{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:16:43Z","timestamp":1793387803046,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["73247"],"award-info":[{"award-number":["73247"]}],"id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.xphs.2025.103801","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:53:24Z","timestamp":1745427204000},"page":"103801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enhanced endometrial receptivity via epigallocatechin gallate (EGCG)-loaded menstrual blood-derived exosomes"],"prefix":"10.1016","volume":"114","author":[{"given":"Ghada S.","family":"Rasool","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaf Mahmood","family":"Shihab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha Hameed","family":"Al-bahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mastafa H.","family":"Al-Musawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourosh","family":"Malek Mohammadi Nouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Mehdinezhad Roshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7391-276X","authenticated-orcid":false,"given":"Hamed","family":"Hajipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.xphs.2025.103801_bib0001","doi-asserted-by":"crossref","DOI":"10.1530\/RAF-24-0042","article-title":"Fertilty care in low and middle income countries: fertility care in low-and middle-income countries","volume":"5","author":"Ombelet","year":"2024","journal-title":"Reprod Fertil"},{"key":"10.1016\/j.xphs.2025.103801_bib0002","first-page":"65","article-title":"Automated grading of early stages of the human embryo development","author":"Chavare","year":"2022","journal-title":"J Pharm Negat Results"},{"key":"10.1016\/j.xphs.2025.103801_bib0003","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s00210-021-02153-8","article-title":"Sildenafil citrate\u2013loaded targeted nanostructured lipid carrier enhances receptivity potential of endometrial cells via LIF and VEGF upregulation","volume":"394","author":"Hajipour","year":"2021","journal-title":"Naunyn-Schmiedeberg's Arch Pharmacol"},{"issue":"5","key":"10.1016\/j.xphs.2025.103801_bib0004","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13385","article-title":"Cytokines in embryonic secretome as potential markers for embryo selection","volume":"85","author":"Bahrami-Asl","year":"2021","journal-title":"Am J Reprod Immunol"},{"issue":"3","key":"10.1016\/j.xphs.2025.103801_bib0005","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12853","article-title":"Lymphocytes immunotherapy for preserving pregnancy: mechanisms and challenges","volume":"80","author":"Hajipour","year":"2018","journal-title":"Am J Reprod Immunol"},{"issue":"6","key":"10.1016\/j.xphs.2025.103801_bib0006","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.3390\/ijms18061305","article-title":"The role of HCG in implantation: a mini-review of molecular and clinical evidence","volume":"18","author":"Makrigiannakis","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xphs.2025.103801_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121444","article-title":"The therapeutic effects and optimal timing of granulocyte colony stimulating factor intrauterine administration during IVF-ET","volume":"317","author":"Won","year":"2023","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.xphs.2025.103801_bib0008","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/nu15020320","article-title":"Assessing the hepatic safety of epigallocatechin gallate (EGCG) in reproductive-aged women","volume":"15","author":"Siblini","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.xphs.2025.103801_bib0009","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-078989","article-title":"Fibroids and unexplained infertility treatment with epigallocatechin gallate: a natural compound in green tea (FRIEND)\u2013protocol for a randomised placebo-controlled US multicentre clinical trial of EGCG to improve fertility in women with uterine fibroids","volume":"14","author":"Al-Hendy","year":"2024","journal-title":"BMJ Open"},{"issue":"11","key":"10.1016\/j.xphs.2025.103801_bib0010","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.3390\/biom10111481","article-title":"Protective effects of epigallocatechin gallate (EGCG) on endometrial, breast, and ovarian cancers","volume":"10","author":"Huang","year":"2020","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.xphs.2025.103801_bib0011","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3390\/nu15061439","article-title":"Green tea and benign gynecologic disorders: a new trick for an old beverage?","volume":"15","author":"Hazimeh","year":"2023","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.xphs.2025.103801_bib0012","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1124\/dmd.30.11.1246","article-title":"Contribution of presystemic hepatic extraction to the low oral bioavailability of green tea catechins in rats","volume":"30","author":"Cai","year":"2002","journal-title":"Drug Metab Disposit"},{"issue":"1","key":"10.1016\/j.xphs.2025.103801_bib0013","doi-asserted-by":"crossref","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.xphs.2025.103801_bib0014","article-title":"Protective effects of canthaxanthin-loaded seminal exosomes on the quality of human spermatozoa during cryopreservation","volume":"96","author":"Ali","year":"2024","journal-title":"J Drug Deliv Sci Technol"},{"issue":"1","key":"10.1016\/j.xphs.2025.103801_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/19396368.2024.2306420","article-title":"Engineered exosome as a biological nanoplatform for drug delivery of Rosmarinic acid to improve implantation in mice with induced endometritis","volume":"70","author":"Taravat","year":"2024","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.xphs.2025.103801_bib0016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-018-1105-9","article-title":"Menstrual blood-derived stem cells: toward therapeutic mechanisms, novel strategies, and future perspectives in the treatment of diseases","volume":"10","author":"Chen","year":"2019","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"10.1016\/j.xphs.2025.103801_bib0017","article-title":"Promising effects of exosomes from menstrual blood-derived mesenchymal stem cells on endometriosis","volume":"23","author":"Asl","year":"2023","journal-title":"Reprod Biol"},{"issue":"10","key":"10.1016\/j.xphs.2025.103801_bib0018","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1093\/humrep\/dem263","article-title":"Histone deacetylase inhibitor-induced glycodelin enhances the initial step of implantation","volume":"22","author":"Uchida","year":"2007","journal-title":"Hum Reprod"},{"issue":"3","key":"10.1016\/j.xphs.2025.103801_bib0019","doi-asserted-by":"crossref","first-page":"R85","DOI":"10.1530\/RAF-21-0023","article-title":"Organoids to model the endometrium: implantation and beyond","volume":"2","author":"Rawlings","year":"2021","journal-title":"Reprod Fertil"},{"issue":"1","key":"10.1016\/j.xphs.2025.103801_bib0020","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4103\/2277-9175.218029","article-title":"Evaluation of endometrial angiogenesis in mice uterus before implantation in natural cycles followed by use of human menopausal gonadotropin-human chorionic gonadotropin drugs and epigallocatechin gallate","volume":"6","author":"Rashidi","year":"2017","journal-title":"Adv Biomed Res"},{"issue":"3","key":"10.1016\/j.xphs.2025.103801_bib0021","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1093\/humrep\/den417","article-title":"Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model","volume":"24","author":"Xu","year":"2009","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xphs.2025.103801_bib0022","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00418-008-0390-2","article-title":"Subcutaneous injection, from birth, of epigallocatechin-3-gallate, a component of green tea, limits the onset of muscular dystrophy in mdx mice: a quantitative histological, immunohistochemical and electrophysiological study","volume":"129","author":"Nakae","year":"2008","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.xphs.2025.103801_bib0023","first-page":"1","article-title":"Uterine receptivity is reflected by LIF expression in the cervix","author":"Fukui","year":"2022","journal-title":"Reprod Sci"},{"issue":"2","key":"10.1016\/j.xphs.2025.103801_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2022.100647","article-title":"The roles and expression of HOXA\/Hoxa10 gene: a prospective marker of mammalian female fertility?","volume":"22","author":"Ekanayake","year":"2022","journal-title":"Reprod Biol"},{"issue":"1","key":"10.1016\/j.xphs.2025.103801_bib0025","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a023002","article-title":"The role of Hox genes in female reproductive tract development, adult function, and fertility","volume":"6","author":"Du","year":"2016","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"10.1016\/j.xphs.2025.103801_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.613277","article-title":"Approaches to improve endometrial receptivity in case of repeated implantation failures","volume":"9","author":"Makrigiannakis","year":"2021","journal-title":"Front Cell Develop Biol"},{"issue":"1","key":"10.1016\/j.xphs.2025.103801_bib0027","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s13287-023-03551-w","article-title":"Menstrual blood-derived endometrial stem cell, a unique and promising alternative in the stem cell-based therapy for chemotherapy-induced premature ovarian insufficiency","volume":"14","author":"Zhang","year":"2023","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"10.1016\/j.xphs.2025.103801_bib0028","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1039\/C5BM00583C","article-title":"From structures to functions: insights into exosomes as promising drug delivery vehicles","volume":"4","author":"Ren","year":"2016","journal-title":"Biomater Sci"},{"issue":"1\u20132","key":"10.1016\/j.xphs.2025.103801_bib0029","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ijpharm.2012.03.032","article-title":"Solid lipid nanoparticles as intracellular drug transporters: an investigation of the uptake mechanism and pathway","volume":"430","author":"Martins","year":"2012","journal-title":"Int J Pharma"},{"key":"10.1016\/j.xphs.2025.103801_bib0030","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3389\/fimmu.2014.00403","article-title":"Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness","volume":"5","author":"Baixauli","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.xphs.2025.103801_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.878058","article-title":"Exosome: the \u201coff-the-shelf\u201d cellular nanocomponent as a potential pathogenic agent, a disease biomarker, and neurotherapeutics","volume":"13","author":"Ghosh","year":"2022","journal-title":"Front Pharmacol"},{"issue":"2","key":"10.1016\/j.xphs.2025.103801_bib0032","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1021\/acsbiomaterials.2c01329","article-title":"Exosome-based smart drug delivery tool for cancer theranostics","volume":"9","author":"Kar","year":"2023","journal-title":"ACS Biomater Sci Eng"},{"issue":"1","key":"10.1016\/j.xphs.2025.103801_bib0033","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev-physchem-040513-103718","article-title":"Physical chemistry of nanomedicine: understanding the complex behaviors of nanoparticles in vivo","volume":"66","author":"Lane","year":"2015","journal-title":"Annu Rev Phys Chem"},{"key":"10.1016\/j.xphs.2025.103801_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119351","article-title":"A human chorionic gonadotropin (hCG) delivery platform using engineered uterine exosomes to improve endometrial receptivity","volume":"275","author":"Hajipour","year":"2021","journal-title":"Life Sci"},{"issue":"3","key":"10.1016\/j.xphs.2025.103801_bib0035","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.nano.2015.10.012","article-title":"Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells","volume":"12","author":"Kim","year":"2016","journal-title":"Nanomed: Nanotechnol Biol Med"},{"issue":"6","key":"10.1016\/j.xphs.2025.103801_bib0036","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/aps.2017.12","article-title":"Engineering exosomes as refined biological nanoplatforms for drug delivery","volume":"38","author":"Luan","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.xphs.2025.103801_bib0037","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jconrel.2022.05.027","article-title":"Exosomes: large-scale production, isolation, drug loading efficiency, and biodistribution and uptake","volume":"347","author":"Kimiz-Gebologlu","year":"2022","journal-title":"J Controll Release"},{"issue":"2","key":"10.1016\/j.xphs.2025.103801_bib0038","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J Extracell Vesicl"},{"issue":"5","key":"10.1016\/j.xphs.2025.103801_bib0039","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1095\/biolreprod.116.143503","article-title":"Extracellular vesicles in the intrauterine environment: challenges and potential functions","volume":"95","author":"Nguyen","year":"2016","journal-title":"Biol Reprod"},{"issue":"8","key":"10.1016\/j.xphs.2025.103801_bib0040","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","article-title":"Membrane vesicles as conveyors of immune responses","volume":"9","author":"Th\u00e9ry","year":"2009","journal-title":"Nat Rev Immunol"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354925002588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354925002588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T08:03:46Z","timestamp":1751616226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354925002588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0022354925002588"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2025.103801","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced endometrial receptivity via epigallocatechin gallate (EGCG)-loaded menstrual blood-derived exosomes","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2025.103801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Pharmacists Association. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103801"}}