{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:13:43Z","timestamp":1780982023244,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.xphs.2022.04.003","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T21:52:19Z","timestamp":1649454739000},"page":"2505-2513","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hydrophobic Derivatives of Sulfated Hyaluronic Acid as Drug Delivery Systems for Multi-Target Intra-Articular Treatment of Post-Traumatic Osteoarthritis"],"prefix":"10.1016","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-8635","authenticated-orcid":false,"given":"Cristian","family":"Guarise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Tessari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Pavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pluda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Di Lucia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Barbera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devis","family":"Galesso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xphs.2022.04.003_bib0001","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrd1693","article-title":"Osteoarthritis \u2014 an untreatable disease?","volume":"4","author":"Wieland","year":"2005","journal-title":"Nat Rev Drug Discov"},{"issue":"57","key":"10.1016\/j.xphs.2022.04.003_bib0002","first-page":"1","article-title":"Post-traumatic osteoarthritis following ACL injury","volume":"22","author":"Wang","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.xphs.2022.04.003_bib0003","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.actbio.2020.05.005","article-title":"Early changes in cartilage pericellular matrix micromechanobiology portend the onset of post-traumatic osteoarthritis","volume":"111","author":"Chery","year":"2020","journal-title":"Acta Biomater"},{"key":"10.1016\/j.xphs.2022.04.003_bib0004","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1007\/s00167-019-05461-y","article-title":"Post-traumatic osteoarthritis diagnosed within 5 years following ACL reconstruction","volume":"28","author":"Bodkin","year":"2020","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.xphs.2022.04.003_bib0005","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2016-000279","article-title":"Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation","volume":"2","author":"Punzi","year":"2016","journal-title":"RMD Open"},{"issue":"4","key":"10.1016\/j.xphs.2022.04.003_bib0006","doi-asserted-by":"crossref","first-page":"14207","DOI":"10.4238\/2015.November.13.4","article-title":"Cartilage oligomeric matrix protein and matrix metalloproteinase-3 expression in the serum and joint fluid of a reversible osteoarthritis rabbit model","volume":"13","author":"Chu","year":"2015","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.xphs.2022.04.003_bib0007","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1471-2474-13-126","article-title":"Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid","volume":"13","author":"Heard","year":"2012","journal-title":"BMC Musculoskelet Disord"},{"issue":"88","key":"10.1016\/j.xphs.2022.04.003_bib0008","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases","volume":"92","author":"Visse","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.xphs.2022.04.003_bib0009","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ijbiomac.2015.12.003","article-title":"Hyaluronic acid alkyl derivative: a novel inhibitor of metalloproteases and hyaluronidases","volume":"84","author":"Pavan","year":"2016","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.xphs.2022.04.003_bib0010","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1319569111","article-title":"TRPV4-mediated chondrocyte mechanotransduction","author":"O'Conor","year":"2014","journal-title":"PNAS"},{"issue":"1","key":"10.1016\/j.xphs.2022.04.003_bib0011","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/19336950.2021.1903184","article-title":"Mechanosensory and mechanotransductive processes mediated by ion channels in articular chondrocytes: potential therapeutic targets for osteoarthritis","volume":"15","author":"Zhang","year":"2021","journal-title":"Channels"},{"key":"10.1016\/j.xphs.2022.04.003_bib0012","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ng.945","article-title":"Mutations in TRPV4 cause an inherited arthropathy of hands and feet","volume":"43","author":"Lamand\u00e9","year":"2011","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.xphs.2022.04.003_bib0013","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00210-014-1078-x","article-title":"TRPV4 as a therapeutic target for joint diseases","volume":"388","author":"McNulty","year":"2015","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"17","key":"10.1016\/j.xphs.2022.04.003_bib0014","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.2174\/156802611796904861","article-title":"A. TRPV4 agonists and antagonists","volume":"11","author":"Vincent","year":"2011","journal-title":"Curr Top Med Chem"},{"issue":"1","key":"10.1016\/j.xphs.2022.04.003_bib0015","doi-asserted-by":"crossref","first-page":"10928","DOI":"10.1038\/s41598-019-47342-x","article-title":"Transient Receptor Potential vanilloid 4 ion channel in C-fibres is involved in mechanonociception of the normal and inflamed joint","volume":"29","author":"Richter","year":"2019","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.xphs.2022.04.003_bib0016","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s40268-015-0082-z","article-title":"mTOR: a potential therapeutic target in osteoarthritis?","volume":"15","author":"Pal","year":"2015","journal-title":"Drugs R D"},{"issue":"10","key":"10.1016\/j.xphs.2022.04.003_bib0017","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1002\/jor.24049","article-title":"mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees","volume":"36","author":"Katsara","year":"2018","journal-title":"J Orthop Res"},{"issue":"9","key":"10.1016\/j.xphs.2022.04.003_bib0018","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1080\/08941939.2019.1574321","article-title":"Rapamycin inhibits Nf-\u039aB activation by autophagy to reduce catabolism in human chondrocytes","volume":"33","author":"Liu","year":"2020","journal-title":"J Invest Surg"},{"issue":"6","key":"10.1016\/j.xphs.2022.04.003_bib0019","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.18632\/aging.102937","article-title":"Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis","volume":"17","author":"Bao","year":"2020","journal-title":"Aging"},{"issue":"2","key":"10.1016\/j.xphs.2022.04.003_bib0020","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/jcb.24362","article-title":"Vertical inhibition of the PI3K\/Akt\/mTOR pathway for the treatment of osteoarthritis","volume":"114","author":"Chen","year":"2013","journal-title":"J Cell Biochem"},{"issue":"4","key":"10.1016\/j.xphs.2022.04.003_bib0021","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/08916934.2019.1643844","article-title":"Local intra-articular injection of rapamycin inhibits NLRP3 activity and prevents osteoarthritis in mouse DMM models","volume":"52","author":"Xu","year":"2019","journal-title":"Autoimmunity"},{"key":"10.1016\/j.xphs.2022.04.003_bib0022","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1039\/D0BM00596G","article-title":"Rapamycin\u2013PLGA microparticles prevent senescence, sustain cartilage matrix production under stress and exhibit prolonged retention in mouse joint","volume":"8","author":"Dhanabalan","year":"2020","journal-title":"Biomater Sci"},{"key":"10.1016\/j.xphs.2022.04.003_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120807","article-title":"PLGA-based nanomedicines manufacturing: technologies overview and challenges in industrial scale-up","volume":"605","author":"Operti","year":"2021","journal-title":"Int J Pharm"},{"issue":"7","key":"10.1016\/j.xphs.2022.04.003_bib0024","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1080\/08927014.2018.1491555","article-title":"Dopamine-functionalized sulphated hyaluronic acid as a titanium implant coating enhances biofilm prevention and promotes osseointegration","volume":"34","author":"Guarise","year":"2018","journal-title":"Biofouling"},{"issue":"5","key":"10.1016\/j.xphs.2022.04.003_bib0025","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0960-894X(00)00026-3","article-title":"Protease inhibitors: synthesis of clostridium histolyticum collagenase inhibitors incorporating sulfonyl-l-alanine hydroxamate moieties","volume":"6","author":"Scozzafava","year":"2000","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.xphs.2022.04.003_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116132","article-title":"Amphiphilic peptide-based MMP3 inhibitors for intra-articular treatment of knee OA","volume":"38","author":"Guarise","year":"2021","journal-title":"Bioorg Med Chem"},{"issue":"2","key":"10.1016\/j.xphs.2022.04.003_bib0027","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/0003-2697(91)90084-7","article-title":"Use of Nile red as a fluorescent probe for the study of the hydrophobic properties of protein-sodium dodecyl sulfate complexes in solution","volume":"199","author":"Daban","year":"1991","journal-title":"Anal Biochem"},{"issue":"4","key":"10.1016\/j.xphs.2022.04.003_bib0028","doi-asserted-by":"crossref","first-page":"664","DOI":"10.3390\/lubricants3040664","article-title":"Development of a synthetic synovial fluid for tribological testing","volume":"3","author":"Bortel","year":"2015","journal-title":"Lubricants"},{"issue":"7\u20139","key":"10.1016\/j.xphs.2022.04.003_bib0029","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s10719-005-1390-2","article-title":"Serum hyaluronidase aberrations in metabolic and morphogenetic disorders","volume":"22","author":"Fiszer-Szafarz","year":"2005","journal-title":"Glycoconj J"},{"issue":"1","key":"10.1016\/j.xphs.2022.04.003_bib0030","doi-asserted-by":"crossref","first-page":"S286","DOI":"10.1016\/j.joca.2018.02.577","article-title":"Matrix metalloprotease 3 (MMP3) inhibition effect of a viscosupplement based on a hyaluronic acid amide derivative (HYADD4)","volume":"26","author":"Guarise","year":"2018","journal-title":"Osteoarthritis and cartilage"},{"issue":"9","key":"10.1016\/j.xphs.2022.04.003_bib0031","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1002\/1529-0131(200009)43:9<1916::AID-ANR2>3.0.CO;2-I","article-title":"The role of the chondrocyte in osteoarthritis","volume":"43","author":"Goldring","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.xphs.2022.04.003_bib0032","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1039\/C7PY00832E","article-title":"Aqueous solution behaviour of novel water-soluble amphiphilic copolymers with elevated hydrophobic unit content","volume":"8","author":"Jiang","year":"2017","journal-title":"Polym Chem"},{"key":"10.1016\/j.xphs.2022.04.003_bib0033","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/1099-1395(200010)13:10<591::AID-POC305>3.0.CO;2-2","article-title":"Polarity study of some 1-alkyl-3-methylimidazolium ambient-temperature ionic liquids with the solvatochromic dye, Nile Red","volume":"13","author":"Carmichael","year":"2000","journal-title":"J Phys Org Chem"},{"key":"10.1016\/j.xphs.2022.04.003_bib0034","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cplett.2008.09.001","article-title":"Nile red probing for the micelle-to-vesicle transition of AOT in aqueous solution","volume":"464","author":"Lin","year":"2008","journal-title":"Chem Phys Lett"},{"key":"10.1016\/j.xphs.2022.04.003_bib0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40591-016-0048-8","article-title":"Albumin-based drug delivery: harnessing nature to cure disease","volume":"27","author":"Larsen","year":"2016","journal-title":"Mol Cell Ther"},{"key":"10.1016\/j.xphs.2022.04.003_bib0036","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jddst.2018.11.012","article-title":"Simulated synovial fluids for in vitro drug and prodrug release testing of depot injectables intended for joint injection","volume":"49","author":"Thing","year":"2019","journal-title":"J Drug Deliv Sci Technol"},{"issue":"3","key":"10.1016\/j.xphs.2022.04.003_bib0037","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.bbrc.2009.09.007","article-title":"Identification and characterization of novel TRPV4 modulators","volume":"389","author":"Vincent","year":"2009","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354922001551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354922001551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:37:38Z","timestamp":1758361058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354922001551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0022354922001551"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2022.04.003","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrophobic Derivatives of Sulfated Hyaluronic Acid as Drug Delivery Systems for Multi-Target Intra-Articular Treatment of Post-Traumatic Osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2022.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}