{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:19:40Z","timestamp":1784866780097,"version":"3.55.0"},"reference-count":99,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.xphs.2022.10.001","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T11:41:17Z","timestamp":1665402077000},"page":"760-770","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Budesonide-Loaded Bilosomes as a Targeted Delivery Therapeutic Approach Against Acute Lung Injury in Rats"],"prefix":"10.1016","volume":"112","author":[{"given":"Heba F.","family":"Salem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada Abdelsabour","family":"Moubarak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1328-5987","authenticated-orcid":false,"given":"Adel A.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-5583","authenticated-orcid":false,"given":"Abeer A.A.","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-2645","authenticated-orcid":false,"given":"Alaa H.","family":"Salama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0001","first-page":"167","article-title":"Budesonide: a new corticosteroid in bronchial asthma","volume":"61","author":"Ellul-Micallef","year":"1980","journal-title":"Eur J Respir Dis"},{"issue":"7","key":"10.1016\/j.xphs.2022.10.001_bib0002","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.3390\/v13071411","article-title":"Antiviral effect of budesonide against SARS-CoV-2","volume":"13","author":"Heinen","year":"2021","journal-title":"Viruses"},{"issue":"8","key":"10.1016\/j.xphs.2022.10.001_bib0003","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.3109\/21691401.2015.1129614","article-title":"Budesonide-loaded solid lipid nanoparticles for pulmonary delivery: preparation, optimization, and aerodynamic behavior","volume":"44","author":"Esmaeili","year":"2016","journal-title":"Artif Cells, Nanomed Biotechnol"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.10.001_bib0004","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ijpharm.2015.03.033","article-title":"Investigating the potential of employing bilosomes as a novel vesicular carrier for transdermal delivery of tenoxicam","volume":"485","author":"Al-Mahallawi","year":"2015","journal-title":"Int J Pharm"},{"issue":"12","key":"10.1016\/j.xphs.2022.10.001_bib0005","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.3390\/nano10122472","article-title":"Novel surface-modified bilosomes as functional and biocompatible nanocarriers of hybrid compounds","volume":"10","author":"Waglewska","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.xphs.2022.10.001_bib0006","article-title":"Phytochemical delivery through nanocarriers: a review","author":"Ahmad","year":"2020","journal-title":"Colloids Surf B"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0007","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.apsb.2018.06.005","article-title":"Adapting liposomes for oral drug delivery","volume":"9","author":"He","year":"2019","journal-title":"Acta Pharmaceutica Sinica B"},{"issue":"5","key":"10.1016\/j.xphs.2022.10.001_bib0008","article-title":"Bilosomes based drug delivery system","volume":"2","author":"Chilkawar","year":"2015","journal-title":"J Chem Appl"},{"issue":"6","key":"10.1016\/j.xphs.2022.10.001_bib0009","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s13346-012-0083-1","article-title":"Niosomes as a vesicular carrier for topical administration of minoxidil: formulation and in vitro assessment","volume":"3","author":"Mali","year":"2013","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.xphs.2022.10.001_bib0010","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/382959","article-title":"Serratiopeptidase niosomal gel with potential in topical delivery","volume":"2014","author":"Shinde","year":"2014","journal-title":"J Pharmaceut"},{"issue":"3-4","key":"10.1016\/j.xphs.2022.10.001_bib0011","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/08982100500364131","article-title":"The effect of cholesterol in the liposome bilayer on the stabilization of incorporated retinol","volume":"15","author":"Lee","year":"2005","journal-title":"J Liposome Res"},{"issue":"10","key":"10.1016\/j.xphs.2022.10.001_bib0012","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1002\/jps.23674","article-title":"In vitro characterization of a liposomal formulation of celecoxib containing 1, 2-distearoyl-sn-glycero-3-phosphocholine, cholesterol, and polyethylene glycol and its functional effects against colorectal cancer cell lines","volume":"102","author":"Erdo\u011f","year":"2013","journal-title":"J Pharm Sci"},{"issue":"sup1","key":"10.1016\/j.xphs.2022.10.001_bib0013","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1080\/21691401.2018.1443117","article-title":"Ion-sensitive in situ hydrogels of natamycin bilosomes for enhanced and prolonged ocular pharmacotherapy: in vitro permeability, cytotoxicity and in vivo evaluation","volume":"46","author":"Janga","year":"2018","journal-title":"Artif Cells, Nanomed Biotechnol"},{"key":"10.1016\/j.xphs.2022.10.001_bib0014","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.2147\/IJN.S213613","article-title":"Tailoring of PEGylated bilosomes for promoting the transdermal delivery of olmesartan medoxomil: in-vitro characterization, ex-vivo permeation and in-vivo assessment","volume":"14","author":"Albash","year":"2019","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.xphs.2022.10.001_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fbio.2016.04.005","article-title":"Effect of composition, hydrogenation of phospholipids and lyophilization on the characteristics of eugenol-loaded liposomes prepared by ethanol injection method","volume":"15","author":"Sebaaly","year":"2016","journal-title":"Food Biosci"},{"issue":"4","key":"10.1016\/j.xphs.2022.10.001_bib0016","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1080\/08982104.2016.1239634","article-title":"Enhancement of the topical tolnaftate delivery for the treatment of tinea pedis via provesicular gel systems","volume":"27","author":"AbouSamra","year":"2017","journal-title":"J Liposome Res"},{"issue":"7","key":"10.1016\/j.xphs.2022.10.001_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-020-01823-9","article-title":"Formulation and evaluation of novel hybridized nanovesicles for enhancing buccal delivery of ciclopirox olamine","volume":"21","author":"AbouSamra","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.xphs.2022.10.001_bib0018","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.2147\/DDDT.S113775","article-title":"Sublingual fast dissolving niosomal films for enhanced bioavailability and prolonged effect of metoprolol tartrate","volume":"10","author":"Allam","year":"2016","journal-title":"Drug Des Dev Ther"},{"issue":"6","key":"10.1016\/j.xphs.2022.10.001_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e07207","article-title":"L-carnitine alleviated acute lung injuries induced by potassium dichromate in rats: involvement of Nrf2\/HO-1 signaling pathway","volume":"7","author":"Salama","year":"2021","journal-title":"Heliyon"},{"issue":"12","key":"10.1016\/j.xphs.2022.10.001_bib0020","first-page":"168","article-title":"Comparative evaluation of protective effects of green tea and lycopene in potassium dichromate-induced acute renal failure in rats","volume":"6","author":"Salama","year":"2014","journal-title":"J Chem Pharm Res"},{"issue":"2","key":"10.1016\/j.xphs.2022.10.001_bib0021","first-page":"40","article-title":"Ameliorative effects of phosphodiesterase (PDE) inhibitors in potassium dichromate-induced acute renal failure in rats","volume":"36","author":"Salama","year":"2016","journal-title":"Int J Pharm Sci Rev Res"},{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0022","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151486","article-title":"Renoprotective effect of lactoferrin against chromium-induced acute kidney injury in rats: involvement of IL-18 and IGF-1 inhibition","volume":"11","author":"Hegazy","year":"2016","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.xphs.2022.10.001_bib0023","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3858\/emm.2011.43.9.060","article-title":"Protective effect of 4, 4\u2032-diaminodiphenylsulfone against paraquat-induced mouse lung injury","volume":"43","author":"Cho","year":"2011","journal-title":"Exp Mol Med"},{"issue":"2","key":"10.1016\/j.xphs.2022.10.001_bib0024","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s11010-020-03935-z","article-title":"SARS-CoV-2 mediated lung inflammatory responses in host: targeting the cytokine storm for therapeutic interventions","volume":"476","author":"Asrani","year":"2021","journal-title":"Mol Cell Biochem"},{"issue":"10223","key":"10.1016\/j.xphs.2022.10.001_bib0025","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet North Am Ed"},{"issue":"10","key":"10.1016\/j.xphs.2022.10.001_bib0026","article-title":"Insights into SARS-CoV-2 genome, structure, evolution, pathogenesis and therapies: structural genomics approach","volume":"1866","author":"Naqvi","year":"2020","journal-title":"Biochimica et Biophysica Acta (BBA)-Mol Basis Dis"},{"key":"10.1016\/j.xphs.2022.10.001_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109721","article-title":"Drugs targeting various stages of the SARS-CoV-2 life cycle: exploring promising drugs for the treatment of Covid-19","volume":"74","author":"Poduri","year":"2020","journal-title":"Cell Signall"},{"key":"10.1016\/j.xphs.2022.10.001_bib0028","doi-asserted-by":"crossref","first-page":"9783","DOI":"10.2147\/IJN.S278688","article-title":"Bilosomes as promising nanovesicular carriers for improved transdermal delivery: construction, in vitro optimization, ex vivo permeation and in vivo evaluation","volume":"15","author":"Ahmed","year":"2020","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.xphs.2022.10.001_bib0029","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.2147\/IJN.S319255","article-title":"Liver targeting of daclatasvir via tailoring sterically stabilized bilosomes: fabrication, comparative in vitro\/in vivo appraisal and biodistribution studies","volume":"16","author":"El-Nabarawi","year":"2021","journal-title":"Int J Nanomed"},{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0030","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.xphs.2021.11.007","article-title":"Harnessing of doxylamine succinate\/pyridoxine hydrochloride-dual laden bilosomes as a novel combinatorial nanoparadigm for intranasal delivery: in vitro optimization and in vivo pharmacokinetic appraisal","volume":"111","author":"Salem","year":"2022","journal-title":"J Pharm Sci"},{"issue":"4","key":"10.1016\/j.xphs.2022.10.001_bib0031","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/03639045.2017.1402922","article-title":"Exploiting bilosomes for delivering bioactive polysaccharide isolated from Enteromorpha intestinalis for hacking hepatocellular carcinoma","volume":"44","author":"Matloub","year":"2018","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.xphs.2022.10.001_bib0032","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ejps.2018.01.044","article-title":"Enhanced transdermal delivery of ondansetron using nanovesicular systems: fabrication, characterization, optimization and ex-vivo permeation study-Box-Cox transformation practical example","volume":"115","author":"Habib","year":"2018","journal-title":"Eur J Pharm Sci"},{"issue":"8","key":"10.1016\/j.xphs.2022.10.001_bib0033","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1208\/s12249-018-1145-6","article-title":"Bioavailability enhancement of aripiprazole via silicosan particles: Preparation, characterization and in vivo evaluation","volume":"19","author":"Mahmoud","year":"2018","journal-title":"AAPS PharmSciTech"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0034","first-page":"91","article-title":"Pulmonary delivery of liposomal dry powder inhaler formulation for effective treatment of idiopathic pulmonary fibrosis","volume":"13","author":"Chennakesavulu","year":"2018","journal-title":"Asian J Pharm Sci"},{"issue":"5","key":"10.1016\/j.xphs.2022.10.001_bib0035","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1007\/s13346-020-00856-8","article-title":"Promising bioadhesive ofloxacin-loaded polymeric nanoparticles for the treatment of ocular inflammation: formulation and in vivo evaluation","volume":"11","author":"Salama","year":"2021","journal-title":"Drug Deliv Transl Res"},{"issue":"2","key":"10.1016\/j.xphs.2022.10.001_bib0036","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3109\/1061186X.2012.734311","article-title":"Design and development of liposomes for colon targeted drug delivery","volume":"21","author":"Gupta","year":"2013","journal-title":"J Drug Targeting"},{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0037","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s13346-018-0499-3","article-title":"Evaluation and optimization of pH-responsive niosomes as a carrier for efficient treatment of breast cancer","volume":"8","author":"Salem","year":"2018","journal-title":"Drug Deliv Transl Res"},{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0038","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s13346-016-0280-4","article-title":"Design and optimization of gastro-retentive microballoons for enhanced bioavailability of cinnarizine","volume":"6","author":"Ammar","year":"2016","journal-title":"Drug Deliv Transl Res"},{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0039","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s13346-015-0277-4","article-title":"A trial for the design and optimization of pH-sensitive microparticles for intestinal delivery of cinnarizine","volume":"6","author":"Ammar","year":"2016","journal-title":"Drug Deliv Transl Res"},{"issue":"12","key":"10.1016\/j.xphs.2022.10.001_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0168688","article-title":"Intranasal chromium induces acute brain and lung injuries in rats: assessment of different potential hazardous effects of environmental and occupational exposure to chromium and introduction of a novel pharmacological and toxicological animal model","volume":"11","author":"Salama","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.xphs.2022.10.001_bib0041","first-page":"214","article-title":"Antiasthmatic effects of evening primrose oil in ovalbumin-allergic rats","volume":"7","author":"Salama","year":"2015","journal-title":"Pharm Lett"},{"key":"10.1016\/j.xphs.2022.10.001_bib0042","series-title":"Theory and Practice of Histological Techniques","author":"Banchroft","year":"1996"},{"issue":"5","key":"10.1016\/j.xphs.2022.10.001_bib0043","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/10611860801927598","article-title":"Pharmacokinetics and targeting property of TFu-loaded liposomes with different sizes after intravenous and oral administration","volume":"16","author":"Sun","year":"2008","journal-title":"J Drug Target"},{"issue":"11","key":"10.1016\/j.xphs.2022.10.001_bib0044","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1080\/03639045.2018.1504963","article-title":"Formulation design and optimization of novel soft glycerosomes for enhanced topical delivery of celecoxib and cupferron by Box-Behnken statistical design","volume":"44","author":"Salem","year":"2018","journal-title":"Drug Dev Ind Pharm"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.10.001_bib0045","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ijpharm.2008.05.031","article-title":"Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes","volume":"361","author":"Mokhtar","year":"2008","journal-title":"Int J Pharm"},{"issue":"2","key":"10.1016\/j.xphs.2022.10.001_bib0046","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12282-019-01014-w","article-title":"Preparation, characterization, and evaluation of the anticancer activity of Artemether-loaded Nano-Niosomes against breast cancer","volume":"27","author":"Mirzaei-Parsa","year":"2020","journal-title":"Breast Cancer"},{"issue":"4","key":"10.1016\/j.xphs.2022.10.001_bib0047","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3109\/03639045.2013.782502","article-title":"Ceramide-2 nanovesicles for effective transdermal delivery: development, characterization and pharmacokinetic evaluation","volume":"40","author":"Gaur","year":"2014","journal-title":"Drug Dev Ind Pharm"},{"issue":"2","key":"10.1016\/j.xphs.2022.10.001_bib0048","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s13346-019-00688-1","article-title":"A novel nanogel loaded with chitosan decorated bilosomes for transdermal delivery of terbutaline sulfate: artificial neural network optimization, in vitro characterization and in vivo evaluation","volume":"10","author":"El Menshawe","year":"2020","journal-title":"Drug Deliv Transl Res"},{"issue":"7","key":"10.1016\/j.xphs.2022.10.001_bib0049","first-page":"521","article-title":"Effect of span 60, Labrasol, and cholesterol on Labisia pumila loaded niosomes quality","volume":"11","author":"Ya'akob","year":"2017","journal-title":"Int J Biotechnol Bioeng"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0050","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ijpharm.2018.07.005","article-title":"Preparation of novel phospholipid-based sonocomplexes for improved intestinal permeability of rosuvastatin: in vitro characterization, dynamic simulation, Caco-2 cell line permeation and in vivo assessment studies","volume":"548","author":"Abd-Elsalam","year":"2018","journal-title":"Int J Pharm"},{"issue":"6","key":"10.1016\/j.xphs.2022.10.001_bib0051","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1080\/03639040500529077","article-title":"Effect of phospholipid composition on characterization of liposomes containing 9-nitrocamptothecin","volume":"32","author":"Chen","year":"2006","journal-title":"Drug Dev Ind Pharm"},{"issue":"9","key":"10.1016\/j.xphs.2022.10.001_bib0052","doi-asserted-by":"crossref","DOI":"10.1002\/ejlt.201800039","article-title":"Comparative effects of cholesterol and \u03b2-sitosterol on the liposome membrane characteristics","volume":"120","author":"Jovanovi\u0107","year":"2018","journal-title":"Eur J Lipid Sci Technol"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08982104.2019.1577256","article-title":"Bilosomes as a novel carrier for the cutaneous delivery for dapsone as a potential treatment of acne: preparation, characterization and in vivo skin deposition assay","volume":"30","author":"El-Nabarawi","year":"2020","journal-title":"J Liposome Res"},{"issue":"12)","key":"10.1016\/j.xphs.2022.10.001_bib0054","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1080\/03639045.2017.1361968","article-title":"Improved hepatoprotective activity of silymarin via encapsulation in the novel vesicular nanosystem bilosomes","volume":"43","author":"Mohsen","year":"2017","journal-title":"Drug Dev Ind Pharm"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5173(94)90228-3","article-title":"Preparation and properties of vesicles (niosomes) of sorbitan monoesters (Span 20, 40, 60 and 80) and a sorbitan triester (Span 85)","volume":"105","author":"Yoshioka","year":"1994","journal-title":"Int J Pharm"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.10.001_bib0056","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0927-7765(03)00080-8","article-title":"Characterization of vesicles prepared with various non-ionic surfactants mixed with cholesterol","volume":"30","author":"Manosroi","year":"2003","journal-title":"Colloids Surf B"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0057","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1208\/pt0801001","article-title":"Liposomes as an ocular delivery system for acetazolamide: in vitro and in vivo studies","volume":"8","author":"Hathout","year":"2007","journal-title":"Aaps Pharmscitech"},{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0058","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3109\/08982104.2013.801489","article-title":"Transfersomal lyophilized gel of buspirone HCl: formulation, evaluation and statistical optimization","volume":"23","author":"Shamma","year":"2013","journal-title":"J Liposome Res"},{"key":"10.1016\/j.xphs.2022.10.001_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2021.105978","article-title":"Micellar buccal film for safe and effective control of seizures: preparation, in vitro characterization, ex vivo permeation studies and in vivo assessment","volume":"166","author":"Salama","year":"2021","journal-title":"Eur J Pharm Sci"},{"issue":"5","key":"10.1016\/j.xphs.2022.10.001_bib0060","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/jps.22422","article-title":"Design and evaluation of controlled-release niosomes and discomes for naltrexone hydrochloride ocular delivery","volume":"100","author":"Abdelkader","year":"2011","journal-title":"J Pharm Sci"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0061","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3109\/10837450.2012.751406","article-title":"Preparation, characterization and permeation studies of a nanovesicular system containing diclofenac for transdermal delivery","volume":"19","author":"Gaur","year":"2014","journal-title":"Pharm Dev Technol"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0062","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/08982104.2019.1593450","article-title":"Double-loaded liposomes encapsulating lycopene \u03b2-cyclodextrin complexes: preparation, optimization, and evaluation","volume":"30","author":"Jhan","year":"2020","journal-title":"J Liposome Res"},{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0063","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1208\/s12249-008-9105-1","article-title":"Niosome-encapsulated gentamicin for ophthalmic controlled delivery","volume":"9","author":"Abdelbary","year":"2008","journal-title":"AAPS Pharmscitech"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.10.001_bib0064","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpharm.2005.05.009","article-title":"Effect of cholesterol and temperature on the elastic properties of niosomal membranes","volume":"300","author":"Nasseri","year":"2005","journal-title":"Int J Pharm"},{"issue":"sup1","key":"10.1016\/j.xphs.2022.10.001_bib0065","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1080\/21691401.2018.1430700","article-title":"Development and biological evaluation of vesicles containing bile salt of telmisartan for the treatment of diabetic nephropathy","volume":"46","author":"Ahad","year":"2018","journal-title":"Artif Cells, Nanomed Biotechnol"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0066","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejpb.2007.01.020","article-title":"Development, characterization and in vivo evaluation of benzocaine-loaded liposomes","volume":"67","author":"Mura","year":"2007","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.xphs.2022.10.001_bib0067","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.2147\/DDDT.S144652","article-title":"A novel transdermal nanoethosomal gel of betahistine dihydrochloride for weight gain control: in-vitro and in-vivo characterization","volume":"11","author":"El-Menshawe","year":"2017","journal-title":"Drug Des Dev Ther"},{"key":"10.1016\/j.xphs.2022.10.001_bib0068","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jphotobiol.2015.10.017","article-title":"Formulation and stabilization of riboflavin in liposomal preparations","volume":"153","author":"Ahmad","year":"2015","journal-title":"J Photochem Photobiol, B"},{"issue":"5","key":"10.1016\/j.xphs.2022.10.001_bib0069","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1208\/s12249-018-1025-0","article-title":"Dapsone-loaded invasomes as a potential treatment of acne: preparation, characterization, and in vivo skin deposition assay","volume":"19","author":"El-Nabarawi","year":"2018","journal-title":"Aaps Pharmscitech"},{"issue":"6","key":"10.1016\/j.xphs.2022.10.001_bib0070","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1080\/03639045.2017.1287717","article-title":"Nanoethosomes for transdermal delivery of tropisetron HCl: multi-factorial predictive modeling, characterization, and ex vivo skin permeation","volume":"43","author":"Abdel Messih","year":"2017","journal-title":"Drug Dev Ind Pharm"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.10.001_bib0071","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ijpharm.2013.11.017","article-title":"Enhanced in vitro and in vivo skin deposition of apigenin delivered using ethosomes","volume":"460","author":"Shen","year":"2014","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0072","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.rinphs.2011.10.002","article-title":"Nanosized ethosomes bearing ketoprofen for improved transdermal delivery","volume":"1","author":"Chourasia","year":"2011","journal-title":"Results Pharma Sci"},{"key":"10.1016\/j.xphs.2022.10.001_bib0073","unstructured":"Lenherr G, Csaba N, Thwala NL, Niu Z, and Alonso MJ, Nanocapsular formulation of active pharmaceutical ingredients. 2017, Google Patents."},{"issue":"1-2","key":"10.1016\/j.xphs.2022.10.001_bib0074","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0378-5173(98)00169-0","article-title":"Non-ionic surfactant based vesicles (niosomes) in drug delivery","volume":"172","author":"Uchegbu","year":"1998","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2022.10.001_bib0075","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.foodchem.2017.10.144","article-title":"Hydroxypropyl-\u00df-cyclodextrin as a membrane protectant during freeze-drying of hydrogenated and non-hydrogenated liposomes and molecule-in-cyclodextrin-in-liposomes: application to trans-anethole","volume":"267","author":"Gharib","year":"2018","journal-title":"Food Chem"},{"key":"10.1016\/j.xphs.2022.10.001_bib0076","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.foodchem.2015.01.067","article-title":"Preparation and characterization of clove essential oil-loaded liposomes","volume":"178","author":"Sebaaly","year":"2015","journal-title":"Food Chem"},{"issue":"10","key":"10.1016\/j.xphs.2022.10.001_bib0077","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1016\/j.xphs.2020.06.017","article-title":"Preparation and characterization of ascosome vesicles loaded with Khellin","volume":"109","author":"Risaliti","year":"2020","journal-title":"J Pharm Sci"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.10.001_bib0078","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijpharm.2005.11.006","article-title":"Increasing bioavailability of silymarin using a buccal liposomal delivery system: preparation and experimental design investigation","volume":"308","author":"El-Samaligy","year":"2006","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0079","first-page":"561","article-title":"Nanoparticles-a review","volume":"5","author":"Mohanraj","year":"2006","journal-title":"Trop J Pharmaceut Res"},{"issue":"2","key":"10.1016\/j.xphs.2022.10.001_bib0080","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3109\/10717540903509027","article-title":"Controlled release application of multilamellar vesicles: a novel drug delivery approach","volume":"17","author":"Agnihotri","year":"2010","journal-title":"Drug Deliv"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.10.001_bib0081","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ijpharm.2005.09.023","article-title":"Preparation and evaluation of reverse-phase evaporation and multilamellar niosomes as ophthalmic carriers of acetazolamide","volume":"306","author":"Guinedi","year":"2005","journal-title":"Int J Pharm"},{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0082","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s13346-020-00716-5","article-title":"Integrated nanovesicular\/self-nanoemulsifying system (INV\/SNES) for enhanced dual ocular drug delivery: statistical optimization, in vitro and in vivo evaluation","volume":"10","author":"Yousry","year":"2020","journal-title":"Drug Deliv Transl Res"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0083","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jsps.2017.10.012","article-title":"Applications of nanoparticle systems in drug delivery technology","volume":"26","author":"Rizvi","year":"2018","journal-title":"Saudi Pharmaceut J"},{"key":"10.1016\/j.xphs.2022.10.001_bib0084","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/262194","article-title":"Solubility enhancement of budesonide and statistical optimization of coating variables for targeted drug delivery","volume":"2014","author":"Bhatt","year":"2014","journal-title":"J Pharmaceut"},{"issue":"6","key":"10.1016\/j.xphs.2022.10.001_bib0085","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3109\/10717544.2014.896428","article-title":"Formulation of tretinoin-loaded topical proniosomes for treatment of acne: in-vitro characterization, skin irritation test and comparative clinical study","volume":"22","author":"Rahman","year":"2015","journal-title":"Drug Deliv"},{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0086","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1208\/pt030318","article-title":"Preparation of budesonide and budesonide-PLA microparticles using supercritical fluid precipitation technology","volume":"3","author":"Martin","year":"2002","journal-title":"AAPS PharmSciTech"},{"issue":"2","key":"10.1016\/j.xphs.2022.10.001_bib0087","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/08982104.2018.1524482","article-title":"Evaluation of bilosomes as nanocarriers for transdermal delivery of tizanidine hydrochloride: in vitro and ex vivo optimization","volume":"29","author":"Khalil","year":"2019","journal-title":"J Liposome Res"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0088","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12890-016-0251-z","article-title":"Budesonide ameliorates lung injury induced by large volume ventilation","volume":"16","author":"Ju","year":"2016","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.xphs.2022.10.001_bib0089","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7264383","article-title":"Intranasal application of budesonide attenuates lipopolysaccharide-induced acute lung injury by suppressing nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 inflammasome activation in mice","volume":"2019","author":"Dong","year":"2019","journal-title":"J Immunol Res"},{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0090","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1365-2222.02193.x","article-title":"Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling","volume":"35","author":"McMillan","year":"2005","journal-title":"Clin Exp Allergy"},{"issue":"5","key":"10.1016\/j.xphs.2022.10.001_bib0091","article-title":"[The expression of transforming growth factor beta-1 in rat model of chronic obstructive pulmonary disease and the effects of early drugs intervention]","volume":"33","author":"Wu","year":"2004","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0092","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4103\/1658-354X.197369","article-title":"Effect of nebulized budesonide on respiratory mechanics and oxygenation in acute lung injury\/acute respiratory distress syndrome: randomized controlled study","volume":"11","author":"Mohamed","year":"2017","journal-title":"Saudi J Anaesthesia"},{"issue":"9","key":"10.1016\/j.xphs.2022.10.001_bib0093","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.rmed.2005.12.003","article-title":"Inhibition of pyocyanin-potentiated IL-8 release by steroids in bronchial epithelial cells","volume":"100","author":"Pan","year":"2006","journal-title":"Respir Med"},{"issue":"4","key":"10.1016\/j.xphs.2022.10.001_bib0094","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000088623","article-title":"Budesonide reduces superoxide and peroxynitrite anion chemiluminescence during human neutrophil bursts","volume":"75","author":"Braga","year":"2005","journal-title":"Pharmacology"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.10.001_bib0095","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijpharm.2013.11.028","article-title":"Enhanced oral absorption of insulin-loaded liposomes containing bile salts: a mechanistic study","volume":"460","author":"Niu","year":"2014","journal-title":"Int J Pharm"},{"issue":"11","key":"10.1016\/j.xphs.2022.10.001_bib0096","doi-asserted-by":"crossref","first-page":"e27898","DOI":"10.1371\/journal.pone.0027898","article-title":"Budesonide and formoterol reduce early innate anti-viral immune responses in vitro","volume":"6","author":"Davies","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.xphs.2022.10.001_bib0097","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1164\/ajrccm.163.1.9807061","article-title":"Acute anti-inflammatory effects of inhaled budesonide in asthma: a randomized controlled trial","volume":"163","author":"Gibson","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.xphs.2022.10.001_bib0098","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1164\/ajrccm.162.3.9910077","article-title":"Inhaled budesonide decreases airway inflammatory response to allergen","volume":"162","author":"Becky Kelly","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.xphs.2022.10.001_bib0099","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1513\/AnnalsATS.201307-220OC","article-title":"Immediate antiinflammatory effects of inhaled budesonide in patients with asthma","volume":"11","author":"Mendes","year":"2014","journal-title":"Ann Am Thoracic Soc"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354922004531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354922004531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:41:09Z","timestamp":1758361269000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354922004531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":99,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0022354922004531"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2022.10.001","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Budesonide-Loaded Bilosomes as a Targeted Delivery Therapeutic Approach Against Acute Lung Injury in Rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2022.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc. on behalf of American Pharmacists Association.","name":"copyright","label":"Copyright"}]}}