{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:14:10Z","timestamp":1777724050734,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["2017.0801"],"award-info":[{"award-number":["2017.0801"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2013-CoG 614739-A _HERO"],"award-info":[{"award-number":["ERC-2013-CoG 614739-A _HERO"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.xphs.2020.02.002","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T10:46:17Z","timestamp":1581763577000},"page":"1819-1826","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Preparation, Physicochemical Characterization and In\u00a0Vitro and In\u00a0Vivo Activity Against Heligmosomoides polygyrus of Novel Oral Formulations of Albendazole and Mebendazole"],"prefix":"10.1016","volume":"109","author":[{"given":"Valentin","family":"Buchter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"Priotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dar\u00edo","family":"Leonardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda C.","family":"Lamas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10117","key":"10.1016\/j.xphs.2020.02.002_bib1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0140-6736(17)31930-X","article-title":"Soil-transmitted helminth infections","volume":"391","author":"Jourdan","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.xphs.2020.02.002_bib3","series-title":"Investing to overcome the global impact of neglected tropical diseases Third WHO report on neglected tropical diseases","year":"2015"},{"key":"10.1016\/j.xphs.2020.02.002_bib4","doi-asserted-by":"crossref","first-page":"j4307","DOI":"10.1136\/bmj.j4307","article-title":"Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis","volume":"358","author":"Moser","year":"2017","journal-title":"BMJ"},{"issue":"16","key":"10.1016\/j.xphs.2020.02.002_bib5","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1001\/jama.299.16.1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis","volume":"299","author":"Keiser","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.xphs.2020.02.002_bib6","series-title":"Guideline: Preventive Chemotherapy to Control Soil-Transmitted Helminth Infections in At-Risk Population Groups Guideline: Preventive Chemotherapy to Control Soil-Transmitted Helminth Infections in At-Risk Population Groups","year":"2017"},{"issue":"3","key":"10.1016\/j.xphs.2020.02.002_bib7","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1208\/s12249-017-0927-6","article-title":"Application of fluorescence emission for characterization of albendazole and ricobendazole micellar systems: elucidation of the molecular mechanism of drug solubilization process","volume":"19","author":"Priotti","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.xphs.2020.02.002_bib8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jpba.2016.01.035","article-title":"Mebendazole crystal forms in tablet formulations. An ATR-FTIR\/chemometrics approach to polymorph assignment","volume":"122","author":"Calvo","year":"2016","journal-title":"J\u00a0Pharm Biomed Anal"},{"issue":"3","key":"10.1016\/j.xphs.2020.02.002_bib9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1016212804288","article-title":"A\u00a0theoretical basis for a biopharmaceutic drug classification: the correlation of in\u00a0vitro drug product dissolution and in\u00a0vivo bioavailability","volume":"12","author":"Amidon","year":"1995","journal-title":"Pharm Res"},{"issue":"1","key":"10.1016\/j.xphs.2020.02.002_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.2042-7158.1998.tb03303.x","article-title":"Biopharmaceutics: absorption studies of albendazole and some physicochemical properties of the drug and its metabolite albendazole sulphoxide","volume":"50","author":"Jung","year":"1997","journal-title":"J\u00a0Pharm Pharmacol"},{"key":"10.1016\/j.xphs.2020.02.002_bib11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejps.2014.01.009","article-title":"The Biopharmaceutics Classification System: subclasses for in\u00a0vivo predictive dissolution (IPD) methodology and IVIVC","volume":"57","author":"Tsume","year":"2014","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.xphs.2020.02.002_bib12","series-title":"List of Nationally Authorised Medicinal Products","year":"2016"},{"issue":"7","key":"10.1016\/j.xphs.2020.02.002_bib13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.31083\/ph.2013.6507","article-title":"Salt screening and characterization for poorly soluble, weak basic compounds: case study albendazole","volume":"68","author":"Paulekuhn","year":"2013","journal-title":"Pharmazie"},{"issue":"2","key":"10.1016\/j.xphs.2020.02.002_bib14","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bmcl.2015.11.067","article-title":"Promising applications in drug delivery systems of a novel \u00e2-cyclodextrin derivative obtained by green synthesis","volume":"26","author":"Garc\u00eda","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"issue":"2","key":"10.1016\/j.xphs.2020.02.002_bib15","doi-asserted-by":"crossref","first-page":"e88234","DOI":"10.1371\/journal.pone.0088234","article-title":"Modified \u03b2-cyclodextrin inclusion complex to improve the physicochemical properties of albendazole. Complete in\u00a0vitro evaluation and characterization","volume":"9","author":"Garc\u00eda","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.xphs.2020.02.002_bib16","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3390\/ma8020486","article-title":"Exploring the preparation of albendazole-loaded chitosan-tripolyphosphate nanoparticles","volume":"8","author":"Kang","year":"2015","journal-title":"Materials"},{"key":"10.1016\/j.xphs.2020.02.002_bib17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.colsurfb.2012.08.017","article-title":"Dissolution process analysis using model-free Noyes-Whitney integral equation","volume":"102","author":"Hattori","year":"2013","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"1-2","key":"10.1016\/j.xphs.2020.02.002_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2006.07.011","article-title":"A\u00a0century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system","volume":"321","author":"Dokoumetzidis","year":"2006","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2020.02.002_bib19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.powtec.2014.11.002","article-title":"A\u00a0novel method for determining surface free energy of powders using Washburn's equation without calculating capillary factor and contact angle","volume":"271","author":"Ji","year":"2015","journal-title":"Powder Technol"},{"key":"10.1016\/j.xphs.2020.02.002_bib20","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s40995-017-0150-z","article-title":"Albendazole and praziquantel chitosan nanoparticles: preparation, characterization, and in\u00a0vitro release study","volume":"42","author":"Torabi","year":"2017","journal-title":"Iran J Sci Technol Trans Sci"},{"issue":"35","key":"10.1016\/j.xphs.2020.02.002_bib21","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1002\/anie.200701355","article-title":"A\u00a0versatile bottom-up assembly approach to colloidal spheres from nanocrystals","volume":"46","author":"Bai","year":"2007","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.xphs.2020.02.002_bib22","series-title":"United States Pharmacopeia and National Formulary (USP 30-NF 25)","year":"2006"},{"key":"10.1016\/j.xphs.2020.02.002_bib23","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.2147\/IJN.S141504","article-title":"A\u00a0top-down technique to improve the solubility and bioavailability of aceclofenac: in\u00a0vitro and in\u00a0vivo studies","volume":"12","author":"Narayan","year":"2017","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.xphs.2020.02.002_bib24","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejpb.2018.09.018","article-title":"The influence of polymer excipients on the dissolution and recrystallization behavior of ketoconazole: application, variation and practical aspects of a pH shift method","volume":"133","author":"Ullrich","year":"2018","journal-title":"Eur J Pharm Biopharm"},{"issue":"1","key":"10.1016\/j.xphs.2020.02.002_bib25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.2042-7158.1975.tb09378.x","article-title":"The concept of dissolution efficiency","volume":"27","author":"Khan","year":"1975","journal-title":"J\u00a0Pharm Pharmacol"},{"issue":"4","key":"10.1016\/j.xphs.2020.02.002_bib26","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jsps.2018.01.015","article-title":"Comparison between the dissolution profiles of nine meloxicam tablet brands commercially available in Buenos Aires, Argentina","volume":"26","author":"Simionato","year":"2018","journal-title":"Saudi Pharm J"},{"issue":"1-2","key":"10.1016\/j.xphs.2020.02.002_bib27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijpharm.2010.10.002","article-title":"Changed crystallinity of mebendazole solid dispersion: improved anthelmintic activity","volume":"403","author":"Garc\u00eda-Rodriguez","year":"2011","journal-title":"Int J Pharm"},{"issue":"6","key":"10.1016\/j.xphs.2020.02.002_bib28","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00281-012-0347-3","article-title":"Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus","volume":"34","author":"Reynolds","year":"2012","journal-title":"Semin Immunopathol"},{"issue":"2","key":"10.1016\/j.xphs.2020.02.002_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ijpddr.2017.03.005","article-title":"Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in\u00a0vitro and in\u00a0vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes","volume":"7","author":"Cowan","year":"2017","journal-title":"Int J Parasitol Drugs Drug Resist"},{"issue":"3","key":"10.1016\/j.xphs.2020.02.002_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics11030134","article-title":"Formulation development of albendazole-loaded self-microemulsifying chewable tablets to enhance dissolution and bioavailability","volume":"11","author":"Sawatdee","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.xphs.2020.02.002_bib31","first-page":"1","article-title":"Evaluation and study of mebendazole polymorphs present in raw materials and tablets available in the Brazilian pharmaceutical market","volume":"4","author":"Garbuio","year":"2014","journal-title":"J\u00a0Appl Pharm Sci"},{"issue":"1","key":"10.1016\/j.xphs.2020.02.002_bib32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1211\/jpp.60.1.0008","article-title":"Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments","volume":"60","author":"McConnell","year":"2007","journal-title":"J\u00a0Pharm Pharmacol"},{"issue":"9","key":"10.1016\/j.xphs.2020.02.002_bib33","doi-asserted-by":"crossref","first-page":"e0003950","DOI":"10.1371\/journal.pntd.0003950","article-title":"Efficacy of albendazole-chitosan microsphere-based treatment for alveolar echinococcosis in mice","volume":"9","author":"Abulaihaiti","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.xphs.2020.02.002_bib34","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s00436-018-5849-z","article-title":"In\u00a0vitro and in\u00a0vivo effects of chitosan-praziquantel and chitosan-albendazole nanoparticles on Echinococcus granulosus metacestodes","volume":"117","author":"Torabi","year":"2018","journal-title":"Parasitol Res"},{"issue":"6","key":"10.1016\/j.xphs.2020.02.002_bib35","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.parint.2013.08.009","article-title":"Novel albendazole formulations given during the intestinal phase of Trichinella spiralis infection reduce effectively parasitic muscle burden in mice","volume":"62","author":"Garc\u00eda","year":"2013","journal-title":"Parasitol Int"},{"key":"10.1016\/j.xphs.2020.02.002_bib36","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.molstruc.2018.02.060","article-title":"Synthesis, characterization and solubility of a new anthelmintic salt: mebendazole nitrate","volume":"1161","author":"Guti\u00e9rrez","year":"2018","journal-title":"J\u00a0Mol Struct"},{"key":"10.1016\/j.xphs.2020.02.002_bib37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejps.2015.11.012","article-title":"An in\u00a0vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: design, implementation, and evaluation","volume":"82","author":"Kourentas","year":"2016","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"10.1016\/j.xphs.2020.02.002_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","article-title":"Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans","volume":"114","author":"Brunetti","year":"2010","journal-title":"Acta Trop"},{"issue":"3","key":"10.1016\/j.xphs.2020.02.002_bib39","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/jps.24319","article-title":"Physicochemical characterization of cyclodextrin\u2013drug interactions in the solid state and the effect of water on these interactions","volume":"104","author":"Ogawa","year":"2015","journal-title":"J\u00a0Pharm Sci"},{"issue":"3","key":"10.1016\/j.xphs.2020.02.002_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics10030098","article-title":"Co-amorphous solid dispersions for solubility and absorption improvement of drugs: composition, preparation, characterization and formulations for oral delivery","volume":"10","author":"Karagianni","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.xphs.2020.02.002_bib41","series-title":"Chitosan. Comprehensive Biomaterials","first-page":"279","author":"Barbosa","year":"2017"},{"key":"10.1016\/j.xphs.2020.02.002_bib42","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s13346-018-0591-8","article-title":"Synthesis and characterization of a new cyclodextrin derivative with improved properties to design oral dosage forms","volume":"9","author":"Garc\u00eda","year":"2018","journal-title":"Drug Deliv Transl Res"},{"issue":"3","key":"10.1016\/j.xphs.2020.02.002_bib43","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00436-017-5740-3","article-title":"Inclusion complex and nanoclusters of cyclodextrin to increase the solubility and efficacy of albendazole","volume":"117","author":"Pacheco","year":"2018","journal-title":"Parasitol Res"},{"issue":"9","key":"10.1016\/j.xphs.2020.02.002_bib44","first-page":"3659","article-title":"Complexation of albendazole with hydroxypropyl-\u03b2-cyclodextrin significantly improves its pharmacokinetic profile, cell cytotoxicity and antitumor efficacy in nude mice","volume":"32","author":"Ehteda","year":"2012","journal-title":"Anticancer Res"},{"issue":"2","key":"10.1016\/j.xphs.2020.02.002_bib45","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jconrel.2007.07.018","article-title":"The utility of cyclodextrins for enhancing oral bioavailability","volume":"123","author":"Carrier","year":"2007","journal-title":"J\u00a0Control Release"},{"issue":"3","key":"10.1016\/j.xphs.2020.02.002_bib46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1208\/s12248-010-9203-3","article-title":"The use of biorelevant dissolution media to forecast the in\u00a0vivo performance of a drug","volume":"12","author":"Klein","year":"2010","journal-title":"AAPS J"},{"issue":"3","key":"10.1016\/j.xphs.2020.02.002_bib47","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.xphs.2018.10.044","article-title":"Application of a refined\u00a0developability classification system","volume":"108","author":"Rosenberger","year":"2019","journal-title":"J\u00a0Pharm Sci"},{"issue":"5","key":"10.1016\/j.xphs.2020.02.002_bib48","first-page":"267","article-title":"Effect of gastric pH on the bioavailability of albendazole in rabbits","volume":"4","author":"Kohri","year":"1998","journal-title":"Pharm Pharmacol Commun"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920300757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920300757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:28Z","timestamp":1777420828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354920300757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0022354920300757"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2020.02.002","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preparation, Physicochemical Characterization and In\u00a0Vitro and In\u00a0Vivo Activity Against Heligmosomoides polygyrus of Novel Oral Formulations of Albendazole and Mebendazole","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2020.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}