{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:12:33Z","timestamp":1774681953503,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.xphs.2019.01.027","type":"journal-article","created":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T15:26:46Z","timestamp":1549121206000},"page":"2143-2152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["A Delivery System for Oral Administration of Proteins\/Peptides Through Bile Acid Transport Channels"],"prefix":"10.1016","volume":"108","author":[{"given":"Siwen","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Bin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biyun","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suling","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changshan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xphs.2019.01.027_bib1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ejpb.2018.04.025","article-title":"Challenges in the local delivery of peptides and proteins for oral mucositis management","volume":"128","author":"Campos","year":"2018","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.xphs.2019.01.027_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cis.2018.02.002","article-title":"Encapsulation, protection, and delivery of bioactive proteins and peptides using nanoparticle and microparticle systems: a review","volume":"253","author":"McClements","year":"2018","journal-title":"Adv Colloid Interface Sci"},{"key":"10.1016\/j.xphs.2019.01.027_bib3","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jconrel.2018.07.045","article-title":"Physicochemical, pharmacokinetic and pharmacodynamic analyses of amphiphilic cyclodextrin-based nanoparticles designed to enhance intestinal delivery of insulin","volume":"286","author":"Presas","year":"2018","journal-title":"J\u00a0Control Release"},{"issue":"36","key":"10.1016\/j.xphs.2019.01.027_bib4","doi-asserted-by":"crossref","first-page":"9826","DOI":"10.1016\/j.biomaterials.2011.08.087","article-title":"A\u00a0review of the prospects for polymeric nanoparticle platforms in oral insulin delivery","volume":"32","author":"Chen","year":"2011","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.xphs.2019.01.027_bib5","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/0735-6757(93)90018-7","article-title":"Gas gangrene from subcutaneous insulin administration","volume":"11","author":"Chin","year":"1993","journal-title":"Am J Emerg Med"},{"issue":"5","key":"10.1016\/j.xphs.2019.01.027_bib6","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3109\/02652048.2011.576782","article-title":"Poly(N-vinylcaprolactam-co-methacrylic acid) hydrogel microparticles for oral insulin delivery","volume":"28","author":"Mundargi","year":"2011","journal-title":"J\u00a0Microencapsul"},{"issue":"31","key":"10.1016\/j.xphs.2019.01.027_bib7","doi-asserted-by":"crossref","first-page":"7733","DOI":"10.1016\/j.biomaterials.2013.06.047","article-title":"The use of low molecular weight protamine chemical chimera to enhance monomeric insulin intestinal absorption","volume":"34","author":"He","year":"2013","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.xphs.2019.01.027_bib8","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/jps.2600820902","article-title":"Gastrointestinal parameters that influence oral medications","volume":"82","author":"Dressman","year":"1993","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.xphs.2019.01.027_bib9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jconrel.2018.08.032","article-title":"Oral peptide delivery: translational challenges due to physiological effects","volume":"287","author":"Tyagi","year":"2018","journal-title":"J\u00a0Control Release"},{"issue":"12","key":"10.1016\/j.xphs.2019.01.027_bib10","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1021\/acs.molpharmaceut.5b00602","article-title":"Analysis of intra- and intersubject variability in oral drug absorption in human bioequivalence studies of 113 generic products","volume":"12","author":"Sugihara","year":"2015","journal-title":"Mol Pharm"},{"issue":"7","key":"10.1016\/j.xphs.2019.01.027_bib11","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1021\/acs.molpharmaceut.6b00188","article-title":"Effective enhancement of hypoglycemic effect of insulin by liver-targeted nanoparticles containing cholic acid-modified chitosan derivative","volume":"13","author":"Zhang","year":"2016","journal-title":"Mol Pharm"},{"issue":"1","key":"10.1016\/j.xphs.2019.01.027_bib12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ijpharm.2013.06.056","article-title":"Cholic acid modified N-(2-hydroxy)-propyl-3-trimethylammonium chitosan chloride for superoxide dismutase delivery","volume":"454","author":"Cheng","year":"2013","journal-title":"Int J Pharm"},{"issue":"13-14","key":"10.1016\/j.xphs.2019.01.027_bib13","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.drudis.2012.03.019","article-title":"An overview of natural polymers for oral insulin delivery","volume":"17","author":"Sonia","year":"2012","journal-title":"Drug Discov Today"},{"issue":"1","key":"10.1016\/j.xphs.2019.01.027_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijpharm.2013.08.037","article-title":"Alginate coated chitosan core shell nanoparticles for oral delivery of enoxaparin: in\u00a0vitro and in\u00a0vivo assessment","volume":"456","author":"Bagre","year":"2013","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2019.01.027_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biomaterials.2017.09.022","article-title":"Bile acid transporter mediated endocytosis of oral bile acid conjugated nanocomplex","volume":"147","author":"Park","year":"2017","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.xphs.2019.01.027_bib16","doi-asserted-by":"crossref","first-page":"8893","DOI":"10.1021\/acsnano.8b04315","article-title":"Oral nanoparticles exhibit specific high-efficiency intestinal uptake and lymphatic transport","volume":"12","author":"Kim","year":"2018","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.xphs.2019.01.027_bib17","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1053\/j.gastro.2003.06.005","article-title":"Enterohepatic bile salt transporters in normal physiology and liver disease","volume":"126","author":"Kullak-ublick","year":"2004","journal-title":"Gastroenterology"},{"issue":"7484","key":"10.1016\/j.xphs.2019.01.027_bib18","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature12811","article-title":"Structural basis of the alternating-access mechanism in a bile acid transporter","volume":"505","author":"Zhou","year":"2014","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.xphs.2019.01.027_bib19","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/cphy.c120023","article-title":"Bile acid metabolism and signaling","volume":"3","author":"Chiang","year":"2013","journal-title":"Compr Physiol"},{"issue":"3","key":"10.1016\/j.xphs.2019.01.027_bib20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1021\/mp060022d","article-title":"Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target","volume":"3","author":"Balakrishnan","year":"2006","journal-title":"Mol Pharm"},{"issue":"3","key":"10.1016\/j.xphs.2019.01.027_bib21","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1021\/acsnano.7b01197","article-title":"Advances toward more efficient targeted delivery of nanoparticles in\u00a0vivo: understanding interactions between nanoparticles and cells","volume":"11","author":"Polo","year":"2017","journal-title":"ACS Nano"},{"issue":"12","key":"10.1016\/j.xphs.2019.01.027_bib22","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1023\/A:1016085108889","article-title":"Gastrointestinal uptake of biodegradable microparticles: effect of particle size","volume":"13","author":"Desai","year":"1996","journal-title":"Pharm Res"},{"issue":"6","key":"10.1016\/j.xphs.2019.01.027_bib23","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1021\/acs.molpharmaceut.8b00228","article-title":"Cholesterol and morpholine grafted cationic amphiphilic copolymers for miRNA-34a delivery","volume":"15","author":"Sharma","year":"2018","journal-title":"Mol Pharm"},{"key":"10.1016\/j.xphs.2019.01.027_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.biomaterials.2017.10.022","article-title":"Functional nanoparticles exploit the bile acid pathway to overcome multiple barriers of the intestinal epithelium for oral insulin delivery","volume":"151","author":"Fan","year":"2018","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.xphs.2019.01.027_bib25","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1080\/03639045.2017.1361965","article-title":"Cholesterol derivative-based liposomes for gemcitabine delivery: preparation, in\u00a0vitro, and in\u00a0vivo characterization","volume":"43","author":"Li","year":"2017","journal-title":"Drug Dev Ind Pharm"},{"issue":"2","key":"10.1016\/j.xphs.2019.01.027_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrd1632","article-title":"Recent advances with liposomes as pharmaceutical carriers","volume":"4","author":"Torchilin","year":"2005","journal-title":"Nat Rev Drug Discov"},{"issue":"11","key":"10.1016\/j.xphs.2019.01.027_bib27","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1021\/ja111110e","article-title":"Bacterial toxin-triggered drug release from gold nanoparticle-stabilized liposomes for the treatment of bacterial infection","volume":"133","author":"Pornpattananangkul","year":"2011","journal-title":"J\u00a0Am Chem Soc"},{"issue":"11","key":"10.1016\/j.xphs.2019.01.027_bib28","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.addr.2005.07.008","article-title":"Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems","volume":"57","author":"Takeuchi","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"10.1016\/j.xphs.2019.01.027_bib29","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1080\/10837450.2016.1213745","article-title":"Chitosan\/lecithin liposomal nanovesicles as an oral insulin delivery system","volume":"22","author":"Al-Remawi","year":"2017","journal-title":"Pharm Dev Technol"},{"issue":"6","key":"10.1016\/j.xphs.2019.01.027_bib30","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.nano.2017.05.002","article-title":"Selenium nanoparticles as versatile carriers for oral delivery of insulin: insight into the synergic antidiabetic effect and mechanism","volume":"13","author":"Deng","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.xphs.2019.01.027_bib31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.actbio.2017.10.017","article-title":"Interaction of cruciferin-based nanoparticles with Caco-2 cells and Caco-2\/HT29-MTX co-cultures","volume":"64","author":"Akbari","year":"2017","journal-title":"Acta Biomater"},{"issue":"1","key":"10.1016\/j.xphs.2019.01.027_bib32","doi-asserted-by":"crossref","first-page":"11416","DOI":"10.1038\/s41598-018-29650-w","article-title":"Preparation, physicochemical characterization and antimicrobial activities of novel two phenolic chitosan Schiff base derivatives","volume":"8","author":"Hassan","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.xphs.2019.01.027_bib33","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jconrel.2013.12.034","article-title":"Oral absorption mechanism and anti-angiogenesis effect of taurocholic acid-linked heparin-docetaxel conjugates","volume":"177","author":"Khatun","year":"2014","journal-title":"J\u00a0Control Release"},{"issue":"9","key":"10.1016\/j.xphs.2019.01.027_bib34","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1016\/j.biomaterials.2011.12.038","article-title":"Protease inhibition and absorption enhancement by functional nanoparticles for effective oral insulin delivery","volume":"33","author":"Su","year":"2012","journal-title":"Biomaterials"},{"issue":"3","key":"10.1016\/j.xphs.2019.01.027_bib35","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jconrel.2012.05.029","article-title":"Self-assembled glycol chitosan nanogels containing palmityl-acylated exendin-4 peptide as a long-acting anti-diabetic inhalation system","volume":"161","author":"Lee","year":"2012","journal-title":"J\u00a0Control Release"},{"issue":"26","key":"10.1016\/j.xphs.2019.01.027_bib36","doi-asserted-by":"crossref","first-page":"6272","DOI":"10.1016\/j.biomaterials.2013.05.008","article-title":"Near-infrared light-triggered micelles for fast controlled drug release in deep tissue","volume":"34","author":"Cao","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.xphs.2019.01.027_bib37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.carbpol.2014.12.049","article-title":"Self-assemblied nanocomplexes based on biomimetic amphiphilic chitosan derivatives for protein delivery","volume":"121","author":"Wu","year":"2015","journal-title":"Carbohydr Polym"},{"issue":"27","key":"10.1016\/j.xphs.2019.01.027_bib38","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1016\/j.biomaterials.2012.05.052","article-title":"Somatostatin receptor-mediated tumor-targeting drug delivery using octreotide-PEG-deoxycholic acid conjugate-modified N-deoxycholic acid-O, N-hydroxyethylation chitosan micelles","volume":"33","author":"Huo","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.xphs.2019.01.027_bib39","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.carbpol.2016.12.068","article-title":"Preparation, complexation mechanism and properties of nano-complexes of Astragalus polysaccharide and amphiphilic chitosan derivatives","volume":"161","author":"Lai","year":"2017","journal-title":"Carbohydr Polym"},{"issue":"1-2","key":"10.1016\/j.xphs.2019.01.027_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0169-409X(01)00152-1","article-title":"Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics","volume":"50","author":"Hussain","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"10.1016\/j.xphs.2019.01.027_bib41","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.2042-7158.1988.tb05220.x","article-title":"Gastric emptying of large single unit dosage forms","volume":"40","author":"Davis","year":"1988","journal-title":"J\u00a0Pharm Pharmacol"},{"key":"10.1016\/j.xphs.2019.01.027_bib42","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0378-5173(93)90029-F","article-title":"Gastrointestinal transit of a matrix tablet formulation: comparison of canine and human data","volume":"94","author":"Davis","year":"1993","journal-title":"Int J Pharm"},{"issue":"8","key":"10.1016\/j.xphs.2019.01.027_bib43","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1023\/A:1014849630520","article-title":"Impact of regional intestinal ph modulation on absorption of peptide drugs: oral absorption studies of salmon calcitonin in beagle dogs","volume":"16","author":"Lee","year":"1999","journal-title":"Pharm Res"},{"issue":"1","key":"10.1016\/j.xphs.2019.01.027_bib44","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0378-5173(98)00400-1","article-title":"Gastrointestinal transit of pellets in rats: effect of size and density","volume":"180","author":"Tuleu","year":"1999","journal-title":"Int J Pharm"},{"issue":"10","key":"10.1016\/j.xphs.2019.01.027_bib45","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.2217\/nnm.15.36","article-title":"Oral insulin delivery using deoxycholic acid conjugated PEGylated polyhydroxybutyrate co-polymeric nanoparticles","volume":"10","author":"Chaturvedi","year":"2015","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.xphs.2019.01.027_bib46","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ejpb.2017.03.005","article-title":"Surfactin variants for intra-intestinal delivery of insulin","volume":"115","author":"Zhang","year":"2017","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.xphs.2019.01.027_bib47","article-title":"Optical density ratio of the subretinal fluid in choroidal melanoma and metastasis","author":"Leshno","year":"2017","journal-title":"Retina"},{"issue":"5","key":"10.1016\/j.xphs.2019.01.027_bib48","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/j.drudis.2017.08.011","article-title":"Strategies for the enhanced intracellular delivery of nanomaterials","volume":"23","author":"Azevedo","year":"2018","journal-title":"Drug Discov Today"},{"issue":"26","key":"10.1016\/j.xphs.2019.01.027_bib49","doi-asserted-by":"crossref","first-page":"21847","DOI":"10.1021\/acsami.8b04301","article-title":"Improved cell transfection of siRNA by pH-responsive nanomicelles self-assembled with mPEG- b-PHis- b-PEI copolymers","volume":"10","author":"Xu","year":"2018","journal-title":"ACS Appl Mater Inter"},{"issue":"6","key":"10.1016\/j.xphs.2019.01.027_bib50","doi-asserted-by":"crossref","first-page":"e67100","DOI":"10.1371\/journal.pone.0067100","article-title":"Endocytic trafficking of nanoparticles delivered by cell-penetrating peptides comprised of nona-arginine and a penetration accelerating sequence","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.xphs.2019.01.027_bib51","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/1471-2105-14-349","article-title":"MosaicIA: an ImageJ\/Fiji plugin for spatial pattern and interaction analysis","volume":"14","author":"Shivanandan","year":"2013","journal-title":"BMC Bioinformatics"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354919300772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354919300772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T09:25:59Z","timestamp":1662888359000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354919300772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0022354919300772"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2019.01.027","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Delivery System for Oral Administration of Proteins\/Peptides Through Bile Acid Transport Channels","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2019.01.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}