galarza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue H.","family":"Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva M.","family":"Abarca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Jayachandra","family":"Babu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.xphs.2018.08.013_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.5497\/wjp.v2.i2.47","article-title":"Ocular drug delivery systems: an overview","volume":"2","author":"Patel","year":"2013","journal-title":"World J Pharmacol"},{"issue":"3","key":"10.1016\/j.xphs.2018.08.013_bib2","first-page":"1192","article-title":"In-situ ophthalmic gel forming solution of moxifloxacin hydrochloride for sustained ocular delivery","volume":"7","author":"Sawarkar","year":"2016","journal-title":"Int J Pharm Sci Res"},{"issue":"1","key":"10.1016\/j.xphs.2018.08.013_bib3","first-page":"58","article-title":"Formulation and evaluation of pH-triggered in situ gelling system of levofloxacin","volume":"45","author":"Mohanambal","year":"2011","journal-title":"Indian J Pharm Educ"},{"issue":"4","key":"10.1016\/j.xphs.2018.08.013_bib4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.drudis.2013.10.001","article-title":"In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations","volume":"19","author":"Almeida","year":"2014","journal-title":"Drug Discov Today"},{"issue":"2-3","key":"10.1016\/j.xphs.2018.08.013_bib5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0168-3659(96)01523-4","article-title":"A\u00a0novel in situ-forming ophthalmic drug delivery system from alginates undergoing gelation in the eye","volume":"44","author":"Cohen","year":"1997","journal-title":"J\u00a0Control Release"},{"issue":"5","key":"10.1016\/j.xphs.2018.08.013_bib6","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1081\/DDC-120003445","article-title":"Ocular preparations: the formulation approach","volume":"28","author":"Kaur","year":"2002","journal-title":"Drug Dev Ind Pharm"},{"issue":"4","key":"10.1016\/j.xphs.2018.08.013_bib7","first-page":"1541","article-title":"Basics of ocular drug delivery systems","volume":"2","author":"Tangri","year":"2011","journal-title":"Int J Res Pharm Biomed Sci"},{"key":"10.1016\/j.xphs.2018.08.013_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rinphs.2015.06.001","article-title":"Development and characterization of in-situ gel for ophthalmic formulation containing ciproflaxin hydrochloride","volume":"6","author":"Makwana","year":"2015","journal-title":"Results Pharma Sci"},{"key":"10.1016\/j.xphs.2018.08.013_bib9","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1208\/s12249-018-1094-0","article-title":"Improved ocular delivery of nepafenac by cyclodextrin complexation","volume":"19","author":"Shelley","year":"2018","journal-title":"AAPS PharmSciTech"},{"issue":"2","key":"10.1016\/j.xphs.2018.08.013_bib10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4103\/0975-7406.67003","article-title":"Cyclodextrins in delivery systems: applications","volume":"2","author":"Tiwari","year":"2010","journal-title":"J\u00a0Pharm Bioallied Sci"},{"issue":"1","key":"10.1016\/j.xphs.2018.08.013_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1773-2247(07)50001-8","article-title":"Cyclodextrins in ocular drug delivery: theoretical basis with dexamethasone as a sample drug","volume":"17","author":"Loftsson","year":"2007","journal-title":"J\u00a0Drug Deliv Sci Technol"},{"issue":"8","key":"10.1016\/j.xphs.2018.08.013_bib12","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1248\/cpb.52.900","article-title":"Design and evaluation of cyclodextrin-based drug formulation","volume":"52","author":"Uekama","year":"2004","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"3","key":"10.1016\/j.xphs.2018.08.013_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/02652039109373974","article-title":"Dietary effects of sodium alginate in humans","volume":"8","author":"Anderson","year":"1991","journal-title":"Food Addit Contam"},{"issue":"8","key":"10.1016\/j.xphs.2018.08.013_bib14","first-page":"1","article-title":"Alginate: current use and future perspectives in pharmaceutical and biomedical applications","volume":"2016","author":"Szekalska","year":"2016","journal-title":"Int J Polym Sci"},{"key":"10.1016\/j.xphs.2018.08.013_bib15","doi-asserted-by":"crossref","first-page":"341218","DOI":"10.1155\/2013\/341218","article-title":"Hp-beta-CD-Voriconazole in situ gelling system for ocular drug delivery: in\u00a0vitro, stability, and antifungal activities assessment","volume":"2013","author":"Pawar","year":"2013","journal-title":"Biomed Res Int"},{"issue":"1","key":"10.1016\/j.xphs.2018.08.013_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/0975-7406.149810","article-title":"An alternative in situ gel-formulation of levofloxacin eye drops for prolong ocular retention","volume":"7","author":"Gupta","year":"2015","journal-title":"J\u00a0Pharm Bioallied Sci"},{"issue":"2-3","key":"10.1016\/j.xphs.2018.08.013_bib17","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0168-3659(01)00279-6","article-title":"Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system","volume":"73","author":"Srividya","year":"2001","journal-title":"J\u00a0Control Release"},{"issue":"1-2","key":"10.1016\/j.xphs.2018.08.013_bib18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijpharm.2006.01.029","article-title":"Study of an alginate\/HPMC-based in situ gelling ophthalmic delivery system for gatifloxacin","volume":"315","author":"Liu","year":"2006","journal-title":"Int J Pharm"},{"issue":"2","key":"10.1016\/j.xphs.2018.08.013_bib19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4103\/2230-973X.100042","article-title":"Formulation and evaluation of an in situ gel-forming ophthalmic formulation of moxifloxacin hydrochloride","volume":"2","author":"Mandal","year":"2012","journal-title":"Int J Pharm Investig"},{"key":"10.1016\/j.xphs.2018.08.013_bib20","series-title":"Biopharmaceutics of Ocular Drug Delivery","first-page":"202","author":"Edman","year":"1993"},{"issue":"1-2","key":"10.1016\/j.xphs.2018.08.013_bib21","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ijpharm.2011.03.054","article-title":"Optimization and evaluation of thermoresponsive diclofenac sodium ophthalmic in situ gels","volume":"411","author":"Asasutjarit","year":"2011","journal-title":"Int J Pharm"},{"issue":"9","key":"10.1016\/j.xphs.2018.08.013_bib22","first-page":"901","article-title":"Ocular surface-temperature","volume":"8","author":"Efron","year":"1989","journal-title":"Curr Eye Res"},{"issue":"2","key":"10.1016\/j.xphs.2018.08.013_bib23","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1208\/s12249-010-9413-0","article-title":"In situ gelling gelrite\/alginate formulations as vehicles for ophthalmic drug delivery","volume":"11","author":"Liu","year":"2010","journal-title":"AAPS PharmSciTech"},{"issue":"10","key":"10.1016\/j.xphs.2018.08.013_bib24","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/jps.2600501018","article-title":"Rate of release of medicaments from ointment bases containing drugs in suspension","volume":"50","author":"Higuchi","year":"1961","journal-title":"J\u00a0Pharm Sci"},{"issue":"2","key":"10.1016\/j.xphs.2018.08.013_bib25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-5173(89)90306-2","article-title":"A\u00a0simple equation for the description of solute release .3. Coupling of diffusion and relaxation","volume":"57","author":"Peppas","year":"1989","journal-title":"Int J Pharm"},{"issue":"10","key":"10.1016\/j.xphs.2018.08.013_bib26","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1002\/jps.2600581021","article-title":"Interpretation of percent dissolved-time plots derived from in\u00a0vitro testing of conventional tablets and capsules","volume":"58","author":"Wagner","year":"1969","journal-title":"J\u00a0Pharm Sci"},{"issue":"8","key":"10.1016\/j.xphs.2018.08.013_bib27","first-page":"2593","article-title":"Human corneal epithelial cell viability and morphology after dilute alcohol exposure","volume":"43","author":"Chen","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.xphs.2018.08.013_bib28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.optom.2014.09.001","article-title":"Corneal regeneration after photorefractive keratectomy: a review","volume":"8","author":"Tomas-Juan","year":"2015","journal-title":"J\u00a0Optom"},{"issue":"8","key":"10.1016\/j.xphs.2018.08.013_bib29","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1089\/jop.2013.0063","article-title":"Effect of choroidal perfusion on ocular tissue distribution after intravitreal or suprachoroidal injection in an arterially perfused ex\u00a0vivo pig eye model","volume":"29","author":"Abarca","year":"2013","journal-title":"J\u00a0Ocul Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.xphs.2018.08.013_bib30","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ejpb.2011.11.006","article-title":"A\u00a0pharmacokinetic study of a combination of beta adrenoreceptor antagonists - in the isolated perfused ovine eye","volume":"80","author":"Mains","year":"2012","journal-title":"Eur J Pharm Biopharm"},{"issue":"3","key":"10.1016\/j.xphs.2018.08.013_bib31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/10717540802689008","article-title":"Ophthalmic controlled release in situ gelling systems for ciprofloxacin based on polymeric carriers","volume":"16","author":"Al-Kassas","year":"2009","journal-title":"Drug Deliv"},{"issue":"8","key":"10.1016\/j.xphs.2018.08.013_bib32","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/10717540701606426","article-title":"Sustained ocular drug delivery from a temperature and pH triggered novel in situ gel system","volume":"14","author":"Gupta","year":"2007","journal-title":"Drug Deliv"},{"key":"10.1016\/j.xphs.2018.08.013_bib33","series-title":"Property of Alginate","year":"2018"},{"key":"10.1016\/j.xphs.2018.08.013_bib34","doi-asserted-by":"crossref","first-page":"861904","DOI":"10.1155\/2014\/861904","article-title":"Ophthalmic drug dosage forms: characterisation and research methods","volume":"2014","author":"Baranowski","year":"2014","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.xphs.2018.08.013_bib35","series-title":"Compounding Guide for Ophthalmic Preparations","first-page":"259","author":"McElhiney","year":"2013"},{"issue":"4","key":"10.1016\/j.xphs.2018.08.013_bib36","first-page":"110","article-title":"Analysis of fickian and non-fickian drug release from polymers","volume":"60","author":"Peppas","year":"1985","journal-title":"Pharm Acta Helv"},{"issue":"4","key":"10.1016\/j.xphs.2018.08.013_bib37","first-page":"128","article-title":"Calculation of predominant drug release mechanism using Peppas-Sahlin model (substitution method): a linear regression approach","volume":"6","author":"Baggi","year":"2016","journal-title":"Int J Pharm"},{"issue":"47","key":"10.1016\/j.xphs.2018.08.013_bib38","doi-asserted-by":"crossref","first-page":"25896","DOI":"10.1039\/C4CP03389B","article-title":"Phases in the temporal multiscale evolution of the drug release mechanism in IPN-type chitosan based hydrogels","volume":"16","author":"Bacaita","year":"2014","journal-title":"Phys Chem Chem Phys"},{"issue":"11","key":"10.1016\/j.xphs.2018.08.013_bib39","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/00914030903035469","article-title":"Swelling and diffusion characteristics of interpenetrating network films composed of sodium alginate and gelatin: transport of azure B","volume":"58","author":"Mohanan","year":"2009","journal-title":"Int J Polym Mater"},{"issue":"2","key":"10.1016\/j.xphs.2018.08.013_bib40","first-page":"1","article-title":"A\u00a0novel method to study the effect of pH and excipients on water uptake and swelling behaviour of Carbopol polymers Bangladesh","volume":"13","author":"Sharmin","year":"2010","journal-title":"Pharm J"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354918305148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354918305148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T14:02:57Z","timestamp":1545314577000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354918305148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S0022354918305148"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2018.08.013","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In Situ Gel Formulation for Enhanced Ocular Delivery of Nepafenac","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2018.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc. on behalf of the American Pharmacists Association.","name":"copyright","label":"Copyright"}]}}