{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:21:31Z","timestamp":1771395691631,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.xphs.2026.104162","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T16:13:57Z","timestamp":1768061637000},"page":"104162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of peristaltic pumps and application to fill & finish operations: Part I"],"prefix":"10.1016","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1897-8798","authenticated-orcid":false,"given":"Mostafa","family":"Nakach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6382-152X","authenticated-orcid":false,"given":"Lionel","family":"Bardet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Voll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doriane","family":"Calvet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1271-2833","authenticated-orcid":false,"given":"Jean-Ren\u00e9","family":"Authelin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.xphs.2026.104162_bib0001","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.xphs.2021.09.016","article-title":"Syringe filling of high-concentration mab products using peristaltic pump-based mechanism: challenges and mitigation strategies","volume":"111","author":"Desai","year":"2022","journal-title":"J Pharm Sci"},{"issue":"5","key":"10.1016\/j.xphs.2026.104162_bib0002","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1002\/bit.22336","article-title":"Response of a concentrated monoclonal antibody formulation to high shear","volume":"103","author":"Bee","year":"2009","journal-title":"Biotechnol Bioeng"},{"issue":"3","key":"10.1016\/j.xphs.2026.104162_bib0003","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1081\/PDT-120005728","article-title":"Spalling and sorption of tubing for peristaltic pumps","volume":"7","author":"Bahal","year":"2002","journal-title":"Pharm Dev Technol"},{"issue":"4","key":"10.1016\/j.xphs.2026.104162_bib0004","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1002\/jps.24357","article-title":"Particle shedding from peristaltic pump tubing in biopharmaceutical drug product manufacturing","volume":"104","author":"Saller","year":"2015","journal-title":"J Pharm Sci"},{"issue":"1","key":"10.1016\/j.xphs.2026.104162_bib0005","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.xphs.2019.05.013","article-title":"Effects of tubing type, formulation, and postpumping agitation on nanoparticle and microparticle formation in intravenous immunoglobulin solutions processed with a peristaltic filling pump","volume":"109","author":"Her","year":"2020","journal-title":"J Pharm Sci"},{"issue":"5","key":"10.1016\/j.xphs.2026.104162_bib0006","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.xphs.2022.01.035","article-title":"Proteins on the rack: mechanistic studies on protein particle formation during peristaltic pumping","volume":"111","author":"Deiringer","year":"2022","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.xphs.2026.104162_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122216","article-title":"Reaching the breaking point: effect of tubing characteristics on protein particle formation during peristaltic pumping","volume":"627","author":"Deiringer","year":"2022","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2026.104162_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122635","article-title":"Afraid of the wall of death? Considerations on monoclonal antibody characteristics that trigger aggregation during peristaltic pumping","volume":"633","author":"Deiringer","year":"2023","journal-title":"Int J Pharm"},{"issue":"12","key":"10.1016\/j.xphs.2026.104162_bib0009","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1016\/j.xphs.2022.08.037","article-title":"Modification of tubings for peristaltic pumping of biopharmaceutics","volume":"111","author":"Deiringer","year":"2022","journal-title":"J Pharm Sci"},{"issue":"2","key":"10.1016\/j.xphs.2026.104162_bib0010","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.xphs.2023.11.017","article-title":"Filling unit operation for biological drug products: challenges and considerations","volume":"113","author":"Adler","year":"2024","journal-title":"J Pharm Sci"},{"issue":"2","key":"10.1016\/j.xphs.2026.104162_bib0011","doi-asserted-by":"crossref","first-page":"143","DOI":"10.5731\/pdajpst.2015.005926","article-title":"Filling of high-concentration monoclonal antibody formulations: investigating underlying mechanisms that affect precision of low-volume fill by peristaltic pump","volume":"70","author":"Shieu","year":"2016","journal-title":"PDA J Pharm Sci Technol"},{"issue":"3","key":"10.1016\/j.xphs.2026.104162_bib0012","doi-asserted-by":"crossref","first-page":"417","DOI":"10.5731\/pdajpst.2015.01055","article-title":"Filling of high-concentration monoclonal antibody formulations into pre-filled syringes: investigating formulation-nozzle interactions to minimize nozzle clogging","volume":"69","author":"Shieu","year":"2015","journal-title":"PDA J Pharm Sci Technol"},{"issue":"2","key":"10.1016\/j.xphs.2026.104162_bib0013","doi-asserted-by":"crossref","first-page":"153","DOI":"10.5731\/pdajpst.2014.00973","article-title":"Filling of high-concentration monoclonal antibody formulations into pre-filled syringes: filling parameter investigation and optimization","volume":"68","author":"Shieu","year":"2014","journal-title":"PDA J Pharm Sci Technol"},{"issue":"12","key":"10.1016\/j.xphs.2026.104162_bib0014","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1016\/j.xphs.2017.08.005","article-title":"Syringe filling of high-concentration mAb formulation: slow suck-back pump speed prevented filling needle clogging","volume":"106","author":"Hanslip","year":"2017","journal-title":"J Pharm Sci"},{"issue":"3","key":"10.1016\/j.xphs.2026.104162_bib0015","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.xphs.2018.10.031","article-title":"Syringe filling of a high-concentration mAb formulation: experimental, theoretical, and computational evaluation of filling process parameters that influence the propensity for filling needle clogging","volume":"108","author":"Hanslip","year":"2019","journal-title":"J Pharm Sci"},{"issue":"2","key":"10.1016\/j.xphs.2026.104162_bib0016","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.xphs.2019.11.005","article-title":"Suck-back impact on fluid behavior at filling needle tip","volume":"109","author":"Silva","year":"2020","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.xphs.2026.104162_bib0017","series-title":"M\u00e9canique Et Rh\u00e9ologie Des Fluides","author":"Midoux","year":"1993"},{"key":"10.1016\/j.xphs.2026.104162_bib0018","article-title":"Impact of surface tension, viscosity, pump settings, and nozzle size on filling process capability and accuracy in high-concentration biopharmaceuticals","author":"Chen","year":"2024","journal-title":"J Pharm Sci"},{"issue":"3","key":"10.1016\/j.xphs.2026.104162_bib0019","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.xphs.2019.12.001","article-title":"An empirical quantitative model describing simultaneously temperature and concentration effects on protein solution viscosity","volume":"109","author":"Schwenger","year":"2020","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.xphs.2026.104162_bib0020","unstructured":"Anstonsen H. Parenteral technical report n\u00b0 26 sterilizing filation of liquids 1998."},{"issue":"1","key":"10.1016\/j.xphs.2026.104162_bib0021","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.memsci.2008.07.049","article-title":"Sterilizing filtration\u2014Principles and practice for successful scale-up to manufacturing","volume":"325","author":"Rajniak","year":"2008","journal-title":"J Memb Sci"},{"key":"10.1016\/j.xphs.2026.104162_bib0022","unstructured":"Jenness E., Gupta V. Implementing a single-use solution for fill\u2013Finish manufacturing operations. 2011."}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354926000110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354926000110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T05:37:06Z","timestamp":1771393026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354926000110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0022354926000110"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2026.104162","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of peristaltic pumps and application to fill & finish operations: Part I","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2026.104162","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc. on behalf of American Pharmacists Association.","name":"copyright","label":"Copyright"}],"article-number":"104162"}}