{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:16:40Z","timestamp":1762604200725,"version":"3.44.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.xphs.2020.03.017","type":"journal-article","created":{"date-parts":[[2020,3,30]],"date-time":"2020-03-30T10:50:22Z","timestamp":1585565422000},"page":"2156-2165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Polymorphs of DP-VPA Solid Solutions and Their Physicochemical Properties"],"prefix":"10.1016","volume":"109","author":[{"given":"Chao","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengge","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanchang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi-Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guisen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.xphs.2020.03.017_bib1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/jps.2600580802","article-title":"Pharmaceutical applications of polymorphism","volume":"58","author":"Haleblian","year":"1969","journal-title":"J\u00a0Pharm Sci"},{"issue":"8","key":"10.1016\/j.xphs.2020.03.017_bib2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1021\/cm00044a013","article-title":"Solid-state pharmaceutical chemistry","volume":"6","author":"Byrn","year":"1994","journal-title":"Chem Mater"},{"issue":"3","key":"10.1016\/j.xphs.2020.03.017_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.addr.2003.10.011","article-title":"Regulatory considerations of pharmaceutical solid polymorphism in abbreviated new drug applications (ANDAs)","volume":"56","author":"Raw","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.xphs.2020.03.017_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11814-010-0520-0","article-title":"Solid forms of pharmaceuticals: polymorphs, salts and cocrystals","volume":"28","author":"Sarma","year":"2011","journal-title":"Kor J Chem Eng"},{"issue":"12","key":"10.1016\/j.xphs.2020.03.017_bib5","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1016\/j.xphs.2018.08.003","article-title":"Salts of mefenamic acid with amines: structure, thermal stability, desolvation, and solubility","volume":"107","author":"Bouanga Boudiombo","year":"2018","journal-title":"J\u00a0Pharm Sci"},{"issue":"1","key":"10.1016\/j.xphs.2020.03.017_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jps.2600660104","article-title":"Pharmaceutical salts","volume":"66","author":"Berge","year":"1977","journal-title":"J\u00a0Pharm Sci"},{"issue":"6","key":"10.1016\/j.xphs.2020.03.017_bib7","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1021\/cg050125l","article-title":"Saccharin salts of active pharmaceutical ingredients, their crystal structures, and increased water solubilities","volume":"5","author":"Banerjee","year":"2005","journal-title":"Cryst Growth Des"},{"issue":"3","key":"10.1016\/j.xphs.2020.03.017_bib8","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.addr.2003.10.008","article-title":"Drug polymorphism and dosage form design: a practical perspective","volume":"56","author":"Singhal","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"issue":"7","key":"10.1016\/j.xphs.2020.03.017_bib9","doi-asserted-by":"crossref","first-page":"884","DOI":"10.2174\/092986709787549299","article-title":"Polymorphism and crystallization of active pharmaceutical ingredients (APIs)","volume":"16","author":"Jie","year":"2009","journal-title":"Curr Med Chem"},{"issue":"2","key":"10.1016\/j.xphs.2020.03.017_bib10","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.xphs.2017.10.001","article-title":"New polymorph form of dexamethasone acetate","volume":"107","author":"Silva","year":"2018","journal-title":"J\u00a0Pharm Sci"},{"issue":"9","key":"10.1016\/j.xphs.2020.03.017_bib11","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1002\/jps.20868","article-title":"Characterization and selective crystallization of famotidine polymorphs","volume":"96","author":"Lu","year":"2007","journal-title":"J\u00a0Pharm Sci"},{"issue":"4","key":"10.1016\/j.xphs.2020.03.017_bib12","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.xphs.2016.01.024","article-title":"Solvates of dasatinib: diversity and isostructurality","volume":"105","author":"Sarcevi\u010da","year":"2016","journal-title":"J\u00a0Pharm Sci"},{"issue":"11","key":"10.1016\/j.xphs.2020.03.017_bib13","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1002\/jps.23714","article-title":"Olanzapine solvates","volume":"102","author":"Cavallari","year":"2013","journal-title":"J\u00a0Pharm Sci"},{"issue":"4","key":"10.1016\/j.xphs.2020.03.017_bib14","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.xphs.2016.01.011","article-title":"Polymorphs and versatile solvates of 7-hydroxyisoflavone","volume":"105","author":"Gong","year":"2016","journal-title":"J\u00a0Pharm Sci"},{"issue":"6","key":"10.1016\/j.xphs.2020.03.017_bib15","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/j.xphs.2016.03.040","article-title":"Estimating the aqueous solubility of pharmaceutical hydrates","volume":"105","author":"Franklin","year":"2016","journal-title":"J\u00a0Pharm Sci"},{"issue":"10","key":"10.1016\/j.xphs.2020.03.017_bib16","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.1002\/jps.23257","article-title":"A\u00a0rapid approach to the preliminary assessment of the physical stability of pharmaceutical hydrates","volume":"101","author":"Shimanovich","year":"2012","journal-title":"J\u00a0Pharm Sci"},{"issue":"12","key":"10.1016\/j.xphs.2020.03.017_bib17","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1016\/j.xphs.2018.08.002","article-title":"A\u00a0new hydrate of cyclosporine: structural and physicochemical characterization","volume":"107","author":"Wu","year":"2018","journal-title":"J\u00a0Pharm Sci"},{"issue":"7","key":"10.1016\/j.xphs.2020.03.017_bib18","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.xphs.2019.02.014","article-title":"A\u00a0novel drug-drug cocrystal of levofloxacin and metacetamol: reduced hygroscopicity and improved photostability of levofloxacin","volume":"108","author":"Shinozaki","year":"2019","journal-title":"J\u00a0Pharm Sci"},{"issue":"4","key":"10.1016\/j.xphs.2020.03.017_bib19","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.xphs.2018.10.060","article-title":"Structural characterization and pharmaceutical properties of three novel cocrystals of ethenzamide with aliphatic dicarboxylic acids","volume":"108","author":"Kozak","year":"2019","journal-title":"J\u00a0Pharm Sci"},{"issue":"8","key":"10.1016\/j.xphs.2020.03.017_bib20","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1002\/jps.24048","article-title":"Baicalein\u2013nicotinamide cocrystal with enhanced solubility, dissolution, and oral bioavailability","volume":"103","author":"Huang","year":"2014","journal-title":"J\u00a0Pharm Sci"},{"issue":"1","key":"10.1016\/j.xphs.2020.03.017_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.xphs.2017.09.017","article-title":"Development of a novel amorphous agomelatine formulation with improved storage stability and enhanced bioavailability","volume":"107","author":"Barmpalexis","year":"2018","journal-title":"J\u00a0Pharm Sci"},{"issue":"10","key":"10.1016\/j.xphs.2020.03.017_bib22","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1002\/jps.22643","article-title":"Solubility advantage of amorphous pharmaceuticals, Part 3: is maximum solubility advantage experimentally attainable and sustainable?","volume":"100","author":"Murdande","year":"2011","journal-title":"J\u00a0Pharm Sci"},{"issue":"3","key":"10.1016\/j.xphs.2020.03.017_bib23","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/jps.21903","article-title":"Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis","volume":"99","author":"Murdande","year":"2010","journal-title":"J\u00a0Pharm Sci"},{"issue":"2","key":"10.1016\/j.xphs.2020.03.017_bib24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.xphs.2016.10.021","article-title":"Challenges in translational development of pharmaceutical cocrystals","volume":"106","author":"Kale","year":"2017","journal-title":"J\u00a0Pharm Sci"},{"issue":"3","key":"10.1016\/j.xphs.2020.03.017_bib25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.tips.2012.12.003","article-title":"The role of co-crystals in pharmaceutical design","volume":"34","author":"Steed","year":"2013","journal-title":"Trends Pharmacol Sci"},{"issue":"6","key":"10.1016\/j.xphs.2020.03.017_bib26","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1021\/cg060838j","article-title":"Diversity in single- and multiple-component crystals. The search for and prevalence of polymorphs and cocrystals","volume":"7","author":"Stahly","year":"2007","journal-title":"Cryst Growth Des"},{"issue":"91","key":"10.1016\/j.xphs.2020.03.017_bib27","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1039\/b315687g","article-title":"Crystal and co-crystal: a second opinion","volume":"5","author":"Dunitz","year":"2003","journal-title":"CrystEngComm"},{"key":"10.1016\/j.xphs.2020.03.017_bib28","series-title":"Mixed Crystals","article-title":"Structures of organic solid solutions","author":"Kitaigorodsky","year":"1984"},{"issue":"6","key":"10.1016\/j.xphs.2020.03.017_bib29","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1021\/acs.cgd.7b01643","article-title":"Engineering crystal properties through solid solutions","volume":"18","author":"Lusi","year":"2018","journal-title":"Cryst Growth Des"},{"key":"10.1016\/j.xphs.2020.03.017_bib30","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1039\/b505883j","article-title":"Building co-crystals with molecular sense and supramolecular sensibility","volume":"7","author":"Aakeroy","year":"2005","journal-title":"CrystEngComm"},{"issue":"6","key":"10.1016\/j.xphs.2020.03.017_bib31","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/jps.2600550610","article-title":"Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures IV: chloramphenicol-urea system","volume":"55","author":"Goldberg","year":"1966","journal-title":"J\u00a0Pharm Sci"},{"issue":"2","key":"10.1016\/j.xphs.2020.03.017_bib32","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1021\/cg800907c","article-title":"Molecular solid solutions with steric complementary pairing from the binary mixtures of 1-naphthylmethylammonium alkanoates","volume":"9","author":"Inoue","year":"2009","journal-title":"Cryst Growth Des"},{"key":"10.1016\/j.xphs.2020.03.017_bib33","doi-asserted-by":"crossref","first-page":"C113","DOI":"10.1107\/S205327331709458X","article-title":"Pharmaceutical solid solutions of antiretroviral drugs","volume":"73","author":"Ayala","year":"2017","journal-title":"Acta Crystallogr A Found Adv"},{"issue":"26","key":"10.1016\/j.xphs.2020.03.017_bib34","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1039\/C7CE00939A","article-title":"Prediction and experimental validation of solid solutions and isopolymorphs of cytosine\/5-flucytosine","volume":"19","author":"Braun","year":"2017","journal-title":"CrystEngComm"},{"issue":"6","key":"10.1016\/j.xphs.2020.03.017_bib35","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1021\/acs.cgd.8b00164","article-title":"Novel solid solution of the antiretroviral drugs lamivudine and emtricitabine","volume":"18","author":"Fonseca","year":"2018","journal-title":"Cryst Growth Des"},{"issue":"7","key":"10.1016\/j.xphs.2020.03.017_bib36","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/dta.2579","article-title":"Determination of DP-VPA and its active metabolite, VPA, in human plasma, urine, and feces by UPLC\u2013MS\/MS: a clinical pharmacokinetics and excretion study","volume":"11","author":"Li","year":"2019","journal-title":"Drug Test Anal"},{"issue":"1","key":"10.1016\/j.xphs.2020.03.017_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.eplepsyres.2012.10.001","article-title":"Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI)","volume":"103","author":"Bialer","year":"2013","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.xphs.2020.03.017_bib38","first-page":"921","article-title":"Dp-Vpa D-Pharm","volume":"3","author":"Labiner","year":"2002","journal-title":"Curr Opin Invest Drugs"},{"key":"10.1016\/j.xphs.2020.03.017_bib39","first-page":"283","article-title":"New generation of valproic acid","volume":"56","author":"Trojnar","year":"2004","journal-title":"Pol J Pharmacol"},{"year":"2002","series-title":"Phospholipid Derivatives of Valproic Acid and Mixtures Thereof","author":"Kozak","key":"10.1016\/j.xphs.2020.03.017_bib40"},{"key":"10.1016\/j.xphs.2020.03.017_bib41","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0378-5173(97)00378-5","article-title":"Application of attenuated total reflectance FTIR spectroscopy to the analysis of mixtures of pharmaceutical polymorphs","volume":"163","author":"Salari","year":"1998","journal-title":"Int J Pharm"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920301763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920301763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:29:49Z","timestamp":1758360589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354920301763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0022354920301763"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2020.03.017","relation":{},"ISSN":["0022-3549"],"issn-type":[{"type":"print","value":"0022-3549"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymorphs of DP-VPA Solid Solutions and Their Physicochemical Properties","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2020.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}