{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:57:13Z","timestamp":1781816233889,"version":"3.54.5"},"reference-count":18,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["TP220451"],"award-info":[{"award-number":["TP220451"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH125938"],"award-info":[{"award-number":["R01MH125938"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH124839"],"award-info":[{"award-number":["R01MH124839"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH136149"],"award-info":[{"award-number":["R01MH136149"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["RM1MH132648"],"award-info":[{"award-number":["RM1MH132648"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH118278"],"award-info":[{"award-number":["R01MH118278"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES033630"],"award-info":[{"award-number":["R01ES033630"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["STAR Protocols"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.xpro.2025.103905","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T01:28:51Z","timestamp":1750123731000},"page":"103905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protocol for finding genetic variation associated with unmeasured traits through GenomicSEM common-factor GWAS"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1370-3149","authenticated-orcid":false,"given":"Keira J.A.","family":"Johnston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Signer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M.","family":"Huckins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xpro.2025.103905_bib1","article-title":"Chronic overlapping pain conditions and nociplastic pain","volume":"6","author":"Johnston","year":"2025","journal-title":"HGG Adv."},{"key":"10.1016\/j.xpro.2025.103905_bib2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/s41562-019-0566-x","article-title":"Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits","volume":"3","author":"Grotzinger","year":"2019","journal-title":"Nat. Hum. Behav."},{"key":"10.1016\/j.xpro.2025.103905_bib3","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ng.3406","article-title":"An atlas of genetic correlations across human diseases and traits","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xpro.2025.103905_bib4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD Score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xpro.2025.103905_bib5","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"Auton","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.xpro.2025.103905_bib6","doi-asserted-by":"crossref","first-page":"D998","DOI":"10.1093\/nar\/gkae1070","article-title":"The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity","volume":"53","author":"Cerezo","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xpro.2025.103905_bib7","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1093\/bioinformatics\/btab665","article-title":"MungeSumstats: a Bioconductor package for the standardization and quality control of many GWAS summary statistics","volume":"37","author":"Murphy","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.xpro.2025.103905_bib8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.xpro.2025.103905_bib9","unstructured":"2.1 Calculating Sum of Effective Sample Size and Preparing GWAS Summary Statistics \u00b7 GenomicSEM\/GenomicSEM Wiki \u00b7 GitHub. https:\/\/github.com\/GenomicSEM\/GenomicSEM\/wiki\/2.1-Calculating-Sum-of-Effective-Sample-Size-and-Preparing-GWAS-Summary-Statistics."},{"key":"10.1016\/j.xpro.2025.103905_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biopsych.2022.05.029","article-title":"Pervasive Downward Bias in Estimates of Liability-Scale Heritability in Genome-wide Association Study Meta-analysis: A Simple Solution","volume":"93","author":"Grotzinger","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.xpro.2025.103905_bib11","article-title":"Identifying and correcting for misspecifications in GWAS summary statistics and polygenic scores","volume":"3","author":"Priv\u00e9","year":"2022","journal-title":"Human Genet. Genomics Adv."},{"key":"10.1016\/j.xpro.2025.103905_bib12","article-title":"Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities","volume":"2","author":"Mallard","year":"2022","journal-title":"Cell Genom."},{"key":"10.1016\/j.xpro.2025.103905_bib13","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s10519-019-09951-0","article-title":"A Genetic Investigation of the Well-Being Spectrum","volume":"49","author":"Baselmans","year":"2019","journal-title":"Behav. Genet."},{"key":"10.1016\/j.xpro.2025.103905_bib14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41398-024-03152-y","article-title":"Genomic structural equation modeling reveals latent phenotypes in the human cortex with distinct genetic architecture","volume":"14","author":"Morey","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.xpro.2025.103905_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.5808\/GI.2012.10.2.117","article-title":"Sample size and statistical power calculation in genetic association studies","volume":"10","author":"Hong","year":"2012","journal-title":"Genomics Inform."},{"key":"10.1016\/j.xpro.2025.103905_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.989639","article-title":"Polygenic power calculator: Statistical power and polygenic prediction accuracy of genome-wide association studies of complex traits","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.xpro.2025.103905_bib17","unstructured":"Pirinen M. GWAS 3: Statistical power. 2025. https:\/\/www.mv.helsinki.fi\/home\/mjxpirin\/GWAS_course\/material\/GWAS3.html."},{"key":"10.1016\/j.xpro.2025.103905_bib18","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bbi.2022.03.010","article-title":"Genetic association study in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) identifies several potential risk loci","volume":"102","author":"Hajdarevic","year":"2022","journal-title":"Brain Behav. Immun."}],"container-title":["STAR Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666166725003119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666166725003119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:21:50Z","timestamp":1781814110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666166725003119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2666166725003119"],"URL":"https:\/\/doi.org\/10.1016\/j.xpro.2025.103905","relation":{},"ISSN":["2666-1667"],"issn-type":[{"value":"2666-1667","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protocol for finding genetic variation associated with unmeasured traits through GenomicSEM common-factor GWAS","name":"articletitle","label":"Article Title"},{"value":"STAR Protocols","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xpro.2025.103905","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.xhgg.2024.100381","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103905"}}