{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:56:04Z","timestamp":1792446964350,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T00:00:00Z","timestamp":1739664000000},"content-version":"am","delay-in-days":352,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.xphs.2023.09.001","type":"journal-article","created":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T05:25:57Z","timestamp":1694237157000},"page":"718-724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Silk Fibroin-Based Coatings for Pancreatin-Dependent Drug Delivery"],"prefix":"10.1016","volume":"113","author":[{"given":"Natsuda","family":"Navamajiti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apolonia","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4947-8905","authenticated-orcid":false,"given":"Ruonan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6515-8906","authenticated-orcid":false,"given":"Yutaro","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Won","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhi V.","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn","family":"Damrongsakkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorada","family":"Kanokpanont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Steiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Reker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Langer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7851-4077","authenticated-orcid":false,"given":"Giovanni","family":"Traverso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xphs.2023.09.001_bib0001","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1126\/scitranslmed.aau6267","article-title":"A gastric resident drug delivery system for prolonged gram-level dosing of tuberculosis treatment","volume":"11","author":"Verma","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.xphs.2023.09.001_bib0002","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/jps.20742","article-title":"An investigation into the in vivo performance variability of pH responsive polymers for ileo-colonic drug delivery using gamma scintigraphy in humans","volume":"95","author":"Ibekwe","year":"2006","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.xphs.2023.09.001_bib0003","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1517\/17425247.2.1.159","article-title":"TARGITTM technology: coated starch capsules for site-specific drug delivery into the lower gastrointestinal tract","volume":"2","author":"Watts","year":"2005","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.xphs.2023.09.001_bib0004","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s11894-008-0098-4","article-title":"Pharmacology of proton pump inhibitors","volume":"10","author":"Shin","year":"2008","journal-title":"Curr Gastroenterol Rep"},{"key":"10.1016\/j.xphs.2023.09.001_bib0005","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.carbpol.2014.04.091","article-title":"Novel starch based nano scale enteric coatings from soybean meal for colon-specific delivery","volume":"111","author":"Sivapragasam","year":"2014","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.xphs.2023.09.001_bib0006","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/B978-1-78242-311-9.00011-2","article-title":"Silk as a suture material","author":"Thilagavathi","year":"2015","journal-title":"Adv Silk Sci Technol"},{"key":"10.1016\/j.xphs.2023.09.001_bib0007","unstructured":"FDA. GRN No. 1026: Silk fibroin derived from Bombyx mori cocoons. 2022. Available at: https:\/\/www.fda.gov\/food\/generally-recognized-safe-gras\/gras-notice-inventory."},{"key":"10.1016\/j.xphs.2023.09.001_bib0008","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1007\/s10853-018-3137-z","article-title":"Silk fibroin coaxial bead-on-string fiber materials and their drug release behaviors in different pH","volume":"54","author":"Xi","year":"2019","journal-title":"J Mater Sci"},{"issue":"13","key":"10.1016\/j.xphs.2023.09.001_bib0009","doi-asserted-by":"crossref","first-page":"7107","DOI":"10.3390\/ijms22137107","article-title":"Synthesis of pH and glucose responsive silk fibroin hydrogels","volume":"22","author":"Tao","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xphs.2023.09.001_bib0010","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.actbio.2020.07.062","article-title":"pH-responsive silk fibroin-based CuO\/Ag micro\/nano coating endows polyetheretherketone with synergistic antibacterial ability, osteogenesis, and angiogenesis","volume":"115","author":"Yan","year":"2020","journal-title":"Acta Biomater"},{"key":"10.1016\/j.xphs.2023.09.001_bib0011","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.ijbiomac.2022.11.226","article-title":"Synthesis and characterization of a novel, pH-responsive sustained release nanocarrier using polyethylene glycol, graphene oxide, and natural silk fibroin protein by a green nano emulsification method to enhance cancer treatment","volume":"226","author":"Jeshvaghani","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.xphs.2023.09.001_bib0012","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1080\/10717544.2017.1279238","article-title":"pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms","volume":"24","author":"Liu","year":"2017","journal-title":"Drug Deliv"},{"key":"10.1016\/j.xphs.2023.09.001_bib0013","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S1369-7021(12)70091-3","article-title":"Protein-based composite materials","volume":"15","author":"Hu","year":"2012","journal-title":"Mater Today"},{"key":"10.1016\/j.xphs.2023.09.001_bib0014","first-page":"D506","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.xphs.2023.09.001_bib0015","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-1-4939-3167-5_2","article-title":"UniProtKB\/Swiss-Prot, the manually annotated section of the UniProt KnowledgeBase: how to use the entry view","volume":"1374","author":"Boutet","year":"2016","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.xphs.2023.09.001_bib0016","unstructured":"Gibb S. Cleaver: cleavage of polypeptide sequences. R package version 1.26.0. 2020. Available at: https:\/\/github.com\/sgibb\/cleaver\/."},{"key":"10.1016\/j.xphs.2023.09.001_bib0017","series-title":"The Proteomics Protocols Handbook","first-page":"571","article-title":"Protein identification and analysis tools on the ExPASy server","author":"Gasteiger","year":"2005"},{"key":"10.1016\/j.xphs.2023.09.001_bib0018","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1016\/j.biomaterials.2004.07.044","article-title":"Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin","volume":"26","author":"Kim","year":"2005","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.xphs.2023.09.001_bib0019","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1021\/bm200062a","article-title":"Regulation of silk material structure by temperature-controlled water vapor annealing","volume":"12","author":"Hu","year":"2011","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.xphs.2023.09.001_bib0020","unstructured":"Pharma Excipients. EUDRAGIT\u00ae L 100. 2023. Available at: https:\/\/www.pharmaexcipients.com\/product\/eudragit-l-100\/."},{"key":"10.1016\/j.xphs.2023.09.001_bib0021","unstructured":"Pharma Excipients. EUDRAGIT\u00ae S 100. 2023. Available at: https:\/\/www.pharmaexcipients.com\/product\/eudragit-s-100\/."},{"issue":"9","key":"10.1016\/j.xphs.2023.09.001_bib0022","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3390\/pharmaceutics12090853","article-title":"Pharmaceutical application of tablet film coating","volume":"12","author":"Seo","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.xphs.2023.09.001_bib0023","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jcmgh.2016.09.003","article-title":"Large animal models: the key to translational discovery in digestive disease research","volume":"2","author":"Ziegler","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"12","key":"10.1016\/j.xphs.2023.09.001_bib0024","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/jps.2600811208","article-title":"Gastric emptying of tablets and granules in humans, dogs, pigs, and stomach-emptying-controlled rabbits","volume":"81","author":"Aoyagi","year":"1992","journal-title":"J Phar Sci"},{"key":"10.1016\/j.xphs.2023.09.001_bib0025","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/gut.27.8.886","article-title":"Transit of pharmaceutical dosage forms through the small intestine","volume":"27","author":"Davis","year":"1986","journal-title":"Gut"},{"key":"10.1016\/j.xphs.2023.09.001_bib0026","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41467-019-08355-2","article-title":"Ingestible hydrogel device","volume":"10","author":"Liu","year":"2019","journal-title":"Nat Commun"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354923003647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354923003647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:43:18Z","timestamp":1758361398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354923003647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0022354923003647"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2023.09.001","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Silk Fibroin-Based Coatings for Pancreatin-Dependent Drug Delivery","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2023.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}