{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:16:59Z","timestamp":1783718219984,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.xphs.2023.07.016","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T02:01:11Z","timestamp":1689645671000},"page":"3141-3153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Liquid-like Oral Sustained-Release System Based on Acid-Sensitive in situ Hydrogel for Alleviate Gastrointestinal Side Effects of Indobufen"],"prefix":"10.1016","volume":"112","author":[{"given":"Ya","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adric Hii Ru","family":"Khiing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaole","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-329X","authenticated-orcid":false,"given":"Zhenghong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.xphs.2023.07.016_bib0001","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2165\/00003495-199244030-00009","article-title":"Indobufen","volume":"44","author":"Wiseman","year":"1992","journal-title":"Drugs"},{"issue":"5","key":"10.1016\/j.xphs.2023.07.016_bib0002","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/BF00558436","article-title":"Indobufen (K 3920), a new inhibitor of platelet aggregation: effect of food on bioavailability, pharmacokinetic and pharmacodynamic study during repeated oral administration to man","volume":"15","author":"Tamassia","year":"1979","journal-title":"Eur J Clin Pharmacol"},{"issue":"6","key":"10.1016\/j.xphs.2023.07.016_bib0003","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.3390\/molecules23061452","article-title":"Anticoagulant activities of indobufen, an antiplatelet drug","volume":"23","author":"Liu","year":"2018","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.xphs.2023.07.016_bib0004","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/S0022-5223(94)70392-2","article-title":"Effects of antiplatelet therapy with indobufen or aspirin-dipyridamole on graft patency one year after coronary artery bypass grafting","volume":"107","author":"Rajah","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"10094","key":"10.1016\/j.xphs.2023.07.016_bib0005","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0140-6736(16)32404-7","article-title":"Peptic ulcer disease","volume":"390","author":"Lanas","year":"2017","journal-title":"Lancet North Am Ed"},{"issue":"1","key":"10.1016\/j.xphs.2023.07.016_bib0006","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.cardiores.2005.07.013","article-title":"Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism","volume":"69","author":"Eligini","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"11","key":"10.1016\/j.xphs.2023.07.016_bib0007","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1111\/j.1572-0241.1998.00588.x","article-title":"A guideline for the treatment and prevention of NSAID-induced ulcers. Members of the Ad Hoc Committee on Practice Parameters of the American College of Gastroenterology","volume":"93","author":"Lanza","year":"1998","journal-title":"Am J Gastroenterol"},{"issue":"11","key":"10.1016\/j.xphs.2023.07.016_bib0008","first-page":"858","article-title":"The role of anti-ulcerative drugs in treatment and prevention of gastropathies induced by nonsteroidal anti-inflammatory drugs","volume":"50","author":"Fialov\u00e1","year":"2004","journal-title":"Vnitr Lek"},{"issue":"1","key":"10.1016\/j.xphs.2023.07.016_bib0009","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00198-018-4788-y","article-title":"Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies","volume":"30","author":"Poly","year":"2019","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.xphs.2023.07.016_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119880","article-title":"Intragastric amorphous calcium carbonate consumption triggered generation of in situ hydrogel piece for sustained drug release","volume":"590","author":"Xu","year":"2020","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2023.07.016_bib0011","doi-asserted-by":"crossref","unstructured":"Patlolla V G R, Peter Holbrook W, Gizurarson S, et al. Doxycycline and Monocaprin In Situ Hydrogel: Effect on Stability, Mucoadhesion and Texture Analysis and In Vitro Release. 2019, 5(4): 47.","DOI":"10.3390\/gels5040047"},{"issue":"11","key":"10.1016\/j.xphs.2023.07.016_bib0012","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1016\/j.biomaterials.2012.01.007","article-title":"Alginate derivatization: a review of chemistry, properties and applications","volume":"33","author":"Sn","year":"2012","journal-title":"Biomaterials"},{"issue":"12","key":"10.1016\/j.xphs.2023.07.016_bib0013","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1016\/j.progpolymsci.2014.07.010","article-title":"Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review","volume":"39","author":"Sosnik","year":"2014","journal-title":"Prog Polym Sci"},{"issue":"18","key":"10.1016\/j.xphs.2023.07.016_bib0014","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1039\/c2sm07465f","article-title":"Magnesium ions and alginate do form hydrogels: a rheological study","volume":"8","author":"Topuz","year":"2012","journal-title":"Soft Matter"},{"issue":"1-2","key":"10.1016\/j.xphs.2023.07.016_bib0015","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ijpharm.2014.03.038","article-title":"Application of gellan gum in pharmacy and medicine","volume":"466","author":"Osma\u0142ek","year":"2014","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2023.07.016_bib0016","doi-asserted-by":"crossref","unstructured":"Kanesaka S, Watanabe T, Matsukawa S J B. Binding effect of Cu2+ as a trigger on the sol-to-gel and the coil-to-helix transition processes of polysaccharide, gellan gum. 2004, 5(3): 863-8.","DOI":"10.1021\/bm030072t"},{"issue":"8","key":"10.1016\/j.xphs.2023.07.016_bib0017","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s003960050446","article-title":"Non-Newtonian flow behaviour of gellan gum aqueous solutions","volume":"277","author":"Miyoshi","year":"1999","journal-title":"Colloid Polym Sci"},{"key":"10.1016\/j.xphs.2023.07.016_bib0018","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.physa.2019.03.119","article-title":"Statistical investigation for developing a new model for rheological behavior of Silica-ethylene glycol\/Water hybrid Newtonian nanofluid using experimental data","volume":"525","author":"Ruhani","year":"2019","journal-title":"Physica A"},{"issue":"07","key":"10.1016\/j.xphs.2023.07.016_bib0019","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1055\/s-0043-102952","article-title":"Development of multiple-unit floating drug delivery system of clarithromycin: formulation, in vitro dissolution by modified dissolution apparatus, in vivo radiographic studies in human volunteers","volume":"67","author":"Reddy","year":"2017","journal-title":"Drug Res"},{"issue":"2","key":"10.1016\/j.xphs.2023.07.016_bib0020","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jconrel.2010.11.034","article-title":"Gastrointestinal contents in fasted state and post-lipid ingestion: in vivo measurements and in vitro models for studying oral drug delivery","volume":"151","author":"Di","year":"2011","journal-title":"J Controlled Release"},{"key":"10.1016\/j.xphs.2023.07.016_bib0021","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ejpb.2018.03.002","article-title":"Interindividual and intraindividual variability of fasted state gastric fluid volume and gastric emptying of water","volume":"127","author":"Grimm","year":"2018","journal-title":"Eur J Pharm Biopharm"},{"issue":"7","key":"10.1016\/j.xphs.2023.07.016_bib0022","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/j.1365-2036.2010.04573.x","article-title":"Review article: methods of measuring gastric acid secretion","volume":"33","author":"Ghosh","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.xphs.2023.07.016_bib0023","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cmpb.2010.01.007","article-title":"PKSolver: an add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel","volume":"99","author":"Zhang","year":"2010","journal-title":"Comput Methods Programs Biomed"},{"key":"10.1016\/j.xphs.2023.07.016_bib0024","doi-asserted-by":"crossref","unstructured":"Donati I, Asaro F, Paoletti S J T J O P C B. Experimental evidence of counterion affinity in alginates: the case of nongelling ion Mg2+. 2009, 113(39): 12877-86.","DOI":"10.1021\/jp902912m"},{"issue":"sup146","key":"10.1016\/j.xphs.2023.07.016_bib0025","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/00365528809099130","article-title":"Pepsins and the mucus barrier in peptic ulcer disease","volume":"23","author":"Allen","year":"1988","journal-title":"Scand J Gastroenterol"},{"issue":"1","key":"10.1016\/j.xphs.2023.07.016_bib0026","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.intimp.2015.07.031","article-title":"Protective activity of salidroside against ethanol-induced gastric ulcer via the MAPK\/NF-\u03baB pathway in vivo and in vitro","volume":"28","author":"Chang","year":"2015","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"10.1016\/j.xphs.2023.07.016_bib0027","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/00236772211018587","article-title":"Hematologic and serum biochemistry reference intervals using defined ASCVP methodology for laboratory natal multimammate mice (Mastomys natalensis)","volume":"55","author":"Smith","year":"2021","journal-title":"Lab Anim"},{"issue":"10A","key":"10.1016\/j.xphs.2023.07.016_bib0028","first-page":"1350","article-title":"Evaluation of a new antacid, almagate","volume":"34","author":"Beneyto","year":"1984","journal-title":"Arzneim-Forsch"},{"key":"10.1016\/j.xphs.2023.07.016_bib0029","doi-asserted-by":"crossref","unstructured":"Salelles L, Floury J, Le Feunteun S J F, et al. Pepsin activity as a function of pH and digestion time on caseins and egg white proteins under static in vitro conditions. 2021, 12(24): 12468-78.","DOI":"10.1039\/D1FO02453A"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354923002915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354923002915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:44:31Z","timestamp":1758361471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354923002915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0022354923002915"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2023.07.016","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Liquid-like Oral Sustained-Release System Based on Acid-Sensitive in situ Hydrogel for Alleviate Gastrointestinal Side Effects of Indobufen","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2023.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc. on behalf of American Pharmacists Association.","name":"copyright","label":"Copyright"}]}}