{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T23:08:17Z","timestamp":1782169697078,"version":"3.54.5"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.xphs.2020.09.033","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:27:50Z","timestamp":1601080070000},"page":"135-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Antiplasmodial Combined Formulation of Artemisinin with Peschiera fuchsiaefolia Bis-Indole Alkaloids"],"prefix":"10.1016","volume":"110","author":[{"given":"Kouadio Victorien","family":"Konan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien Canh","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea Alexandru","family":"Mateescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xphs.2020.09.033_bib1","series-title":"World Health Organization. World Malaria Report 2010","first-page":"96","year":"2010"},{"key":"10.1016\/j.xphs.2020.09.033_bib2","series-title":"World Health Organization. Guidelines for the Treatment of Malaria","year":"2015"},{"key":"10.1016\/j.xphs.2020.09.033_bib3","series-title":"World Malaria Report 2016","year":"2016"},{"key":"10.1016\/j.xphs.2020.09.033_bib4","series-title":"World Health Organization. World Malaria Report 2017. The Global Figures","year":"2017"},{"key":"10.1016\/j.xphs.2020.09.033_bib5","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature03342","article-title":"The global distribution of clinical episodes of Plasmodium falciparum malaria","volume":"434","author":"Snow","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.xphs.2020.09.033_bib6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1179\/102453312X13221316477336","article-title":"Malaria: a haematological disease","volume":"17","author":"Akinosoglou","year":"2012","journal-title":"Hematology"},{"key":"10.1016\/j.xphs.2020.09.033_bib7","series-title":"Infectious Diseases","first-page":"1014","article-title":"117 - malaria","author":"Dondorp","year":"2017"},{"key":"10.1016\/j.xphs.2020.09.033_bib8","doi-asserted-by":"crossref","first-page":"e473","DOI":"10.1371\/journal.pmed.0030473","article-title":"The Malaria Atlas Project: developing global maps of malaria risk","volume":"3","author":"Hay","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.xphs.2020.09.033_bib9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1473-3099(08)70069-0","article-title":"Measuring malaria endemicity from intense to interrupted transmission","volume":"8","author":"Hay","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.xphs.2020.09.033_bib10","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1186\/1475-2875-10-378","article-title":"A\u00a0new world malaria map: Plasmodium falciparum endemicity in 2010","volume":"10","author":"Gething","year":"2011","journal-title":"Malar J"},{"key":"10.1016\/j.xphs.2020.09.033_bib11","series-title":"World Health Organization. Malaria Vaccine Development: Status of Vaccine Development","year":"2017"},{"key":"10.1016\/j.xphs.2020.09.033_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.19026\/bjpt.6.5186","article-title":"Antimalarial drug resistance: in the past, current status and future perspectives","volume":"6","author":"Eyasu","year":"2015","journal-title":"Br J Pharmacol Toxicol"},{"key":"10.1016\/j.xphs.2020.09.033_bib13","first-page":"CD000527","article-title":"Artemisinin derivatives for treating severe malaria","author":"McIntosh","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.xphs.2020.09.033_bib14","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0140-6736(93)90362-K","article-title":"Qinghaosu","volume":"341","author":"Hien","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.xphs.2020.09.033_bib15","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1128\/AAC.46.4.1026-1031.2002","article-title":"Artemisinin pharmacokinetics and efficacy in uncomplicated-malaria patients treated with two different dosage regimens","volume":"46","author":"Gordi","year":"2002","journal-title":"Antimicrobial Agents Chemother"},{"key":"10.1016\/j.xphs.2020.09.033_bib16","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S1473-3099(12)70181-0","article-title":"Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study","volume":"12","author":"Amaratunga","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.xphs.2020.09.033_bib17","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"Dondorp","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xphs.2020.09.033_bib18","series-title":"World Health Organization. Susceptibility of Plasmodium Falciparum to Antimalarial Drugs: Report on Global Monitoring: 1996-2004","year":"2005"},{"key":"10.1016\/j.xphs.2020.09.033_bib19","doi-asserted-by":"crossref","first-page":"EI010","DOI":"10.1128\/microbiolspec.EI10-0013-2016","article-title":"Artemisinin-resistant Plasmodium falciparum malaria","volume":"4","author":"Fairhurst","year":"2016","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.xphs.2020.09.033_bib20","first-page":"135","article-title":"World Health Organization. Essential medicines: intensified efforts required to withdraw oral artemisinin-based monotherapies","volume":"28","year":"2014","journal-title":"WHO Drug Inf"},{"key":"10.1016\/j.xphs.2020.09.033_bib21","series-title":"World Health Organization. Global Report on Antimalarial Drug Efficacy and Drug Resistance 2000-2010","year":"2010"},{"key":"10.1016\/j.xphs.2020.09.033_bib22","article-title":"World Health Organization. Regulatory action needed to stop the sale of oral artemisinin-based monotherapy","volume":"24","year":"2010","journal-title":"WHO Drug Inf"},{"key":"10.1016\/j.xphs.2020.09.033_bib23","series-title":"World Health Organization. Withdrawal of Oral Artemisinin-Based Monotherapies","year":"2017"},{"key":"10.1016\/j.xphs.2020.09.033_bib24","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nm.4381","article-title":"Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic","volume":"23","author":"Blasco","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.xphs.2020.09.033_bib25","series-title":"World Health Organization. Paludisme: Traitement du paludisme - tour d'horizon","year":"2018"},{"key":"10.1016\/j.xphs.2020.09.033_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12936-016-1099-7","article-title":"Treatment outcomes in a safety observational study of dihydroartemisinin\/piperaquine (Eurartesim\u00ae) in the treatment of uncomplicated malaria at public health facilities in four African countries","volume":"15","author":"Adjei","year":"2016","journal-title":"Malar J"},{"key":"10.1016\/j.xphs.2020.09.033_bib27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/1475-2875-11-212","article-title":"Therapy of uncomplicated falciparum malaria in Europe: MALTHER\u2013a prospective observational multicentre study","volume":"11","author":"Bouchaud","year":"2012","journal-title":"Malar J"},{"key":"10.1016\/j.xphs.2020.09.033_bib28","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1128\/AAC.41.7.1413","article-title":"Assessment of the pharmacodynamic properties of antimalarial drugs in\u00a0vivo","volume":"41","author":"White","year":"1997","journal-title":"Antimicrobial Agents Chemother"},{"key":"10.1016\/j.xphs.2020.09.033_bib29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/1475-2875-8-203","article-title":"Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysis","volume":"8","author":"Zwang","year":"2009","journal-title":"Malar J"},{"key":"10.1016\/j.xphs.2020.09.033_bib30","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMc1612765","article-title":"Emergence of indigenous artemisinin-resistant Plasmodium falciparum in Africa","volume":"376","author":"Lu","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xphs.2020.09.033_bib31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"Ashley","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xphs.2020.09.033_bib32","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/1099-1573(200102)15:1<30::AID-PTR680>3.0.CO;2-T","article-title":"Biological activities of the plant-derived bisindole voacamine with reference to malaria","volume":"15","author":"Ramanitrahasimbola","year":"2001","journal-title":"Phytother Res"},{"key":"10.1016\/j.xphs.2020.09.033_bib33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1055\/s-0029-1243122","article-title":"Antiplasmodial activity of the alkaloids of Peschiera fuchsiaefolia","volume":"66","author":"Federici","year":"2000","journal-title":"Planta Med"},{"key":"10.1016\/j.xphs.2020.09.033_bib34","first-page":"1505","article-title":"Voacamine, a bisindolic alkaloid from Peschiera fuchsiaefolia, enhances the cytotoxic effect of doxorubicin on multidrug-resistant tumor cells","volume":"23","author":"Meschini","year":"2003","journal-title":"Int J Oncol"},{"key":"10.1016\/j.xphs.2020.09.033_bib35","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1590\/S0103-50532005000800011","article-title":"Qualitative determination of indole alkaloids of Tabernaemontana fuchsiaefolia (Apocynaceae)","volume":"16","author":"Zocoler","year":"2005","journal-title":"J\u00a0Braz Chem Soc"},{"key":"10.1016\/j.xphs.2020.09.033_bib36","series-title":"PubChem Compound Database; CID=11953931","article-title":"National center for biotechnology information","year":"2017"},{"key":"10.1016\/j.xphs.2020.09.033_bib37","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1208\/s12249-019-1315-1","article-title":"Enhanced solubility of alkaloids by complexation with polycarboxylic materials for controlled release formulations: case of Peschiera fuchsiaefolia","volume":"20","author":"Konan","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.xphs.2020.09.033_bib38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ijpharm.2010.04.037","article-title":"The influence of protonation ratio on properties of carboxymethyl starch excipient at various substitution degrees: structural insights and drug release kinetics","volume":"394","author":"Assaad","year":"2010","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2020.09.033_bib39","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s13346-017-0375-6","article-title":"Two release rates from monolithic carboxymethyl starch tablets: formulation, characterization, and in\u00a0vitro\/in\u00a0vivo evaluation","volume":"7","author":"Le","year":"2017","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.xphs.2020.09.033_bib40","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1208\/s12249-010-9437-5","article-title":"Influence of drying procedure and of low degree of substitution on the structural and drug release properties of carboxymethyl starch","volume":"11","author":"Lemieux","year":"2010","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.xphs.2020.09.033_bib41","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1208\/s12249-019-1315-1","article-title":"Enhanced solubility of alkaloids by complexation with polycarboxylic materials for controlled release formulations: case of Peschiera fuchsiaefolia","volume":"20","author":"Konan","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.xphs.2020.09.033_bib42","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ijbiomac.2017.09.053","article-title":"The role of biopolymer matrix films derived from carboxymethyl cellulose, sodium alginate and polyvinyl alcohol on the sustained transdermal release of diltiazem","volume":"107","author":"Anirudhan","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.xphs.2020.09.033_bib43","doi-asserted-by":"crossref","first-page":"e0116553","DOI":"10.1371\/journal.pone.0116553","article-title":"Biomimetic remineralization of demineralized dentine using scaffold of CMC\/ACP nanocomplexes in an in\u00a0vitro tooth model of deep caries","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.xphs.2020.09.033_bib44","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/smll.201101613","article-title":"Engineered redox-responsive PEG detachment mechanism in PEGylated nano-graphene oxide for intracellular drug delivery","volume":"8","author":"Wen","year":"2012","journal-title":"Small"},{"key":"10.1016\/j.xphs.2020.09.033_bib45","series-title":"U.S Pharmacopoeia-National Formulary (USP 40 NF 35)","first-page":"7969","year":"2017"},{"key":"10.1016\/j.xphs.2020.09.033_bib46","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1039\/C6AY01088A","article-title":"Electrolysis-induced fast activation of the ABTS reagent for an antioxidant capacity assay","volume":"8","author":"Konan","year":"2016","journal-title":"Anal Methods"},{"key":"10.1016\/j.xphs.2020.09.033_bib47","first-page":"119","article-title":"A\u00a0simple and rapid spectrophotometric method for the determination of artesunate in pharmaceuticals","volume":"4","author":"Sreevidya","year":"2009","journal-title":"Eurasian J Anal Chem"},{"key":"10.1016\/j.xphs.2020.09.033_bib48","doi-asserted-by":"crossref","first-page":"36583","DOI":"10.1021\/acsami.7b10716","article-title":"In situ silver nanowire deposited cross-linked carboxymethyl cellulose: a potential transdermal anticancer drug carrier","volume":"9","author":"Mandal","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.xphs.2020.09.033_bib49","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.carbpol.2009.12.025","article-title":"Preparation and physicochemical properties of carboxymethyl Fritillaria ussuriensis Maxim. starches","volume":"80","author":"Li","year":"2010","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.xphs.2020.09.033_bib50","doi-asserted-by":"crossref","first-page":"e114634","DOI":"10.1371\/journal.pone.0114634","article-title":"Characterization of different substituted carboxymethyl starch microgels and their interactions with lysozyme","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.xphs.2020.09.033_bib51","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3390\/nu9101105","article-title":"Inhibition of 5\u03b1-reductase, IL-6 secretion, and oxidation process of Equisetum debile Roxb. ex vaucher extract as functional food and nutraceuticals ingredients","volume":"9","author":"Chaiyana","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.xphs.2020.09.033_bib52","first-page":"1881","article-title":"Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review","volume":"52","author":"Rahaiee","year":"2015","journal-title":"J\u00a0Food Sci Technol"},{"key":"10.1016\/j.xphs.2020.09.033_bib53","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1021\/acs.biomac.7b00077","article-title":"Bioinspired polydopamine-coated hemoglobin as potential oxygen carrier with antioxidant properties","volume":"18","author":"Wang","year":"2017","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.xphs.2020.09.033_bib54","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.ejps.2016.10.013","article-title":"Very fast dissolving acid carboxymethylcellulose-rifampicin matrix: development and solid-state characterization","volume":"96","author":"Luciani-Giacobbe","year":"2017","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.xphs.2020.09.033_bib55","doi-asserted-by":"crossref","first-page":"7381","DOI":"10.1039\/C7CC02799K","article-title":"Highly efficient complexation of sanguinarine alkaloid by carboxylatopillar [6] arene: pKa shift, increased solubility and enhanced antibacterial activity","volume":"53","author":"Ping","year":"2017","journal-title":"Chem Commun"},{"key":"10.1016\/j.xphs.2020.09.033_bib56","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1016\/S0040-4039(99)00830-8","article-title":"Ring opening of artemisinin (qinghaosu) and dihydroartemisinin and interception of the open hydroperoxides with formation of N-oxides-a chemical model for antimalarial mode of action","volume":"40","author":"Haynes","year":"1999","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.xphs.2020.09.033_bib57","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1023\/A:1018943329109","article-title":"Decomposition of arteether in simulated stomach acid yielding compounds retaining antimalarial activity","volume":"10","author":"Baker","year":"1993","journal-title":"Pharm Res"},{"key":"10.1016\/j.xphs.2020.09.033_bib58","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ijpharm.2012.06.059","article-title":"Methods for the practical determination of the mechanical strength of tablets-From empiricism to science","volume":"436","author":"Podczeck","year":"2012","journal-title":"Int J Pharm"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920305633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920305633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:31:38Z","timestamp":1758360698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354920305633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0022354920305633"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2020.09.033","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiplasmodial Combined Formulation of Artemisinin with Peschiera fuchsiaefolia Bis-Indole Alkaloids","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2020.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}