{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:13:57Z","timestamp":1778048037113,"version":"3.51.4"},"reference-count":73,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001230","name":"Macquarie University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1173363"],"award-info":[{"award-number":["APP1173363"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.xphs.2025.103795","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T15:22:11Z","timestamp":1744644131000},"page":"103795","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intranasal delivery of temozolomide and desloratadine for brain tumour therapy: A cellular study on nasal epithelial toxicity, transport, and permeability"],"prefix":"10.1016","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-6432","authenticated-orcid":false,"given":"Chun Yuen Jerry","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-1551","authenticated-orcid":false,"given":"Hui Xin","family":"Ong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7173-017X","authenticated-orcid":false,"given":"Daniela","family":"Traini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xphs.2025.103795_bib0001","first-page":"16","article-title":"Blood\u2013brain barrier conquest in glioblastoma nanomedicine: strategies, clinical advances, and emerging challenges","author":"Duan","year":"2024","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.xphs.2025.103795_bib0002","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.5603\/RPOR.a2022.0113","article-title":"Survival and quality of life analysis in glioblastoma multiforme with adjuvant chemoradiotherapy: a retrospective study","volume":"27","author":"Mohammed","year":"2022","journal-title":"Rep Pract Oncol Radiother"},{"issue":"1","key":"10.1016\/j.xphs.2025.103795_bib0003","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12987-020-00230-3","article-title":"A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity","volume":"17","author":"Kadry","year":"2020","journal-title":"Fluids Barriers CNS"},{"issue":"1","key":"10.1016\/j.xphs.2025.103795_bib0004","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1038\/s41467-018-04315-4","article-title":"Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles","volume":"9","author":"Lam","year":"2018","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.xphs.2025.103795_bib0005","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27113507","article-title":"Temozolomide efficacy and metabolism: the implicit relevance of nanoscale delivery systems","volume":"27","author":"Petrenko","year":"2022","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.xphs.2025.103795_bib0006","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.3390\/curroncol31070296","article-title":"Temozolomide (TMZ) in the treatment of glioblastoma multiforme-a literature review and clinical outcomes","volume":"31","author":"Jezierza\u0144ski","year":"2024","journal-title":"Curr Oncol"},{"issue":"2","key":"10.1016\/j.xphs.2025.103795_bib0007","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2024.5668","article-title":"Targeting drug resistance in glioblastoma (Review)","volume":"65","author":"Sherman","year":"2024","journal-title":"Int J Oncol"},{"issue":"7","key":"10.1016\/j.xphs.2025.103795_bib0008","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1007\/s13346-024-01558-1","article-title":"Insulin delivery to the brain via the nasal route: unraveling the potential for Alzheimer\u2019s disease therapy","volume":"14","author":"Wong","year":"2024","journal-title":"Drug Deliv Transl Res"},{"issue":"5","key":"10.1016\/j.xphs.2025.103795_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e09517","article-title":"Intranasal delivery in glioblastoma treatment: prospective molecular treatment modalities","volume":"8","author":"Morales","year":"2022","journal-title":"Heliyon"},{"issue":"4","key":"10.1016\/j.xphs.2025.103795_bib0010","doi-asserted-by":"crossref","first-page":"101029","DOI":"10.1016\/j.tranon.2021.101029","article-title":"Improved survival in several cancers with use of H(1)-antihistamines desloratadine and loratadine","volume":"14","author":"Fritz","year":"2021","journal-title":"Transl Oncol"},{"issue":"1","key":"10.1016\/j.xphs.2025.103795_bib0011","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41467-023-44477-4","article-title":"Molecular mechanism of antihistamines recognition and regulation of the histamine H1 receptor","volume":"15","author":"Wang","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.xphs.2025.103795_bib0012","first-page":"14","article-title":"Readily available drugs and other interventions to potentially improve the efficacy of immune checkpoint blockade in cancer","author":"Coleman","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.xphs.2025.103795_bib0013","doi-asserted-by":"crossref","DOI":"10.1177\/1533033820926591","article-title":"Desloratadine, a novel antigrowth reagent for bladder cancer","volume":"19","author":"Ma","year":"2020","journal-title":"Technol Cancer Res Treat"},{"issue":"9","key":"10.1016\/j.xphs.2025.103795_bib0014","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/jnci\/djz217","article-title":"Antihistamines and ovarian cancer survival: nationwide cohort study and in vitro cell viability assay","volume":"112","author":"Verdoodt","year":"2020","journal-title":"J Natl Cancer Inst"},{"issue":"8","key":"10.1016\/j.xphs.2025.103795_bib0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s12032-023-02117-3","article-title":"Proapoptotic and proautophagy effect of H1-receptor antagonist desloratadine in human glioblastoma cell lines","volume":"40","author":"Vidicevic-Novakovic","year":"2023","journal-title":"Med Oncol"},{"key":"10.1016\/j.xphs.2025.103795_bib0016","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ejpb.2023.06.015","article-title":"Engineered dry powders for the nose-to-brain delivery of transforming growth factor-beta","volume":"189","author":"Wong","year":"2023","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.xphs.2025.103795_bib0017","doi-asserted-by":"crossref","first-page":"104848","DOI":"10.1016\/j.jddst.2023.104848","article-title":"Impact of amino acids on the properties of nasal dry powders","volume":"87","author":"Baldelli","year":"2023","journal-title":"J Drug Deliv Sci Tech"},{"issue":"1","key":"10.1016\/j.xphs.2025.103795_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227174","article-title":"Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells","volume":"15","author":"Han","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.xphs.2025.103795_bib0019","doi-asserted-by":"crossref","first-page":"120487","DOI":"10.1016\/j.lfs.2022.120487","article-title":"The application of in vitro cellular assays for analysis of electronic cigarettes impact on the airway","volume":"298","author":"Wong","year":"2022","journal-title":"Life Sci"},{"issue":"6","key":"10.1016\/j.xphs.2025.103795_bib0020","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1002\/vms3.620","article-title":"Temozolomide is additive with cytotoxic effect of irradiation in canine glioma cell lines","volume":"7","author":"Tresch","year":"2021","journal-title":"Vet Med Sci"},{"issue":"10","key":"10.1016\/j.xphs.2025.103795_bib0021","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1158\/1535-7163.MCT-21-0228","article-title":"Molecular dosimetry of temozolomide: quantification of critical lesions, correlation to cell death responses, and threshold doses","volume":"20","author":"Stratenwerth","year":"2021","journal-title":"Mol Cancer Ther"},{"issue":"4","key":"10.1016\/j.xphs.2025.103795_bib0022","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/sj.cdd.4401359","article-title":"Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells","volume":"11","author":"Kanzawa","year":"2004","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.xphs.2025.103795_bib0023","doi-asserted-by":"crossref","first-page":"131827","DOI":"10.1016\/j.jhazmat.2023.131827","article-title":"Neurotoxicity of the air-borne particles: from molecular events to human diseases","volume":"457","author":"Liu","year":"2023","journal-title":"J Hazard Mater"},{"issue":"3","key":"10.1016\/j.xphs.2025.103795_bib0024","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202402117","article-title":"Synthesis, aromatase inhibition, cytotoxicity and molecular docking studies of new fluorinated and non-fluorinated thiourea ferivatives of fesloratadine","volume":"22","author":"Sajid","year":"2025","journal-title":"Chem Biodiversity"},{"key":"10.1016\/j.xphs.2025.103795_bib0025","doi-asserted-by":"crossref","first-page":"124009","DOI":"10.1016\/j.ijpharm.2024.124009","article-title":"Nasal delivery of encapsulated recombinant ACE2 as a prophylactic drug for SARS-CoV-2","volume":"655","author":"Baldelli","year":"2024","journal-title":"Intl J Pharm"},{"key":"10.1016\/j.xphs.2025.103795_bib0026","doi-asserted-by":"crossref","first-page":"104958","DOI":"10.1016\/j.jff.2022.104958","article-title":"Synergistic inhibitory effect of \u03b1-humulene and sclareol on human pancreatic cancer cells","volume":"89","author":"Kang","year":"2022","journal-title":"J Funct Foods"},{"key":"10.1016\/j.xphs.2025.103795_bib0027","series-title":"Analysis of drug interactions, in cancer cell culture: Methods and protocols","first-page":"421","author":"Bijnsdorp","year":"2011"},{"key":"10.1016\/j.xphs.2025.103795_bib0028","article-title":"Enhancing nose-to-brain drug delivery: a comparative study of peptide formulations using a multidose nasal spray","author":"Wong","year":"2024","journal-title":"Respiratory Drug Delivery"},{"key":"10.1016\/j.xphs.2025.103795_bib0029","doi-asserted-by":"crossref","first-page":"122024","DOI":"10.1016\/j.ijpharm.2022.122024","article-title":"Validation of a cell integrated next-generation impactor to assess in vitro drug transport of physiologically relevant aerosolised particles","volume":"624","author":"Wong","year":"2022","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2025.103795_bib0030","doi-asserted-by":"crossref","first-page":"943982","DOI":"10.1155\/2012\/943982","article-title":"Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research","volume":"2012","author":"Stewart","year":"2012","journal-title":"J Allergy"},{"key":"10.1016\/j.xphs.2025.103795_bib0031","doi-asserted-by":"crossref","first-page":"123922","DOI":"10.1016\/j.ijpharm.2024.123922","article-title":"An overview of in vitro and in vivo techniques for characterization of intranasal protein and peptide formulations for brain targeting","volume":"654","author":"Wong","year":"2024","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2025.103795_bib0032","doi-asserted-by":"crossref","first-page":"121989","DOI":"10.1016\/j.ijpharm.2022.121989","article-title":"Development of excipients free inhalable co-spray-dried tobramycin and diclofenac formulations for cystic fibrosis using two and three fluid nozzles","volume":"624","author":"Marasini","year":"2022","journal-title":"Int J Pharm"},{"issue":"8","key":"10.1016\/j.xphs.2025.103795_bib0033","first-page":"1080","article-title":"Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein","volume":"29","author":"Wang","year":"2001","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.xphs.2025.103795_bib0034","doi-asserted-by":"crossref","first-page":"118720","DOI":"10.1016\/j.ijpharm.2019.118720","article-title":"Bio-nanotechnological advancement of orally administered insulin nanoparticles: comprehensive review of experimental design for physicochemical characterization","volume":"572","author":"Wong","year":"2019","journal-title":"Int J Pharm"},{"issue":"27","key":"10.1016\/j.xphs.2025.103795_bib0035","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1007\/s00216-018-1319-9","article-title":"Quantification of BSA-loaded chitosan\/oligonucleotide nanoparticles using reverse-phase high-performance liquid chromatography","volume":"410","author":"Wong","year":"2018","journal-title":"Anal Bioanal Chem"},{"issue":"1","key":"10.1016\/j.xphs.2025.103795_bib0036","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijpharm.2018.07.041","article-title":"Recent advancements in oral administration of insulin-loaded liposomal drug delivery systems for diabetes mellitus","volume":"549","author":"Wong","year":"2018","journal-title":"Int J Pharm"},{"issue":"7","key":"10.1016\/j.xphs.2025.103795_bib0037","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/1061186X.2017.1400552","article-title":"The role of chitosan on oral delivery of peptide-loaded nanoparticle formulation","volume":"26","author":"Wong","year":"2018","journal-title":"J Drug Target"},{"issue":"1","key":"10.1016\/j.xphs.2025.103795_bib0038","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijpharm.2017.12.036","article-title":"Microparticles, microcapsules and microspheres: a review of recent developments and prospects for oral delivery of insulin","volume":"537","author":"Wong","year":"2018","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2025.103795_bib0039","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jconrel.2017.09.003","article-title":"Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment","volume":"264","author":"Wong","year":"2017","journal-title":"J Control Rel"},{"issue":"7","key":"10.1016\/j.xphs.2025.103795_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10071706","article-title":"Micro- and nanosized carriers for nose-to-brain drug delivery in neurodegenerative disorders","volume":"10","author":"Boyuklieva","year":"2022","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.xphs.2025.103795_bib0041","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/1061186X.2020.1726356","article-title":"Cellular assays and applied technologies for characterisation of orally administered protein nanoparticles: a systematic review","volume":"28","author":"Wong","year":"2020","journal-title":"J Drug Target"},{"key":"10.1016\/j.xphs.2025.103795_bib0042","doi-asserted-by":"crossref","first-page":"101738","DOI":"10.1016\/j.jddst.2020.101738","article-title":"Formulation and characterisation of insulin-loaded chitosan nanoparticles capable of inducing glucose uptake in skeletal muscle cells in vitro","volume":"57","author":"Wong","year":"2020","journal-title":"J Drug Deliv Sci Tech"},{"issue":"3","key":"10.1016\/j.xphs.2025.103795_bib0043","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1208\/s12249-020-01648-6","article-title":"Lyophilisation improves bioactivity and stability of insulin-loaded polymeric-oligonucleotide nanoparticles for diabetes treatment","volume":"21","author":"Wong","year":"2020","journal-title":"AAPS PharmSciTech"},{"issue":"3","key":"10.1016\/j.xphs.2025.103795_bib0044","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/jphp.12694","article-title":"In-vitro evaluation of enteric coated insulin tablets containing absorption enhancer and enzyme inhibitor","volume":"69","author":"Wong","year":"2017","journal-title":"J Pharm Pharmacol"},{"issue":"9","key":"10.1016\/j.xphs.2025.103795_bib0045","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/jphp.12607","article-title":"Oral delivery of insulin for treatment of diabetes: status quo, challenges and opportunities","volume":"68","author":"Wong","year":"2016","journal-title":"J Pharm Pharmacol"},{"issue":"6","key":"10.1016\/j.xphs.2025.103795_bib0046","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25063217","article-title":"A review of approaches to potentiate the activity of temozolomide against glioblastoma to overcome resistance","volume":"25","author":"Karve","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.xphs.2025.103795_bib0047","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.gendis.2022.02.007","article-title":"Cancer chemotherapy and beyond: current status, drug candidates, associated risks and progress in targeted therapeutics","volume":"10","author":"Anand","year":"2023","journal-title":"Genes Dis"},{"issue":"24","key":"10.1016\/j.xphs.2025.103795_bib0048","doi-asserted-by":"crossref","first-page":"10126","DOI":"10.1039\/D4DT00426D","volume":"53","author":"Rijwan","year":"2024","journal-title":"Dalton Trans"},{"key":"10.1016\/j.xphs.2025.103795_bib0049","doi-asserted-by":"crossref","first-page":"122667","DOI":"10.1016\/j.ijpharm.2023.122667","article-title":"Microfluidics assembly of inhalable liposomal ciprofloxacin characterised by an innovative in vitro pulmonary model","volume":"635","author":"Zhang","year":"2023","journal-title":"Int J Pharm"},{"issue":"3","key":"10.1016\/j.xphs.2025.103795_bib0050","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1021\/acs.molpharmaceut.3c00639","article-title":"A cell-based nasal model for screening the deposition, biocompatibility, and transport of aerosolized PLGA nanoparticles","volume":"21","author":"Maaz","year":"2024","journal-title":"Mol Pharm"},{"issue":"1","key":"10.1016\/j.xphs.2025.103795_bib0051","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.1038\/s41598-020-62848-5","article-title":"Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity screens","volume":"10","author":"Larsson","year":"2020","journal-title":"Sci Rep"},{"issue":"12","key":"10.1016\/j.xphs.2025.103795_bib0052","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1111\/jphp.13359","article-title":"C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage","volume":"72","author":"Wong","year":"2020","journal-title":"J Pharm Pharmacol"},{"issue":"9","key":"10.1016\/j.xphs.2025.103795_bib0053","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1080\/1061186X.2020.1759078","article-title":"Current status and applications of animal models in pre-clinical development of orally administered insulin-loaded nanoparticles","volume":"28","author":"Wong","year":"2020","journal-title":"J Drug Target"},{"issue":"8","key":"10.1016\/j.xphs.2025.103795_bib0054","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1080\/03639045.2020.1788061","article-title":"Development of orally administered insulin-loaded polymeric-oligonucleotide nanoparticles: statistical optimization and physicochemical characterization","volume":"46","author":"Wong","year":"2020","journal-title":"Drug Dev Ind Pharm"},{"issue":"1","key":"10.1016\/j.xphs.2025.103795_bib0055","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/17425247.2022.2026922","article-title":"Combining experimental and computational techniques to understand and improve dry powder inhalers","volume":"19","author":"Chaugule","year":"2022","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.xphs.2025.103795_bib0056","doi-asserted-by":"crossref","first-page":"1168408","DOI":"10.3389\/fbioe.2023.1168408","article-title":"Nose-to-brain delivery of self-assembled curcumin-lactoferrin nanoparticles: characterization, neuroprotective effect and in vivo pharmacokinetic study","volume":"11","author":"Li","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"issue":"6","key":"10.1016\/j.xphs.2025.103795_bib0057","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1093\/jpp\/rgaa052","article-title":"\u03b2-Cyclodextrin-containing chitosan-oligonucleotide nanoparticles improve insulin bioactivity, gut cellular permeation and glucose consumption","volume":"73","author":"Wong","year":"2021","journal-title":"J Pharm Pharmacol"},{"issue":"4","key":"10.1016\/j.xphs.2025.103795_bib0058","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/1061186X.2020.1817042","article-title":"Fabrication techniques for the preparation of orally administered insulin nanoparticles","volume":"29","author":"Wong","year":"2021","journal-title":"J Drug Target"},{"key":"10.1016\/j.xphs.2025.103795_bib0059","doi-asserted-by":"crossref","first-page":"104700","DOI":"10.1016\/j.jddst.2023.104700","article-title":"Nose to brain delivery of radiolabeled chemotherapeutic micelles: meeting the unmet needs of brain tumors","volume":"86","author":"Upadhaya","year":"2023","journal-title":"J Drug Del Sci Tech"},{"issue":"8","key":"10.1016\/j.xphs.2025.103795_bib0060","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1080\/17425247.2023.2231850","article-title":"Advances in soft mist inhalers","volume":"20","author":"Komalla","year":"2023","journal-title":"Expert Opin Drug Deliv"},{"issue":"4","key":"10.1016\/j.xphs.2025.103795_bib0061","first-page":"513","article-title":"Temozolomide: an updated overview of resistance mechanisms, nanotechnology advances and clinical applications","volume":"19","author":"Ortiz","year":"2021","journal-title":"Curr Neuropharmacol"},{"issue":"10","key":"10.1016\/j.xphs.2025.103795_bib0062","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140131","article-title":"Temozolomide resistance in glioblastoma cell lines: implication of MGMT, MMR, P-Glycoprotein and CD133 expression","volume":"10","author":"Perazzoli","year":"2015","journal-title":"PLoS One"},{"issue":"23","key":"10.1016\/j.xphs.2025.103795_bib0063","doi-asserted-by":"crossref","first-page":"38022","DOI":"10.18632\/oncotarget.16723","article-title":"Combination therapy in combating cancer","volume":"8","author":"Bayat Mokhtari","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.xphs.2025.103795_bib0064","doi-asserted-by":"crossref","first-page":"108968","DOI":"10.1016\/j.nucmedbio.2024.108968","article-title":"Brain drug delivery from the nasal olfactory region is enhanced using lauroylcholine chloride: an estimation using in vivo PET imaging","volume":"138","author":"Fukakusa","year":"2024","journal-title":"Nucl Med Biol"},{"key":"10.1016\/j.xphs.2025.103795_bib0065","doi-asserted-by":"crossref","first-page":"663626","DOI":"10.3389\/fimmu.2021.663626","article-title":"Nasal epithelial barrier integrity and tight junctions disruption in allergic rhinitis: overview and pathogenic Insights","volume":"12","author":"Nur Husna","year":"2021","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.xphs.2025.103795_bib0066","first-page":"1080","article-title":"Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein","volume":"29","author":"Wang","year":"2001","journal-title":"Drug Metab Dispos"},{"issue":"1","key":"10.1016\/j.xphs.2025.103795_bib0067","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jpba.2008.09.043","article-title":"Acid\u2013base equilibria and solubility of loratadine and desloratadine in water and micellar media","volume":"49","author":"Popovi\u0107","year":"2009","journal-title":"J Pharm Biomed Anal"},{"issue":"3","key":"10.1016\/j.xphs.2025.103795_bib0068","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3906\/kim-2101-42","article-title":"Electrochemical evaluation of the desloratadine at bismuth film electrode in the presence of cationic surfactant: highly sensitive determination in pharmaceuticals and human urine by Linear sweep-cathodic stripping voltammetry","volume":"45","author":"Altunkaynak","year":"2021","journal-title":"Turk J Chem"},{"issue":"1","key":"10.1016\/j.xphs.2025.103795_bib0069","doi-asserted-by":"crossref","first-page":"21053","DOI":"10.1038\/s41598-022-25399-5","article-title":"Desloratadine, an FDA-approved cationic amphiphilic drug, inhibits SARS-CoV-2 infection in cell culture and primary human nasal epithelial cells by blocking viral entry","volume":"12","author":"Morin-Dewaele","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.xphs.2025.103795_bib0070","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jconrel.2023.05.012","article-title":"Temozolomide-fatty acid conjugates for glioblastoma multiforme: in vitro and in vivo evaluation","volume":"359","author":"Jatyan","year":"2023","journal-title":"J Control Rel"},{"issue":"3","key":"10.1016\/j.xphs.2025.103795_bib0071","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1248\/yakushi.129.353","article-title":"Evaluation of stability of temozolomide in solutions after opening the capsule","volume":"129","author":"Kodawara","year":"2009","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.xphs.2025.103795_bib0072","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ejpb.2019.01.015","article-title":"Biophysical interaction of temozolomide and its active metabolite with biomembrane models: the relevance of drug-membrane interaction for glioblastoma multiforme therapy","volume":"136","author":"Ramalho","year":"2019","journal-title":"Eur J Pharm Biopharm"},{"issue":"4","key":"10.1016\/j.xphs.2025.103795_bib0073","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/aced23","article-title":"High-throughput bioprinting of the nasal epithelium using patient-derived nasal epithelial cells","volume":"15","author":"Deniz Derman","year":"2023","journal-title":"Biofabrication"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354925002527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354925002527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T08:02:44Z","timestamp":1751616164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354925002527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":73,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0022354925002527"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2025.103795","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intranasal delivery of temozolomide and desloratadine for brain tumour therapy: A cellular study on nasal epithelial toxicity, transport, and permeability","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2025.103795","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Pharmacists Association. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103795"}}