{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:34:24Z","timestamp":1792010064316,"version":"4.4.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.xphs.2020.09.013","type":"journal-article","created":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T10:59:03Z","timestamp":1599908343000},"page":"412-421","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression"],"prefix":"10.1016","volume":"110","author":[{"given":"Raju","family":"Khatri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Kulick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.B.","family":"Rementer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"Fallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Sykes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda P.","family":"Schauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina M.","family":"Malinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merrie","family":"Mosedale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul B.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela D.M.","family":"Kashuba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim A.","family":"Boggess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim L.R.","family":"Brouwer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.xphs.2020.09.013_bib1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1053\/j.semperi.2015.08.002","article-title":"Epidemiology of medications use in pregnancy","volume":"39","author":"Ayad","year":"2015","journal-title":"Semin Perinatol"},{"issue":"1","key":"10.1016\/j.xphs.2020.09.013_bib2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/cpt.382","article-title":"Pregnancy-related pharmacokinetic changes","volume":"100","author":"Tasnif","year":"2016","journal-title":"Clin Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.xphs.2020.09.013_bib3","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1097\/AOG.0000000000000743","article-title":"Lessons learned in pediatric clinical research to evaluate safe and effective use of drugs in pregnancy","volume":"125","author":"Gonzalez","year":"2015","journal-title":"Obstet Gynecol"},{"issue":"6","key":"10.1016\/j.xphs.2020.09.013_bib4","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/cpt.1084","article-title":"Physiologically based pharmacokinetic modeling in pregnancy: a systematic review of published models","volume":"104","author":"Dallmann","year":"2018","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.xphs.2020.09.013_bib5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1124\/dmd.112.049718","article-title":"Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice","volume":"41","author":"Shuster","year":"2013","journal-title":"Drug Metab Dispos"},{"issue":"2","key":"10.1016\/j.xphs.2020.09.013_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1124\/dmd.110.035790","article-title":"Altered cytochrome P450 expression in mice during pregnancy","volume":"39","author":"Koh","year":"2011","journal-title":"Drug Metab Dispos"},{"issue":"3","key":"10.1016\/j.xphs.2020.09.013_bib7","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1124\/mol.107.043851","article-title":"Effect of pregnancy on cytochrome P450 3a and P-glycoprotein expression and activity in the mouse: mechanisms, tissue specificity, and time course","volume":"74","author":"Zhang","year":"2008","journal-title":"Mol Pharmacol"},{"issue":"4","key":"10.1016\/j.xphs.2020.09.013_bib8","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/j.2040-4603.2013.tb00537.x","article-title":"Hormonal regulation of hepatic drug biotransformation and transport systems","volume":"3","author":"Ruiz","year":"2013","journal-title":"Compr Physiol"},{"issue":"6","key":"10.1016\/j.xphs.2020.09.013_bib9","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1517\/17425251003677755","article-title":"Altered drug metabolism during pregnancy: hormonal regulation of drug-metabolizing enzymes","volume":"6","author":"Jeong","year":"2010","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"2","key":"10.1016\/j.xphs.2020.09.013_bib10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1124\/dmd.112.050245","article-title":"Drug metabolism and transport during pregnancy: how does drug disposition change during pregnancy and what are the mechanisms that cause such changes?","volume":"41","author":"Isoherranen","year":"2013","journal-title":"Drug Metab Dispos"},{"issue":"2","key":"10.1016\/j.xphs.2020.09.013_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1124\/dmd.112.046276","article-title":"Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone","volume":"41","author":"Choi","year":"2013","journal-title":"Drug Metab Dispos"},{"issue":"1-2","key":"10.1016\/j.xphs.2020.09.013_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jsbmb.2008.03.027","article-title":"Estetrol: a unique steroid in human pregnancy","volume":"110","author":"Holinka","year":"2008","journal-title":"J\u00a0Steroid Biochem"},{"issue":"2","key":"10.1016\/j.xphs.2020.09.013_bib13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1124\/dmd.112.049015","article-title":"Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines","volume":"41","author":"Papageorgiou","year":"2013","journal-title":"Drug Metab Dispos"},{"issue":"3","key":"10.1016\/j.xphs.2020.09.013_bib14","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.fertnstert.2005.02.045","article-title":"Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry","volume":"84","author":"Soldin","year":"2005","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.xphs.2020.09.013_bib15","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1124\/dmd.112.047118","article-title":"Quantitative prediction of CYP2B6 induction by estradiol during pregnancy: potential explanation for increased methadone clearance during pregnancy","volume":"41","author":"Dickmann","year":"2013","journal-title":"Drug Metab Dispos"},{"issue":"1","key":"10.1016\/j.xphs.2020.09.013_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bcp.2012.03.016","article-title":"Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy","volume":"84","author":"Koh","year":"2012","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"10.1016\/j.xphs.2020.09.013_bib17","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1124\/dmd.114.062984","article-title":"Prediction of gestational age-dependent induction of in\u00a0vivo hepatic CYP3A activity based on HepaRG cells and human hepatocytes","volume":"43","author":"Zhang","year":"2015","journal-title":"Drug Metab Dispos"},{"issue":"9","key":"10.1016\/j.xphs.2020.09.013_bib18","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1002\/jps.22612","article-title":"Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy, and prospects","volume":"100","author":"Ohtsuki","year":"2011","journal-title":"J\u00a0Pharm Sci"},{"issue":"1","key":"10.1016\/j.xphs.2020.09.013_bib19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1021\/tx500444e","article-title":"Survey of human oxidoreductases and cytochrome P450 enzymes involved in the metabolism of xenobiotic and natural chemicals","volume":"28","author":"Rendic","year":"2015","journal-title":"Chem Res Toxicol"},{"issue":"5","key":"10.1016\/j.xphs.2020.09.013_bib20","first-page":"1","article-title":"Impact of antihypertensive treatment on maternal and perinatal outcomes in pregnancy complicated by chronic hypertension: a systematic review and meta-analysis","volume":"6","author":"Webster","year":"2017","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.xphs.2020.09.013_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2147\/IBPC.S77344","article-title":"Current best practice in the management of hypertensive disorders in pregnancy","volume":"9","author":"Townsend","year":"2016","journal-title":"Integr Blood Press Control"},{"issue":"5","key":"10.1016\/j.xphs.2020.09.013_bib22","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1056\/NEJMcp0804872","article-title":"Chronic hypertension in pregnancy","volume":"365","author":"Seely","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"1","key":"10.1016\/j.xphs.2020.09.013_bib23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/HYPERTENSIONAHA.117.10803","article-title":"Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.xphs.2020.09.013_bib24","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1053\/j.semperi.2015.08.011","article-title":"A\u00a0review of oral labetalol and nifedipine in mild to moderate hypertension in pregnancy","volume":"39","author":"Clark","year":"2015","journal-title":"Semin Perinatol"},{"issue":"3","key":"10.1016\/j.xphs.2020.09.013_bib25","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/j.1875-9114.1992.tb04505.x","article-title":"Oral nifedipine pharmacokinetics in pregnancy-induced hypertension","volume":"12","author":"Prevost","year":"1992","journal-title":"Pharmacotherapy"},{"issue":"4 Pt 1","key":"10.1016\/j.xphs.2020.09.013_bib26","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/0002-9378(91)90446-X","article-title":"Nifedipine pharmacokinetics and pharmacodynamics during the immediate postpartum period in patients with preeclampsia","volume":"165","author":"Barton","year":"1991","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.xphs.2020.09.013_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/psp.2012.2","article-title":"A\u00a0PBPK model to predict disposition of CYP3A-metabolized drugs in pregnant women: verification and discerning the site of CYP3A induction","volume":"1","author":"Ke","year":"2012","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"key":"10.1016\/j.xphs.2020.09.013_bib28","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1038\/psp.2012.5","article-title":"A\u00a0semi-mechanistic metabolism model of CYP3A substrates in pregnancy: predicting changes in midazolam and nifedipine pharmacokinetics","volume":"1","author":"Quinney","year":"2012","journal-title":"CPT Pharmacometrics Syst Pharmacol"},{"issue":"6","key":"10.1016\/j.xphs.2020.09.013_bib29","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s40262-017-0594-5","article-title":"A\u00a0physiologically based pharmacokinetic model for pregnant women to predict the pharmacokinetics of drugs metabolized via several enzymatic pathways","volume":"57","author":"Dallmann","year":"2018","journal-title":"Clin Pharmacokinet"},{"issue":"2","key":"10.1016\/j.xphs.2020.09.013_bib30","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/toxsci\/kfw047","article-title":"Subtoxic alterations in hepatocyte-derived exosomes: an early step in drug-induced liver injury?","volume":"151","author":"Holman","year":"2016","journal-title":"Toxicol Sci"},{"issue":"1","key":"10.1016\/j.xphs.2020.09.013_bib31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/toxsci\/kfx206","article-title":"miR-122 release in exosomes precedes overt tolvaptan-induced necrosis in a primary human hepatocyte micropatterned coculture model","volume":"161","author":"Mosedale","year":"2018","journal-title":"Toxicol Sci"},{"issue":"3","key":"10.1016\/j.xphs.2020.09.013_bib32","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3109\/03602530903491881","article-title":"Sandwich-cultured hepatocytes: an in\u00a0vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity","volume":"42","author":"Swift","year":"2010","journal-title":"Drug Metab Rev"},{"issue":"8","key":"10.1016\/j.xphs.2020.09.013_bib33","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/0002-9378(72)90185-8","article-title":"Plasma estrone, estradiol, estriol, progesterone, and 17-hydroxyprogesterone in human pregnancy. I. Normal pregnancy","volume":"112","author":"Tulchinsky","year":"1972","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"10.1016\/j.xphs.2020.09.013_bib34","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1194\/jlr.M053199","article-title":"Functional characterization of cytochrome P450-derived epoxyeicosatrienoic acids in adipogenesis and obesity","volume":"55","author":"Zha","year":"2014","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.xphs.2020.09.013_bib35","doi-asserted-by":"crossref","first-page":"106590","DOI":"10.1016\/j.vascn.2019.106590","article-title":"Targeted quantitative proteomic analysis of drug metabolizing enzymes and transporters by nano LC-MS\/MS in the sandwich cultured human hepatocyte model","volume":"98","author":"Khatri","year":"2019","journal-title":"J\u00a0Pharmacol Toxicol Methods"},{"issue":"9","key":"10.1016\/j.xphs.2020.09.013_bib36","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1007\/s11095-016-1966-5","article-title":"Quantification of four efflux drug transporters in liver and kidney across species using targeted quantitative proteomics by isotope dilution NanoLC-MS\/MS","volume":"33","author":"Fallon","year":"2016","journal-title":"Pharm Res"},{"issue":"7","key":"10.1016\/j.xphs.2020.09.013_bib37","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1124\/dmd.31.7.938","article-title":"In\u00a0vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes P450: role of CYP3A4 and CYP3A5","volume":"31","author":"Patki","year":"2003","journal-title":"Drug Metab Dispos"},{"issue":"10","key":"10.1016\/j.xphs.2020.09.013_bib38","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1056\/NEJMra1704286","article-title":"Circulating extracellular vesicles in human disease","volume":"379","author":"Shah","year":"2018","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.xphs.2020.09.013_bib39","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/cpt.1328","article-title":"From endogenous compounds as biomarkers to plasma-derived nanovesicles as liquid biopsy; has the golden age of translational pharmacokinetics-absorption, distribution, metabolism, excretion-drug-drug interaction science finally arrived?","volume":"105","author":"Rodrigues","year":"2019","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.xphs.2020.09.013_bib40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/toxsci\/kfy015","article-title":"Optimized methods to explore the mechanistic and biomarker potential of hepatocyte-derived exosomes in drug-induced liver injury","volume":"163","author":"Thacker","year":"2018","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.xphs.2020.09.013_bib41","doi-asserted-by":"crossref","first-page":"17319","DOI":"10.1038\/srep17319","article-title":"Isolation of exosomes by differential centrifugation: theoretical analysis of a commonly used protocol","volume":"5","author":"Livshits","year":"2015","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.xphs.2020.09.013_bib42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1124\/dmd.111.042259","article-title":"Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities","volume":"40","author":"Ohtsuki","year":"2012","journal-title":"Drug Metab Dispos"},{"issue":"3","key":"10.1016\/j.xphs.2020.09.013_bib43","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/bcp.12207","article-title":"Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19","volume":"77","author":"Ke","year":"2014","journal-title":"Br J Clin Pharmacol"},{"issue":"8","key":"10.1016\/j.xphs.2020.09.013_bib44","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1124\/dmd.30.8.883","article-title":"Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7","volume":"30","author":"Williams","year":"2002","journal-title":"Drug Metab Dispos"},{"issue":"4","key":"10.1016\/j.xphs.2020.09.013_bib45","first-page":"275","article-title":"Nifedipine pharmacokinetics are influenced by CYP3A5 genotype when used as a preterm labor tocolytic","volume":"30","author":"Haas","year":"2013","journal-title":"Am J Perinatol"},{"issue":"3","key":"10.1016\/j.xphs.2020.09.013_bib46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1208\/s12248-019-0316-z","article-title":"Mechanisms of CYP3A induction during pregnancy: studies in HepaRG cells","volume":"21","author":"Sachar","year":"2019","journal-title":"AAPS J"},{"issue":"1","key":"10.1016\/j.xphs.2020.09.013_bib47","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/00498250701744633","article-title":"Regulation of UDP-glucuronosyltransferase (UGT) 1A1 by progesterone and its impact on labetalol elimination","volume":"38","author":"Jeong","year":"2008","journal-title":"Xenobiotica"},{"issue":"1","key":"10.1016\/j.xphs.2020.09.013_bib48","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1124\/dmd.110.035766","article-title":"Pregnancy decreases rat CYP1A2 activity and expression","volume":"39","author":"Walker","year":"2011","journal-title":"Drug Metab Dispos"},{"issue":"2","key":"10.1016\/j.xphs.2020.09.013_bib49","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1124\/dmd.109.030270","article-title":"Identification of novel substrates for human cytochrome P450 2J2","volume":"38","author":"Lee","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.xphs.2020.09.013_bib50","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.toxlet.2017.03.028","article-title":"Pregnane X receptor regulates the AhR\/Cyp1A1 pathway and protects liver cells from benzo-[alpha]-pyrene-induced DNA damage","volume":"275","author":"Cui","year":"2017","journal-title":"Toxicol Lett"},{"issue":"3","key":"10.1016\/j.xphs.2020.09.013_bib51","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1124\/mol.65.3.730","article-title":"Regulation of mouse renal CYP2J5 expression by sex hormones","volume":"65","author":"Ma","year":"2004","journal-title":"Mol Pharmacol"},{"issue":"12","key":"10.1016\/j.xphs.2020.09.013_bib52","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1016\/j.xphs.2017.07.016","article-title":"Concept: the use of targeted immunoaffinity proteomics for routine assessment of in\u00a0vitro enzyme induction","volume":"106","author":"MacLean","year":"2017","journal-title":"J\u00a0Pharm Sci"},{"issue":"4","key":"10.1016\/j.xphs.2020.09.013_bib53","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1124\/dmd.113.055384","article-title":"Human placental lactogen induces CYP2E1 expression via PI 3-kinase pathway in female human hepatocytes","volume":"42","author":"Lee","year":"2014","journal-title":"Drug Metab Dispos"},{"issue":"1","key":"10.1016\/j.xphs.2020.09.013_bib54","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/bcp.13793","article-title":"Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure","volume":"85","author":"Rowland","year":"2019","journal-title":"Br J Clin Pharmacol"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920305116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920305116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:32:59Z","timestamp":1758360779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354920305116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0022354920305116"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2020.09.013","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2020.09.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}