{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:36:35Z","timestamp":1785569795667,"version":"3.56.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972216"],"award-info":[{"award-number":["31972216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970140"],"award-info":[{"award-number":["31970140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270201"],"award-info":[{"award-number":["32270201"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021C02064"],"award-info":[{"award-number":["2021C02064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Plant Communications"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.xplc.2023.100724","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T11:48:46Z","timestamp":1695815326000},"page":"100724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["SP-141 targets Trs85 to inhibit rice blast fungus infection and functions as a potential broad-spectrum antifungal agent"],"prefix":"10.1016","volume":"5","author":[{"given":"Xi-Yu","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Ming","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Li","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Dong","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7466-1261","authenticated-orcid":false,"given":"Xiao-Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Cheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xplc.2023.100724_bib1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.cell.2013.01.030","article-title":"A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility","volume":"152","author":"Bassik","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.xplc.2023.100724_bib2","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.cell.2008.04.049","article-title":"The Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering Complexes","volume":"133","author":"Cai","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.xplc.2023.100724_bib3","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1111\/1462-2920.15949","article-title":"MoOpy2 is essential for fungal development, pathogenicity, and autophagy in Magnaporthe oryzae","volume":"24","author":"Cai","year":"2022","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.xplc.2023.100724_bib4","doi-asserted-by":"crossref","first-page":"946","DOI":"10.4161\/auto.5.7.9161","article-title":"MgAtg9 trafficking in Magnaporthe oryzae","volume":"5","author":"Dong","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.xplc.2023.100724_bib5","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.febslet.2009.10.022","article-title":"Amphipathic helices and membrane curvature","volume":"584","author":"Drin","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.xplc.2023.100724_bib6","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020107608","article-title":"Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1","volume":"40","author":"Galindo","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.xplc.2023.100724_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1247\/csf.28.49","article-title":"The Early Secretory Pathway Contributes to Autophagy in Yeast","volume":"28","author":"Hamasaki","year":"2003","journal-title":"Cell Struct. Funct."},{"key":"10.1016\/j.xplc.2023.100724_bib8","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/s41564-020-00790-y","article-title":"Discovery of broad-spectrum fungicides that block septin-dependent infection processes of pathogenic fungi","volume":"5","author":"He","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.xplc.2023.100724_bib9","doi-asserted-by":"crossref","first-page":"11281","DOI":"10.1073\/pnas.88.24.11281","article-title":"Penetration of hard substrates by a fungus employing enormous turgor pressures","volume":"88","author":"Howard","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xplc.2023.100724_bib10","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1242\/jcs.196196","article-title":"Atg9A trafficking through the recycling endosomes is required for autophagosome formation","volume":"129","author":"Imai","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.xplc.2023.100724_bib11","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020107607","article-title":"Structural basis of TRAPPIII-mediated Rab1 activation","volume":"40","author":"Joiner","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.xplc.2023.100724_bib12","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1091\/mbc.11.12.4403","article-title":"The TRAPP Complex Is a Nucleotide Exchanger for Ypt1 and Ypt31\/32","volume":"11","author":"Jones","year":"2000","journal-title":"MBoC"},{"key":"10.1016\/j.xplc.2023.100724_bib13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/38418","article-title":"Glycerol generates turgor in rice blast","volume":"389","author":"de Jong","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.xplc.2023.100724_bib14","doi-asserted-by":"crossref","first-page":"15967","DOI":"10.1073\/pnas.0901477106","article-title":"Genome-wide functional analysis reveals that infection-associated fungal autophagy is necessary for rice blast disease","volume":"106","author":"Kershaw","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xplc.2023.100724_bib15","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.1073\/pnas.1121299109","article-title":"Regulation of selective autophagy onset by a Ypt\/Rab GTPase module","volume":"109","author":"Lipatova","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xplc.2023.100724_bib16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4161\/auto.6.1.10438","article-title":"The cysteine protease MoAtg4 interacts with MoAtg8 and is required for differentiation and pathogenesis in Magnaporthe oryzae","volume":"6","author":"Liu","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.xplc.2023.100724_bib17","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.4161\/auto.21274","article-title":"Autophagy vitalizes the pathogenicity of pathogenic fungi","volume":"8","author":"Liu","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.xplc.2023.100724_bib18","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1128\/EC.00011-07","article-title":"Involvement of a Magnaporthe grisea Serine\/Threonine Kinase Gene, Mg ATG1 , in Appressorium Turgor and Pathogenesis","volume":"6","author":"Liu","year":"2007","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.xplc.2023.100724_bib19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00294-009-0259-5","article-title":"An autophagy gene, MgATG5, is required for cell differentiation and pathogenesis in Magnaporthe oryzae","volume":"55","author":"Lu","year":"2009","journal-title":"Curr. Genet."},{"key":"10.1016\/j.xplc.2023.100724_bib20","doi-asserted-by":"crossref","first-page":"7811","DOI":"10.1073\/pnas.1000063107","article-title":"Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy","volume":"107","author":"Lynch-Day","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xplc.2023.100724_bib21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10822-013-9644-8","article-title":"Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments","volume":"27","author":"Sastry","year":"2013","journal-title":"J. Comput. Aided Mol. Des."},{"key":"10.1016\/j.xplc.2023.100724_bib22","doi-asserted-by":"crossref","first-page":"33669","DOI":"10.1074\/jbc.M501701200","article-title":"Trs85 (Gsg1), a Component of the TRAPP Complexes, Is Required for the Organization of the Preautophagosomal Structure during Selective Autophagy via the Cvt Pathway","volume":"280","author":"Meiling-Wesse","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.xplc.2023.100724_bib23","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: Renovation of Cells and Tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.xplc.2023.100724_bib24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4161\/auto.1.1.1512","article-title":"Early Secretory Pathway Gene TRS85 is Required for Selective Macroautophagy of Peroxisomes in Yarrowia lipolytica","volume":"1","author":"Nazarko","year":"2005","journal-title":"Autophagy"},{"key":"10.1016\/j.xplc.2023.100724_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/cr.2013.169","article-title":"Historical landmarks of autophagy research","volume":"24","author":"Ohsumi","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.xplc.2023.100724_bib26","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.4161\/auto.24483","article-title":"Live-cell imaging of Aspergillus nidulans autophagy: RAB1 dependence, Golgi independence and ER involvement","volume":"9","author":"Pinar","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.xplc.2023.100724_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cbpa.2018.06.004","article-title":"Inhibitors of protein\u2013protein interactions (PPIs): an analysis of scaffold choices and buried surface area","volume":"44","author":"Ran","year":"2018","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.xplc.2023.100724_bib28","series-title":"Current Topics in Developmental Biology","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2153(06)74001-7","article-title":"Membrane Origin for Autophagy","author":"Reggiori","year":"2006"},{"key":"10.1016\/j.xplc.2023.100724_bib29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.pbi.2015.05.013","article-title":"Regulation of appressorium development in pathogenic fungi","volume":"26","author":"Ryder","year":"2015","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.xplc.2023.100724_bib30","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.aaq0892","article-title":"A single fungal MAP kinase controls plant cell-to-cell invasion by the rice blast fungus","volume":"359","author":"Sakulkoo","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.xplc.2023.100724_bib31","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(88)90433-3","article-title":"The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery","volume":"52","author":"Segev","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.xplc.2023.100724_bib32","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S1534-5807(02)00373-8","article-title":"Mechanism of Cargo Selection in the Cytoplasm to Vacuole Targeting Pathway","volume":"3","author":"Shintani","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.xplc.2023.100724_bib33","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.xplc.2023.100724_bib34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev.micro.57.030502.090957","article-title":"On the Trail of a Cereal Killer: Exploring the Biology of Magnaporthe grisea","volume":"57","author":"Talbot","year":"2003","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.xplc.2023.100724_bib35","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.pbi.2009.05.008","article-title":"The emerging role of autophagy in plant pathogen attack and host defence","volume":"12","author":"Talbot","year":"2009","journal-title":"Curr. Opin. Plant Biol."},{"key":"10.1016\/j.xplc.2023.100724_bib36","doi-asserted-by":"crossref","first-page":"19432","DOI":"10.1073\/pnas.1316356110","article-title":"The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathway","volume":"110","author":"Tan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xplc.2023.100724_bib37","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1083\/jcb.201705214","article-title":"The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway","volume":"217","author":"Thomas","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.xplc.2023.100724_bib38","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.1124550","article-title":"Autophagic Fungal Cell Death Is Necessary for Infection by the Rice Blast Fungus","volume":"312","author":"Veneault-Fourrey","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.xplc.2023.100724_bib39","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1038\/ncomms6086","article-title":"The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models","volume":"5","author":"Wang","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xplc.2023.100724_bib40","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1053\/j.gastro.2014.07.001","article-title":"Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice","volume":"147","author":"Wang","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.xplc.2023.100724_bib41","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jmb.2017.01.003","article-title":"Structural Biology of the Cvt Pathway","volume":"429","author":"Yamasaki","year":"2017","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.xplc.2023.100724_bib42","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1091\/mbc.e04-11-1035","article-title":"Atg11 Links Cargo to the Vesicle-forming Machinery in the Cytoplasm to Vacuole Targeting Pathway","volume":"16","author":"Yorimitsu","year":"2005","journal-title":"MBoC"},{"key":"10.1016\/j.xplc.2023.100724_bib43","article-title":"The Small GTPase FgRab1 Plays Indispensable Roles in the Vegetative Growth, Vesicle Fusion, Autophagy and Pathogenicity of Fusarium graminearum","volume":"15","author":"Yuan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.xplc.2023.100724_bib44","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1080\/15548627.2020.1848129","article-title":"A VASt-domain protein regulates autophagy, membrane tension, and sterol homeostasis in rice blast fungus","volume":"17","author":"Zhu","year":"2021","journal-title":"Autophagy"}],"container-title":["Plant Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590346223002705?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590346223002705?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:59:29Z","timestamp":1778914769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590346223002705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S2590346223002705"],"URL":"https:\/\/doi.org\/10.1016\/j.xplc.2023.100724","relation":{},"ISSN":["2590-3462"],"issn-type":[{"value":"2590-3462","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SP-141 targets Trs85 to inhibit rice blast fungus infection and functions as a potential broad-spectrum antifungal agent","name":"articletitle","label":"Article Title"},{"value":"Plant Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xplc.2023.100724","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"100724"}}