{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:22:46Z","timestamp":1790169766487,"version":"4.1.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.xphs.2020.07.022","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T20:44:10Z","timestamp":1596833050000},"page":"3370-3377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Thermodynamics of the Enantiotropic Pharmaceutical Compound Benzocaine and Solubility in Pure Organic Solvents"],"prefix":"10.1016","volume":"109","author":[{"given":"Dominic","family":"Cheuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sv\u00e4rd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5ke C.","family":"Rasmuson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xphs.2020.07.022_bib1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.yrtph.2014.07.002","article-title":"More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in\u00a0vitro systems","volume":"70","author":"Hartman","year":"2014","journal-title":"Regul Toxicol Pharmacol"},{"key":"10.1016\/j.xphs.2020.07.022_bib2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1213\/ane.0b013e318187c4b1","article-title":"Methemoglobinemia related to local anesthetics: a summary of 242 episodes","volume":"108","author":"Guay","year":"2009","journal-title":"Anesth Analg"},{"key":"10.1016\/j.xphs.2020.07.022_bib3","first-page":"229","article-title":"Crystal structure of benzocaine\u2014a local anaesthetic","volume":"98","author":"Sinha","year":"1987","journal-title":"J\u00a0Chem Sci"},{"key":"10.1016\/j.xphs.2020.07.022_bib4","doi-asserted-by":"crossref","first-page":"o708","DOI":"10.1107\/S1600536802009674","article-title":"Monoclinic form of ethyl 4-aminobenzoate (benzocaine)","volume":"58","author":"Lynch","year":"2002","journal-title":"Acta Crystallogr E"},{"key":"10.1016\/j.xphs.2020.07.022_bib5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1107\/S0108768109018898","article-title":"On the polymorphism of benzocaine; a low-temperature structural phase transition for form (II)","volume":"65","author":"Chan","year":"2009","journal-title":"Acta Crystallogr B"},{"key":"10.1016\/j.xphs.2020.07.022_bib6","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ijpharm.2013.08.031","article-title":"Benzocaine polymorphism: pressure\u2013temperature phase diagram involving forms II and III","volume":"456","author":"Gana","year":"2013","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2020.07.022_bib7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ijpharm.2017.08.101","article-title":"The discovery and investigation of a crystalline solid solution of an active pharmaceutical ingredient","volume":"532","author":"Patel","year":"2017","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2020.07.022_bib8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jpba.2004.07.013","article-title":"Solubility\u00a0and phase separation of benzocaine and salicylic acid in 1,4-dioxane\u2013water mixtures at several temperatures","volume":"36","author":"Pe\u00f1a","year":"2004","journal-title":"J\u00a0Pharm Biomed Anal"},{"key":"10.1016\/j.xphs.2020.07.022_bib9","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1023\/A:1021825509697","article-title":"Thermodynamic study of the solubility of benzocaine in some organic and aqueous solvents","volume":"31","author":"\u00c1vila","year":"2002","journal-title":"J\u00a0Solut Chem"},{"key":"10.1016\/j.xphs.2020.07.022_bib10","first-page":"106","article-title":"Solubilization by cosoivents III: diazepam and benzocaine in binary solvents","volume":"39","author":"Rubino","year":"1985","journal-title":"PDA J Pharm Sci Technol"},{"key":"10.1016\/j.xphs.2020.07.022_bib11","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1039\/C5CE00147A","article-title":"Investigation into solid and solution properties of quinizarin","volume":"17","author":"Cheuk","year":"2015","journal-title":"CrystEngComm"},{"key":"10.1016\/j.xphs.2020.07.022_bib12","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ijpharm.2005.04.025","article-title":"Structural characteristics and crystal polymorphism of three local anaesthetic bases: crystal polymorphism of local anaesthetic drugs: part VII","volume":"298","author":"Schmidt","year":"2005","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2020.07.022_bib13","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1016\/j.xphs.2019.02.013","article-title":"Solid and solution state thermodynamics of polymorphs of butamben (butyl 4-aminobenzoate) in pure organic solvents","volume":"108","author":"Sv\u00e4rd","year":"2019","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.xphs.2020.07.022_bib14","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1021\/cr00032a005","article-title":"Solvatochromic dyes as solvent polarity indicators","volume":"94","author":"Reichardt","year":"1994","journal-title":"Chem Rev"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920304135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920304135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:30:30Z","timestamp":1758360630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354920304135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0022354920304135"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2020.07.022","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thermodynamics of the Enantiotropic Pharmaceutical Compound Benzocaine and Solubility in Pure Organic Solvents","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2020.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of the American Pharmacists Association\u00ae.","name":"copyright","label":"Copyright"}]}}