{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:56:24Z","timestamp":1776448584904,"version":"3.51.2"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013806","name":"Shenyang Pharmaceutical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.xphs.2026.104232","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:26:10Z","timestamp":1772497570000},"page":"104232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["HS15-based nanotherapeutics for direct nose-to-brain delivery against central nervous system fungal"],"prefix":"10.1016","volume":"115","author":[{"given":"Gaoshuo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingwang","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7196-0103","authenticated-orcid":false,"given":"Yuling","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xphs.2026.104232_bib0001","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-023-00472-z","article-title":"Cryptococcal meningitis","volume":"9","author":"Tugume","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.xphs.2026.104232_bib0002","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1016\/j.apsb.2021.04.010","article-title":"Delivery strategies of amphotericin B for invasive fungal infections","volume":"11","author":"Wang","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.xphs.2026.104232_bib0003","doi-asserted-by":"crossref","first-page":"ii3","DOI":"10.1093\/jac\/dkac351","article-title":"Liposomal amphotericin B\u2014the past","volume":"77","author":"Br\u00fcggemann","year":"2022","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.xphs.2026.104232_bib0004","doi-asserted-by":"crossref","first-page":"ii11","DOI":"10.1093\/jac\/dkac352","article-title":"Liposomal amphotericin B\u2014the present","volume":"77","author":"Maertens","year":"2022","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.xphs.2026.104232_bib0005","first-page":"46","article-title":"Polymer-mediated delivery of amphotericin B for fungal infections","author":"Chen","year":"2025","journal-title":"Macromol Rapid Commun"},{"key":"10.1016\/j.xphs.2026.104232_bib0006","doi-asserted-by":"crossref","first-page":"eabb4429","DOI":"10.1126\/sciadv.abb4429","article-title":"Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection","volume":"6","author":"Ma","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.xphs.2026.104232_bib0007","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s40262-017-0548-y","article-title":"Penetration of vancomycin into the cerebrospinal fluid: a systematic review","volume":"56","author":"Beach","year":"2017","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.xphs.2026.104232_bib0008","doi-asserted-by":"crossref","first-page":"114338","DOI":"10.1016\/j.addr.2022.114338","article-title":"Intrathecal delivery and its applications in leptomeningeal disease","volume":"186","author":"Khang","year":"2022","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.xphs.2026.104232_bib0009","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jconrel.2022.06.067","article-title":"Noninvasive ultrasonic induction of cerebrospinal fluid flow enhances intrathecal drug delivery","volume":"349","author":"Aryal","year":"2022","journal-title":"J Control Release"},{"key":"10.1016\/j.xphs.2026.104232_bib0010","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s40121-024-01086-y","article-title":"Acute infusion-related side effects of amphotericin B lipid complex (ABLC) in oncohematological patients: real-world data from Brazilian reference centers","volume":"14","author":"Cavassin","year":"2024","journal-title":"Infect Dis Ther"},{"key":"10.1016\/j.xphs.2026.104232_bib0011","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/17425247.2018.1429401","article-title":"Lipid nanoparticles for intranasal administration: application to nose-to-brain delivery","volume":"15","author":"Battaglia","year":"2018","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.xphs.2026.104232_bib0012","article-title":"Non-invasive strategies for nose-to-brain drug delivery","volume":"10","author":"Trevino","year":"2021","journal-title":"J Clin Trials"},{"key":"10.1016\/j.xphs.2026.104232_bib0013","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jconrel.2017.09.001","article-title":"Progress in brain targeting drug delivery system by nasal route","volume":"268","author":"Khan","year":"2017","journal-title":"J Control Release"},{"key":"10.1016\/j.xphs.2026.104232_bib0014","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1021\/acs.molpharmaceut.1c00366","article-title":"Structure and fate of nanoparticles designed for the nasal delivery of poorly soluble drugs","volume":"18","author":"Clementino","year":"2021","journal-title":"Mol Pharm"},{"key":"10.1016\/j.xphs.2026.104232_bib0015","article-title":"Tetrahedral framework nucleic acids as an efficient nasal-to-brain delivery carrier via neural transport pathways","author":"Zhang","year":"2025","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.xphs.2026.104232_bib0016","article-title":"Nanoodor particles deliver drugs to central nervous system via olfactory pathway","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv Sci"},{"key":"10.1016\/j.xphs.2026.104232_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5455\/annalsmedres.2022.10.325","article-title":"Physiology of nose-to-brain pathways and current approaches to intranasal treatment","volume":"29","author":"var","year":"2022","journal-title":"Ann Med Res"},{"key":"10.1016\/j.xphs.2026.104232_bib0018","doi-asserted-by":"crossref","first-page":"2201332","DOI":"10.1183\/13993003.01332-2022","article-title":"Nebulised liposomal amphotericin-B: a promising strategy for preventing ABPA relapse","volume":"60","author":"Liu","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.xphs.2026.104232_bib0019","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ijpharm.2017.04.074","article-title":"Preparation and characterization of isoniazid-loaded crude soybean lecithin liposomes","volume":"526","author":"Nkanga","year":"2017","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2026.104232_bib0020","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ijpharm.2018.09.047","article-title":"A study on the role of cholesterol and phosphatidylcholine in various features of liposomal doxorubicin: from liposomal preparation to therapy","volume":"551","author":"Farzaneh","year":"2018","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2026.104232_bib0021","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.3109\/10717544.2016.1167270","article-title":"Preparation and evaluation of icariside II-loaded binary mixed micelles using Solutol HS15 and Pluronic F127 as carriers","volume":"23","author":"Hou","year":"2016","journal-title":"Drug Deliv"},{"key":"10.1016\/j.xphs.2026.104232_bib0022","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1039\/c3py00042g","article-title":"Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs\u2020","volume":"4","author":"Wang","year":"2013","journal-title":"Polym Chem"},{"key":"10.1016\/j.xphs.2026.104232_bib0023","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1177\/153303460500400605","article-title":"Long-circulating polymeric nanovectors for tumor-selective gene delivery","volume":"4","author":"Kommareddy","year":"2005","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.xphs.2026.104232_bib0024","doi-asserted-by":"crossref","first-page":"10130","DOI":"10.1021\/acsnano.8b04947","article-title":"Dense and dynamic polyethylene glycol shells cloak nanoparticles from uptake by liver endothelial cells for long blood circulation","volume":"12","author":"Zhou","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.xphs.2026.104232_bib0025","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.ijpharm.2019.04.052","article-title":"Critical process parameters in manufacturing of liposomal formulations of amphotericin","volume":"565","author":"Rivnay","year":"2019","journal-title":"B Int J Pharm"},{"key":"10.1016\/j.xphs.2026.104232_bib0026","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2016.06.017","article-title":"DLS and zeta potential \u2013 what they are and what they are not?","volume":"235","author":"Bhattacharjee","year":"2016","journal-title":"J Control Rele"},{"key":"10.1016\/j.xphs.2026.104232_bib0027","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1002\/smll.201403799","article-title":"Passively targeted curcumin-loaded PEGylated PLGA nanocapsules for colon cancer therapy in vivo","volume":"11","author":"Klippstein","year":"2015","journal-title":"Small"},{"key":"10.1016\/j.xphs.2026.104232_bib0028","doi-asserted-by":"crossref","first-page":"112998","DOI":"10.1016\/j.ecoenv.2021.112998","article-title":"Fine particulate matter exposure exacerbated nasal mucosal damage in allergic rhinitis mice via NLRP3 mediated pyroptosis","volume":"228","author":"Li","year":"2021","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.xphs.2026.104232_bib0029","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1016\/j.apsb.2021.01.014","article-title":"Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder","volume":"11","author":"Pang","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.xphs.2026.104232_bib0030","doi-asserted-by":"crossref","first-page":"110377","DOI":"10.1016\/j.cbi.2023.110377","article-title":"Antifungal effect of the liposome encapsulation of the trans- caryophylene and its association with fluconazole","volume":"373","author":"Bezerra","year":"2023","journal-title":"Chem-Biol Interact"},{"key":"10.1016\/j.xphs.2026.104232_bib0031","article-title":"Advances of liposomal mediated nanocarriers for the treatment of dermatophyte infections","volume":"9","author":"Mousavi","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.xphs.2026.104232_bib0032","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jbiosc.2022.06.005","article-title":"Preparation of amphotericin B-loaded hybrid liposomes and the integration of chitin-binding proteins for enhanced antifungal activity","volume":"134","author":"Santoso","year":"2022","journal-title":"J Biosci Bioeng"},{"key":"10.1016\/j.xphs.2026.104232_bib0033","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3390\/pharmaceutics11020084","article-title":"Nanoemulsions for \u201cnose-to-brain\u201d drug delivery","volume":"11","author":"Bonferoni","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.xphs.2026.104232_bib0034","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1007\/s13346-020-00747-y","article-title":"Nose-to-brain delivery: exploring newer domains for glioblastoma multiforme management","volume":"10","author":"Upadhaya","year":"2020","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.xphs.2026.104232_bib0035","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s004410050030","article-title":"Olfactory epithelium consisting of supporting cells and horizontal basal cells in the posterior nasal cavity of mice","volume":"299","author":"Suzuki","year":"2000","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.xphs.2026.104232_bib0036","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s40005-022-00589-5","article-title":"Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors","volume":"53","author":"Jeong","year":"2022","journal-title":"J Pharm Investig"},{"key":"10.1016\/j.xphs.2026.104232_bib0037","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2500\/ajra.2015.29.4149","article-title":"The blood-brain barrier and nasal drug delivery to the central nervous system","volume":"29","author":"Miyake","year":"2015","journal-title":"Am J Rhinol Allergy"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235492600081X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002235492600081X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:20:36Z","timestamp":1776446436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002235492600081X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S002235492600081X"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2026.104232","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HS15-based nanotherapeutics for direct nose-to-brain delivery against central nervous system fungal","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2026.104232","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104232"}}