{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:04:45Z","timestamp":1790121885937,"version":"4.0.1"},"reference-count":9,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["STAR Protocols"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.xpro.2026.104736","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:57:11Z","timestamp":1785175031000},"page":"104736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protocol to study the antitumor and metabolic effects of intermittent fasting plus cisplatin and metformin in ovarian cancer PDX models"],"prefix":"10.1016","volume":"7","author":[{"given":"Ludovica","family":"Perotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Capellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Guffanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Ronchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Corna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Cerullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Matteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Scanziani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Tiddia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Funari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Damia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Brunelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1705-186X","authenticated-orcid":false,"given":"Francesca","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xpro.2026.104736_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.114300","article-title":"Intermittent fasting enhances cisplatin-metformin efficacy in therapy-resistant ovarian cancer PDXs","volume":"29","author":"Capellini","year":"2026","journal-title":"iScience"},{"key":"10.1016\/j.xpro.2026.104736_bib2","doi-asserted-by":"crossref","first-page":"6980","DOI":"10.1158\/0008-5472.CAN-14-0274","article-title":"Patient-derived ovarian tumor xenografts recapitulate human clinicopathology and genetic alterations","volume":"74","author":"Ricci","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.xpro.2026.104736_bib3","doi-asserted-by":"crossref","DOI":"10.1177\/1758835919839543","article-title":"Overcoming platinum-acquired resistance in ovarian cancer patient-derived xenografts","volume":"11","author":"Ricci","year":"2019","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.xpro.2026.104736_bib4","first-page":"690","article-title":"Experimental evaluation of potential anticancer agents. I. Quantitative therapeutic evaluation of certain purine analogs","volume":"21","author":"Schabel","year":"1961","journal-title":"Cancer Res."},{"key":"10.1016\/j.xpro.2026.104736_bib5","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1093\/gerona\/glab244","article-title":"Plasmatic Hippuric Acid as a Hallmark of Frailty in an Italian Cohort: The Mediation Effect of Fruit-Vegetable Intake","volume":"76","author":"Brunelli","year":"2021","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.xpro.2026.104736_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/metabo13010013","article-title":"EASY-FIA: A Readably Usable Standalone Tool for High-Resolution Mass Spectrometry Metabolomics Data Pre-Processing","volume":"13","author":"Morabito","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.xpro.2026.104736_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2047-217X-2-13","article-title":"The role of reporting standards for metabolite annotation and identification in metabolomic studies","volume":"2","author":"Salek","year":"2013","journal-title":"GigaScience"},{"key":"10.1016\/j.xpro.2026.104736_bib8","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s11306-014-0686-2","article-title":"Fast Swinnex filtration (FSF): a fast and robust sampling and extraction method suitable for metabolomics analysis of cultures grown in complex media","volume":"11","author":"McCloskey","year":"2015","journal-title":"Metabolomics"},{"key":"10.1016\/j.xpro.2026.104736_bib9","unstructured":"ICH Guideline M10 on Bioanalytical Method Validation and Study Sample Analysis EMA\/CHMP\/ICH\/172948\/2019."}],"container-title":["STAR Protocols"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666166726003898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666166726003898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:34:11Z","timestamp":1790120051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666166726003898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2666166726003898"],"URL":"https:\/\/doi.org\/10.1016\/j.xpro.2026.104736","relation":{},"ISSN":["2666-1667"],"issn-type":[{"value":"2666-1667","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protocol to study the antitumor and metabolic effects of intermittent fasting plus cisplatin and metformin in ovarian cancer PDX models","name":"articletitle","label":"Article Title"},{"value":"STAR Protocols","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xpro.2026.104736","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.isci.2025.114300","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104736"}}