{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:13:56Z","timestamp":1793196836641,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI120176"],"award-info":[{"award-number":["UM1AI120176"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871481"],"award-info":[{"award-number":["81871481"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571802"],"award-info":[{"award-number":["81571802"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2016J06020"],"award-info":[{"award-number":["2016J06020"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201706655015"],"award-info":[{"award-number":["201706655015"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.xphs.2020.02.010","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T09:19:19Z","timestamp":1582017559000},"page":"1780-1788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Optimizing a Novel Au-Grafted Lipid Nanoparticle Through Chelation Chemistry for High Photothermal Biologic Activity"],"prefix":"10.1016","volume":"109","author":[{"given":"Yu","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxin","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney J.Y.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.xphs.2020.02.010_bib1","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.3390\/ijms19071979","article-title":"Gold nanoparticles in diagnostics and therapeutics for human cancer","volume":"19","author":"Singh","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.xphs.2020.02.010_bib2","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1039\/b806051g","article-title":"Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity","volume":"38","author":"Boisselier","year":"2009","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.xphs.2020.02.010_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jcis.2016.10.065","article-title":"How does the size of gold nanoparticles depend on citrate to gold ratio in Turkevich synthesis? Final answer to a debated question","volume":"492","author":"Shi","year":"2017","journal-title":"J\u00a0Colloid Interface Sci"},{"issue":"24","key":"10.1016\/j.xphs.2020.02.010_bib4","doi-asserted-by":"crossref","first-page":"9910","DOI":"10.1021\/ja303787e","article-title":"Ultrahigh nanoparticle stability against salt, pH, and solvent with retained surface accessibility via depletion stabilization","volume":"134","author":"Zhang","year":"2012","journal-title":"J\u00a0Am Chem Soc"},{"issue":"1","key":"10.1016\/j.xphs.2020.02.010_bib5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1039\/C7BM00747G","article-title":"Zwitterionic stealth peptide-protected gold nanoparticles enable long circulation without the accelerated blood clearance phenomenon","volume":"6","author":"Zhao","year":"2017","journal-title":"Biomater Sci"},{"key":"10.1016\/j.xphs.2020.02.010_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2017.08.017","article-title":"RGD peptide-modified fluorescent gold nanoclusters as highly efficient tumor-targeted radiotherapy sensitizers","volume":"144","author":"Liang","year":"2017","journal-title":"Biomaterials"},{"issue":"37","key":"10.1016\/j.xphs.2020.02.010_bib7","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1039\/C7NR04062H","article-title":"Multivalent gold nanoparticle-peptide conjugates for targeting intracellular bacterial infections","volume":"9","author":"Chowdhury","year":"2017","journal-title":"Nanoscale"},{"key":"10.1016\/j.xphs.2020.02.010_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.carbpol.2017.10.042","article-title":"Green synthesis of bioactive polysaccharide-capped gold nanoparticles for lymph node CT imaging","volume":"181","author":"Uthaman","year":"2018","journal-title":"Carbohyd Polym"},{"key":"10.1016\/j.xphs.2020.02.010_bib9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biomaterials.2016.07.009","article-title":"Gold nanoparticle-DNA aptamer conjugate-assisted delivery of antimicrobial peptide effectively eliminates intracellular Salmonella enterica serovar Typhimurium","volume":"104","author":"Yeom","year":"2016","journal-title":"Biomaterials"},{"issue":"9","key":"10.1016\/j.xphs.2020.02.010_bib10","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/smll.201303329","article-title":"Near infrared light-triggered drug generation and release from gold nanoparticle carriers for photodynamic therapy","volume":"10","author":"Cheng","year":"2014","journal-title":"Small"},{"issue":"16","key":"10.1016\/j.xphs.2020.02.010_bib11","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.2174\/0929867325666180117111404","article-title":"Surface-bioengineered gold nanoparticles for biomedical applications","volume":"25","author":"Miao","year":"2018","journal-title":"Curr Med Chem"},{"issue":"13","key":"10.1016\/j.xphs.2020.02.010_bib12","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.2217\/nnm.14.147","article-title":"Gold nanoparticle-mediated photothermal therapy: current status and future perspective","volume":"9","author":"Hwang","year":"2014","journal-title":"Nanomedicine"},{"issue":"7","key":"10.1016\/j.xphs.2020.02.010_bib13","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2217\/nnm.14.55","article-title":"Targeted radiotherapy with gold nanoparticles: current status and future perspectives","volume":"9","author":"Ngwa","year":"2014","journal-title":"Nanomedicine"},{"issue":"3","key":"10.1016\/j.xphs.2020.02.010_bib14","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1039\/C0CS00018C","article-title":"Biodistribution and toxicity of engineered gold nanoparticles: a review of in\u00a0vitro and in\u00a0vivo studies","volume":"40","author":"Khlebtsov","year":"2011","journal-title":"Chem Soc Rev"},{"issue":"8","key":"10.1016\/j.xphs.2020.02.010_bib15","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.nano.2014.06.005","article-title":"Short- and long-term distribution and toxicity of gold nanoparticles in the rat after a single-dose intravenous administration","volume":"10","author":"Fraga","year":"2014","journal-title":"Nanomedicine"},{"issue":"8","key":"10.1016\/j.xphs.2020.02.010_bib16","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1007\/s11671-009-9334-6","article-title":"Assessment of the in\u00a0vivo toxicity of gold nanoparticles","volume":"4","author":"Chen","year":"2009","journal-title":"Nanoscale Res Lett"},{"issue":"9","key":"10.1016\/j.xphs.2020.02.010_bib17","doi-asserted-by":"crossref","first-page":"e13082","DOI":"10.1371\/journal.pone.0013082","article-title":"Novel Gd nanoparticles enhance vascular contrast for high-resolution magnetic resonance imaging","volume":"5","author":"Bui","year":"2010","journal-title":"PLoS One"},{"issue":"32","key":"10.1016\/j.xphs.2020.02.010_bib18","doi-asserted-by":"crossref","first-page":"15700","DOI":"10.1021\/jp061667w","article-title":"Turkevich method for gold nanoparticle synthesis revisited","volume":"110","author":"Kimling","year":"2006","journal-title":"J\u00a0Phys Chem B"},{"issue":"11","key":"10.1016\/j.xphs.2020.02.010_bib19","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1021\/ac0702084","article-title":"Determination of size and concentration of gold nanoparticles from UV-vis spectra","volume":"79","author":"Haiss","year":"2007","journal-title":"Anal Chem"},{"key":"10.1016\/j.xphs.2020.02.010_bib20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.colsurfa.2012.01.031","article-title":"Gold nanoparticles formation in the aqueous system of gold(III) chloride complex ions and hydrazine sulfate-Kinetic studies","volume":"397","author":"Streszewski","year":"2012","journal-title":"Colloids Surf"},{"key":"10.1016\/j.xphs.2020.02.010_bib21","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.talanta.2018.02.088","article-title":"Recent biomedical applications of gold nanoparticles: a review","volume":"184","author":"Elahi","year":"2018","journal-title":"Talanta"},{"issue":"2","key":"10.1016\/j.xphs.2020.02.010_bib22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.canlet.2004.02.004","article-title":"Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles","volume":"209","author":"O'Neal","year":"2004","journal-title":"Cancer Lett"},{"issue":"9","key":"10.1016\/j.xphs.2020.02.010_bib23","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1002\/smll.200700794","article-title":"Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles","volume":"4","author":"Kong","year":"2008","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.xphs.2020.02.010_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12645-016-0021-x","article-title":"Gold nanoparticles for cancer radiotherapy: a review","volume":"7","author":"Haume","year":"2016","journal-title":"Cancer Nanotechnol"},{"issue":"6","key":"10.1016\/j.xphs.2020.02.010_bib25","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1166\/jbn.2016.2218","article-title":"Synthesis, physico-chemical properties, and biomedical applications of gold nanorods-A review","volume":"12","author":"Marangoni","year":"2016","journal-title":"J\u00a0Biomed Nanotechnol"},{"key":"10.1016\/j.xphs.2020.02.010_bib26","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.colsurfb.2018.04.005","article-title":"The systematic evaluation of size-dependent toxicity and multi-time biodistribution of gold nanoparticles","volume":"167","author":"Li","year":"2018","journal-title":"Colloids Surf"},{"issue":"4","key":"10.1016\/j.xphs.2020.02.010_bib27","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1177\/0192623318770608","article-title":"Gold nanoparticle toxicity in mice and rats: species differences","volume":"46","author":"Bahamonde","year":"2018","journal-title":"Toxicol Pathol"},{"issue":"13","key":"10.1016\/j.xphs.2020.02.010_bib28","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1002\/anie.201807847","article-title":"Renal clearable Luminescent gold nanoparticles: from the bench to the clinic","volume":"58","author":"Yu","year":"2019","journal-title":"Angew Chem Int Ed Engl"},{"issue":"7","key":"10.1016\/j.xphs.2020.02.010_bib29","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1039\/C1CS15237H","article-title":"The golden age: gold nanoparticles for biomedicine","volume":"41","author":"Dreaden","year":"2012","journal-title":"Chem Soc Rev"},{"issue":"9","key":"10.1016\/j.xphs.2020.02.010_bib30","doi-asserted-by":"crossref","first-page":"8992","DOI":"10.1021\/nn502146r","article-title":"Enhancing radiotherapy by lipid nanocapsule-mediated delivery of amphiphilic gold nanoparticles to intracellular membranes","volume":"8","author":"Yang","year":"2014","journal-title":"ACS Nano"},{"issue":"43","key":"10.1016\/j.xphs.2020.02.010_bib31","doi-asserted-by":"crossref","first-page":"12244","DOI":"10.1021\/acs.langmuir.7b02446","article-title":"Reversible self-assembly of glutathione-coated gold nanoparticle clusters via pH-Tunable interactions","volume":"33","author":"Moaseri","year":"2017","journal-title":"Langmuir"},{"issue":"11","key":"10.1016\/j.xphs.2020.02.010_bib32","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1021\/nl402813q","article-title":"Thermally reversible aggregation of gold nanoparticles in polymer nanocomposites through Hydrogen bonding","volume":"13","author":"Heo","year":"2013","journal-title":"Nano Lett"},{"key":"10.1016\/j.xphs.2020.02.010_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ejps.2017.05.001","article-title":"Preparation of liposomes containing small gold nanoparticles using electrostatic interactions","volume":"105","author":"Dichello","year":"2017","journal-title":"Eur J Pharm Sci"},{"issue":"12","key":"10.1016\/j.xphs.2020.02.010_bib34","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.1002\/anie.201800736","article-title":"Reversible clustering of gold nanoparticles under confinement","volume":"57","author":"Sanchez-Iglesias","year":"2018","journal-title":"Angew Chem Int Ed Engl"},{"issue":"6","key":"10.1016\/j.xphs.2020.02.010_bib35","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1097\/QAD.0000000000001405","article-title":"Long-acting combination anti-HIV\u00a0drug suspension enhances and sustains higher drug levels in\u00a0lymph\u00a0node cells than in blood cells and plasma","volume":"31","author":"Kraft","year":"2017","journal-title":"AIDS"},{"issue":"17","key":"10.1016\/j.xphs.2020.02.010_bib36","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1097\/QAD.0000000000000421","article-title":"Long-acting three-drug combination anti-HIV nanoparticles enhance drug exposure in primate plasma and cells within lymph nodes and blood","volume":"28","author":"Freeling","year":"2014","journal-title":"AIDS"},{"issue":"9","key":"10.1016\/j.xphs.2020.02.010_bib37","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1158\/0008-5472.CAN-08-4242","article-title":"Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas","volume":"69","author":"von Maltzahn","year":"2009","journal-title":"Cancer Res"},{"issue":"8","key":"10.1016\/j.xphs.2020.02.010_bib38","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.nano.2014.05.006","article-title":"Gold nanoparticle hyperthermia reduces radiotherapy dose","volume":"10","author":"Hainfeld","year":"2014","journal-title":"Nanomedicine"},{"issue":"5","key":"10.1016\/j.xphs.2020.02.010_bib39","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1021\/nl080496z","article-title":"Modulation of in\u00a0vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy","volume":"8","author":"Diagaradjane","year":"2008","journal-title":"Nano Lett"},{"issue":"33","key":"10.1016\/j.xphs.2020.02.010_bib40","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.2174\/0929867321666140706143402","article-title":"Iron chelating strategies in systemic metal overload, neurodegeneration and cancer","volume":"21","author":"Gumienna-Kontecka","year":"2014","journal-title":"Curr Med Chem"},{"issue":"5-6","key":"10.1016\/j.xphs.2020.02.010_bib41","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10557-017-6759-5","article-title":"Chelation therapy as a cardiovascular therapeutic strategy: the rationale and the data in review","volume":"31","author":"Mathew","year":"2017","journal-title":"Cardiovasc Drug Ther"},{"issue":"36","key":"10.1016\/j.xphs.2020.02.010_bib42","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.2174\/09298673113209990146","article-title":"Chemistry and pharmacological properties of some natural and synthetic antioxidants for heavy metal toxicity","volume":"20","author":"Flora","year":"2013","journal-title":"Curr Med Chem"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920300836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920300836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:29:13Z","timestamp":1758360553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354920300836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0022354920300836"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2020.02.010","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimizing a Novel Au-Grafted Lipid Nanoparticle Through Chelation Chemistry for High Photothermal Biologic Activity","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2020.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc. on behalf of the American Pharmacists Association.","name":"copyright","label":"Copyright"}]}}