{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:18:04Z","timestamp":1780467484003,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011760","name":"Chettinad Academy of Research and Education","doi-asserted-by":"publisher","award":["\/AR-Research\/2022-06"],"award-info":[{"award-number":["\/AR-Research\/2022-06"]}],"id":[{"id":"10.13039\/501100011760","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011760","name":"Chettinad Academy of Research and Education","doi-asserted-by":"publisher","award":["004\/Regr"],"award-info":[{"award-number":["004\/Regr"]}],"id":[{"id":"10.13039\/501100011760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.xphs.2023.08.014","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T11:22:01Z","timestamp":1692616921000},"page":"2891-2900","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Combinatorial Effect of Doxorubicin Entrapped in Alginate-Chitosan Hybrid Polymer and Cerium Oxide Nanocomposites on Skin Cancer Management in Mice"],"prefix":"10.1016","volume":"112","author":[{"given":"M.K.","family":"Shurfa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnishwar","family":"Girigoswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sakthi Devi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karthick","family":"Harini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopikrishna","family":"Agraharam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balasubramanian","family":"Deepika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pragya","family":"Pallavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koyeli","family":"Girigoswami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.xphs.2023.08.014_bib0001","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.xphs.2023.08.014_bib0002","first-page":"24","article-title":"A brief overview of telomeres and telomerase in aging and cancer","author":"Lateef","year":"2023","journal-title":"Curr Appl Sci Technol"},{"issue":"3","key":"10.1016\/j.xphs.2023.08.014_bib0003","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41568-019-0238-1","article-title":"A framework for advancing our understanding of cancer-associated fibroblasts","volume":"20","author":"Sahai","year":"2020","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.xphs.2023.08.014_bib0004","article-title":"Classification of melanoma skin cancer using convolutional neural network","volume":"10","author":"Refianti","year":"2019","journal-title":"Int J Adv Comput Sci Appl"},{"key":"10.1016\/j.xphs.2023.08.014_bib0005","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejca.2021.04.029","article-title":"Epidemiology of cutaneous melanoma and keratinocyte cancer in white populations 1943\u20132036","volume":"152","author":"Garbe","year":"2021","journal-title":"Eur J Cancer"},{"issue":"5","key":"10.1016\/j.xphs.2023.08.014_bib0006","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1073\/pnas.1811067116","article-title":"Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer","volume":"116","author":"Blando","year":"2019","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"10.1016\/j.xphs.2023.08.014_bib0007","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF00403734","article-title":"Acceleration of the development of benzopyrene-induced skin cancer in mice by microwave radiation","volume":"274","author":"Szudzi\u0144ski","year":"1982","journal-title":"Arch Dermatol Res"},{"issue":"1","key":"10.1016\/j.xphs.2023.08.014_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/chemistry4010001","article-title":"Nanoencapsulated myricetin to improve antioxidant activity and bioavailability: a study on zebrafish embryos","volume":"4","author":"Agraharam","year":"2021","journal-title":"Chem"},{"issue":"4","key":"10.1016\/j.xphs.2023.08.014_bib0009","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2174\/1573401316999200901120458","article-title":"An overview of nanoformulated nutraceuticals and their therapeutic approaches","volume":"17","author":"De","year":"2021","journal-title":"Curr Nutr Food Sci"},{"issue":"3","key":"10.1016\/j.xphs.2023.08.014_bib0010","article-title":"Nano resveratrol and its anticancer activity","volume":"23","author":"Balasubramanian","year":"2023","journal-title":"Curr Appl Sci Technol"},{"issue":"4","key":"10.1016\/j.xphs.2023.08.014_bib0011","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1021\/acsabm.9b00039","article-title":"Excitation wavelength independent carbon-decorated ferrite nanodots for multimodal diagnosis and stimuli responsive therapy","volume":"2","author":"Sharmiladevi","year":"2019","journal-title":"ACS Appl Bio Mater"},{"key":"10.1016\/j.xphs.2023.08.014_bib0012","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1039\/D1MA00069A","article-title":"Nano-enabled theranostics for cancer","volume":"2","author":"Sharmiladevi","year":"2021","journal-title":"Mater Adv."},{"issue":"8","key":"10.1016\/j.xphs.2023.08.014_bib0013","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1021\/acsbiomaterials.0c00409","article-title":"Water\u2013nanomaterial interaction to escalate twin-mode magnetic resonance imaging","volume":"6","author":"Haribabu","year":"2020","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.xphs.2023.08.014_bib0014","series-title":"Biomedical Translational Research:","first-page":"339","article-title":"Potential of Magnetic Resonance (MR) methods in clinical cancer research","author":"Jagannathan","year":"2022"},{"key":"10.1016\/j.xphs.2023.08.014_bib0015","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bcab.2018.11.029","article-title":"Diagnostic biosensors in medicine\u2013a review","volume":"17","author":"Metkar","year":"2019","journal-title":"Biocatal Agric Biotechnol"},{"key":"10.1016\/j.xphs.2023.08.014_bib0016","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.msec.2017.04.118","article-title":"ZnO nanoflower based sensitive nano-biosensor for amyloid detection","volume":"78","author":"Akhtar","year":"2017","journal-title":"Mater Sci Eng C"},{"issue":"7","key":"10.1016\/j.xphs.2023.08.014_bib0017","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3390\/gels8070441","article-title":"Smart hydrogel formed by alginate-g-poly (N-isopropylacrylamide) and chitosan through polyelectrolyte complexation and its controlled release properties","volume":"8","author":"Liu","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.xphs.2023.08.014_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcab.2019.101124","article-title":"Cerium oxide nanocluster based nanobiosensor for ROS detection","volume":"19","author":"Thendral","year":"2019","journal-title":"Biocatal Agric Biotechnol"},{"issue":"4","key":"10.1016\/j.xphs.2023.08.014_bib0019","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1002\/jcp.27303","article-title":"Evaluation of anticancer effects of cerium oxide nanoparticles on mouse fibrosarcoma cell line","volume":"234","author":"Nourmohammadi","year":"2019","journal-title":"J Cell Physiol"},{"issue":"23","key":"10.1016\/j.xphs.2023.08.014_bib0020","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1056\/NEJMcibr061443","article-title":"A better way for a cancer cell to die","volume":"354","author":"Lake","year":"2006","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.xphs.2023.08.014_bib0021","first-page":"463","article-title":"Synthesis and character of cerium oxide (CeO 2) nanoparticles by the precipitation method","volume":"53","author":"Liu","year":"2014","journal-title":"Metalurgija"},{"issue":"4","key":"10.1016\/j.xphs.2023.08.014_bib0022","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s40995-022-01337-y","article-title":"Synthesis, characterization and applications of GO\u2013TiO2 nanocomposites in textile dye remediation","volume":"46","author":"Keerthana","year":"2022","journal-title":"Iran J Sci Technol Trans A"},{"issue":"5","key":"10.1016\/j.xphs.2023.08.014_bib0023","doi-asserted-by":"crossref","first-page":"652","DOI":"10.2174\/1567201814666170825160617","article-title":"Influence of divalent cation on morphology and drug delivery efficiency of mixed polymer nanoparticles","volume":"15","author":"Deepika","year":"2018","journal-title":"Curr Drug Delivery"},{"key":"10.1016\/j.xphs.2023.08.014_bib0024","doi-asserted-by":"crossref","first-page":"15","DOI":"10.12659\/MSMBR.893327","article-title":"Dual AO\/EB staining to detect apoptosis in osteosarcoma cells compared with flow cytometry","volume":"21","author":"Liu","year":"2015","journal-title":"Medic Sci Monitor Basic Res"},{"key":"10.1016\/j.xphs.2023.08.014_bib0025","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.msec.2019.03.086","article-title":"ZnO Nanoflower petals mediated amyloid degradation-An in vitro electrokinetic potential approach","volume":"101","author":"Girigoswami","year":"2019","journal-title":"Mater Sci Eng C"},{"issue":"19","key":"10.1016\/j.xphs.2023.08.014_bib0026","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.3390\/molecules27196241","article-title":"Evaluation of the anticancer potential of Rosa damascena Mill. Callus extracts against the human colorectal adenocarcinoma cell line","volume":"27","author":"Darwish","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.xphs.2023.08.014_bib0027","first-page":"413","article-title":"Laboratory animal analgesia, anesthesia, and euthanasia","volume":"1","author":"Hedenqvist","year":"2003","journal-title":"Handb Lab Anim Sci"},{"issue":"4","key":"10.1016\/j.xphs.2023.08.014_bib0028","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1258\/002367796780739871","article-title":"Recommendations for euthanasia of experimental animals: Part 1","volume":"30","author":"Close","year":"1996","journal-title":"Lab Anim"},{"issue":"9","key":"10.1016\/j.xphs.2023.08.014_bib0029","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.2217\/nnm.13.133","article-title":"Cerium oxide nanoparticles: applications and prospects in nanomedicine","volume":"8","author":"Das","year":"2013","journal-title":"Nanomedicine"},{"issue":"45","key":"10.1016\/j.xphs.2023.08.014_bib0030","doi-asserted-by":"crossref","first-page":"27194","DOI":"10.1039\/D0RA04736H","article-title":"Cerium oxide nanoparticles: properties, biosynthesis and biomedical application","volume":"10","author":"Singh","year":"2020","journal-title":"RSC Adv"},{"issue":"5","key":"10.1016\/j.xphs.2023.08.014_bib0031","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/smll.200700824","article-title":"Synthesis of biocompatible dextran-coated nanoceria with pH-dependent antioxidant properties","volume":"4","author":"Perez","year":"2008","journal-title":"Small"},{"key":"10.1016\/j.xphs.2023.08.014_bib0032","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1477-3163-5-14","article-title":"Reactive oxygen species: role in the development of cancer and various chronic conditions","volume":"5","author":"Waris","year":"2006","journal-title":"J Carcinog"},{"issue":"4","key":"10.1016\/j.xphs.2023.08.014_bib0033","doi-asserted-by":"crossref","first-page":"853","DOI":"10.4103\/0973-1482.139267","article-title":"An overview of doxorubicin formulations in cancer therapy","volume":"10","author":"Rivankar","year":"2014","journal-title":"J Cancer Res Therap"},{"issue":"7","key":"10.1016\/j.xphs.2023.08.014_bib0034","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1158\/1535-7163.MCT-13-0950","article-title":"Combination of conventional chemotherapeutics with redox-active cerium oxide nanoparticles\u2014a novel aspect in cancer therapyredox-active cerium oxide nanoparticles in cancer therapy","volume":"13","author":"Sack","year":"2014","journal-title":"Mol Cancer Ther"},{"issue":"2","key":"10.1016\/j.xphs.2023.08.014_bib0035","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/antiox7020031","article-title":"Nanotherapy and reactive oxygen species (ROS) in cancer: a novel perspective","volume":"7","author":"Brenneisen","year":"2018","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.xphs.2023.08.014_bib0036","doi-asserted-by":"crossref","first-page":"8952","DOI":"10.1021\/acsomega.8b01060","article-title":"CeO2 nanoparticles-loaded pH-responsive microparticles with antitumoral properties as therapeutic modulators for osteosarcoma","volume":"3","author":"Tapeinos","year":"2018","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.xphs.2023.08.014_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-09876-w","article-title":"Nanoceria-mediated delivery of doxorubicin enhances the anti-tumour efficiency in ovarian cancer cells via apoptosis","volume":"7","author":"Das","year":"2017","journal-title":"Sci Rep"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354923003362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354923003362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:36Z","timestamp":1777420836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354923003362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":37,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0022354923003362"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2023.08.014","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combinatorial Effect of Doxorubicin Entrapped in Alginate-Chitosan Hybrid Polymer and Cerium Oxide Nanocomposites on Skin Cancer Management in Mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2023.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}