{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T19:14:54Z","timestamp":1772824494162,"version":"3.50.1"},"reference-count":62,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.xphs.2022.11.003","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T11:41:56Z","timestamp":1667648516000},"page":"837-843","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis"],"prefix":"10.1016","volume":"112","author":[{"given":"Javier","family":"Avenda\u00f1o-Godoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Gabriela","family":"Poblete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Godoy","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2080-9870","authenticated-orcid":false,"given":"Carolina","family":"G\u00f3mez-Gaete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.xphs.2022.11.003_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10051109","article-title":"Low-grade inflammation in the pathogenesis of osteoarthritis: Cellular and molecular mechanisms and strategies for future therapeutic intervention","volume":"10","author":"Terkawi","year":"2022","journal-title":"Biomedicines"},{"issue":"3","key":"10.1016\/j.xphs.2022.11.003_bib0002","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.proghi.2006.02.003","article-title":"Osteoarthritis: cellular and molecular changes in degenerating cartilage","volume":"40","author":"Lorenz","year":"2006","journal-title":"Prog Histochem Cytochem"},{"key":"10.1016\/j.xphs.2022.11.003_bib0003","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8293921","article-title":"The role of inflammation in the pathogenesis of osteoarthritis","volume":"2020","author":"Chow","year":"2020","journal-title":"Mediators Inflamm"},{"issue":"1","key":"10.1016\/j.xphs.2022.11.003_bib0004","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"10.1016\/j.xphs.2022.11.003_bib0005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1759720X09359104","article-title":"Effects of diacerein at the molecular level in the osteoarthritis disease process","volume":"2","author":"Martel-Pelletier","year":"2010","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.xphs.2022.11.003_bib0006","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ejps.2016.10.010","article-title":"Development, characterization and in vitro evaluation of biodegradable rhein-loaded microparticles for treatment of osteoarthritis","volume":"96","author":"G\u00f3mez-Gaete","year":"2017","journal-title":"Eur J Pharm Sci"},{"issue":"3","key":"10.1016\/j.xphs.2022.11.003_bib0007","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1053\/joca.2000.0383","article-title":"Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes","volume":"9","author":"Tamura","year":"2001","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"10.1016\/j.xphs.2022.11.003_bib0008","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1053\/joca.1999.0289","article-title":"Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage","volume":"8","author":"Moldovan","year":"2000","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"10.1016\/j.xphs.2022.11.003_bib0009","first-page":"546","article-title":"Rhein, a diacerhein-derived metabolite, modulates the expression of matrix degrading enzymes and the cell proliferation of articular chondrocytes by inhibiting ERK and JNK-AP-1 dependent pathways","volume":"25","author":"Legendre","year":"2007","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"10.1016\/j.xphs.2022.11.003_bib0010","first-page":"753","article-title":"In vitro effects of diacerhein and rhein on interleukin 1 and tumor necrosis factor-alpha systems in human osteoarthritic synovium and chondrocytes","volume":"25","author":"Martel-Pelletier","year":"1998","journal-title":"J Rheumatol"},{"issue":"12","key":"10.1016\/j.xphs.2022.11.003_bib0011","first-page":"2417","article-title":"Diacerhein and rhein reduce the interleukin 1 beta stimulated inducible nitric oxide synthesis level and activity while stimulating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes","volume":"25","author":"Pelletier","year":"1998","journal-title":"J Rheumatol"},{"key":"10.1016\/j.xphs.2022.11.003_bib0012","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jpba.2012.12.004","article-title":"Comparative pharmacokinetics study of three anthraquinones in rat plasma after oral administration of Radix et Rhei Rhizoma extract and Dahuang Fuzi Tang by high performance liquid chromatography-mass spectrometry","volume":"76","author":"Li","year":"2013","journal-title":"J Pharm Biomed Anal"},{"issue":"16","key":"10.1016\/j.xphs.2022.11.003_bib0013","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/jssc.201200378","article-title":"UPLC-MS\/MS performing pharmacokinetic and biodistribution studies of rhein","volume":"35","author":"Sun","year":"2012","journal-title":"J Sep Sci"},{"issue":"2","key":"10.1016\/j.xphs.2022.11.003_bib0014","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejpb.2009.06.009","article-title":"Intra-articular drug delivery systems for the treatment of rheumatic diseases: a review of the factors influencing their performance","volume":"73","author":"Butoescu","year":"2009","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.xphs.2022.11.003_bib0015","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.2147\/DDDT.S357386","article-title":"Knee osteoarthritis therapy: Recent advances in intra-articular drug delivery systems","volume":"16","author":"Ma","year":"2022","journal-title":"Drug Des Devel Ther."},{"issue":"1","key":"10.1016\/j.xphs.2022.11.003_bib0016","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1080\/10717544.2021.1943056","article-title":"Poly(lactic-co-glycolic acid) microsphere production based on quality by design: A review","volume":"28","author":"Hua","year":"2021","journal-title":"Drug Deliv"},{"key":"10.1016\/j.xphs.2022.11.003_bib0017","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jconrel.2019.05.003","article-title":"Injectable, long-acting PLGA formulations: Analyzing PLGA and understanding microparticle formation","volume":"304","author":"Park","year":"2019","journal-title":"J Control Release"},{"issue":"5","key":"10.1016\/j.xphs.2022.11.003_bib0018","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3109\/10717544.2012.700962","article-title":"Intra-articular lornoxicam loaded PLGA microspheres: enhanced therapeutic efficiency and decreased systemic toxicity in the treatment of osteoarthritis","volume":"19","author":"Zhang","year":"2012","journal-title":"Drug Deliv"},{"issue":"7","key":"10.1016\/j.xphs.2022.11.003_bib0019","doi-asserted-by":"crossref","first-page":"536","DOI":"10.3109\/10717544.2011.596584","article-title":"Enhanced targeting efficiency of PLGA microspheres loaded with Lornoxicam for intra-articular administration","volume":"18","author":"Zhang","year":"2011","journal-title":"Drug Deliv"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.11.003_bib0020","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ijpharm.2004.04.003","article-title":"Biodegradable ibuprofen-loaded PLGA microspheres for intraarticular administration. Effect of Labrafil addition on release in vitro","volume":"279","author":"Fernandez-Carballido","year":"2004","journal-title":"Int J Pharm"},{"issue":"8","key":"10.1016\/j.xphs.2022.11.003_bib0021","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11080419","article-title":"Design and in vivo pharmacokinetic evaluation of triamcinolone acetonide microcrystals-loaded PLGA microsphere for increased drug retention in knees after intra-articular injection","volume":"11","author":"Ho","year":"2019","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.xphs.2022.11.003_bib0022","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2174\/1567201817666200917124759","article-title":"Study on the slow-release mometasone furoate injection of PLGA for the treatment of knee arthritis","volume":"18","author":"Liang","year":"2021","journal-title":"Curr Drug Deliv"},{"key":"10.1016\/j.xphs.2022.11.003_bib0023","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.actbio.2019.11.052","article-title":"Sustained low-dose dexamethasone delivery via a PLGA microsphere-embedded agarose implant for enhanced osteochondral repair","volume":"102","author":"Stefani","year":"2020","journal-title":"Acta Biomater"},{"issue":"9","key":"10.1016\/j.xphs.2022.11.003_bib0024","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1002\/bkcs.10897","article-title":"A novel stable crystalline triamcinolone acetonide-loaded PLGA microsphere for prolonged release after intra-articular injection","volume":"37","author":"Ho","year":"2016","journal-title":"bull Korean Chem Soc"},{"issue":"3","key":"10.1016\/j.xphs.2022.11.003_bib0025","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.ejpb.2009.03.003","article-title":"Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: physicochemical and magnetic properties, in vitro and in vivo drug release","volume":"72","author":"Butoescu","year":"2009","journal-title":"Eur J Pharm Biopharm"},{"issue":"2","key":"10.1016\/j.xphs.2022.11.003_bib0026","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/jbm.b.31822","article-title":"Development of chondroitin sulfate encapsulated PLGA microsphere delivery systems with controllable multiple burst releases for treating osteoarthritis","volume":"97","author":"Jiang","year":"2011","journal-title":"J Biomed Mater Res B"},{"issue":"21","key":"10.1016\/j.xphs.2022.11.003_bib0027","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.1016\/j.biomaterials.2013.03.066","article-title":"Sulforaphane-PLGA microspheres for the intra-articular treatment of osteoarthritis","volume":"34","author":"Ko","year":"2013","journal-title":"Biomaterials"},{"issue":"11","key":"10.1016\/j.xphs.2022.11.003_bib0028","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1002\/jor.23562","article-title":"Single intra-articular injection of fluvastatin-PLGA microspheres reduces cartilage degradation in rabbits with experimental osteoarthritis","volume":"35","author":"Goto","year":"2017","journal-title":"J Orthop Res"},{"key":"10.1016\/j.xphs.2022.11.003_bib0029","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.biomaterials.2016.02.022","article-title":"PLGA-based microcarriers induce mesenchymal stem cell chondrogenesis and stimulate cartilage repair in osteoarthritis","volume":"88","author":"Morille","year":"2016","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.xphs.2022.11.003_bib0030","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.actbio.2012.03.015","article-title":"Sustained release of PTH(1-34) from PLGA microspheres suppresses osteoarthritis progression in rats","volume":"8","author":"Eswaramoorthy","year":"2012","journal-title":"Acta Biomater"},{"issue":"15","key":"10.1016\/j.xphs.2022.11.003_bib0031","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1039\/D0BM00596G","article-title":"Rapamycin-PLGA microparticles prevent senescence, sustain cartilage matrix production under stress and exhibit prolonged retention in mouse joints","volume":"8","author":"Dhanabalan","year":"2020","journal-title":"Biomater Sci"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.11.003_bib0032","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijpharm.2012.08.006","article-title":"Development and evaluation of sustained-release clonidine-loaded PLGA microparticles","volume":"437","author":"Gaignaux","year":"2012","journal-title":"Int J Pharm"},{"issue":"2","key":"10.1016\/j.xphs.2022.11.003_bib0033","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ejpb.2007.12.014","article-title":"Gamma-irradiation effects on biopharmaceutical properties of PLGA microspheres loaded with SPf66 synthetic vaccine","volume":"69","author":"Igartua","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"issue":"7","key":"10.1016\/j.xphs.2022.11.003_bib0034","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1007\/s11095-013-1019-2","article-title":"Gamma irradiation of active self-healing PLGA microspheres for efficient aqueous encapsulation of vaccine antigens","volume":"30","author":"Desai","year":"2013","journal-title":"Pharm Res"},{"issue":"3","key":"10.1016\/j.xphs.2022.11.003_bib0035","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0168-3659(01)00401-1","article-title":"Gamma irradiation effects on stability of poly(lactide-co-glycolide) microspheres containing clonazepam","volume":"75","author":"Montanari","year":"2001","journal-title":"J Control Release"},{"issue":"8","key":"10.1016\/j.xphs.2022.11.003_bib0036","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1080\/03639045.2018.1445263","article-title":"Optimization of rhein-loaded polymeric nanoparticles using a factorial design and evaluation of the cytotoxic and anti-inflammatory effects","volume":"44","author":"G\u00f3mez-Gaete","year":"2018","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.xphs.2022.11.003_bib0037","first-page":"158","article-title":"Rhein laden pH-responsive polymeric nanoparticles for treatment of osteoarthritis","volume":"10","author":"Hu","year":"2020"},{"issue":"11","key":"10.1016\/j.xphs.2022.11.003_bib0038","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1080\/03639045.2017.1353519","article-title":"Biodegradable nanoparticles for improved kidney bioavailability of rhein: Preparation, characterization, plasma, and kidney pharmacokinetics","volume":"43","author":"Wei","year":"2017","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.xphs.2022.11.003_bib0039","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.2147\/IJN.S166445","article-title":"Kidney-targeted drug delivery via rhein-loaded polyethyleneglycol-co-polycaprolactone-co-polyethylenimine nanoparticles for diabetic nephropathy therapy","volume":"13","author":"Chen","year":"2018","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.xphs.2022.11.003_bib0040","first-page":"2301","article-title":"Preparation, characterization, and in vivo study of rhein-loaded poly(lactic-co-glycolic acid) nanoparticles for oral delivery","volume":"9","author":"Yuan","year":"2015","journal-title":"Drug Des Devel Ther."},{"issue":"6","key":"10.1016\/j.xphs.2022.11.003_bib0041","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1021\/acs.biomac.1c00425","article-title":"Entrapment of macrophage-target nanoparticles by yeast microparticles for rhein delivery in ulcerative colitis treatment","volume":"22","author":"Chen","year":"2021","journal-title":"Biomacromolecules"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.11.003_bib0042","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jconrel.2007.03.022","article-title":"Particle shape: a new design parameter for micro- and nanoscale drug delivery carriers","volume":"121","author":"Champion","year":"2007","journal-title":"J Control Release"},{"key":"10.1016\/j.xphs.2022.11.003_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2019.109353","article-title":"Role of particle shape on efficient and organ-based drug delivery","volume":"122","author":"Nejati","year":"2020","journal-title":"Eur Polym J"},{"issue":"2","key":"10.1016\/j.xphs.2022.11.003_bib0044","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1208\/s12249-009-9226-1","article-title":"Formulation and performance characterization of radio-sterilized \"progestin-only\" microparticles intended for contraception","volume":"10","author":"Puthli","year":"2009","journal-title":"AAPS PharmSciTech"},{"issue":"1","key":"10.1016\/j.xphs.2022.11.003_bib0045","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tvjl.2010.09.019","article-title":"Intra-articular drug delivery: The challenge to extend drug residence time within the joint","volume":"190","author":"Edwards","year":"2011","journal-title":"Vet J"},{"issue":"3-4","key":"10.1016\/j.xphs.2022.11.003_bib0046","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/08982100701557129","article-title":"Biodistribution and clearance of intra-articular liposomes in a large animal model using a radiographic marker","volume":"17","author":"Edwards","year":"2007","journal-title":"J Liposome Res"},{"issue":"1","key":"10.1016\/j.xphs.2022.11.003_bib0047","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jconrel.2007.01.013","article-title":"Optimum conditions for efficient phagocytosis of rifampicin-loaded PLGA microspheres by alveolar macrophages","volume":"119","author":"Hirota","year":"2007","journal-title":"J Control Release"},{"issue":"8","key":"10.1016\/j.xphs.2022.11.003_bib0048","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s11095-008-9562-y","article-title":"Role of particle size in phagocytosis of polymeric microspheres","volume":"25","author":"Champion","year":"2008","journal-title":"Pharm Res"},{"key":"10.1016\/j.xphs.2022.11.003_bib0049","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.addr.2012.09.004","article-title":"Biodegradation and biocompatibility of PLA and PLGA microspheres","volume":"64","author":"Anderson","year":"2012","journal-title":"Adv Drug Deliv Rev"},{"issue":"9","key":"10.1016\/j.xphs.2022.11.003_bib0050","first-page":"694","article-title":"Effects of gamma-irradiation on PLGA microspheres loaded with thienorphine","volume":"66","author":"Yang","year":"2011","journal-title":"Pharmazie"},{"issue":"6","key":"10.1016\/j.xphs.2022.11.003_bib0051","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1080\/09687860400008437","article-title":"Sterilized ibuprofen-loaded poly(D,L-lactide-co-glycolide) microspheres for intra-articular administration: effect of gamma-irradiation and storage","volume":"21","author":"Fernandez-Carballido","year":"2004","journal-title":"J Microencapsul"},{"issue":"3","key":"10.1016\/j.xphs.2022.11.003_bib0052","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0168-3659(03)00153-6","article-title":"Poly(lactide-co-glycolide) microspheres containing bupivacaine: comparison between gamma and beta irradiation effects","volume":"90","author":"Montanari","year":"2003","journal-title":"J Control Release"},{"issue":"1-2","key":"10.1016\/j.xphs.2022.11.003_bib0053","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijpharm.2006.01.034","article-title":"Radiosterilisation of indomethacin PLGA\/PEG-derivative microspheres: protective effects of low temperature during gamma-irradiation","volume":"313","author":"Fernandez-Carballido","year":"2006","journal-title":"Int J Pharm"},{"issue":"5","key":"10.1016\/j.xphs.2022.11.003_bib0054","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/BF03218376","article-title":"The effect of gamma irradiation on PLGA and release Behavior of BCNU from PLGA wafer","volume":"11","author":"Lee","year":"2003","journal-title":"Macromol Res"},{"key":"10.1016\/j.xphs.2022.11.003_bib0055","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1590\/S0104-66322010000200001","article-title":"Mechanism of controlled release kinetics from medical devices","volume":"27","author":"Raval","year":"2010","journal-title":"Braz J Chem Eng"},{"issue":"4","key":"10.1016\/j.xphs.2022.11.003_bib0056","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s40204-020-00139-y","article-title":"Recent advances in the formulation of PLGA microparticles for controlled drug delivery","volume":"9","author":"Lagreca","year":"2020","journal-title":"Prog Biomater"},{"key":"10.1016\/j.xphs.2022.11.003_bib0057","unstructured":"FDA. Guidance for industry: Dissolution testing of immediate release solid oral dosage forms 1997 [Available from: https:\/\/www.fda.gov\/media\/70936\/download."},{"issue":"3","key":"10.1016\/j.xphs.2022.11.003_bib0058","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1208\/s12248-010-9185-1","article-title":"DDSolver: an add-in program for modeling and comparison of drug dissolution profiles","volume":"12","author":"Zhang","year":"2010","journal-title":"AAPS J"},{"issue":"2","key":"10.1016\/j.xphs.2022.11.003_bib0059","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1021\/acs.molpharmaceut.6b00896","article-title":"Effect of particle size on drug loading and release kinetics of gefitinib-loaded PLGA microspheres","volume":"14","author":"Chen","year":"2017","journal-title":"Mol Pharm"},{"issue":"2","key":"10.1016\/j.xphs.2022.11.003_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14020359","article-title":"Poly(lactic acid)-based microparticles for drug delivery applications: an overview of recent advances","volume":"14","author":"Vlachopoulos","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.xphs.2022.11.003_bib0061","series-title":"Drug Delivery Nanoparticles Formulation and Characterization","author":"Pathak","year":"2009"},{"issue":"3","key":"10.1016\/j.xphs.2022.11.003_bib0062","first-page":"217","article-title":"Kinetic modeling on drug release from controlled drug delivery systems","volume":"67","author":"Dash","year":"2010","journal-title":"Acta Pol Pharm"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354922005135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354922005135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:41:30Z","timestamp":1758361290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354922005135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0022354922005135"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2022.11.003","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the Effects of Gamma Radiation Sterilization on Rhein-Loaded Biodegradable Microparticles for the Treatment of Osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2022.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}