{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:47:30Z","timestamp":1792234050754,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.xphs.2026.104525","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:19:50Z","timestamp":1791933590000},"page":"104525","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Macrophage-membrane-camouflaged lipid\u2013polymer hybrid nanoparticles for target-specific biofilm penetration and eradication of methicillin-resistant staphylococcus aureus"],"prefix":"10.1016","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1129-1021","authenticated-orcid":false,"given":"Dalia A.","family":"Gaber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.xphs.2026.104525_bib0001","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.biomaterials.2008.12.013","article-title":"PLGA-Lecithin-PEG Core-Shell Nanoparticles for Controlled Drug Delivery","volume":"30","author":"Chan","year":"2009","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.xphs.2026.104525_bib0002","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1021\/nn800275r","article-title":"Self-Assembled Lipid\u2013Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform","volume":"2","author":"Zhang","year":"2008","journal-title":"ACS Nano"},{"issue":"8","key":"10.1016\/j.xphs.2026.104525_bib0003","first-page":"692","article-title":"Cell Membrane-Coated Nanoparticles: Emerging Clinical Opportunities","volume":"13","author":"Fang","year":"2018","journal-title":"Nature Nanotechnology"},{"issue":"12","key":"10.1016\/j.xphs.2026.104525_bib0004","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nrmicro.2017.99","article-title":"Targeting Microbial Biofilms: Current and Prospective Therapeutic Strategies","volume":"15","author":"Koo","year":"2017","journal-title":"Nature Reviews Microbiology"},{"issue":"3","key":"10.1016\/j.xphs.2026.104525_bib0005","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1021\/acsinfecdis.4c01016","article-title":"Anti-Intracellular MRSA Activity of Antibiotic-Loaded Lipid\u2013Polymer Hybrid Nanoparticles and Their Effectiveness in Murine Skin Wound Infection Models","volume":"11","author":"Wang","year":"2025","journal-title":"ACS Infectious Diseases"},{"key":"10.1016\/j.xphs.2026.104525_bib0006","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejpb.2020.04.010","article-title":"Lipid\u2013Polymer Hybrid Nanoparticles Carrying Linezolid Improve Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Harbored Inside Bone Cells and Biofilms","volume":"151","author":"Forgier","year":"2020","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"issue":"3","key":"10.1016\/j.xphs.2026.104525_bib0007","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/jac\/dkh546","article-title":"Daptomycin: A Lipopeptide Antibiotic for the Treatment of Serious Gram-Positive Infections","volume":"55","author":"Steenbergen","year":"2005","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"7","key":"10.1016\/j.xphs.2026.104525_bib0008","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.3390\/ma11071245","article-title":"Combination of Vancomycin and Cefazolin Lipid Nanoparticles for Overcoming Antibiotic Resistance of MRSA","volume":"11","author":"Bhise","year":"2018","journal-title":"Materials"},{"issue":"11","key":"10.1016\/j.xphs.2026.104525_bib0009","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1002\/adhm.201500129","article-title":"Macrophage Cell Membrane-Camouflaged Mesoporous Silica Nanocapsules for Active Targeting and Treatment of Bacterial Infections","volume":"4","author":"Xuan","year":"2015","journal-title":"Advanced Healthcare Materials"},{"issue":"2","key":"10.1016\/j.xphs.2026.104525_bib0010","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1021\/nl504798g","article-title":"Modulating Antibacterial Immunity via Bacterial Membrane-Coated Nanoparticles","volume":"15","author":"Gao","year":"2015","journal-title":"Nano Letters"},{"issue":"110","key":"10.1016\/j.xphs.2026.104525_bib0011","first-page":"91072","article-title":"Nanoantibiotics in the Clinic: A Review","volume":"5","author":"Kalhapure","year":"2015","journal-title":"RSC Advances"},{"issue":"2","key":"10.1016\/j.xphs.2026.104525_bib0012","first-page":"540","article-title":"Antibacterial Efficacy of Inhalable Levofloxacin-Loaded Lipid-Polymer Hybrid Nanoparticles Against Biofilm-Forming Pseudomonas aeruginosa","volume":"81","author":"Cheow","year":"2010","journal-title":"Colloids and Surfaces B: Biointerfaces"},{"issue":"6","key":"10.1016\/j.xphs.2026.104525_bib0013","first-page":"4120","article-title":"Biointerface Interactions of Antibiotic-Loaded Polymeric Nanoparticles with Bacterial Biofilms","volume":"15","author":"Subbiah","year":"2015","journal-title":"Journal of Nanoscience and Nanotechnology"},{"issue":"1","key":"10.1016\/j.xphs.2026.104525_bib0014","first-page":"56","article-title":"Probing the Mobility of Nanoparticles in Microbial Biofilms","volume":"162","author":"Forier","year":"2012","journal-title":"Journal of Controlled Release"},{"issue":"2","key":"10.1016\/j.xphs.2026.104525_bib0015","article-title":"Macrophage Membrane-Coated Nanoparticles for Managing Bacterial Sepsis","volume":"1","author":"Angsantikul","year":"2018","journal-title":"Advanced Therapeutics"},{"key":"10.1016\/j.xphs.2026.104525_bib0016","first-page":"35","article-title":"In Vivo Treatment of Helicobacter pylori Infection with Liposomal Linolenic Acid Formulation","volume":"177","author":"Thamphiwatana","year":"2014","journal-title":"Journal of Controlled Release"},{"issue":"16","key":"10.1016\/j.xphs.2026.104525_bib0017","first-page":"2089","article-title":"Daptomycin: Mechanisms of Action and Resistance and Strategies to Overcome Resistance","volume":"21","author":"Fuller","year":"2015","journal-title":"Current Pharmaceutical Design"},{"issue":"4","key":"10.1016\/j.xphs.2026.104525_bib0018","article-title":"Microbially Derived Extracellular Polymeric Substances (EPS) and Nanoparticle Transport Kinetics in Biofilm Matrices","volume":"167","author":"Bhattacharya","year":"2021","journal-title":"Microbiology"},{"issue":"18","key":"10.1016\/j.xphs.2026.104525_bib0019","first-page":"2441","article-title":"Envisaging Nanomedicine for Biofilm Elimination in Chronic Wound Infections","volume":"11","author":"Buhmann","year":"2016","journal-title":"Nanomedicine"},{"issue":"30","key":"10.1016\/j.xphs.2026.104525_bib0020","article-title":"Macrophage-Membrane-Camouflaged Nanoparticles for Targeted Endotoxin Neutralization and Sepsis Management","volume":"15","author":"Li","year":"2019","journal-title":"Small"},{"issue":"3","key":"10.1016\/j.xphs.2026.104525_bib0021","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejpb.2013.07.002","article-title":"Lipid-Polymer Hybrid Nanoparticles as a New Generation Delivery Platform","volume":"85","author":"Hadinoto","year":"2013","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"issue":"4","key":"10.1016\/j.xphs.2026.104525_bib0022","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.nano.2012.11.010","article-title":"Core-Shell Lipid-Polymer Hybrid Nanoparticles as a Potential Drug Delivery System","volume":"9","author":"Mandal","year":"2013","journal-title":"Nanomedicine: Nanotechnology, Biology and Medicine"},{"key":"10.1016\/j.xphs.2026.104525_bib0023","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.2147\/IJN.S198353","article-title":"Lipid-Polymer Hybrid Nanoparticles as a Potential Nanocarrier for Drug Delivery","volume":"14","author":"Mukherjee","year":"2019","journal-title":"International Journal of Nanomedicine"},{"key":"10.1016\/j.xphs.2026.104525_bib0024","first-page":"281","article-title":"Lipid-Polymer Hybrid Nanoparticles: Synthesis, Characterization and Biomedical Applications","volume":"41","author":"Dave","year":"2017","journal-title":"Journal of Drug Delivery Science and Technology"},{"issue":"5","key":"10.1016\/j.xphs.2026.104525_bib0025","first-page":"512","article-title":"Bacterial EPS Matrix Permeation and Dynamic Diffusion of Positively vs Negatively Charged Nanocarriers","volume":"35","author":"Flesch","year":"2019","journal-title":"Biofouling"},{"issue":"5","key":"10.1016\/j.xphs.2026.104525_bib0026","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1128\/JB.185.5.1485-1491.2003","article-title":"Diffusion in Biofilms","volume":"185","author":"Stewart","year":"2003","journal-title":"Journal of Bacteriology"},{"issue":"9","key":"10.1016\/j.xphs.2026.104525_bib0027","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrmicro2415","article-title":"The Biofilm Matrix","volume":"8","author":"Flemming","year":"2010","journal-title":"Nature Reviews Microbiology"},{"issue":"9","key":"10.1016\/j.xphs.2026.104525_bib0028","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of Nanoparticle Design for Overcoming Biological Barriers to Drug Delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nature Biotechnology"},{"key":"10.1016\/j.xphs.2026.104525_bib0029","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a Strategy for Improving Nanoparticle-Based Drug Delivery","volume":"99","author":"Suk","year":"2016","journal-title":"Advanced Drug Delivery Reviews"},{"issue":"36","key":"10.1016\/j.xphs.2026.104525_bib0030","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1002\/anie.200902672","article-title":"Poly(ethylene glycol) in Drug Delivery: Pros and Cons as Well as Potential Alternatives","volume":"49","author":"Knop","year":"2010","journal-title":"Angewandte Chemie International Edition"},{"issue":"2","key":"10.1016\/j.xphs.2026.104525_bib0031","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/wnan.1157","article-title":"Recent Advances in Stealth Coating of Nanoparticle Drug Delivery Systems","volume":"4","author":"Amoozgar","year":"2012","journal-title":"WIREs Nanomedicine and Nanobiotechnology"},{"issue":"10","key":"10.1016\/j.xphs.2026.104525_bib0032","first-page":"3871","article-title":"Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release","volume":"45","author":"Kamaly","year":"2016","journal-title":"Chemical Society Reviews"},{"issue":"2","key":"10.1016\/j.xphs.2026.104525_bib0033","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jconrel.2012.01.043","article-title":"PLGA-Based Nanoparticles: An Overview of Biomedical Applications","volume":"161","author":"Danhier","year":"2012","journal-title":"Journal of Controlled Release"},{"issue":"3","key":"10.1016\/j.xphs.2026.104525_bib0034","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier","volume":"3","author":"Makadia","year":"2011","journal-title":"Polymers"},{"issue":"1","key":"10.1016\/j.xphs.2026.104525_bib0035","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jsps.2017.10.012","article-title":"Applications of Nanoparticle Systems in Drug Delivery Technology","volume":"26","author":"Rizvi","year":"2018","journal-title":"Saudi Pharmaceutical Journal"},{"issue":"4","key":"10.1016\/j.xphs.2026.104525_bib0036","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/mp800051m","article-title":"Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles","volume":"5","author":"Alexis","year":"2008","journal-title":"Molecular Pharmaceutics"},{"issue":"1","key":"10.1016\/j.xphs.2026.104525_bib0037","first-page":"93","article-title":"Opsonization, Circulation Time, and Non-Immunogenicity of Systemic Nanoparticles","volume":"307","author":"Owens","year":"2006","journal-title":"International Journal of Pharmaceutics"},{"issue":"7","key":"10.1016\/j.xphs.2026.104525_bib0038","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nmat2442","article-title":"Understanding Biophysicochemical Interactions at the Nano\u2013Bio Interface","volume":"8","author":"Nel","year":"2009","journal-title":"Nature Materials"},{"issue":"12","key":"10.1016\/j.xphs.2026.104525_bib0039","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nnano.2012.207","article-title":"Biomolecular Coronas Provide the Biological Identity of Nanosystems","volume":"7","author":"Monopoli","year":"2012","journal-title":"Nature Nanotechnology"},{"issue":"6","key":"10.1016\/j.xphs.2026.104525_bib0040","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.nantod.2016.10.005","article-title":"Emerging Concepts in Nanoparticle\u2013Protein Corona","volume":"11","author":"Mahmoudi","year":"2016","journal-title":"Nano Today"},{"key":"10.1016\/j.xphs.2026.104525_bib0041","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/s41467-017-00600-w","article-title":"Mechanistic Understanding of In Vivo Protein Corona Formation","volume":"8","author":"Bertrand","year":"2017","journal-title":"Nature Communications"},{"issue":"4","key":"10.1016\/j.xphs.2026.104525_bib0042","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nnano.2015.330","article-title":"Protein Adsorption as a Key Factor in Targeting Nanoparticles","volume":"11","author":"Sch\u00f6ttler","year":"2016","journal-title":"Nature Nanotechnology"},{"issue":"3","key":"10.1016\/j.xphs.2026.104525_bib0043","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S1748-0132(07)70083-X","article-title":"Targeted Nanoparticles for Antibacterial and Anti-Inflammatory Applications","volume":"2","author":"Gu","year":"2007","journal-title":"Nano Today"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354926003758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354926003758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:17:06Z","timestamp":1792232226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354926003758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S0022354926003758"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2026.104525","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophage-membrane-camouflaged lipid\u2013polymer hybrid nanoparticles for target-specific biofilm penetration and eradication of methicillin-resistant staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2026.104525","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104525"}}