{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:50:54Z","timestamp":1776271854238,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.xphs.2019.05.016","type":"journal-article","created":{"date-parts":[[2019,5,25]],"date-time":"2019-05-25T10:32:23Z","timestamp":1558780343000},"page":"3124-3129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development of an In\u00a0Vivo Retrodialysis Calibration Method Using Stable Isotope Labeling to Monitor Metabolic Pathways in the Tumor Microenvironment via Microdialysis"],"prefix":"10.1016","volume":"108","author":[{"given":"Derek W.","family":"Bartlett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aidong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick","family":"Kindt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.xphs.2019.05.016_bib1","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic competition in the tumor microenvironment is a driver of cancer progression","volume":"162","author":"Chang","year":"2015","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.xphs.2019.05.016_bib2","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1002\/1873-3468.12784","article-title":"Immunosuppressive enzymes in the tumor microenvironment","volume":"591","author":"Molinier-Frenkel","year":"2017","journal-title":"FEBS Lett"},{"key":"10.1016\/j.xphs.2019.05.016_bib3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fimmu.2017.00248","article-title":"Metabolic hallmarks of tumor and immune cells in the tumor microenvironment","volume":"8","author":"Renner","year":"2017","journal-title":"Front Immunol"},{"issue":"24","key":"10.1016\/j.xphs.2019.05.016_bib4","doi-asserted-by":"crossref","first-page":"6795","DOI":"10.1158\/0008-5472.CAN-17-2285","article-title":"Discovery of Ido1 inhibitors: from bench to bedside","volume":"77","author":"Prendergast","year":"2017","journal-title":"Cancer Res"},{"issue":"10","key":"10.1016\/j.xphs.2019.05.016_bib5","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1158\/2326-6066.CIR-18-0056","article-title":"A2AR antagonism with CPI-444 induces antitumor responses and augments efficacy to anti-PD-(L)1 and anti-CTLA-4 in preclinical models","volume":"6","author":"Willingham","year":"2018","journal-title":"Cancer Immunol Res"},{"issue":"10","key":"10.1016\/j.xphs.2019.05.016_bib6","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nrc.2016.71","article-title":"From Krebs to clinic: glutamine metabolism to cancer therapy","volume":"16","author":"Altman","year":"2016","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"10.1016\/j.xphs.2019.05.016_bib7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nm.4464","article-title":"Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models","volume":"24","author":"Schulte","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.xphs.2019.05.016_bib8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fonc.2015.00115","article-title":"Tumor interstitial fluid formation, characterization, and clinical implications","volume":"5","author":"Wagner","year":"2015","journal-title":"Front Oncol"},{"key":"10.1016\/j.xphs.2019.05.016_bib9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1755-1536-3-12","article-title":"Interstitial fluid: the overlooked component of the tumor microenvironment?","volume":"3","author":"Wiig","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"5","key":"10.1016\/j.xphs.2019.05.016_bib10","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1208\/s12248-017-0108-2","article-title":"Microdialysis as an important technique in systems pharmacology-a historical and methodological review","volume":"19","author":"Hammarlund-Udenaes","year":"2017","journal-title":"AAPS J"},{"key":"10.1016\/j.xphs.2019.05.016_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0701s47","article-title":"Overview of brain microdialysis","author":"Chefer","year":"2009","journal-title":"Curr Protoc Neurosci"},{"issue":"4","key":"10.1016\/j.xphs.2019.05.016_bib12","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1208\/s12248-017-0050-3","article-title":"Microdialysis: the key to physiologically based model prediction of human CNS target site concentrations","volume":"19","author":"Yamamoto","year":"2017","journal-title":"AAPS J"},{"issue":"13","key":"10.1016\/j.xphs.2019.05.016_bib13","first-page":"2602","article-title":"The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine","volume":"57","author":"Blay","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.xphs.2019.05.016_bib14","series-title":"Applications of Microdialysis in Pharmaceutical Science","first-page":"403","article-title":"Microdialysis use in tumors: drug disposition and tumor response","author":"Zhou","year":"2011"},{"key":"10.1016\/j.xphs.2019.05.016_bib15","doi-asserted-by":"crossref","first-page":"42733","DOI":"10.1038\/srep42733","article-title":"Increased nutrient availability in dense breast tissue of postmenopausal women in\u00a0vivo","volume":"7","author":"Abrahamsson","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.xphs.2019.05.016_bib16","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1208\/s12248-017-0114-4","article-title":"Microdialysis coupled with LC-MS\/MS for in\u00a0vivo neurochemical monitoring","volume":"19","author":"Zestos","year":"2017","journal-title":"AAPS J"},{"key":"10.1016\/j.xphs.2019.05.016_bib17","series-title":"Microdialysis in Drug Development","first-page":"13","article-title":"Recovery and calibration techniques: toward quantitative microdialysis","author":"de Lange","year":"2013"},{"issue":"8","key":"10.1016\/j.xphs.2019.05.016_bib18","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.xphs.2018.04.021","article-title":"Simultaneous retrodialysis by calibrator for rapid in\u00a0vivo recovery determination in target site microdialysis","volume":"107","author":"Yu","year":"2018","journal-title":"J\u00a0Pharm Sci"},{"issue":"5","key":"10.1016\/j.xphs.2019.05.016_bib19","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1021\/cn300199m","article-title":"In\u00a0vivo calibration of microdialysis using infusion of stable-isotope labeled neurotransmitters","volume":"4","author":"Hershey","year":"2013","journal-title":"ACS Chem Neurosci"},{"issue":"2","key":"10.1016\/j.xphs.2019.05.016_bib20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0024-3205(90)90043-Q","article-title":"Steady-state theory for quantitative microdialysis of solutes and water in\u00a0vivo and in\u00a0vitro","volume":"46","author":"Bungay","year":"1990","journal-title":"Life Sci"},{"key":"10.1016\/j.xphs.2019.05.016_bib21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/978-1-4615-4709-9_35","article-title":"Effect of kynurenine on tryptophan-albumin binding in human plasma","volume":"467","author":"Cangiano","year":"1999","journal-title":"Adv Exp Med Biol"},{"issue":"12","key":"10.1016\/j.xphs.2019.05.016_bib22","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1172\/JCI103568","article-title":"Unbound amino acid concentrations in human blood plasmas","volume":"36","author":"McMenamy","year":"1957","journal-title":"J\u00a0Clin Invest"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354919303181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354919303181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:27:00Z","timestamp":1758360420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354919303181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0022354919303181"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2019.05.016","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of an In\u00a0Vivo Retrodialysis Calibration Method Using Stable Isotope Labeling to Monitor Metabolic Pathways in the Tumor Microenvironment via Microdialysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2019.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}