{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:14:39Z","timestamp":1784924079265,"version":"3.55.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,7,21]],"date-time":"2027-07-21T00:00:00Z","timestamp":1816128000000},"content-version":"am","delay-in-days":354,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL171915-01A1"],"award-info":[{"award-number":["R01HL171915-01A1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["CIRM\/DISC0-15654"],"award-info":[{"award-number":["CIRM\/DISC0-15654"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008453","name":"Ontario Institute for Regenerative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL155104"],"award-info":[{"award-number":["R01HL155104"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advancesinpediatrics.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Advances in Pediatrics"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.yapd.2025.12.004","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T20:24:00Z","timestamp":1769718240000},"page":"145-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Down Syndrome"],"prefix":"10.1016","volume":"73","author":[{"given":"Kinsa Thi","family":"Oo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najibe","family":"Abou-Antoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soula","family":"Danopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Al Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.yapd.2025.12.004_bib1","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/bdra.20735","article-title":"Updated National Birth Prevalence estimates for selected birth defects in the United States, 2004-2006","volume":"88","author":"Parker","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"issue":"9","key":"10.1016\/j.yapd.2025.12.004_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.gim.2025.101505","article-title":"Prenatal screening for trisomy 21 (Down syndrome) using first- and second-trimester biochemistry and nuchal translucency: a technical standard of the American College of Medical Genetics and Genomics (ACMG)","volume":"27","author":"Palomaki","year":"2025","journal-title":"Genet Med"},{"issue":"24","key":"10.1016\/j.yapd.2025.12.004_bib3","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1056\/NEJMra1706537","article-title":"Down Syndrome","volume":"382","author":"Bull","year":"2020","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.yapd.2025.12.004_bib4","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1016\/j.gim.2022.08.029","article-title":"Estimation of the number of people with Down syndrome in Australia and New Zealand","volume":"24","author":"de Graaf","year":"2022","journal-title":"Genet Med"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13858-3","article-title":"Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation","volume":"7","author":"Sullivan","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.yapd.2025.12.004_bib6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/dmcn.12868","article-title":"Morbidity and medication in a large population of individuals with Down syndrome compared to the general population","volume":"58","author":"Alexander","year":"2016","journal-title":"Dev Med Child Neurol"},{"issue":"19","key":"10.1016\/j.yapd.2025.12.004_bib7","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.036214","article-title":"Council on cardiovascular R, intervention. Trisomy 21 and congenital heart disease: impact on health and functional outcomes from birth through adolescence: a scientific statement from the American Heart Association","volume":"13","author":"Peterson","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.yapd.2025.12.004_bib8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.16220","article-title":"Trisomy 21 consistently activates the interferon response","volume":"5","author":"Sullivan","year":"2016","journal-title":"eLife"},{"issue":"5","key":"10.1016\/j.yapd.2025.12.004_bib9","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/CIRCULATIONAHA.122.059706","article-title":"Cardiovascular complications of Down syndrome: scoping review and expert consensus","volume":"147","author":"Dimopoulos","year":"2023","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yapd.2025.12.004_bib10","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031392","article-title":"Impact of Down syndrome on survival among patients with congenital heart disease","volume":"13","author":"Engsner","year":"2024","journal-title":"J Am Heart Assoc"},{"issue":"9","key":"10.1016\/j.yapd.2025.12.004_bib11","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1017\/S1047951125109347","article-title":"A change of heart: the evolution of care for children with Trisomy 21 and CHD","volume":"35","author":"Petrikas","year":"2025","journal-title":"Cardiol Young"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s40119-021-00251-5","article-title":"Pulmonary hypertension in the population with Down syndrome","volume":"11","author":"Bush","year":"2022","journal-title":"Cardiol Ther"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33549\/physiolres.934791","article-title":"Cardiovascular physiology and pathophysiology in Down syndrome","volume":"71","author":"Cilhoroz","year":"2022","journal-title":"Physiol Res"},{"issue":"6","key":"10.1016\/j.yapd.2025.12.004_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0326566","article-title":"Rare and novel variant load threshold for KIF7, GJA1 and PDE1C genes elevates the risk of severity of congenital heart defects in Down syndrome","volume":"20","author":"Ganguly","year":"2025","journal-title":"PLoS One"},{"issue":"731","key":"10.1016\/j.yapd.2025.12.004_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.add6883","article-title":"Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome","volume":"16","author":"Lana-Elola","year":"2024","journal-title":"Sci Transl Med"},{"issue":"8091","key":"10.1016\/j.yapd.2025.12.004_bib16","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/s41586-025-09593-9","article-title":"Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21","volume":"647","author":"Ranade","year":"2025","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.yapd.2025.12.004_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/ppul.71339","article-title":"Large airway and lung findings in symptomatic children and young adults with Down syndrome","volume":"60","author":"DeBoer","year":"2025","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.yapd.2025.12.004_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijporl.2020.109968","article-title":"Obstructive sleep apnea in children with Down syndrome - prevalence and evaluation of surgical treatment","volume":"133","author":"Nerfeldt","year":"2020","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12887-022-03111-w","article-title":"Effect of adenotonsillectomy on the growth, development, and comprehensive cognitive abilities of children with obstructive sleep apnea: a prospective single-arm study","volume":"22","author":"Shan","year":"2022","journal-title":"BMC Pediatr"},{"issue":"10","key":"10.1016\/j.yapd.2025.12.004_bib20","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.hlc.2010.07.005","article-title":"Endothelin receptor antagonists are an effective long term treatment option in pulmonary arterial hypertension associated with congenital heart disease with or without trisomy 21","volume":"19","author":"Kermeen","year":"2010","journal-title":"Heart Lung Circ"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/path.5735","article-title":"Prenatal histological, cellular, and molecular anomalies in trisomy 21 lung","volume":"255","author":"Danopoulos","year":"2021","journal-title":"J Pathol"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib22","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12969-021-00592-4","article-title":"Diffuse alveolar hemorrhage in children with trisomy 21","volume":"19","author":"Bloom","year":"2021","journal-title":"Pediatr Rheumatol Online J"},{"key":"10.1016\/j.yapd.2025.12.004_bib23","article-title":"The transcriptional landscape of developing human trisomy 21 lungs","author":"Bhattacharya","year":"2025","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"2","key":"10.1016\/j.yapd.2025.12.004_bib24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1165\/rcmb.2024-0361OC","article-title":"Elevated senescence markers in developing trisomy 21 human lungs","volume":"73","author":"Belgacemi","year":"2025","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s00383-022-05359-w","article-title":"Effect of trisomy 21 on long-term gastrointestinal outcomes in duodenal atresia","volume":"39","author":"Zrinyi","year":"2023","journal-title":"Pediatr Surg Int"},{"issue":"15","key":"10.1016\/j.yapd.2025.12.004_bib26","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1055\/s-0044-1786874","article-title":"Prevalence and outcomes of gastrointestinal anomalies in Down syndrome","volume":"41","author":"Elgendy","year":"2024","journal-title":"Am J Perinatol"},{"issue":"8","key":"10.1016\/j.yapd.2025.12.004_bib27","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/ajmg.a.61258","article-title":"Gastrointestinal disorders in Down syndrome","volume":"179","author":"Bermudez","year":"2019","journal-title":"Am J Med Genet"},{"issue":"9","key":"10.1016\/j.yapd.2025.12.004_bib28","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.jpedsurg.2018.11.013","article-title":"Down syndrome and postoperative complications in children undergoing intestinal operations","volume":"54","author":"Cairo","year":"2019","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.yapd.2025.12.004_bib29","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jss.2025.03.020","article-title":"Trisomy 21 children with duodenal atresia or anorectal malformation: NSQIP-P surgical outcomes study","volume":"310","author":"Gely","year":"2025","journal-title":"J Surg Res"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.arcped.2019.11.008","article-title":"Feeding problems and gastrointestinal diseases in Down syndrome","volume":"27","author":"Ravel","year":"2020","journal-title":"Arch Pediatr"},{"issue":"12","key":"10.1016\/j.yapd.2025.12.004_bib31","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1177\/0009922820941247","article-title":"Incidence of celiac disease in Down syndrome: a longitudinal, population-based birth cohort study","volume":"59","author":"Ostermaier","year":"2020","journal-title":"Clin Pediatr"},{"issue":"6","key":"10.1016\/j.yapd.2025.12.004_bib32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S2352-4642(19)30400-6","article-title":"Nutritional challenges in children and adolescents with Down syndrome","volume":"4","author":"Nordstrom","year":"2020","journal-title":"Lancet Child Adolesc Health"},{"issue":"9","key":"10.1016\/j.yapd.2025.12.004_bib33","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1249\/MSS.0000000000003739","article-title":"Exercise therapy in Down syndrome: a systematic review and meta-analysis focused on muscle strength, redox balance, and inflammatory profile","volume":"57","author":"DE Luca Corr\u00eaa","year":"2025","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"10.1016\/j.yapd.2025.12.004_bib34","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/MPG.0000000000003825","article-title":"The spectrum of duodenal histologic findings in patients with trisomy 21: a multicenter study","volume":"77","author":"Alexander","year":"2023","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"10.1016\/j.yapd.2025.12.004_bib35","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4274\/Jcrpe.884","article-title":"Profile of hypothyroidism in Down's syndrome","volume":"5","author":"Cebeci","year":"2013","journal-title":"J Clin Res Pediatr Endocrinol"},{"issue":"3","key":"10.1016\/j.yapd.2025.12.004_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/edm2.337","article-title":"Thyroid abnormalities in children with Down syndrome at St. Paul's hospital millennium medical college, Ethiopia","volume":"5","author":"Mulu","year":"2022","journal-title":"Endocrinol Diabetes Metab"},{"issue":"3","key":"10.1016\/j.yapd.2025.12.004_bib37","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/adc.79.3.242","article-title":"Thyroid dysfunction in Down's syndrome: relation to age and thyroid autoimmunity","volume":"79","author":"Karlsson","year":"1998","journal-title":"Arch Dis Child"},{"issue":"4","key":"10.1016\/j.yapd.2025.12.004_bib38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/pedi.13333","article-title":"Increased referrals for congenital hyperinsulinism genetic testing in children with trisomy 21 reflects the high burden of non-genetic risk factors in this group","volume":"23","author":"Hewat","year":"2022","journal-title":"Pediatr Diabetes"},{"issue":"6","key":"10.1016\/j.yapd.2025.12.004_bib39","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1007\/s00125-010-1686-z","article-title":"Down's syndrome in diabetic patients aged <20 years: an analysis of metabolic status, glycaemic control and autoimmunity in comparison with type 1 diabetes","volume":"53","author":"Rohrer","year":"2010","journal-title":"Diabetologia"},{"issue":"7","key":"10.1016\/j.yapd.2025.12.004_bib40","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.2337\/db19-0045","article-title":"Trisomy 21 is a cause of permanent neonatal diabetes that is autoimmune but not HLA associated","volume":"68","author":"Johnson","year":"2019","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.yapd.2025.12.004_bib41","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1111\/dom.16155","article-title":"Beta cell function and global glucose metabolism are impaired in Dp(16)1Yey mouse model of Down syndrome","volume":"27","author":"Tolu","year":"2025","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.yapd.2025.12.004_bib42","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2025.05.432","article-title":"Oxidative stress characterizes the dysfunction of thermogenic adipose tissue in a mouse model of Down syndrome","volume":"237","author":"Castelli","year":"2025","journal-title":"Free Radic Biol Med"},{"issue":"9","key":"10.1016\/j.yapd.2025.12.004_bib43","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/jir.12259","article-title":"Understanding the causes of obesity in children with trisomy 21: hyperphagia vs physical inactivity","volume":"60","author":"Foerste","year":"2016","journal-title":"J Intellect Disabil Res"},{"issue":"13","key":"10.1016\/j.yapd.2025.12.004_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111883","article-title":"IGF1 deficiency integrates stunted growth and neurodegeneration in Down syndrome","volume":"41","author":"Araya","year":"2022","journal-title":"Cell Rep"},{"issue":"5","key":"10.1016\/j.yapd.2025.12.004_bib45","doi-asserted-by":"crossref","first-page":"e1204","DOI":"10.1542\/peds.2015-1652","article-title":"Growth charts for children with Down syndrome in the United States","volume":"136","author":"Zemel","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.yapd.2025.12.004_bib46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2017.07.026","article-title":"Neurogenesis impairment: an early developmental defect in Down syndrome","volume":"114","author":"Stagni","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.yapd.2025.12.004_bib47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.freeradbiomed.2017.10.002","article-title":"GABAergic over-inhibition, a promising hypothesis for cognitive deficits in Down syndrome","volume":"114","author":"Zorrilla de San Martin","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.yapd.2025.12.004_bib48","article-title":"Accelerated tempo of cortical neurogenesis in Down syndrome","author":"Ding","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.yapd.2025.12.004_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2025.121489","article-title":"Early white matter microstructure alterations in infants with Down syndrome","volume":"321","author":"Azrak","year":"2025","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.yapd.2025.12.004_bib50","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/mp.2016.253","article-title":"Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development","volume":"23","author":"Dang","year":"2018","journal-title":"Mol Psychiatry"},{"issue":"13","key":"10.1016\/j.yapd.2025.12.004_bib51","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1093\/hmg\/dds134","article-title":"Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory","volume":"21","author":"Martin","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"2\u20133","key":"10.1016\/j.yapd.2025.12.004_bib52","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0022-510X(89)90019-1","article-title":"The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome","volume":"89","author":"Mann","year":"1989","journal-title":"J Neurol Sci"},{"issue":"2","key":"10.1016\/j.yapd.2025.12.004_bib53","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0047-6374(88)90041-3","article-title":"The pathological association between Down syndrome and Alzheimer disease","volume":"43","author":"Mann","year":"1988","journal-title":"Mech Ageing Dev"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib54","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41698-024-00614-w","article-title":"Targeting the DYRK1A kinase prevents cancer progression and metastasis and promotes cancer cells response to G1\/S targeting chemotherapy drugs","volume":"8","author":"Laham","year":"2024","journal-title":"npj Precis Oncol"},{"issue":"20","key":"10.1016\/j.yapd.2025.12.004_bib55","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1001\/jama.280.20.1777","article-title":"Cholinesterase inhibition for Alzheimer disease: a meta-analysis of the tacrine trials. Dementia Trialists' Collaboration","volume":"280","author":"Qizilbash","year":"1998","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.yapd.2025.12.004_bib56","doi-asserted-by":"crossref","first-page":"75","DOI":"10.18773\/austprescr.2024.021","article-title":"New and emerging drug therapies for Alzheimer disease","volume":"47","author":"Waite","year":"2024","journal-title":"Aust Prescr"},{"key":"10.1016\/j.yapd.2025.12.004_bib57","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2024.1416736","article-title":"Case report: down syndrome regression disorder, catatonia, and psychiatric and immunomodulatory interventions","volume":"15","author":"Connors","year":"2024","journal-title":"Front Psychiatry"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib58","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41398-023-02579-z","article-title":"Immunotherapy responsiveness and risk of relapse in Down syndrome regression disorder","volume":"13","author":"Santoro","year":"2023","journal-title":"Transl Psychiatry"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib59","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s11689-022-09446-w","article-title":"Evidence of neuroinflammation and immunotherapy responsiveness in individuals with Down syndrome regression disorder","volume":"14","author":"Santoro","year":"2022","journal-title":"J Neurodev Disord"},{"issue":"2","key":"10.1016\/j.yapd.2025.12.004_bib60","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.braindev.2003.12.010","article-title":"Multi-institutional study on the correlation between chromosomal abnormalities and epilepsy","volume":"27","author":"Kumada","year":"2005","journal-title":"Brain Dev"},{"issue":"9199","key":"10.1016\/j.yapd.2025.12.004_bib61","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0140-6736(99)05264-2","article-title":"Risks of leukaemia and solid tumours in individuals with Down's syndrome","volume":"355","author":"Hasle","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.yapd.2025.12.004_bib62","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jpeds.2021.03.001","article-title":"Leukemia risk in a cohort of 3.9 million children with and without Down syndrome","volume":"234","author":"Marlow","year":"2021","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.yapd.2025.12.004_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2019.06.007","article-title":"Mechanisms of progression of myeloid preleukemia to transformed myeloid leukemia in children with Down syndrome","volume":"36","author":"Labuhn","year":"2019","journal-title":"Cancer Cell"},{"issue":"20","key":"10.1016\/j.yapd.2025.12.004_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015325","article-title":"Hematologic neoplasms associated with Down syndrome: cellular and molecular heterogeneity of the diseases","volume":"24","author":"Peroni","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.yapd.2025.12.004_bib65","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.99323","article-title":"JAK inhibition decreases the autoimmune burden in Down syndrome","volume":"13","author":"Rachubinski","year":"2024","journal-title":"eLife"},{"issue":"5","key":"10.1016\/j.yapd.2025.12.004_bib66","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1136\/archdischild-2018-315751","article-title":"Musculoskeletal anomalies in children with Down syndrome: an observational study","volume":"104","author":"Foley","year":"2019","journal-title":"Arch Dis Child"},{"issue":"6","key":"10.1016\/j.yapd.2025.12.004_bib67","doi-asserted-by":"crossref","first-page":"e453","DOI":"10.1016\/S2468-2667(23)00057-9","article-title":"Multiple morbidity across the lifespan in people with Down syndrome or intellectual disabilities: a population-based cohort study using electronic health records","volume":"8","author":"Baksh","year":"2023","journal-title":"Lancet Public Health"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib68","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1186\/s13018-025-06105-3","article-title":"Surgical management strategies for atlantoaxial instability\/dislocation in Down syndrome","volume":"20","author":"Gao","year":"2025","journal-title":"J Orthop Surg Res"},{"issue":"10","key":"10.1016\/j.yapd.2025.12.004_bib69","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1002\/ajmg.a.62403","article-title":"Health care transition for individuals with Down syndrome: a needs assessment","volume":"185","author":"VanZant","year":"2021","journal-title":"Am J Med Genet"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib70","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13195-025-01778-8","article-title":"Plasma biomarkers for early detection of Alzheimer'S disease: a cross-sectional study in a Japanese cohort","volume":"17","author":"Kubota","year":"2025","journal-title":"Alzheimers Res Ther"},{"issue":"5","key":"10.1016\/j.yapd.2025.12.004_bib71","doi-asserted-by":"crossref","first-page":"e395","DOI":"10.1212\/WNL.0000000000006852","article-title":"Brain myoinositol as a potential marker of amyloid-related pathology: a longitudinal study","volume":"92","author":"Voevodskaya","year":"2019","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.yapd.2025.12.004_bib72","doi-asserted-by":"crossref","DOI":"10.52225\/nrj.v5i1.1244","article-title":"BMPR-II, caspase-3, HIF-1alpha, and VE-cadherin profile in Down syndrome children with and without congenital heart disease and pulmonary hypertension","volume":"5","author":"Widjaja","year":"2025","journal-title":"Narra J"},{"issue":"2","key":"10.1016\/j.yapd.2025.12.004_bib73","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgaf022","article-title":"Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells","volume":"4","author":"Hashizume","year":"2025","journal-title":"PNAS Nexus"}],"container-title":["Advances in Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065310125000349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065310125000349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:44:14Z","timestamp":1784922254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065310125000349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0065310125000349"],"URL":"https:\/\/doi.org\/10.1016\/j.yapd.2025.12.004","relation":{},"ISSN":["0065-3101"],"issn-type":[{"value":"0065-3101","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in Down Syndrome","name":"articletitle","label":"Article Title"},{"value":"Advances in Pediatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yapd.2025.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}