{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:55:35Z","timestamp":1781816135734,"version":"3.54.5"},"reference-count":6,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20220190"],"award-info":[{"award-number":["BK20220190"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010854","name":"Jiangsu Provincial Health Commission","doi-asserted-by":"publisher","award":["M2021002"],"award-info":[{"award-number":["M2021002"]}],"id":[{"id":"10.13039\/501100010854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M711584"],"award-info":[{"award-number":["2022M711584"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072651"],"award-info":[{"award-number":["82072651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203657"],"award-info":[{"award-number":["82203657"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["STAR Protocols"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.xpro.2025.103907","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T06:55:20Z","timestamp":1750229720000},"page":"103907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protocol for adeno-associated virus-mediated gene delivery to accelerate pancreatic carcinogenesis in mice"],"prefix":"10.1016","volume":"6","author":[{"given":"Hongzhen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xpro.2025.103907_bib1","article-title":"Disrupting AGR2\/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy","volume":"6","author":"Li","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.xpro.2025.103907_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/gutjnl-2014-307616","article-title":"A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras\/Mek\/Erk-induced hyperactive mTOR signalling","volume":"65","author":"Kong","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.xpro.2025.103907_bib3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1538\/expanim.14-0050","article-title":"Vital signs monitoring during injectable and inhalant anesthesia in mice","volume":"64","author":"Tsukamoto","year":"2015","journal-title":"Exp. Anim."},{"key":"10.1016\/j.xpro.2025.103907_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1089\/hgtb.2016.089","article-title":"Efficient Gene Delivery and Expression in Pancreas and Pancreatic Tumors by Capsid-Optimized AAV8 Vectors","volume":"28","author":"Chen","year":"2017","journal-title":"Hum. Gene Ther. Part B Methods"},{"key":"10.1016\/j.xpro.2025.103907_bib5","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1136\/gutjnl-2023-330788","article-title":"Pancreas-directed AAV8-hSPINK1 gene therapy safely and effectively protects against pancreatitis in mice","volume":"73","author":"Wang","year":"2024","journal-title":"Gut"},{"key":"10.1016\/j.xpro.2025.103907_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1182\/blood-2013-01-306647","article-title":"Immune responses to AAV vectors: overcoming barriers to successful gene therapy","volume":"122","author":"Mingozzi","year":"2013","journal-title":"Blood"}],"container-title":["STAR Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666166725003132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666166725003132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:15:18Z","timestamp":1781813718000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666166725003132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":6,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2666166725003132"],"URL":"https:\/\/doi.org\/10.1016\/j.xpro.2025.103907","relation":{},"ISSN":["2666-1667"],"issn-type":[{"value":"2666-1667","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protocol for adeno-associated virus-mediated gene delivery to accelerate pancreatic carcinogenesis in mice","name":"articletitle","label":"Article Title"},{"value":"STAR Protocols","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xpro.2025.103907","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.xcrm.2024.101927","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103907"}}