{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:28:55Z","timestamp":1786652935569,"version":"build-2736575974"},"reference-count":66,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011821","name":"Saudi Arabia Ministry of Education","doi-asserted-by":"publisher","award":["0073-1446-S"],"award-info":[{"award-number":["0073-1446-S"]}],"id":[{"id":"10.13039\/501100011821","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.xphs.2026.104310","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T22:50:30Z","timestamp":1777762230000},"page":"104310","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development and evaluation of sorafenib and curcumin co-loaded microemulsion gel for the management of breast cancer"],"prefix":"10.1016","volume":"115","author":[{"given":"Md. Abul","family":"Barkat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afaf F.","family":"Almuqati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshita","family":"Barkat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulkareem Ali","family":"Alanezi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal Shwaikh","family":"Alanazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokesh","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh Kumar","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8159-8005","authenticated-orcid":false,"given":"Kaisar","family":"Raza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xphs.2026.104310_bib0001","first-page":"10","article-title":"Cancer statistics","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J Clin"},{"issue":"10","key":"10.1016\/j.xphs.2026.104310_bib0002","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.7150\/ijbs.93697","article-title":"Using Combination therapy to overcome diverse challenges of Immune Checkpoint Inhibitors treatment","volume":"20","author":"Birnboim-Perach","year":"2024","journal-title":"Int J Biol Sci"},{"issue":"10","key":"10.1016\/j.xphs.2026.104310_bib0003","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1158\/1535-7163.MCT-08-0013","article-title":"Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling","volume":"7","author":"Wilhelm","year":"2008","journal-title":"Mol Cancer Ther"},{"issue":"10","key":"10.1016\/j.xphs.2026.104310_bib0004","doi-asserted-by":"crossref","first-page":"8959","DOI":"10.1021\/acsabm.5c01119","article-title":"Lipid-extruded PEGylated liposomes of repurposed Sorafenib for triple-negative breast cancer: a mechanistically enhanced nanoplatform with improved In vivo pharmacokinetics and targeted biodistribution","volume":"8","author":"Pawar","year":"2025","journal-title":"ACS Appl Bio Mater"},{"issue":"3","key":"10.1016\/j.xphs.2026.104310_bib0005","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1440-1681.2011.05648.x","article-title":"Discovery of curcumin, a component of golden spice, and its miraculous biological activities","volume":"39","author":"Gupta","year":"2012","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"6","key":"10.1016\/j.xphs.2026.104310_bib0006","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol Pharm"},{"issue":"2","key":"10.1016\/j.xphs.2026.104310_bib0007","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.3390\/molecules20022728","article-title":"The multifaceted role of curcumin in cancer prevention and treatment","volume":"20","author":"Shanmugam","year":"2015","journal-title":"Molecules"},{"issue":"15","key":"10.1016\/j.xphs.2026.104310_bib0008","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1042\/CS20160935","article-title":"Curcumin mediates anticancer effects by modulating multiple cell signaling pathways","volume":"131","author":"Kunnumakkara","year":"2017","journal-title":"Clin Sci"},{"issue":"10","key":"10.1016\/j.xphs.2026.104310_bib0009","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/foods6100092","article-title":"Curcumin: a review of its effects on Human health","volume":"6","author":"Hewlings","year":"2017","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.xphs.2026.104310_bib0010","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0169-409X(00)00103-4","article-title":"Microemulsion-based media as novel drug delivery systems","volume":"45","author":"Lawrence","year":"2000","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"10.1016\/j.xphs.2026.104310_bib0011","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4103\/2230-973X.104397","article-title":"Formulation and evaluation of microemulsion-based hydrogel for topical delivery","volume":"2","author":"Sabale","year":"2012","journal-title":"Int J Pharm Investig"},{"key":"10.1016\/j.xphs.2026.104310_bib0012","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1208\/s12249-015-0464-0","article-title":"Benzyl benzoate-loaded microemulsion for topical applications: enhanced dermatokinetic profile and better delivery promises","volume":"17","author":"Sharma","year":"2016","journal-title":"AAPS PharmSciTech"},{"issue":"7","key":"10.1016\/j.xphs.2026.104310_bib0013","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3390\/ph16070999","article-title":"Topical microemulsions: skin irritation potential and anti-inflammatory effects of herbal substances","volume":"16","author":"Leanpolchareanchai","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.xphs.2026.104310_bib0014","doi-asserted-by":"crossref","DOI":"10.34172\/apb.2021.040","article-title":"Tailored limonene-based nanosized microemulsion: formulation, physicochemical characterization and In-vivo skin irritation assessment","author":"Mehanna","year":"2020","journal-title":"Adv Pharm Bull"},{"issue":"3","key":"10.1016\/j.xphs.2026.104310_bib0015","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3109\/02652048.2010.546435","article-title":"Novel dithranol phospholipid microemulsion for topical application: development, characterization and percutaneous absorption studies","volume":"28","author":"Raza","year":"2011","journal-title":"J Microencapsul"},{"issue":"6","key":"10.1016\/j.xphs.2026.104310_bib0016","doi-asserted-by":"crossref","first-page":"612","DOI":"10.4103\/0378-6323.72451","article-title":"Novel drug delivery systems in topical treatment of psoriasis: rigors and vigors","volume":"76","author":"Katare","year":"2010","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.1016\/j.xphs.2026.104310_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2022.110323","article-title":"Breast cancers originating from the terminal ductal lobular units: in situ and invasive acinar adenocarcinoma of the breast, AAB","volume":"152","author":"Tab\u00e1r","year":"2022","journal-title":"Eur J Radiol"},{"issue":"2","key":"10.1016\/j.xphs.2026.104310_bib0018","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3390\/bioengineering12020133","article-title":"Liposomal nanocarriers to enhance skin delivery of chemotherapeutics in cancer therapy","volume":"12","author":"Liu","year":"2025","journal-title":"Bioengineering"},{"issue":"4","key":"10.1016\/j.xphs.2026.104310_bib0019","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4103\/idoj.idoj_712_24","article-title":"Cutaneous presentations of metastatic carcinoma breast: a case series","volume":"16","author":"Mandli","year":"2025","journal-title":"Indian Dermatol Online J"},{"issue":"1","key":"10.1016\/j.xphs.2026.104310_bib0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4274\/ejbh.galenos.2024.2024-9-9","article-title":"A comprehensive review on current knowledge and future potential of topical therapies in breast cancer treatment","volume":"21","author":"Thilagam","year":"2025","journal-title":"Eur J Breast Health"},{"issue":"2","key":"10.1016\/j.xphs.2026.104310_bib0021","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.xphs.2026.104310_bib0022","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: the in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"10.1016\/j.xphs.2026.104310_bib0023","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.phrs.2011.03.001","article-title":"Cancer prevention by tea: evidence from laboratory studies","volume":"64","author":"Yang","year":"2011","journal-title":"Pharmacol Res"},{"issue":"25","key":"10.1016\/j.xphs.2026.104310_bib0024","doi-asserted-by":"crossref","first-page":"7514","DOI":"10.1021\/jf049243r","article-title":"Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration","volume":"52","author":"Heo","year":"2004","journal-title":"J Agric Food Chem"},{"issue":"3\u20134","key":"10.1016\/j.xphs.2026.104310_bib0025","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1021210910821","article-title":"Mechanisms of cancer chemoprevention by Soy Isoflavone Genistein","volume":"21","author":"Sarkar","year":"2002","journal-title":"Cancer Metast Rev"},{"issue":"8","key":"10.1016\/j.xphs.2026.104310_bib0026","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1080\/10408390601062054","article-title":"Black pepper and its pungent principle-piperine: a review of diverse physiological effects","volume":"47","author":"Srinivasan","year":"2007","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"10.1016\/j.xphs.2026.104310_bib0027","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/10826076.2011.597068","article-title":"Development and validation of Rp-Hplc method for simultaneous estimation of diclofenac diethylamine and curcumin in transdermal gels","volume":"35","author":"Chaudhary","year":"2012","journal-title":"J Liq Chromatogr Relat Technol"},{"key":"10.1016\/j.xphs.2026.104310_bib0028","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1442762","article-title":"HPLC-UV method development and validation for anticancer drug sorafenib and the co-prescribed drug dexamethasone: application to pharmacokinetic evaluation of sorafenib nanoformulations","volume":"16","author":"Mateen","year":"2025","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.xphs.2026.104310_bib0029","unstructured":"NCT07072611. A DoubleBlind, PlaceboControlled phase I clinical trial to evaluate safety, tolerability, and pharmacokinetics of SOFSKN in healthy participants. Study includes SOFSKN at 0.25%, 0.5%, 1%, and 2% w\/w. ClinicalTrials.gov.. 2025."},{"key":"10.1016\/j.xphs.2026.104310_bib0030","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.2147\/IJN.S210320","article-title":"Nano encapsulated curcumin: and its potential for biomedical applications","volume":"15","author":"Chen","year":"2020","journal-title":"Int J Nanomed"},{"issue":"8","key":"10.1016\/j.xphs.2026.104310_bib0031","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.3390\/ijms26083641","article-title":"Formulation and characterization of carbopol-based porphyrin gels for targeted dermato-oncological therapy: physicochemical and pharmacotechnical insights","volume":"26","author":"Ozon","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xphs.2026.104310_bib0032","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.vibspec.2016.07.011","article-title":"Fourier transform infrared spectroscopy supported by multivariate statistics in compatibility study of atenolol with excipients","volume":"86","author":"Rojek","year":"2016","journal-title":"Vib Spectrosc"},{"issue":"5","key":"10.1016\/j.xphs.2026.104310_bib0033","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/wrr.12909","article-title":"Nisin loaded carbopol gel against Pseudomonas aeruginosa infected third-degree burns: a therapeutic intervention","volume":"29","author":"Preet","year":"2021","journal-title":"Wound Repair Regener"},{"issue":"1","key":"10.1016\/j.xphs.2026.104310_bib0034","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-17333-6","article-title":"Oral sorafenib-loaded microemulsion for breast cancer: evidences from the in-vitro evaluations and pharmacokinetic studies","volume":"12","author":"Chaurawal","year":"2022","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.xphs.2026.104310_bib0035","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3390\/gels8060384","article-title":"Formulation development and ex-vivo permeability of curcumin hydrogels under the influence of natural chemical enhancers","volume":"8","author":"Nawaz","year":"2022","journal-title":"Gels"},{"issue":"3","key":"10.1016\/j.xphs.2026.104310_bib0036","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s11095-020-02790-3","article-title":"Sorafenib loaded inhalable polymeric nanocarriers against non-small cell lung cancer","volume":"37","author":"Shukla","year":"2020","journal-title":"Pharm Res"},{"key":"10.1016\/j.xphs.2026.104310_bib0037","doi-asserted-by":"crossref","DOI":"10.1177\/2168479019875338","article-title":"In vitro skin permeation methodology for over-the-counter topical dermatologic products","author":"Oh","year":"2019","journal-title":"Ther Innov Regul Sci"},{"issue":"6","key":"10.1016\/j.xphs.2026.104310_bib0038","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00403-024-03140-8","article-title":"Lipid-based microemulsion gel for the topical delivery of methotrexate: an optimized, rheologically acceptable formulation with conducive dermatokinetics","volume":"316","author":"Mishra","year":"2024","journal-title":"Arch Dermatol Res"},{"issue":"5","key":"10.1016\/j.xphs.2026.104310_bib0039","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1021\/mp300722f","article-title":"Nanocolloidal carriers of isotretinoin: antimicrobial activity against propionibacterium acnes and dermatokinetic modeling","volume":"10","author":"Raza","year":"2013","journal-title":"Mol Pharm"},{"issue":"5","key":"10.1016\/j.xphs.2026.104310_bib0040","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2174\/1389200218666170306104042","article-title":"Dermatokinetics as an important tool to assess the bioavailability of drugs by topical nanocarriers","volume":"18","author":"Thotakura","year":"2017","journal-title":"Curr Drug Metab"},{"issue":"7","key":"10.1016\/j.xphs.2026.104310_bib0041","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3109\/03639045.2011.631548","article-title":"Self-microemulsifying smaller molecular volume oil (Capmul MCM) using non-ionic surfactants: a delivery system for poorly water-soluble drug","volume":"38","author":"Bandivadeka","year":"2012","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.xphs.2026.104310_bib0042","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ijpharm.2019.03.010","article-title":"Cytotoxicity and permeability enhancement of Capmul\u00aeMCM in nanoemulsion formulation","volume":"561","author":"Bunchongprasert","year":"2019","journal-title":"Int J Pharm"},{"issue":"11","key":"10.1016\/j.xphs.2026.104310_bib0043","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1023\/A:1016268311867","article-title":"Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects","volume":"12","author":"Constantinides","year":"1995","journal-title":"Pharm Res"},{"issue":"1","key":"10.1016\/j.xphs.2026.104310_bib0044","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1208\/s12249-008-9178-x","article-title":"Nanoemulsion components screening and selection: a technical note","volume":"10","author":"Azeem","year":"2009","journal-title":"AAPS PharmSciTech"},{"issue":"4","key":"10.1016\/j.xphs.2026.104310_bib0045","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1517\/17425241003596337","article-title":"Microemulsions as drug delivery systems to improve the solubility and the bioavailability of poorly water-soluble drugs","volume":"7","author":"He","year":"2010","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.xphs.2026.104310_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2022.119596","article-title":"Labrasol mediated enhanced solubilization of natural hydrophobic drugs in pluronic micelles: physicochemical and in vitro release studies","volume":"361","author":"Kaur","year":"2022","journal-title":"J Mol Liq"},{"issue":"3","key":"10.1016\/j.xphs.2026.104310_bib0047","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3109\/10717544.2014.923067","article-title":"Phospholipid microemulsion-based hydrogel for enhanced topical delivery of lidocaine and prilocaine: qbD-based development and evaluation","volume":"23","author":"Negi","year":"2016","journal-title":"Drug Deliv"},{"issue":"7","key":"10.1016\/j.xphs.2026.104310_bib0048","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3390\/gels9070587","article-title":"Microemulsion-based keratin\u2013Chitosan gel for improvement of skin permeation\/retention and activity of curcumin","volume":"9","author":"Niu","year":"2023","journal-title":"Gels"},{"issue":"4","key":"10.1016\/j.xphs.2026.104310_bib0049","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ejps.2011.09.016","article-title":"Complement activation by polyethoxylated pharmaceutical surfactants: cremophor-EL, tween-80 and tween-20","volume":"45","author":"Weiszh\u00e1r","year":"2012","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"10.1016\/j.xphs.2026.104310_bib0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/pharmaceutics10020057","article-title":"Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems","volume":"10","author":"Danaei","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.xphs.2026.104310_bib0051","series-title":"Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids","article-title":"Pharmacokinetics and biodistribution of the nanoparticles","author":"Raza","year":"2017"},{"issue":"5","key":"10.1016\/j.xphs.2026.104310_bib0052","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ejps.2005.01.001","article-title":"Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells","volume":"24","author":"Sha","year":"2005","journal-title":"Eur J Pharm Sci"},{"issue":"3","key":"10.1016\/j.xphs.2026.104310_bib0053","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3390\/pharmaceutics17030301","article-title":"Curcumin microemulsions: influence of compositions on the dermal penetration efficacy","volume":"17","author":"Alkhaldi","year":"2025","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.xphs.2026.104310_bib0054","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s13555-024-01321-x","article-title":"Influence of cosmetic skincare products with pH\u2009<\u20095 on the skin microbiome: a randomized clinical evaluation","volume":"15","author":"Janssens-B\u00f6cker","year":"2025","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.xphs.2026.104310_bib0055","series-title":"Introduction to Spectroscopy","author":"Pavia","year":"2019"},{"issue":"1","key":"10.1016\/j.xphs.2026.104310_bib0056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5173(79)90025-5","article-title":"The rheological properties of carbopol gels I. Continuous shear and creep properties of carbopol gels","volume":"2","author":"Barry","year":"1979","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2026.104310_bib0057","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124762","article-title":"Strategic development of aceclofenac loaded organosomes for topical application: an explorative ex-vivo and in-vivo investigation for arthritis","volume":"666","author":"Sharma","year":"2024","journal-title":"Int J Pharm"},{"issue":"3","key":"10.1016\/j.xphs.2026.104310_bib0058","doi-asserted-by":"crossref","DOI":"10.17795\/ijcp2331","article-title":"Anticancer activity of curcumin on Human breast adenocarcinoma: role of Mcl-1 gene","volume":"8","author":"Khazaei Koohpar","year":"2015","journal-title":"Iran J Cancer Prev"},{"issue":"9","key":"10.1016\/j.xphs.2026.104310_bib0059","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.3390\/cancers16091695","article-title":"Synergistic action of benzyl isothiocyanate and sorafenib in a nanoparticle delivery system for enhanced triple-negative breast cancer treatment","volume":"16","author":"Wang","year":"2024","journal-title":"Cancers"},{"key":"10.1016\/j.xphs.2026.104310_bib0060","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.646554","article-title":"Enhancing permeation of drug molecules across the skin via delivery in nanocarriers: novel strategies for effective transdermal applications","volume":"9","author":"Yu","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"issue":"3","key":"10.1016\/j.xphs.2026.104310_bib0061","article-title":"Improved topical delivery of Sorafenib-meglumine antimoniate: elastic nano-liposomal formulation for the treatment of cutaneous leishmaniasis","volume":"4","author":"Khan","year":"2024","journal-title":"J Health Rehabil Res"},{"issue":"3","key":"10.1016\/j.xphs.2026.104310_bib0062","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjidi.2024.100271","article-title":"Identification of keratinocyte cytoprotectants against toxicity by the multikinase inhibitor Sorafenib using drug repositioning","volume":"4","author":"Kamata","year":"2024","journal-title":"JID Innov"},{"key":"10.1016\/j.xphs.2026.104310_bib0063","first-page":"1","article-title":"Curcumin improves keratinocyte proliferation, inflammation, and oxidative stress through mediating the SPAG5\/FOXM1 axis in an In vitro model of actinic dermatitis by ultraviolet","volume":"2022","author":"Chen","year":"2022","journal-title":"Dis Markers"},{"key":"10.1016\/j.xphs.2026.104310_bib0064","first-page":"1","article-title":"Curcumin protects Human keratinocytes against inorganic arsenite-induced acute cytotoxicity through an NRF2-dependent mechanism","volume":"2013","author":"Zhao","year":"2013","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"10.1016\/j.xphs.2026.104310_bib0065","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41597-024-03026-4","article-title":"An update of skin permeability data based on a systematic review of recent research","volume":"11","author":"Chedik","year":"2024","journal-title":"Sci Data"},{"issue":"2","key":"10.1016\/j.xphs.2026.104310_bib0066","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1021\/acsptsci.4c00679","article-title":"Drug repurposing and nanotechnology for topical skin cancer treatment: redirecting toward targeted and synergistic antitumor effects","volume":"8","author":"Martins","year":"2025","journal-title":"ACS Pharmacol Transl Sci"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354926001590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354926001590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:28:22Z","timestamp":1786649302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354926001590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":66,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0022354926001590"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2026.104310","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and evaluation of sorafenib and curcumin co-loaded microemulsion gel for the management of breast cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2026.104310","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104310"}}