{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:58:59Z","timestamp":1790776739851,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.xphs.2026.104444","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:35:52Z","timestamp":1785368152000},"page":"104444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Technical note on the impact of particle flocculation on the dissolution and bioavailability of triamcinolone acetonide injectable suspensions"],"prefix":"10.1016","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0192-3739","authenticated-orcid":false,"given":"Maziar","family":"Kakhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xphs.2026.104444_bib0001","unstructured":"Drugs@FDA: FDA-approved Drugs - see approval date(s) and history, letters, labels, reviews for NDA 014901. https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/index.cfm?event=overview.process&ApplNo=014901."},{"key":"10.1016\/j.xphs.2026.104444_bib0002","unstructured":"Drugs@FDA: search for \"triamcinolone acetonide\", expand the product listed as \u2018TRIAMCINOLONE ACETONIDE\u2019 and search for \u2018INJECTABLE\u2019. https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/index.cfm."},{"key":"10.1016\/j.xphs.2026.104444_bib0003","series-title":"FDA Draft Guidance on Triamcinolone Acetonide","year":"2025"},{"key":"10.1016\/j.xphs.2026.104444_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120767","article-title":"Impact of particle flocculation on the dissolution and bioavailability of injectable suspensions","volume":"604","author":"Smith","year":"2021","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2026.104444_bib0005","series-title":"FDA Draft Guidance on Triamcinolone Acetonide","year":"2023"},{"key":"10.1016\/j.xphs.2026.104444_bib0006","series-title":"Drugs@FDA: Kenalog-40 Injection Label (NDA 014901\/S-055)","year":"2024"},{"key":"10.1016\/j.xphs.2026.104444_bib0007","series-title":"Rheology - Principles, Measurements, and Applications","author":"Macosko","year":"1994"},{"key":"10.1016\/j.xphs.2026.104444_bib0008","article-title":"Supplementary material to impact of particle flocculation on the dissolution and bioavailability of injectable suspensions","volume":"604","author":"Appendix","year":"2021","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2026.104444_bib0009","series-title":"Nursing Skills: Preparing and Administering Intramuscular Injections","year":"2017"},{"key":"10.1016\/j.xphs.2026.104444_bib0010","unstructured":"Hamilton Company, Needle Gauge Chart., last accessed August 1, 2026. https:\/\/www.hamiltoncompany.com\/knowledge-base\/article\/needle-gauge-chart."},{"key":"10.1016\/j.xphs.2026.104444_bib0011","series-title":"Drugs@FDA: Drug Approval Package: ZILRETTA (TRIAMCINOLONE ACETONIDE), Clinical Pharmacology and Biopharmaceutics Review(s)","year":"2017"},{"key":"10.1016\/j.xphs.2026.104444_bib0012","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jconrel.2021.06.023","article-title":"Evaluating parameters affecting drug fate at the intramuscular injection site","volume":"336","author":"McCartan","year":"2021","journal-title":"J Controll Release"},{"key":"10.1016\/j.xphs.2026.104444_bib0013","series-title":"Non-Newtonian Math","author":"Wheeler","year":"2019"},{"key":"10.1016\/j.xphs.2026.104444_bib0014","unstructured":"RheoSense. More Than Meets the Eye \u2013 Estimating blinking Shear Rates., last accessed August 1, 2026. https:\/\/www.rheosense.com\/hubfs\/Application_Notes\/m-VROC_(General_Applications)\/BioPharma\/m-VROC-APP35%20(2-18)%20Viscosity%20of%20Ophthalmic%20Solutions.pdf?hsLang=en."},{"key":"10.1016\/j.xphs.2026.104444_bib0015","unstructured":"RheoSense. Predicting Injection Force from Viscosity Data Part 1: Theoretical Foundation, last accessed August 1, 2026. https:\/\/www.rheosense.com\/hubfs\/Predicting%20Injection%20Force%20from%20Viscosity%20Data%20Part%201%20Theoretical%20Foundation.pdf"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354926002935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354926002935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:24:35Z","timestamp":1790774675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354926002935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0022354926002935"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2026.104444","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Technical note on the impact of particle flocculation on the dissolution and bioavailability of triamcinolone acetonide injectable suspensions","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2026.104444","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of American Pharmacists Association\u00ae.","name":"copyright","label":"Copyright"}],"article-number":"104444"}}