{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:07:08Z","timestamp":1790230028208,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2018YFC0808401"],"award-info":[{"award-number":["2018YFC0808401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51474158"],"award-info":[{"award-number":["51474158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province of China","doi-asserted-by":"publisher","award":["2016CFA088"],"award-info":[{"award-number":["2016CFA088"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.xphs.2020.02.003","type":"journal-article","created":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T02:15:18Z","timestamp":1581732918000},"page":"1772-1779","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["A Novel Controllable Pneumatic Needle-Free Injection System for Larger-Volume Drug Delivery"],"prefix":"10.1016","volume":"109","author":[{"given":"Dongping","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanqing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.xphs.2020.02.003_bib1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrd1304","article-title":"Current status and future potential of transdermal drug delivery","volume":"3","author":"Prausnitz","year":"2004","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"10.1016\/j.xphs.2020.02.003_bib2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.addr.2005.12.003","article-title":"Needle-free vaccine delivery","volume":"58","author":"Giudice","year":"2006","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"10.1016\/j.xphs.2020.02.003_bib3","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.addr.2012.07.016","article-title":"Devices for overcoming biological barriers: the use of physical forces to disrupt the barriers","volume":"65","author":"Mitragotri","year":"2013","journal-title":"Adv Drug Deliv Rev"},{"issue":"12","key":"10.1016\/j.xphs.2020.02.003_bib4","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nri1728","article-title":"Immunization without needles","volume":"5","author":"Mitragotri","year":"2005","journal-title":"Nat Rev Immunol"},{"issue":"13","key":"10.1016\/j.xphs.2020.02.003_bib5","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1089\/10430340260201644","article-title":"Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular\/intradermal routes","volume":"13","author":"Epstein","year":"2002","journal-title":"Hum Gene Ther"},{"issue":"3","key":"10.1016\/j.xphs.2020.02.003_bib6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1053\/apnr.2002.34142","article-title":"Intramuscular injection: an integrative research review and guideline for evidence-based practice","volume":"15","author":"Nicoll","year":"2002","journal-title":"Appl Nurs Res"},{"issue":"12","key":"10.1016\/j.xphs.2020.02.003_bib7","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/j.1365-4632.2010.04627.x","article-title":"Clinical results of skin remodeling using a novel pneumatic technology","volume":"49","author":"Alex","year":"2010","journal-title":"Int J Dermatol"},{"issue":"4","key":"10.1016\/j.xphs.2020.02.003_bib8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1467-2995.2012.00717.x","article-title":"Onset, duration and efficacy of four methods of local anesthesia of the horn bud in calves","volume":"39","author":"Fierheller","year":"2012","journal-title":"Vet Anaesth Analg"},{"issue":"8","key":"10.1016\/j.xphs.2020.02.003_bib9","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1208\/s12249-017-0779-0","article-title":"An innovative needle-free injection system: comparison to 1 mL standard subcutaneous injection","volume":"18","author":"Kojic","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.xphs.2020.02.003_bib10","first-page":"7341","article-title":"A\u00a0compound ampoule for large-volume controllable jet injection","volume":"2015","author":"Ruddy","year":"2015","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"10.1016\/j.xphs.2020.02.003_bib11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2018.04.054","article-title":"The effect of jet speed on large volume jet injection","volume":"280","author":"McKeage","year":"2018","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.xphs.2020.02.003_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jconrel.2018.10.025","article-title":"Power-efficient controlled jet injection using a compound ampoule","volume":"291","author":"McKeage","year":"2018","journal-title":"J\u00a0Control Release"},{"issue":"9","key":"10.1016\/j.xphs.2020.02.003_bib13","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.medengphy.2011.12.010","article-title":"Needle-free jet injection using real-time controlled linear Lorentz-force actuators","volume":"34","author":"Taberner","year":"2012","journal-title":"Med Eng Phys"},{"key":"10.1016\/j.xphs.2020.02.003_bib14","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1109\/IEMBS.2006.260243","article-title":"A\u00a0portable needle-free jet injector based on a custom high power-density voice-coil actuator","volume":"1","author":"Taberner","year":"2006","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"issue":"1-2","key":"10.1016\/j.xphs.2020.02.003_bib15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jconrel.2007.08.017","article-title":"Piezoelectric control of needle-free transdermal drug delivery","volume":"124","author":"Stachowiak","year":"2007","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.xphs.2020.02.003_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2017.09.013","article-title":"Recent advances of controlled drug delivery using microfluidic platforms","volume":"128","author":"Sanjay","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"10.1016\/j.xphs.2020.02.003_bib17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jconrel.2009.01.003","article-title":"Dynamic control of needle-free jet injection","volume":"135","author":"Stachowiak","year":"2009","journal-title":"J\u00a0Control Release"},{"issue":"10","key":"10.1016\/j.xphs.2020.02.003_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JBO.22.10.105003","article-title":"Toward jet\u00a0injection by continuous-wave laser cavitation","volume":"22","author":"Rodr\u00edguez","year":"2017","journal-title":"J\u00a0Biomed Opt"},{"issue":"8","key":"10.1016\/j.xphs.2020.02.003_bib19","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1007\/s12206-019-0728-9","article-title":"Numerical analysis and simulation of an impulse driven piezoelectric needle-free jet injector","volume":"33","author":"Trimzi","year":"2019","journal-title":"J\u00a0Mech Sci Technol"},{"issue":"5","key":"10.1016\/j.xphs.2020.02.003_bib20","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1109\/TMECH.2017.2725345","article-title":"Optimization of portable electronically-controlled needle-free jet injection systems","volume":"22","author":"Ruddy","year":"2017","journal-title":"IEEE-ASME T Mech"},{"key":"10.1016\/j.xphs.2020.02.003_bib21","first-page":"292","article-title":"Needle-free small-volume liquid injection system powered by a rotary actuator","volume":"2017","author":"Zhang","year":"2017","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"10.1016\/j.xphs.2020.02.003_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jconrel.2019.05.040","article-title":"Subcutaneous nicotine delivery via needle-free jet injection: a porcine model","volume":"306","author":"Ruddy","year":"2019","journal-title":"J\u00a0Control Release"},{"issue":"10","key":"10.1016\/j.xphs.2020.02.003_bib23","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1517\/17425247.2015.1049531","article-title":"Needle-free delivery of macromolecules through the skin using controllable jet injectors","volume":"12","author":"Hogan","year":"2015","journal-title":"Expert Opin Drug Del"},{"key":"10.1016\/j.xphs.2020.02.003_bib24","doi-asserted-by":"crossref","first-page":"118503","DOI":"10.1016\/j.ijpharm.2019.118503","article-title":"In-vitro studies of jet injections","volume":"568","author":"Rohilla","year":"2019","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2020.02.003_bib25","series-title":"Design of a Linear Permanent Magnet Synchronous Motor for Needle-Free Jet Injection; 2017 IEEE Energy Conversion Congress and Exposition (ECCE 2017). Proceedings of a meeting held 1-5 October 2017, Cincinnati, Ohio, USA","first-page":"4734","year":"2017"},{"key":"10.1016\/j.xphs.2020.02.003_bib26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.biosystemseng.2015.04.010","article-title":"Effect of injection pressure and fluid volume and density on the jet dispersion pattern of needle-free injection devices","volume":"138","author":"Grant","year":"2015","journal-title":"Biosyst Eng"},{"issue":"2","key":"10.1016\/j.xphs.2020.02.003_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.forsciint.2003.11.036","article-title":"Preparing ballistic gelatine\u2014review and proposal for a standard method","volume":"141","author":"Jussila","year":"2004","journal-title":"Forensic Sci Int"},{"issue":"4","key":"10.1016\/j.xphs.2020.02.003_bib28","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.xphs.2017.12.001","article-title":"A\u00a0mathematical model and experimental verification of optimal nozzle diameter in needle-free injection","volume":"107","author":"Zeng","year":"2018","journal-title":"J\u00a0Pharm Sci"},{"issue":"11","key":"10.1016\/j.xphs.2020.02.003_bib29","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1007\/s12206-019-1051-1","article-title":"An experimental study of a spring-loaded needle-free injector: influence of the ejection volume and injector orifice diameter","volume":"33","author":"Zeng","year":"2019","journal-title":"J\u00a0Mech Sci Technol"},{"issue":"11","key":"10.1016\/j.xphs.2020.02.003_bib30","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1023\/A:1020753329492","article-title":"Transdermal drug delivery by jet injectors: energetics of jet formation and penetration","volume":"19","author":"Joy","year":"2002","journal-title":"Pharm Res"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920300769?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920300769?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:28:26Z","timestamp":1758360506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354920300769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0022354920300769"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2020.02.003","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Novel Controllable Pneumatic Needle-Free Injection System for Larger-Volume Drug Delivery","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2020.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}