{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:15:13Z","timestamp":1790100913185,"version":"4.0.1"},"reference-count":5,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004937","name":"BMBF Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["111879"],"award-info":[{"award-number":["111879"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["1\u20132"],"award-info":[{"award-number":["1\u20132"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["2544\/1-1"],"award-info":[{"award-number":["2544\/1-1"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["5-1"],"award-info":[{"award-number":["5-1"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008316","name":"Baden-W\u00fcrttemberg Stiftung gGmbH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008316","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["STAR Protocols"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.xpro.2021.100913","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T12:20:25Z","timestamp":1638966025000},"page":"100913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Differentiation of human pluripotent stem cells into pancreatic duct-like organoids"],"prefix":"10.1016","volume":"2","author":[{"given":"Markus","family":"Breunig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Merkle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7902-590X","authenticated-orcid":false,"given":"Michael Karl","family":"Melzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Heller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Seufferlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Hohwieler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Kleger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xpro.2021.100913_bib1","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.stem.2021.03.005","article-title":"Modelling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells","volume":"28","author":"Breunig","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xpro.2021.100913_bib2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41467-017-00561-0","article-title":"Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors","volume":"8","author":"Cogger","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xpro.2021.100913_bib3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.stemcr.2015.02.017","article-title":"Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines","volume":"4","author":"Nostro","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.xpro.2021.100913_bib5","doi-asserted-by":"crossref","first-page":"e27564","DOI":"10.7554\/eLife.27564","article-title":"Reconstructing human pancreatic differentiation by mapping specific cell populations during development","volume":"21","author":"Ramond","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.xpro.2021.100913_bib4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0076-6879(06)06054-X","article-title":"Using three-dimensional acinar structures for molecular and cell biological assays","volume":"406","author":"Xiang","year":"2006","journal-title":"Methods Enzymol."}],"container-title":["STAR Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666166721006195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666166721006195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T19:46:48Z","timestamp":1762976808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666166721006195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S2666166721006195"],"URL":"https:\/\/doi.org\/10.1016\/j.xpro.2021.100913","relation":{},"ISSN":["2666-1667"],"issn-type":[{"value":"2666-1667","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differentiation of human pluripotent stem cells into pancreatic duct-like organoids","name":"articletitle","label":"Article Title"},{"value":"STAR Protocols","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xpro.2021.100913","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.stem.2021.03.005","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"100913"}}