{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T11:40:45Z","timestamp":1769341245783,"version":"3.49.0"},"reference-count":75,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["advancesinpediatrics.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Pediatrics"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.yapd.2017.03.004","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T00:15:17Z","timestamp":1499300117000},"page":"111-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Alternatives in the Treatment of Short Stature"],"prefix":"10.1016","volume":"64","author":[{"given":"Roberto","family":"Lanes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura G.","family":"Gonz\u00e1lez Brice\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yapd.2017.03.004_bib1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0022-3476(89)80341-5","article-title":"Six-year results of luteinizing hormone releasing hormone (LHRH) agonist treatment in children with LHRH-dependent precocious puberty","volume":"115","author":"Manasco","year":"1989","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.yapd.2017.03.004_bib2","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1210\/jcem-73-6-1235","article-title":"Adult height in precocious puberty after long-term treatment with deslorelin","volume":"73","author":"Oertner","year":"1991","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib3","first-page":"415","article-title":"Adult height in girls with idiopathic true precocious puberty","volume":"79","author":"Brauner","year":"1994","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib4","first-page":"546","article-title":"Long term effect of gonadotropin-releasing hormone agonist therapy on final and near final height in 26 children with true precocious puberty treated at a median age of less than five years","volume":"80","author":"Paul","year":"1995","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib5","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1515\/JPEM.2004.17.5.759","article-title":"Accelerated versus slowly progressive forms of puberty in girls with precocious and early puberty. Gonadotropin suppressive effect and final height obtained with two different analogs","volume":"17","author":"Lanes","year":"2004","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF01955894","article-title":"Failure to improve height prediction in short-stature pubertal adolescents by inhibiting puberty with luteinizing hormone-releasing hormone analogue","volume":"152","author":"Lindner","year":"1993","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.yapd.2017.03.004_bib7","first-page":"3318","article-title":"Gonadotropin-releasing hormone agonist treatment of girls with constitutional short stature and normal pubertal development","volume":"81","author":"Carel","year":"1996","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib8","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1210\/jcem.84.10.6032","article-title":"Lack of effect of GnRH agonists on final height in girls with advanced puberty: a randomized long-term pilot study","volume":"84","author":"Bouvattier","year":"1999","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib9","first-page":"1334","article-title":"Effect of deslorelin-induced pubertal delay on the growth of adolescents with short stature and normally timed puberty: preliminary results","volume":"77","author":"Municchi","year":"1993","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib10","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1056\/NEJMoa013555","article-title":"Treatment with a luteinizing hormone-releasing hormone agonist in adolescents with short stature","volume":"348","author":"Yanovski","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.yapd.2017.03.004_bib11","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0022-3476(95)70473-6","article-title":"Combination treatment with growth hormone and gonadotropin-releasing hormone analogs in short normal girls","volume":"126","author":"Saggese","year":"1995","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.yapd.2017.03.004_bib12","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000183889","article-title":"Growth of short normal children in puberty treated for 3 years with growth hormone alone or in association with gonadotropin-releasing hormone agonist","volume":"41","author":"Job","year":"1994","journal-title":"Horm Res"},{"key":"10.1016\/j.yapd.2017.03.004_bib13","first-page":"3596","article-title":"Adult height in short normal adolescent girls treated with gonadotropin-releasing hormone analog and growth hormone","volume":"80","author":"Balducci","year":"1995","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1046\/j.1365-2265.1998.00499.x","article-title":"Final height alter combined growth hormone and gonadotrophin-releasing hormone analogue therapy in short healthy children entering into normally timed puberty","volume":"49","author":"Lanes","year":"1998","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.yapd.2017.03.004_bib15","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1210\/jcem.85.2.6387","article-title":"Adult height in short normal girls treated with gonadotropin-releasing hormone analogs and growth hormone","volume":"85","author":"Pasquino","year":"2000","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.yapd.2017.03.004_bib16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1210\/jc.2009-1577","article-title":"Effectiveness of the combined recombinant human growth hormone and gonadotropic-releasing hormone analog therapy in pubertal patients with short stature due to SHOX deficiency","volume":"95","author":"Scalco","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib17","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1210\/jc.2006-2272","article-title":"Final height outcome after three years of growth hormone and gonadotropin-releasing hormone agonist treatment in short adolescents with relatively early puberty","volume":"92","author":"Van Gool","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"7\u20138","key":"10.1016\/j.yapd.2017.03.004_bib18","first-page":"651","article-title":"Is the growth outcome of children with idiopathic short stature and isolated growth hormone deficiency following treatment with growth hormone and a luteinizing hormone-releasing hormone agonist superior to that obtained by GH alone?","volume":"25","author":"Colmenares","year":"2012","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib19","first-page":"1886","article-title":"Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength, and adiposity","volume":"83","author":"Mauras","year":"1998","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.yapd.2017.03.004_bib20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1159\/000197862","article-title":"Body mass index and body composition in adolescents treated with gonadotropin-releasing hormone analogue triptorelin depot for central precocious puberty: data at near final height","volume":"89","author":"Chiocca","year":"2009","journal-title":"Neuroendocrinology"},{"issue":"12","key":"10.1016\/j.yapd.2017.03.004_bib21","first-page":"4480","article-title":"Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty","volume":"84","author":"Palmert","year":"1999","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib22","first-page":"1","article-title":"Higher prevalence of obesity and overweight without an adverse metabolic profile in girls with central precocious puberty compared to girls with\u00a0early puberty, regardless of GnRH analogue treatment","volume":"5","author":"Colmenares","year":"2014","journal-title":"Int J Pediatr Endocrinol"},{"key":"10.1016\/j.yapd.2017.03.004_bib23","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jpeds.2006.05.026","article-title":"Reproductive outcome in patients treated and not treated for idiopathic early puberty: long-term results of a randomized trial in adults","volume":"149","author":"Cassio","year":"2006","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.yapd.2017.03.004_bib24","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1016\/S0021-9258(20)79736-X","article-title":"The involvement of human placental microsomal cytochrome P-450 in aromatization","volume":"249","author":"Thompson","year":"1974","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.yapd.2017.03.004_bib25","first-page":"63","article-title":"Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention","volume":"1766","author":"Cavalieri","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.yapd.2017.03.004_bib26","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1158\/1078-0432.CCR-04-2187","article-title":"Aromatase inhibition: translation into a successful therapeutic approach","volume":"11","author":"Geisler","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.yapd.2017.03.004_bib27","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1021\/jm0508282","article-title":"CYP19 (aromatase) 1-[(benzofuran-2-yl)(phenylmethyl) pyridine, -imidazole, and -triazole inhibitors: synthesis and biological evaluation","volume":"49","author":"Saberi","year":"2006","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.yapd.2017.03.004_bib28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0960-0760(90)90481-Y","article-title":"Aromatase inhibitors and hormone dependent cancers","volume":"37","author":"Brodie","year":"1990","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.yapd.2017.03.004_bib29","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1677\/erc.0.0060293","article-title":"Estrogen production in endometriosis and use of aromatase inhibitors to treat endometriosis","volume":"6","author":"Bulun","year":"1999","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.yapd.2017.03.004_bib30","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1210\/jc.2006-2350","article-title":"2007 Letrozole treatment of precocious puberty in girls with the McCune-Albright syndrome: a pilot study","volume":"92","author":"Feuillan","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"Suppl 3","key":"10.1016\/j.yapd.2017.03.004_bib31","first-page":"897","article-title":"McCune-Albright syndrome\u2014the German experience","volume":"15","author":"Albers","year":"2002","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1067\/mpd.2001.110527","article-title":"Height outcome in congenital adrenal hyperplasia caused by 21-hydroxylase deficiency: a meta-analysis","volume":"138","author":"Eugster","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.yapd.2017.03.004_bib33","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1210\/jcem-27-9-1239","article-title":"Aminoglutethimide (Elipten-Ciba) as an inhibitor of adrenal steroidogenesis: mechanism of action and therapeutic trial","volume":"27","author":"Cash","year":"1967","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib34","doi-asserted-by":"crossref","first-page":"4428","DOI":"10.1210\/jc.2004-0082","article-title":"Safety and efficacy of anastrozole for the treatment of pubertal gynecomastia: a randomized, double-blind, placebo-controlled trial","volume":"89","author":"Plourde","year":"2004","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib35","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1056\/NEJM199410203311604","article-title":"Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man","volume":"331","author":"Smith","year":"1994","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.yapd.2017.03.004_bib36","first-page":"3689","article-title":"Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens","volume":"80","author":"Morishima","year":"1995","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib37","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/BF03345059","article-title":"Delayed closure of epiphyseal cartilages induced by the aromatase inhibitor anastrozole. Would it help short children grow up?","volume":"23","author":"Faglia","year":"2000","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.yapd.2017.03.004_bib38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.mce.2006.04.031","article-title":"Use of aromatase inhibitors to increase final height","volume":"254-255","author":"Dunkel","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.yapd.2017.03.004_bib39","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/S0140-6736(00)04895-9","article-title":"A\u00a0specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomised controlled trial","volume":"357","author":"Wickman","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.yapd.2017.03.004_bib40","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1365-2265.2006.02499.x","article-title":"Treatment with the aromatase inhibitor letrozole during adolescence increases near-final height in boys with constitutional delay of puberty","volume":"64","author":"Hero","year":"2006","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.yapd.2017.03.004_bib41","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1515\/JPEM.2004.17.12.1597","article-title":"An open label 12-month pilot trial on the effects of the aromatase inhibitor anastrozole in growth hormone (GH)-treated GH deficient adolescent boys","volume":"17","author":"Mauras","year":"2004","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib42","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1210\/jc.2007-1559","article-title":"Anastrazole increases predicted adult height of short adolescent males treated with growth hormone: a randomized placebo-controlled, multicenter trial for one to three years","volume":"93","author":"Mauras","year":"2008","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib43","doi-asserted-by":"crossref","first-page":"6396","DOI":"10.1210\/jc.2005-1392","article-title":"Inhibition of estrogen biosynthesis with a potent aromatase inhibitor increases predicted adult height in boys with idiopathic short stature: a randomized controlled trial","volume":"90","author":"Hero","year":"2005","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.yapd.2017.03.004_bib44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1687-9856-2015-4","article-title":"A\u00a0randomized pilot trial of growth hormone with anastrozole versus growth hormone alone, starting at the very end of puberty in adolescents with idiopathic short stature","volume":"2015","author":"Rothenbuhler","year":"2015","journal-title":"Int J Pediatr Endocrinol"},{"key":"10.1016\/j.yapd.2017.03.004_bib45","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1210\/jc.2016-2891","article-title":"Randomized trial of aromatase inhibitors, growth hormone or combination in pubertal boys with idiopathic short stature","volume":"101","author":"Mauras","year":"2016","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib46","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1159\/000315482","article-title":"A\u00a0double-blind, placebo-controlled comparison of letrozole to oxandrolone effects upon growth and puberty of children with constitutional delay of puberty and idiopathic short stature","volume":"74","author":"Salehpour","year":"2010","journal-title":"Horm Res Paediatr"},{"issue":"0","key":"10.1016\/j.yapd.2017.03.004_bib47","first-page":"725","article-title":"Outcome analysis of aromatase inhibitor therapy to increase adult height in males with predicted short adult stature and\/or rapid pubertal progress: a retrospective chart review","volume":"27","author":"Shams","year":"2014","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib48","first-page":"OR32","article-title":"Aromatase inhibitor may delay skeletal maturation and improve final adult height in females","volume":"120","author":"Turpin","year":"2004","journal-title":"Endocr Soc 86th Annu Meet"},{"key":"10.1016\/j.yapd.2017.03.004_bib49","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1575-0922(09)71403-2","article-title":"Inhibidores de la aromatasa: \u00bfpueden mejorar el crecimiento esquel\u00e9tico?","volume":"56","author":"Aud\u00ed Parera","year":"2009","journal-title":"Endocrinol Nutr"},{"key":"10.1016\/j.yapd.2017.03.004_bib50","first-page":"290","article-title":"Impact of aromatase inhibitor therapy on bone turnover, cortical bone growth and vertebral morphology in pre- and peripubertal boys with idiopathic short stature","volume":"71","author":"Hero","year":"2009","journal-title":"Horm Res"},{"key":"10.1016\/j.yapd.2017.03.004_bib51","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1210\/endo.137.11.8895349","article-title":"Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility","volume":"137","author":"Eddy","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.yapd.2017.03.004_bib52","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1515\/JPEM.2005.18.3.285","article-title":"The effect of letrozole on bone age progression, predicted adult height, and adrenal gland function","volume":"18","author":"Karmazin","year":"2005","journal-title":"J\u00a0Pediatr Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib53","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1530\/eje.0.1460339","article-title":"The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor","volume":"146","author":"Wickman","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.yapd.2017.03.004_bib54","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1210\/jc.2005-2329","article-title":"Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty","volume":"91","author":"Iba\u00f1ez","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib55","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1210\/jc.2006-0336","article-title":"Metformin treatment to prevent early puberty in girls with precocious pubarche","volume":"91","author":"Iba\u00f1ez","year":"2006","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib56","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1056\/NEJM199610313351805","article-title":"Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene","volume":"335","author":"Woods","year":"1996","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.yapd.2017.03.004_bib57","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa022926","article-title":"Growth hormone insensitivity (GHI) associated with a STAT-5b mutation","volume":"349","author":"Kofoed","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.yapd.2017.03.004_bib58","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0022-3476(05)81163-1","article-title":"Stimulation of statural growth by recombinant insulin-like growth factor 1 in a child with growth hormone insensitivity syndrome (Laron type)","volume":"121","author":"Walter","year":"1992","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.yapd.2017.03.004_bib59","first-page":"1393","article-title":"A\u00a0randomized double-blind, placebo-controlled trial of safety and efficacy of recombinant insulin-like growth factor-I in children with growth hormone receptor deficiency","volume":"80","author":"Guevara-Aguirre","year":"1995","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib60","first-page":"629","article-title":"Two-year treatment of GH receptor deficiency (GHRD) with recombinant insulin-like growth factor-I in 22 children: comparison of two dosage levels and to GH treated GH deficiency","volume":"82","author":"Guevara-Aguirre","year":"1997","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib61","first-page":"1504","article-title":"Therapy for 6.5-7.5 years with recombinant insulin-like growth factor 1 in children with growth hormone insensitivity syndrome: a clinical research center study","volume":"86","author":"Backeljauw","year":"2001","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.yapd.2017.03.004_bib62","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1210\/jc.2006-1610","article-title":"Long-term treatment with recombinant IGF-I in children with severe IGF-I deficiency due to growth hormone insensitivity","volume":"92","author":"Chernausek","year":"2007","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib63","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2165\/00063030-200923030-00002","article-title":"Insulin-like growth factor-I deficiency in children with growth hormone insensitivity: current and future treatment options","volume":"23","author":"Kemp","year":"2009","journal-title":"BioDrugs"},{"key":"10.1016\/j.yapd.2017.03.004_bib64","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1203\/PDR.0b013e31819d9e8c","article-title":"A\u00a0pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants","volume":"65","author":"L\u00f6fqvist","year":"2009","journal-title":"Pediatr Res"},{"key":"10.1016\/j.yapd.2017.03.004_bib65","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jpeds.2006.09.040","article-title":"Recombinant human insulin-like growth factor-I (rhIGF-I) and rhIGF-I\/rhIGF-I-binding-protein-3: new growth treatment options?","volume":"150","author":"Rosenbloom","year":"2007","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.yapd.2017.03.004_bib66","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.clinbiochem.2005.04.001","article-title":"Pitfalls of immunoassay and sample for IGF1: comparison assay methodologies using various fresh and stores serum samples","volume":"38","author":"Khosravi","year":"2005","journal-title":"Clin Biochem"},{"key":"10.1016\/j.yapd.2017.03.004_bib67","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1210\/jcem.87.6.8601","article-title":"Free and total insulin-like growth factor (IGF)-1 levels decline during fasting: relationships with insulin and IGF-binding protein-1","volume":"87","author":"Katz","year":"2002","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib68","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0022-3476(95)70302-0","article-title":"Evidence for partial growth hormone insensitivity among patients with idiopathic short stature. The National Cooperative Growth Study","volume":"127","author":"Attie","year":"1995","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.yapd.2017.03.004_bib69","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/S0022-3476(97)70012-X","article-title":"Partial growth-hormone insensitivity: the role of growth-hormone receptor mutations in idiopathic short stature","volume":"131","author":"Goddard","year":"1997","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.yapd.2017.03.004_bib70","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0140-6736(06)69205-2","article-title":"Is there a role for recombinant insulin-like growth factor-I (rhIGF-I) in the treatment of idiopathic short stature?","volume":"368","author":"Rosenbloom","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.yapd.2017.03.004_bib71","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s11154-008-9081-5","article-title":"Advantages and disadvantages of GH\/IGF-I combination treatment","volume":"10","author":"Janssen","year":"2009","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.yapd.2017.03.004_bib72","first-page":"1504","article-title":"Therapy for 6.5\u20137.5 years with recombinant insulin like growth factor I in children with growth hormone insensitivity syndrome: a clinical research center study","volume":"86","author":"Backeljauw","year":"2001","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.yapd.2017.03.004_bib73","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000371798","article-title":"Effectiveness and safety of rhIGF-1 therapy in children: the European Increlex\u00ae Growth Forum Database Experience","volume":"83","author":"Bang","year":"2015","journal-title":"Horm Res Paediatr"},{"issue":"4","key":"10.1016\/j.yapd.2017.03.004_bib74","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/adc.60.4.379","article-title":"Oxandrolone in low dose for constitutional delay of growth and puberty in boys","volume":"60","author":"Stanhope","year":"1985","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.yapd.2017.03.004_bib75","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1056\/NEJM198812153192402","article-title":"Testosterone treatment in adolescent boys with constitutional delay in growth and development","volume":"319","author":"Richman","year":"1988","journal-title":"N\u00a0Engl J Med"}],"container-title":["Advances in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S006531011730004X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S006531011730004X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T20:10:15Z","timestamp":1758744615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S006531011730004X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S006531011730004X"],"URL":"https:\/\/doi.org\/10.1016\/j.yapd.2017.03.004","relation":{},"ISSN":["0065-3101"],"issn-type":[{"value":"0065-3101","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alternatives in the Treatment of Short Stature","name":"articletitle","label":"Article Title"},{"value":"Advances in Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yapd.2017.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}