{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T01:39:22Z","timestamp":1772847562573,"version":"3.50.1"},"reference-count":70,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009252","name":"Science for Life Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.xphs.2020.11.001","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T20:52:57Z","timestamp":1604523177000},"page":"239-250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease"],"prefix":"10.1016","volume":"110","author":[{"given":"Shno","family":"Asad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Wegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christel A.S.","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Phillipson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Artursson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Teleki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.xphs.2020.11.001_bib1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.3748\/wjg.v22.i3.917","article-title":"Inflammatory bowel disease imaging: current practice and future directions","volume":"22","author":"Kilcoyne","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"10218","key":"10.1016\/j.xphs.2020.11.001_bib2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0140-6736(19)32545-0","article-title":"Colorectal cancer in ulcerative colitis: a Scandinavian population-based cohort study","volume":"395","author":"Ol\u00e9n","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cgh.2019.04.012","article-title":"Development and validation of the mucosal inflammation noninvasive index for pediatric Crohn's disease","volume":"18","author":"Cozijnsen","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.xphs.2020.11.001_bib4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/00365513.2016.1185145","article-title":"Evaluation of biomarkers for ulcerative colitis comparing two sampling methods: fecal markers reflect colorectal inflammation both macroscopically and on a cellular level","volume":"76","author":"Peterson","year":"2016","journal-title":"Scand J Clin Lab Invest"},{"issue":"123","key":"10.1016\/j.xphs.2020.11.001_bib5","article-title":"Serum biomarkers for inflammatory bowel disease","volume":"7","author":"Chen","year":"2020","journal-title":"Front Med"},{"issue":"4","key":"10.1016\/j.xphs.2020.11.001_bib6","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/gut.47.4.506","article-title":"A\u00a0simple method for assessing intestinal inflammation in Crohn's disease","volume":"47","author":"Tibble","year":"2000","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.xphs.2020.11.001_bib7","first-page":"396","article-title":"Fecal biomarkers for the diagnosis and management of inflammatory bowel disease","volume":"7","author":"Assche","year":"2011","journal-title":"Gastroenterol Hepatol"},{"key":"10.1016\/j.xphs.2020.11.001_bib8","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3389\/fncel.2014.00389","article-title":"Molecular magnetic resonance imaging of brain-immune interactions","volume":"8","author":"Gauberti","year":"2014","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"10.1016\/j.xphs.2020.11.001_bib9","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1016\/j.bios.2009.04.010","article-title":"Implantable diagnostic device for cancer monitoring","volume":"24","author":"Daniel","year":"2009","journal-title":"Biosens Bioelectron"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4291\/wjgp.v7.i1.27","article-title":"Current application of proteomics in biomarker discovery for inflammatory bowel disease","volume":"7","author":"Chan","year":"2016","journal-title":"World J Gastrointest Pathophysiol"},{"issue":"33","key":"10.1016\/j.xphs.2020.11.001_bib11","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.3748\/wjg.v23.i33.6016","article-title":"Dextran sodium sulfate colitis murine model: an indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis","volume":"23","author":"Eichele","year":"2017","journal-title":"World J Gastroenterol"},{"issue":"2","key":"10.1016\/j.xphs.2020.11.001_bib12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jcmgh.2015.01.006","article-title":"Experimental models of inflammatory bowel diseases","volume":"1","author":"Kiesler","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.xphs.2020.11.001_bib13","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/jps.2600790604","article-title":"Epithelial transport of drugs in cell culture. I: a model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells","volume":"79","author":"Artursson","year":"1990","journal-title":"J\u00a0Pharm Sci"},{"issue":"5","key":"10.1016\/j.xphs.2020.11.001_bib14","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.tiv.2010.04.002","article-title":"Inflammatory parameters in Caco-2 cells: effect of stimuli nature, concentration, combination and cell differentiation","volume":"24","author":"Van De Walle","year":"2010","journal-title":"Toxicol In\u00a0Vitro"},{"issue":"6","key":"10.1016\/j.xphs.2020.11.001_bib15","first-page":"1357","article-title":"In\u00a0vitro effects of dextran sulfate sodium on a Caco-2 cell line and plausible mechanisms for dextran sulfate sodium-induced colitis","volume":"16","author":"Araki","year":"2006","journal-title":"Oncol Rep"},{"issue":"2","key":"10.1016\/j.xphs.2020.11.001_bib16","first-page":"238","article-title":"Clinicopathologic study of dextran sulfate sodium experimental murine colitis","volume":"69","author":"Cooper","year":"1993","journal-title":"Lab Invest"},{"key":"10.1016\/j.xphs.2020.11.001_bib17","first-page":"102","article-title":"Runt intestinal disease","volume":"14","author":"Reilly","year":"1965","journal-title":"Lab Invest"},{"issue":"6","key":"10.1016\/j.xphs.2020.11.001_bib18","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1021\/ac300006b","article-title":"Consecutive proteolytic digestion in an enzyme reactor increases depth of proteomic and phosphoproteomic analysis","volume":"84","author":"Wi\u015bniewski","year":"2012","journal-title":"Anal Chem"},{"issue":"3","key":"10.1016\/j.xphs.2020.11.001_bib19","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1021\/ac026117i","article-title":"Stop and go extraction tips for matrix-assisted laser desorption\/ionization, nanoelectrospray, and LC\/MS sample pretreatment in proteomics","volume":"75","author":"Rappsilber","year":"2003","journal-title":"Anal Chem"},{"key":"10.1016\/j.xphs.2020.11.001_bib20","series-title":"Mitochondria: Practical Protocols","first-page":"69","article-title":"Label-free quantitative analysis of mitochondrial proteomes using the multienzyme digestion-filter aided sample preparation (MED-FASP) and \u201ctotal protein approach\u201d","author":"Wi\u015bniewski","year":"2017"},{"issue":"8","key":"10.1016\/j.xphs.2020.11.001_bib21","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.1021\/ac504689z","article-title":"Fast and sensitive total protein and peptide assays for proteomic analysis","volume":"87","author":"Wi\u015bniewski","year":"2015","journal-title":"Anal Chem"},{"issue":"12","key":"10.1016\/j.xphs.2020.11.001_bib22","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1038\/nprot.2016.136","article-title":"The MaxQuant computational platform for mass spectrometry-based shotgun proteomics","volume":"11","author":"Tyanova","year":"2016","journal-title":"Nat Protoc"},{"issue":"suppl_1","key":"10.1016\/j.xphs.2020.11.001_bib23","doi-asserted-by":"crossref","first-page":"S96","DOI":"10.1093\/bioinformatics\/18.suppl_1.S96","article-title":"Variance stabilization applied to microarray data calibration and to the quantification of differential expression","volume":"18","author":"Huber","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1016\/j.xphs.2020.11.001_bib24","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jprot.2014.07.012","article-title":"Multi-enzyme digestion FASP and the \u2018Total Protein Approach\u2019-based absolute quantification of the Escherichia coli proteome","volume":"109","author":"Wi\u015bniewski","year":"2014","journal-title":"J\u00a0Proteomics"},{"issue":"7","key":"10.1016\/j.xphs.2020.11.001_bib25","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.xphs.2020.11.001_bib26","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R Package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"issue":"10","key":"10.1016\/j.xphs.2020.11.001_bib27","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1039\/C5FO00513B","article-title":"6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS)-treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation","volume":"6","author":"Chang","year":"2015","journal-title":"Food Funct"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib28","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1038\/s41598-020-60175-3","article-title":"The reduction of DSS-induced colitis severity in mice exposed to cigarette smoke is linked to immune modulation and microbial shifts","volume":"10","author":"Lo Sasso","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.xphs.2020.11.001_bib29","doi-asserted-by":"crossref","first-page":"15.25.11","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr Protoc Immunol"},{"issue":"4","key":"10.1016\/j.xphs.2020.11.001_bib30","doi-asserted-by":"crossref","first-page":"260","DOI":"10.15430\/JCP.2015.20.4.260","article-title":"Adequate dextran sodium sulfate-induced colitis model in mice and effective outcome measurement method","volume":"20","author":"Park","year":"2015","journal-title":"J\u00a0Cancer Prev"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41538-020-0065-5","article-title":"Integrated omics profiling of dextran sodium sulfate-induced colitic mice supplemented with Wolfberry (Lycium barbarum)","volume":"4","author":"Aw","year":"2020","journal-title":"NPJ Sci Food"},{"issue":"8","key":"10.1016\/j.xphs.2020.11.001_bib32","first-page":"4557","article-title":"A\u00a0guide to histomorphological evaluation of intestinal inflammation in mouse models","volume":"7","author":"Erben","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib33","doi-asserted-by":"crossref","first-page":"4","DOI":"10.18383\/j.tom.2017.00021","article-title":"Assessing mucosal inflammation in a DSS-induced colitis mouse model by MR colonography","volume":"4","author":"Biton","year":"2018","journal-title":"Tomography"},{"issue":"6","key":"10.1016\/j.xphs.2020.11.001_bib34","doi-asserted-by":"crossref","first-page":"e6073","DOI":"10.1371\/journal.pone.0006073","article-title":"Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis","volume":"4","author":"Yan","year":"2009","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib35","first-page":"e1004","article-title":"Fecal myeloperoxidase as a biomarker for inflammatory bowel disease","volume":"9","author":"Hansberry","year":"2017","journal-title":"Cureus"},{"key":"10.1016\/j.xphs.2020.11.001_bib36","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.pharmthera.2016.07.015","article-title":"S100A8\/A9: from basic science to clinical application","volume":"167","author":"Pruenster","year":"2016","journal-title":"Pharmacol Ther"},{"issue":"36","key":"10.1016\/j.xphs.2020.11.001_bib37","doi-asserted-by":"crossref","first-page":"5584","DOI":"10.3748\/wjg.14.5584","article-title":"Fecal markers of inflammation used as surrogate markers for treatment outcome in relapsing inflammatory bowel disease","volume":"14","author":"Wagner","year":"2008","journal-title":"World J Gastroenterol"},{"issue":"12","key":"10.1016\/j.xphs.2020.11.001_bib38","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1111\/j.1572-0241.1999.01640.x","article-title":"Fecal eosinophil granule-derived proteins reflect disease activity in inflammatory bowel disease","volume":"94","author":"Saitoh","year":"1999","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"10.1016\/j.xphs.2020.11.001_bib39","first-page":"1442","article-title":"Coagulation parameters in inflammatory bowel disease","volume":"7","author":"Dolapcioglu","year":"2014","journal-title":"Int J Clin Exp Med"},{"issue":"3","key":"10.1016\/j.xphs.2020.11.001_bib40","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00441-014-1990-x","article-title":"Characterization of distinct sub-cellular location of transglutaminase type II: changes in intracellular distribution in physiological and pathological states","volume":"358","author":"Piacentini","year":"2014","journal-title":"Cell Tissue Res"},{"issue":"3","key":"10.1016\/j.xphs.2020.11.001_bib41","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/labinvest.2010.186","article-title":"Beneficial effects of treatment with transglutaminase inhibitor cystamine on the severity of inflammation in a rat model of inflammatory bowel disease","volume":"91","author":"Elli","year":"2011","journal-title":"Lab Invest"},{"issue":"12","key":"10.1016\/j.xphs.2020.11.001_bib42","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/ibd.21023","article-title":"Defect in CEACAM family member expression in Crohn's disease IECs is regulated by the transcription factor SOX9","volume":"15","author":"Roda","year":"2009","journal-title":"Inflamm Bowel Dis"},{"issue":"Suppl_2","key":"10.1016\/j.xphs.2020.11.001_bib43","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1097\/00054725-201112002-00241","article-title":"CEACAM5 is upregulated with inflammation in Crohn's colitis in response to IL-22: P-207","volume":"17","author":"Denmark","year":"2011","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbrc.2016.07.066","article-title":"The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells","volume":"478","author":"Zou","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1016\/j.xphs.2020.11.001_bib45","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1159\/000505910","article-title":"Annexin A1 expression capacity as a determinant for disease severity in Crohn's disease","volume":"38","author":"Reischl","year":"2020","journal-title":"Dig Dis"},{"issue":"5","key":"10.1016\/j.xphs.2020.11.001_bib46","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/mi.2015.135","article-title":"Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing","volume":"9","author":"Sumagin","year":"2016","journal-title":"Mucosal Immunol"},{"issue":"suppl_2","key":"10.1016\/j.xphs.2020.11.001_bib47","doi-asserted-by":"crossref","first-page":"S669","DOI":"10.1093\/ecco-jcc\/jjy059","article-title":"Targeting endothelial ligands: ICAM-1\/alicaforsen, MAdCAM-1","volume":"12","author":"Reinisch","year":"2018","journal-title":"J\u00a0Crohns Colitis"},{"issue":"20","key":"10.1016\/j.xphs.2020.11.001_bib48","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1002\/adfm.201600084","article-title":"Chitosan-alginate microcapsules provide gastric protection and intestinal release of ICAM-1-targeting nanocarriers, enabling GI targeting in\u00a0vivo","volume":"26","author":"Ghaffarian","year":"2016","journal-title":"Adv Funct Mater"},{"issue":"5","key":"10.1016\/j.xphs.2020.11.001_bib49","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1177\/2050640613501818","article-title":"Faecal calprotectin and lactoferrin as markers for monitoring disease activity and predicting clinical recurrence in patients with Crohn's disease after ileocolonic resection: a prospective pilot study","volume":"1","author":"Yamamoto","year":"2013","journal-title":"United European Gastroenterol J"},{"issue":"5","key":"10.1016\/j.xphs.2020.11.001_bib50","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00535-011-0516-5","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL) in inflammatory bowel disease: association with pathophysiology of inflammation, established markers, and disease activity","volume":"47","author":"Oikonomou","year":"2012","journal-title":"J\u00a0Gastroenterol"},{"issue":"3","key":"10.1016\/j.xphs.2020.11.001_bib51","first-page":"569","article-title":"Neutrophil gelatinase-associated lipocalin levels in patients with Crohn disease undergoing treatment with infliximab","volume":"58","author":"Bolignano","year":"2010","journal-title":"J\u00a0Invest Med"},{"issue":"10","key":"10.1016\/j.xphs.2020.11.001_bib52","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1111\/j.1572-0241.1999.01439.x","article-title":"Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8, and tumor necrosis factor-alpha in ulcerative colitis","volume":"94","author":"Nielsen","year":"1999","journal-title":"Am J Gastroenterol"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib53","doi-asserted-by":"crossref","first-page":"13295","DOI":"10.1038\/s41598-019-49840-4","article-title":"Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease","volume":"9","author":"Anderson","year":"2019","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.xphs.2020.11.001_bib54","doi-asserted-by":"crossref","first-page":"498","DOI":"10.5606\/ArchRheumatol.2018.6595","article-title":"Cathepsin G and its role in inflammation and autoimmune diseases","volume":"33","author":"Gao","year":"2018","journal-title":"Arch Rheumatol"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib55","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2353\/ajpath.2009.080986","article-title":"Luminal cathepsin G and protease-activated receptor 4: a duet involved in alterations of the colonic epithelial barrier in ulcerative colitis","volume":"175","author":"Dabek","year":"2009","journal-title":"Am J Pathol"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib56","doi-asserted-by":"crossref","first-page":"7834","DOI":"10.1038\/s41598-018-26282-y","article-title":"Functional proteomic profiling of secreted serine proteases in health and inflammatory bowel disease","volume":"8","author":"Denadai-Souza","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.xphs.2020.11.001_bib57","series-title":"Autoantibodies","first-page":"115","article-title":"Chapter 13 - antineutrophil cytoplasmic antibodies with specificity for proteinase 3","author":"Csernok","year":"2014"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib58","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1039\/C8MO00239H","article-title":"Degradation of the extracellular matrix is part of the pathology of ulcerative colitis","volume":"15","author":"Kirov","year":"2019","journal-title":"Mol Omics"},{"issue":"D1","key":"10.1016\/j.xphs.2020.11.001_bib59","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.xphs.2020.11.001_bib60","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3390\/ijms19041045","article-title":"Annexin A1: uncovering the many talents of an old protein","volume":"19","author":"Sheikh","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xphs.2020.11.001_bib61","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.abb.2018.03.012","article-title":"Myeloperoxidase in the inflamed colon: a novel target for treating inflammatory bowel disease","volume":"645","author":"Chami","year":"2018","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"10.1016\/j.xphs.2020.11.001_bib62","doi-asserted-by":"crossref","first-page":"e0115828","DOI":"10.1371\/journal.pone.0115828","article-title":"S100A9 induced inflammatory responses are mediated by distinct damage associated molecular patterns (DAMP) receptors in\u00a0vitro and in\u00a0vivo","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib63","doi-asserted-by":"crossref","first-page":"35014","DOI":"10.1038\/srep35014","article-title":"Lipocalin 2 prevents intestinal inflammation by enhancing phagocytic bacterial clearance in macrophages","volume":"6","author":"Toyonaga","year":"2016","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.xphs.2020.11.001_bib64","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1080\/00365520701427094","article-title":"Relationship between fecal lactoferrin and inflammatory bowel disease","volume":"42","author":"Dai","year":"2007","journal-title":"Scand J Gastroenterol"},{"issue":"7","key":"10.1016\/j.xphs.2020.11.001_bib65","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/CS20150660","article-title":"NOX2-dependent regulation of inflammation","volume":"130","author":"Singel","year":"2016","journal-title":"Clin Sci"},{"issue":"1","key":"10.1016\/j.xphs.2020.11.001_bib66","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00044.2005","article-title":"The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology","volume":"87","author":"Bedard","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.xphs.2020.11.001_bib67","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.9415.1","article-title":"Biology and structure of leukocyte \u03b2 (2) integrins and their role in inflammation","volume":"5","author":"Arnaout","year":"2016","journal-title":"F1000Res"},{"issue":"suppl_2","key":"10.1016\/j.xphs.2020.11.001_bib68","doi-asserted-by":"crossref","first-page":"S653","DOI":"10.1093\/ecco-jcc\/jjy060","article-title":"Gut-selective integrin-targeted therapies for inflammatory bowel disease","volume":"12","author":"Lamb","year":"2018","journal-title":"J\u00a0Crohns Colitis"},{"issue":"6","key":"10.1016\/j.xphs.2020.11.001_bib69","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1189\/jlb.0512231","article-title":"The mannose receptor","volume":"92","author":"Martinez-Pomares","year":"2012","journal-title":"J\u00a0Leukoc Biol"},{"issue":"21","key":"10.1016\/j.xphs.2020.11.001_bib70","doi-asserted-by":"crossref","first-page":"eaaz6717","DOI":"10.1126\/sciadv.aaz6717","article-title":"Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation","volume":"6","author":"Ma","year":"2020","journal-title":"Sci Adv"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920306857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354920306857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:29:45Z","timestamp":1758360585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354920306857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0022354920306857"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2020.11.001","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2020.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of the American Pharmacists Association\u00ae.","name":"copyright","label":"Copyright"}]}}