{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:29:04Z","timestamp":1792589344167,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.xphs.2022.08.016","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T21:42:21Z","timestamp":1660945341000},"page":"3232-3242","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Wharton Jelly Derived Mesenchymal Stem Cell's Exosomes Demonstrate Significant Antileishmanial and Wound Healing Effects in Combination with Aloe-Emodin: An in Vitro Study"],"prefix":"10.1016","volume":"111","author":[{"given":"Gulnaz Yildirim","family":"Koken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah Sefik","family":"Abamor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adil","family":"Allahverdiyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Karaoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.xphs.2022.08.016_bib0001","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jtcme.2014.11.004","article-title":"In vitro and in vivo antileishmanial effects of aloe-emodin on Leishmania major","volume":"5","author":"Dalimi","year":"2015","journal-title":"J Tradit Complement Med"},{"issue":"3","key":"10.1016\/j.xphs.2022.08.016_bib0002","first-page":"399","article-title":"Current scenario of drug development for leishmaniasis","volume":"123","author":"Croft","year":"2006","journal-title":"Indian J Med Res"},{"issue":"2","key":"10.1016\/j.xphs.2022.08.016_bib0003","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.stem.2009.07.001","article-title":"iPS cells can support full-term development of tetraploid blastocyst-complemented embryos","volume":"5","author":"Kang","year":"2009","journal-title":"Cell stem cell"},{"issue":"1","key":"10.1016\/j.xphs.2022.08.016_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-015-0417-0","article-title":"Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis","volume":"13","author":"Zhang","year":"2015","journal-title":"J Transl Med"},{"key":"10.1016\/j.xphs.2022.08.016_bib0005","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00007890-197404000-00001","article-title":"Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues: cloning in vitro and retransplantation in vivo","volume":"17","author":"Friedenstein","year":"1974","journal-title":"Transplantation"},{"key":"10.1016\/j.xphs.2022.08.016_bib0006","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1634\/stemcells.22-4-617","article-title":"Skeletal myogenic differentiation of mesenchymal stem cells isolated from human umbilical cord blood","volume":"22","author":"Gang","year":"2004","journal-title":"Stem Cells"},{"key":"10.1016\/j.xphs.2022.08.016_bib0007","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/j.biochi.2013.04.017","article-title":"Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: role of secretome and exosomes","volume":"95","author":"Maumus","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.xphs.2022.08.016_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2020.151097","article-title":"Mesenchymal stromal cells (MSCs) for neurodegenerative disease: a promising frontier","volume":"99","author":"Shariati","year":"2020","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.xphs.2022.08.016_bib0009","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.1002\/jcp.29803","article-title":"Mesenchymal stromal cells; a new horizon in regenerative medicine","volume":"235","author":"Tavakoli","year":"2020","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.xphs.2022.08.016_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02265-1","article-title":"Mesenchymal stem\/stromal cells as a valuable source for the treatment of immune-mediated disorders","volume":"12","author":"Markov","year":"2021","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.xphs.2022.08.016_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02378-7","article-title":"Mesenchymal stem\/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities","volume":"12","author":"Hassanzadeh","year":"2021","journal-title":"Stem Cell Res Therapy"},{"issue":"4","key":"10.1016\/j.xphs.2022.08.016_bib0012","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9041102","article-title":"Human Wharton's jelly\u2014cellular specificity, stemness potency, animal models, and current application in human clinical trials","volume":"9","author":"Stefa\u0144ska","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.xphs.2022.08.016_bib0013","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1525-1594.2009.00824.x","article-title":"Aging adversely impacts biological properties of human bone marrow-derived mesenchymal stem cells: implications for tissue engineering heart valve construction","volume":"34","author":"Xin","year":"2010","journal-title":"Artif Organs"},{"key":"10.1016\/j.xphs.2022.08.016_bib0014","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00277-012-1438-x","article-title":"Isik S. Donor age and long-term culture affect differentiation and proliferation of human bone marrow mesenchymal stem cells","volume":"91","author":"Zaim","year":"2012","journal-title":"Ann Hematol"},{"issue":"9","key":"10.1016\/j.xphs.2022.08.016_bib0015","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3727\/096368913X667709","article-title":"Paracrine mechanisms of Mesenchymal Stem cell-based therapy: current status and perspectives","volume":"23","author":"Liang","year":"2014","journal-title":"Cell Transplant"},{"key":"10.1016\/j.xphs.2022.08.016_bib0016","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3727\/096368912X657495","article-title":"Neurotrophin-3 accelerates wound healing in diabetic mice by promoting a paracrine response in mesenchymal stem cells","volume":"22","author":"Shen","year":"2013","journal-title":"Cell Transplant"},{"key":"10.1016\/j.xphs.2022.08.016_bib0017","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1089\/scd.2013.0277","article-title":"The paracrine effects of mesenchymal stem cells stimulate the regeneration capacity of endogenous stem cells in the repair of a bladder-outlet-obstruction-induced overactive bladder","volume":"23","author":"Song","year":"2014","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.xphs.2022.08.016_bib0018","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1089\/scd.2012.0095","article-title":"Microvesicles derived from human umbilical cord mesenchymal stem cells stimulated by hypoxia promote angiogenesis both in vitro and in vivo","volume":"21","author":"Zhang","year":"2012","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.xphs.2022.08.016_bib0019","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/stem.1129","article-title":"Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth","volume":"30","author":"Xin","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.xphs.2022.08.016_bib0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fphys.2012.00359","article-title":"Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy","volume":"3","author":"Baglio","year":"2012","journal-title":"Front Physiol"},{"key":"10.1016\/j.xphs.2022.08.016_bib0021","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/CIRCRESAHA.111.253286","article-title":"Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activity","volume":"109","author":"Sahoo","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.xphs.2022.08.016_bib0022","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1242\/jcs.064386","article-title":"Microvesicles: mediators of extracellular communication during cancer progression","volume":"123","author":"Muralidharan-Chari","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1016\/j.xphs.2022.08.016_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00011-008-8210-7","article-title":"Highlights of a new type of intercellular communication: microvesicle-based information transfer","volume":"58","author":"Pap","year":"2009","journal-title":"Inflamm Res"},{"key":"10.1016\/j.xphs.2022.08.016_bib0024","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1034\/j.1600-0854.2002.30502.x","article-title":"The biogenesis and functions of exosomes","volume":"3","author":"Stoorvogel","year":"2002","journal-title":"Traffic"},{"issue":"1","key":"10.1016\/j.xphs.2022.08.016_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-015-0417-0","article-title":"Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis","volume":"13","author":"Zhang","year":"2015","journal-title":"J Transl Med"},{"issue":"2","key":"10.1016\/j.xphs.2022.08.016_bib0026","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.talanta.2010.09.058","article-title":"A novel sensitive detection platform for antitumor herbal drug aloe-emodin based on the graphene modified electrode","volume":"83","author":"Li","year":"2010","journal-title":"Talanta"},{"issue":"1","key":"10.1016\/j.xphs.2022.08.016_bib0027","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.foodchem.2010.10.112","article-title":"Determination of aloe emodin in Aloe vera extracts and commercial formulations by HPLC with tandem UV absorption and fluorescence detection","volume":"126","author":"Mandrioli","year":"2011","journal-title":"Food Chem"},{"issue":"9","key":"10.1016\/j.xphs.2022.08.016_bib0028","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1016\/j.fct.2012.05.047","article-title":"Cell-type dependent response of melanoma cells to aloe emodin","volume":"50","author":"Radovic","year":"2012","journal-title":"Food Chem Toxicol"},{"issue":"5","key":"10.1016\/j.xphs.2022.08.016_bib0029","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.bmc.2013.01.015","article-title":"Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors","volume":"21","author":"Shi","year":"2013","journal-title":"Bioorg Med Chem"},{"issue":"4","key":"10.1016\/j.xphs.2022.08.016_bib0030","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"4","key":"10.1016\/j.xphs.2022.08.016_bib0031","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3390\/jcm9041102","article-title":"Human Wharton's jelly\u2014cellular specificity, stemness potency, animal models, and current application in human clinical trials","volume":"9","author":"Stefa\u0144ska","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.xphs.2022.08.016_bib0032","volume":"22","author":"Thery","year":"2006","journal-title":"Curr Protoc Cell Biol"},{"issue":"19","key":"10.1016\/j.xphs.2022.08.016_bib0033","doi-asserted-by":"crossref","first-page":"6631","DOI":"10.1039\/C5AN00688K","article-title":"Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers","volume":"140","author":"Wu","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.xphs.2022.08.016_bib0034","doi-asserted-by":"crossref","unstructured":"Sokolova V, Ludwig AK, Hornung S, Rotan O, Horn PA, Epple M, Giebel B. Characterisation of exosomes derived from human cells by nanoparticle tracking analysis and scanning electron microscopy B Biointerfaces.2011.","DOI":"10.1016\/j.colsurfb.2011.05.013"},{"issue":"03A","key":"10.1016\/j.xphs.2022.08.016_bib0035","first-page":"3241","article-title":"Combinations of wharton jelly derived exosomes and salisylic acid: a new hope for eradication of cutaneous leishmaniasis","volume":"31","author":"Yildirim Koken","year":"2022","journal-title":"Fresenius Environ Bull"},{"issue":"4","key":"10.1016\/j.xphs.2022.08.016_bib0036","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1017\/S0031182016002523","article-title":"Chemotherapy of leishmaniasis: present challenges","volume":"145","author":"Uliana","year":"2018","journal-title":"Parasitology"},{"issue":"3","key":"10.1016\/j.xphs.2022.08.016_bib0037","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/ced.14919","article-title":"Treatment options for leishmaniasis","volume":"47","author":"Pradhan","year":"2022","journal-title":"Clin Exp Dermatol"},{"issue":"1","key":"10.1016\/j.xphs.2022.08.016_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/scrt417","article-title":"Human Wharton's jelly mesenchymal stem cells promote skin wound healing through paracrine signaling","volume":"5","author":"Arno","year":"2014","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.xphs.2022.08.016_bib0039","first-page":"1","article-title":"Potency of umbilical cord blood-and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing","volume":"6","author":"Kitajima","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.xphs.2022.08.016_bib0040","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10735-017-9711-x","article-title":"Exosomes derived from human amniotic epithelial cells accelerate wound healing and inhibit scar formation","volume":"48","author":"Zhao","year":"2017","journal-title":"J Mol Histol"},{"issue":"2","key":"10.1016\/j.xphs.2022.08.016_bib0041","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/14653240802716590","article-title":"Characterization of bone marrow-derived mesenchymal stromal cells (MSC) based on gene expression profiling of functionally defined MSC subsets","volume":"11","author":"Tormin","year":"2009","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1016\/j.xphs.2022.08.016_bib0042","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/cyto.a.23242","article-title":"Isolation, cultivation, and characterization of human mesenchymal stem cells","volume":"93","author":"Mushahary","year":"2018","journal-title":"Cytometry Part A"},{"key":"10.1016\/j.xphs.2022.08.016_bib0043","series-title":"Mesenchymal Stem Cells in Kidney Repair","first-page":"89","author":"Morigi","year":"2016"},{"issue":"8","key":"10.1016\/j.xphs.2022.08.016_bib0044","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1093\/ndt\/gfs168","article-title":"Therapeutic potential of mesenchymal stem cell-derived microvesicles","volume":"27","author":"Biancone","year":"2012","journal-title":"Nephrol Dialysis Transplant"},{"issue":"10","key":"10.1016\/j.xphs.2022.08.016_bib0045","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1681\/ASN.2014070710","article-title":"AKI recovery induced by mesenchymal stromal cell-derived extracellular vesicles carrying microRNAs","volume":"26","author":"Collino","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.xphs.2022.08.016_bib0046","doi-asserted-by":"crossref","first-page":"e88685","DOI":"10.1371\/journal.pone.0088685","article-title":"Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22","volume":"9","author":"Feng","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.xphs.2022.08.016_bib0047","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ijcard.2014.12.043","article-title":"Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection","volume":"182","author":"Yu","year":"2015","journal-title":"Int J Cardiol"},{"issue":"36","key":"10.1016\/j.xphs.2022.08.016_bib0048","doi-asserted-by":"crossref","first-page":"13495","DOI":"10.1039\/C7NR04557C","article-title":"High-purity capture and release of circulating exosomes using an exosome-specific dual-patterned immunofiltration (ExoDIF) device","volume":"9","author":"Kang","year":"2017","journal-title":"Nanoscale"},{"issue":"1","key":"10.1016\/j.xphs.2022.08.016_bib0049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep37246","article-title":"Digital detection of exosomes by interferometric imaging","volume":"6","author":"Daaboul","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.xphs.2022.08.016_bib0050","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jconrel.2014.07.042","article-title":"Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: a new approach for drug delivery","volume":"192","author":"Pascucci","year":"2014","journal-title":"J Control Release"},{"issue":"7","key":"10.1016\/j.xphs.2022.08.016_bib0051","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1002\/stem.1771","article-title":"HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing","volume":"33","author":"Zhang","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.xphs.2022.08.016_bib0052","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fncel.2018.00317","article-title":"Potential effects of MSC-derived exosomes in neuroplasticity in Alzheimer's disease","author":"Reza-Zaldivar","year":"2018","journal-title":"Front Cellular Neurosci"},{"issue":"11","key":"10.1016\/j.xphs.2022.08.016_bib0053","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.fct.2007.06.005","article-title":"Aloe-emodin-induced apoptosis in human gastric carcinoma cells","volume":"45","author":"Chen","year":"2007","journal-title":"Food Chem Toxicol"},{"issue":"6","key":"10.1016\/j.xphs.2022.08.016_bib0054","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1007\/s00436-008-0899-2","article-title":"In vitro and in vivo activity of Aloe vera leaf exudate in experimental visceral leishmaniasis","volume":"102","author":"Dutta","year":"2008","journal-title":"Parasitol Res"},{"issue":"3","key":"10.1016\/j.xphs.2022.08.016_bib0055","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1164\/rccm.201410-1765OC","article-title":"Therapeutic effects of human mesenchymal stem cell\u2013derived microvesicles in severe pneumonia in mice","volume":"192","author":"Monsel","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"issue":"7","key":"10.1016\/j.xphs.2022.08.016_bib0056","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.4049\/jimmunol.1801534","article-title":"Mesenchymal stem cell\u2013derived extracellular vesicles decrease lung injury in mice","volume":"203","author":"Hao","year":"2019","journal-title":"J Immunol"},{"key":"10.1016\/j.xphs.2022.08.016_bib0057","first-page":"12","article-title":"Stem cell-derived exosome as potential therapeutics for microbial diseases","author":"Keshtkar","year":"2021","journal-title":"Front Microbiol"},{"key":"10.1016\/j.xphs.2022.08.016_bib0058","article-title":"Antibacterial activity and membrane-targeting mechanism of aloe-emodin against Staphylococcus epidermidis","volume":"12","author":"Li","year":"2021","journal-title":"Front Microbiol"},{"key":"10.1016\/j.xphs.2022.08.016_bib0059","article-title":"A multifunctional antibacterial and self-healing hydrogel laden with bone marrow mesenchymal stem cell-derived exosomes for accelerating diabetic wound healing","author":"Geng","year":"2021","journal-title":"Mater Sci Eng: C"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354922003537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354922003537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:39:19Z","timestamp":1758361159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354922003537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":59,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0022354922003537"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2022.08.016","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Wharton Jelly Derived Mesenchymal Stem Cell's Exosomes Demonstrate Significant Antileishmanial and Wound Healing Effects in Combination with Aloe-Emodin: An in Vitro Study","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2022.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc. on behalf of American Pharmacists Association.","name":"copyright","label":"Copyright"}]}}