{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:54:50Z","timestamp":1777593290092,"version":"3.51.4"},"reference-count":79,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Surgery"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.yasu.2012.03.001","type":"journal-article","created":{"date-parts":[[2012,6,7]],"date-time":"2012-06-07T06:00:42Z","timestamp":1339048842000},"page":"73-85","source":"Crossref","is-referenced-by-count":18,"title":["Hypertonic Resuscitation After Severe Injury"],"prefix":"10.1016","volume":"46","author":[{"given":"Eileen M.","family":"Bulger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Hoyt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib1","first-page":"50","article-title":"Hypertonic saline resuscitation of patients with head injury: a prospective, randomized clinical trial","volume":"44","author":"Shackford","year":"1998","journal-title":"J\u00a0Trauma"},{"issue":"2","key":"10.1016\/j.yasu.2012.03.001_bib2","first-page":"277","article-title":"The use of 23.4% hypertonic saline for the management of elevated intracranial pressure in patients with severe traumatic brain injury: a pilot study","volume":"67","author":"Kerwin","year":"2009","journal-title":"J\u00a0Trauma"},{"issue":"Suppl 5","key":"10.1016\/j.yasu.2012.03.001_bib3","first-page":"S89","article-title":"Hypertonic resuscitation: physiologic mechanisms and recommendations for trauma care","volume":"54","author":"Kramer","year":"2003","journal-title":"J\u00a0Trauma"},{"issue":"3","key":"10.1016\/j.yasu.2012.03.001_bib4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00003246-198903000-00012","article-title":"Hypertonic and hyperoncotic resuscitation from severe hemorrhagic shock in dogs: a comparative study","volume":"17","author":"Velasco","year":"1989","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.yasu.2012.03.001_bib5","first-page":"321","article-title":"Issues of concern regarding the use of hypertonic\/hyperoncotic fluid resuscitation of hemorrhagic hypotension","volume":"25","author":"Dubick","year":"2006","journal-title":"Shock"},{"issue":"9","key":"10.1016\/j.yasu.2012.03.001_bib6","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0196-0644(05)80648-1","article-title":"Use of hypertonic saline\/dextran versus lactated Ringer's solution as a resuscitation fluid after uncontrolled aortic hemorrhage in anesthetized swine","volume":"21","author":"Bickell","year":"1992","journal-title":"Ann Emerg Med"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/01.shk.0000168872.37660.d2","article-title":"Benefit of slow infusion of hypertonic saline\/dextran in swine with uncontrolled aortotomy hemorrhage","volume":"24","author":"Bruttig","year":"2005","journal-title":"Shock"},{"issue":"5","key":"10.1016\/j.yasu.2012.03.001_bib8","first-page":"956","article-title":"Limited resuscitation with hypertonic saline, hypertonic sodium acetate, and lactated Ringer's solutions in a model of uncontrolled hemorrhage from a vascular injury","volume":"47","author":"Doucet","year":"1999","journal-title":"J\u00a0Trauma"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00024382-199601000-00011","article-title":"Low-dose hypertonic saline (NaCl 8.0%) treatment of uncontrolled abdominal hemorrhage: effects on arterial versus venous injury","volume":"5","author":"Elgjo","year":"1996","journal-title":"Shock"},{"issue":"6","key":"10.1016\/j.yasu.2012.03.001_bib10","first-page":"751","article-title":"Is hypertonic saline resuscitation safe in \u2018uncontrolled\u2019 hemorrhagic shock?","volume":"28","author":"Gross","year":"1988","journal-title":"J\u00a0Trauma"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.resuscitation.2004.10.012","article-title":"Titrated hypertonic\/hyperoncotic solution for hypotensive fluid resuscitation during uncontrolled hemorrhagic shock in rats","volume":"65","author":"Kentner","year":"2005","journal-title":"Resuscitation"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/archsurg.1992.01420010107017","article-title":"Hypertonic saline treatment of uncontrolled hemorrhagic shock at different periods from bleeding","volume":"127","author":"Krausz","year":"1992","journal-title":"Arch Surg"},{"issue":"4","key":"10.1016\/j.yasu.2012.03.001_bib13","first-page":"674","article-title":"Liver injury as a model of uncontrolled hemorrhagic shock: resuscitation with different hypertonic regimens","volume":"39","author":"Matsuoka","year":"1995","journal-title":"J\u00a0Trauma"},{"issue":"5","key":"10.1016\/j.yasu.2012.03.001_bib14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00024382-200205000-00006","article-title":"Lower dose of hypertonic saline dextran reduces the risk of lethal rebleeding in uncontrolled hemorrhage","volume":"17","author":"Riddez","year":"2002","journal-title":"Shock"},{"issue":"8","key":"10.1016\/j.yasu.2012.03.001_bib15","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/j.1553-2712.2000.tb02060.x","article-title":"Resuscitation of severe uncontrolled hemorrhage: 7.5% sodium chloride\/6% dextran 70 vs 0.9% sodium chloride","volume":"7","author":"Stern","year":"2000","journal-title":"Acad Emerg Med"},{"issue":"6","key":"10.1016\/j.yasu.2012.03.001_bib16","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00024382-200014060-00008","article-title":"Comparison of the effects of bolus vs. slow infusion of 7.5% NaCl\/6% dextran-70 in a model of near-lethal uncontrolled hemorrhage","volume":"14","author":"Stern","year":"2000","journal-title":"Shock"},{"issue":"3","key":"10.1016\/j.yasu.2012.03.001_bib17","first-page":"187","article-title":"Comparative effects of crystalloid and small volume hypertonic hyperoncotic fluid resuscitation on hepatic microcirculation after hemorrhagic shock","volume":"40","author":"Bauer","year":"1993","journal-title":"Circ Shock"},{"issue":"Suppl 5","key":"10.1016\/j.yasu.2012.03.001_bib18","first-page":"S41","article-title":"Hypertonic\/hyperoncotic saline attenuates microcirculatory disturbances after traumatic brain injury","volume":"42","author":"Hartl","year":"1997","journal-title":"J\u00a0Trauma"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib19","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1302\/0301-620X.85B1.11870","article-title":"Small volume hypertonic hydroxyethyl starch reduces acute microvascular dysfunction after closed soft-tissue trauma","volume":"85","author":"Mittlmeier","year":"2003","journal-title":"J\u00a0Bone Joint Surg Br"},{"issue":"Suppl 5","key":"10.1016\/j.yasu.2012.03.001_bib20","first-page":"S133","article-title":"Hypertonic saline and the microcirculation","volume":"54","author":"Pascual","year":"2003","journal-title":"J\u00a0Trauma"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0300-9572(93)90005-B","article-title":"The effect of the type of colloid on the efficacy of hypertonic saline colloid mixtures in hemorrhagic shock: dextran versus hydroxyethyl starch","volume":"25","author":"Strecker","year":"1993","journal-title":"Resuscitation"},{"issue":"2","key":"10.1016\/j.yasu.2012.03.001_bib22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00024382-200302000-00016","article-title":"Dextran modulates microvascular permeability: effect in isotonic and hypertonic solutions","volume":"19","author":"Victorino","year":"2003","journal-title":"Shock"},{"issue":"4","key":"10.1016\/j.yasu.2012.03.001_bib23","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.surg.2006.05.015","article-title":"Hypertonic saline resuscitation improves intestinal microcirculation in a rat model of hemorrhagic shock","volume":"140","author":"Zakaria el","year":"2006","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.yasu.2012.03.001_bib24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.resuscitation.2008.10.014","article-title":"Effects of different resuscitation fluids on the rheologic behavior of red blood cells, blood viscosity and plasma viscosity in experimental hemorrhagic shock","volume":"80","author":"Zhao","year":"2009","journal-title":"Resuscitation"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1165\/ajrcmb.10.1.8292373","article-title":"Neutrophils increase volume during migration in\u00a0vivo and in\u00a0vitro","volume":"10","author":"Worthen","year":"1994","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"10.1016\/j.yasu.2012.03.001_bib26","doi-asserted-by":"crossref","first-page":"C619","DOI":"10.1152\/ajpcell.2000.279.3.C619","article-title":"Hypertonic inhibition of exocytosis in neutrophils: central role for osmotic actin skeleton remodeling","volume":"279","author":"Rizoli","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6 Pt 1","key":"10.1016\/j.yasu.2012.03.001_bib27","doi-asserted-by":"crossref","first-page":"C1623","DOI":"10.1152\/ajpcell.1994.267.6.C1623","article-title":"Migration-associated volume changes in neutrophils facilitate the migratory process in\u00a0vitro","volume":"267","author":"Rosengren","year":"1994","journal-title":"Am J Physiol"},{"issue":"4","key":"10.1016\/j.yasu.2012.03.001_bib28","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1093\/infdis\/169.4.839","article-title":"Bacterial killing by neutrophils in hypertonic environments","volume":"169","author":"Hampton","year":"1994","journal-title":"J\u00a0Infect Dis"},{"issue":"12","key":"10.1016\/j.yasu.2012.03.001_bib29","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1172\/JCI1354","article-title":"Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signaling and activating mitogen-activated protein kinase p38","volume":"101","author":"Junger","year":"1998","journal-title":"J\u00a0Clin Invest"},{"issue":"3","key":"10.1016\/j.yasu.2012.03.001_bib30","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/00024382-199803000-00002","article-title":"Hypertonic saline resuscitation diminishes lung injury by suppressing neutrophil activation after hemorrhagic shock","volume":"9","author":"Angle","year":"1998","journal-title":"Shock"},{"issue":"11","key":"10.1016\/j.yasu.2012.03.001_bib31","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.4049\/jimmunol.161.11.6288","article-title":"Immunomodulatory effects of hypertonic resuscitation on the development of lung inflammation following hemorrhagic shock","volume":"161","author":"Rizoli","year":"1998","journal-title":"J\u00a0Immunol"},{"issue":"2","key":"10.1016\/j.yasu.2012.03.001_bib32","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1189\/jlb.70.2.261","article-title":"Effects of hypertonic saline on expression of human\u00a0polymorphonuclear leukocyte adhesion molecules","volume":"70","author":"Thiel","year":"2001","journal-title":"J\u00a0Leukoc Biol"},{"issue":"2","key":"10.1016\/j.yasu.2012.03.001_bib33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/jsre.1999.5581","article-title":"Hypertonic immunomodulation is reversible and accompanied by changes in CD11b expression","volume":"83","author":"Rizoli","year":"1999","journal-title":"J\u00a0Surg Res"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00024382-200014010-00004","article-title":"Does the timing of hypertonic saline resuscitation affect its potential to prevent lung damage?","volume":"14","author":"Murao","year":"2000","journal-title":"Shock"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/01.sla.0000193608.93127.b1","article-title":"The immunomodulatory effects of hypertonic saline resuscitation in patients sustaining traumatic hemorrhagic shock: a randomized, controlled, double-blinded trial","volume":"243","author":"Rizoli","year":"2006","journal-title":"Ann Surg"},{"issue":"4","key":"10.1016\/j.yasu.2012.03.001_bib36","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/01.sla.0000251367.44890.ae","article-title":"Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock","volume":"245","author":"Bulger","year":"2006","journal-title":"Ann Surg"},{"issue":"5","key":"10.1016\/j.yasu.2012.03.001_bib37","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/SHK.0b013e318231ee2e","article-title":"Increased neutrophil adenosine A3 receptor expression is associated with hemorrhagic shock and injury severity in trauma patients","volume":"36","author":"Bulger","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.yasu.2012.03.001_bib38","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.4049\/jimmunol.168.3.1389","article-title":"Hypertonic preconditioning inhibits macrophage responsiveness to endotoxin","volume":"168","author":"Cuschieri","year":"2002","journal-title":"J\u00a0Immunol"},{"issue":"4","key":"10.1016\/j.yasu.2012.03.001_bib39","first-page":"190","article-title":"Hypertonic saline enhances cellular immune function","volume":"42","author":"Junger","year":"1994","journal-title":"Circ Shock"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00024382-199507000-00007","article-title":"Hypertonic\/hyperoncotic fluids reverse prostaglandin E2 (PGE2)-induced T-cell suppression","volume":"4","author":"Coimbra","year":"1995","journal-title":"Shock"},{"issue":"2","key":"10.1016\/j.yasu.2012.03.001_bib41","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/jsre.1996.0329","article-title":"Hypertonic saline resuscitation restores hemorrhage-induced immunosuppression by decreasing prostaglandin E2 and interleukin-4 production","volume":"64","author":"Coimbra","year":"1996","journal-title":"J\u00a0Surg Res"},{"issue":"4","key":"10.1016\/j.yasu.2012.03.001_bib42","first-page":"602","article-title":"Hypertonic saline resuscitation decreases susceptibility to sepsis after hemorrhagic shock","volume":"42","author":"Coimbra","year":"1997","journal-title":"J\u00a0Trauma"},{"issue":"3","key":"10.1016\/j.yasu.2012.03.001_bib43","doi-asserted-by":"crossref","first-page":"C840","DOI":"10.1152\/ajpcell.2001.281.3.C840","article-title":"Hypertonicity rescues T cells from suppression by trauma-induced anti- inflammatory mediators","volume":"281","author":"Loomis","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"10.1016\/j.yasu.2012.03.001_bib44","first-page":"367","article-title":"The use of hypertonic saline in the treatment of traumatic brain injury","volume":"50","author":"Doyle","year":"2001","journal-title":"J\u00a0Trauma"},{"issue":"6","key":"10.1016\/j.yasu.2012.03.001_bib45","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3171\/jns.1995.83.6.0949","article-title":"Cerebral perfusion pressure: management protocol and clinical results","volume":"83","author":"Rosner","year":"1995","journal-title":"J\u00a0Neurosurg"},{"issue":"7","key":"10.1016\/j.yasu.2012.03.001_bib46","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1097\/00003246-199607000-00027","article-title":"Cerebral effects of resuscitation with hypertonic saline and a new low- sodium hypertonic fluid in hemorrhagic shock and head injury","volume":"24","author":"Sheikh","year":"1996","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.yasu.2012.03.001_bib47","first-page":"182","article-title":"Combined hemorrhagic shock and head injury: effects of hypertonic saline (7.5%) resuscitation","volume":"31","author":"Battistella","year":"1991","journal-title":"J\u00a0Trauma"},{"key":"10.1016\/j.yasu.2012.03.001_bib48","first-page":"494","article-title":"7.2% NaCl\/10% dextran 60 versus 20% mannitol for treatment of intracranial hypertension","volume":"60","author":"Berger","year":"1994","journal-title":"Acta Neurochir Suppl"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib49","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1227\/00006123-199507000-00015","article-title":"Reduction of post-traumatic intracranial hypertension by hypertonic\/hyperoncotic saline\/dextran and hypertonic mannitol","volume":"37","author":"Berger","year":"1995","journal-title":"Neurosurgery"},{"issue":"11","key":"10.1016\/j.yasu.2012.03.001_bib50","first-page":"1510","article-title":"A\u00a0comparison of the cerebral and cardiovascular effects of complete resuscitation with isotonic and hypertonic saline, hetastarch, and whole blood following hemorrhage","volume":"29","author":"Ducey","year":"1989","journal-title":"J\u00a0Trauma"},{"issue":"5","key":"10.1016\/j.yasu.2012.03.001_bib51","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00003246-198505000-00008","article-title":"Effects on intracranial pressure of resuscitation from hemorrhagic shock with hypertonic saline versus lactated Ringer's solution","volume":"13","author":"Prough","year":"1985","journal-title":"Crit Care Med"},{"issue":"4","key":"10.1016\/j.yasu.2012.03.001_bib52","first-page":"484","article-title":"Effect of a hypertonic lactated Ringer's solution on intracranial pressure and cerebral water content in a model of traumatic brain injury","volume":"29","author":"Zornow","year":"1989","journal-title":"J\u00a0Trauma"},{"issue":"3","key":"10.1016\/j.yasu.2012.03.001_bib53","first-page":"344","article-title":"Hypertonic saline (7.5%) versus mannitol: a comparison for treatment of acute head injuries","volume":"35","author":"Freshman","year":"1993","journal-title":"J\u00a0Trauma"},{"issue":"9","key":"10.1016\/j.yasu.2012.03.001_bib54","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1097\/00003246-200009000-00032","article-title":"Use of hypertonic saline solutions in treatment of cerebral edema and intracranial hypertension","volume":"28","author":"Qureshi","year":"2000","journal-title":"Crit Care Med"},{"issue":"7","key":"10.1016\/j.yasu.2012.03.001_bib55","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/00003246-199807000-00032","article-title":"A\u00a0prospective, randomized, and controlled study of fluid management in children with severe head injury: lactated Ringer's solution versus hypertonic saline","volume":"26","author":"Simma","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1016\/j.yasu.2012.03.001_bib56","first-page":"31","article-title":"Treatment of elevated intracranial pressure by infusions of 10% saline in severely head injured patients","volume":"71","author":"Schatzmann","year":"1998","journal-title":"Acta Neurochir Suppl"},{"issue":"3","key":"10.1016\/j.yasu.2012.03.001_bib57","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/00003246-199803000-00011","article-title":"Use of hypertonic (3%) saline\/acetate infusion in the treatment of cerebral edema: effect on intracranial pressure and lateral displacement of the brain","volume":"26","author":"Qureshi","year":"1998","journal-title":"Crit Care Med"},{"issue":"1","key":"10.1016\/j.yasu.2012.03.001_bib58","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0090-3019(91)90197-H","article-title":"Cerebrospinal fluid endothelin-1 and endothelin-3 levels in normal and neurosurgical patients: a clinical study and literature review","volume":"35","author":"Kraus","year":"1991","journal-title":"Surg Neurol"},{"issue":"1 Pt 2","key":"10.1016\/j.yasu.2012.03.001_bib59","first-page":"H323","article-title":"Sodium hyperosmolarity of intestinal lymph causes arteriolar vasodilation in part mediated by EDRF","volume":"265","author":"Steenbergen","year":"1993","journal-title":"Am J Physiol"},{"issue":"9","key":"10.1016\/j.yasu.2012.03.001_bib60","first-page":"1203","article-title":"Human glial cell production of lipoxygenase-generated eicosanoids: a potential role in the pathophysiology of vascular changes following traumatic brain injury","volume":"29","author":"Hariri","year":"1989","journal-title":"J\u00a0Trauma"},{"issue":"1\u20132","key":"10.1016\/j.yasu.2012.03.001_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(99)01235-4","article-title":"Effects of hyperosmolarity and ion substitutions on amino acid efflux from the ischemic rat cerebral cortex","volume":"828","author":"Phillis","year":"1999","journal-title":"Brain Res"},{"issue":"8","key":"10.1016\/j.yasu.2012.03.001_bib62","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1089\/neu.2008.0868","article-title":"Resuscitation with hypertonic saline-dextran reduces serum biomarker levels and correlates with outcome in severe traumatic brain injury patients","volume":"26","author":"Baker","year":"2009","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.yasu.2012.03.001_bib63","first-page":"331","article-title":"Use of a 7.5% NaCl\/6% dextran 70 solution in the resuscitation of injured patients in the emergency room","volume":"299","author":"Holcroft","year":"1989","journal-title":"Prog Clin Biol Res"},{"issue":"3","key":"10.1016\/j.yasu.2012.03.001_bib64","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00000658-198709000-00006","article-title":"3% NaCl and 7.5% NaCl\/dextran 70 in the resuscitation of severely injured patients","volume":"206","author":"Holcroft","year":"1987","journal-title":"Ann Surg"},{"issue":"5","key":"10.1016\/j.yasu.2012.03.001_bib65","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/00000658-199105000-00014","article-title":"Prehospital hypertonic saline\/dextran infusion for post-traumatic hypotension. The U.S.A. Multicenter Trial","volume":"213","author":"Mattox","year":"1991","journal-title":"Ann Surg"},{"issue":"9","key":"10.1016\/j.yasu.2012.03.001_bib66","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1001\/archsurg.1993.01420210067009","article-title":"A\u00a0multicenter trial for resuscitation of injured patients with 7.5% sodium chloride. The effect of added dextran 70. The Multicenter Group for the Study of Hypertonic Saline in Trauma Patients","volume":"128","author":"Vassar","year":"1993","journal-title":"Arch Surg"},{"issue":"9","key":"10.1016\/j.yasu.2012.03.001_bib67","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1001\/archsurg.1991.01410330019002","article-title":"7.5% sodium chloride\/dextran for resuscitation of trauma patients undergoing helicopter transport","volume":"126","author":"Vassar","year":"1991","journal-title":"Arch Surg"},{"issue":"5","key":"10.1016\/j.yasu.2012.03.001_bib68","first-page":"622","article-title":"Prehospital resuscitation of hypotensive trauma patients with 7.5% NaCl versus 7.5% NaCl with added dextran: a controlled trial","volume":"34","author":"Vassar","year":"1993","journal-title":"J\u00a0Trauma"},{"issue":"4","key":"10.1016\/j.yasu.2012.03.001_bib69","first-page":"380","article-title":"Hypertonic solutions in the treatment of hypovolemic shock: a prospective, randomized study in patients admitted to the emergency room","volume":"111","author":"Younes","year":"1992","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.yasu.2012.03.001_bib70","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00024382-199702000-00001","article-title":"Prognostic factors to predict outcome following the administration of hypertonic\/hyperoncotic solution in hypovolemic patients","volume":"7","author":"Younes","year":"1997","journal-title":"Shock"},{"key":"10.1016\/j.yasu.2012.03.001_bib71","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1399-6576.1997.tb05509.x","article-title":"Efficacy of hypertonic saline dextran (HSD) in patients with traumatic hypotension: meta-analysis of individual patient data","volume":"110","author":"Wade","year":"1997","journal-title":"Acta Anaesthesiol Scand Suppl"},{"issue":"Suppl 5","key":"10.1016\/j.yasu.2012.03.001_bib72","first-page":"S61","article-title":"Individual patient cohort analysis of the efficacy of hypertonic saline\/dextran in patients with traumatic brain injury and hypotension","volume":"42","author":"Wade","year":"1997","journal-title":"J\u00a0Trauma"},{"issue":"3","key":"10.1016\/j.yasu.2012.03.001_bib73","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0039-6060(97)90135-5","article-title":"Efficacy of hypertonic 7.5% saline and 6% dextran-70 in treating trauma: a meta-analysis of controlled clinical studies","volume":"122","author":"Wade","year":"1997","journal-title":"Surgery"},{"issue":"11","key":"10.1016\/j.yasu.2012.03.001_bib74","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1001\/jama.291.11.1350","article-title":"Prehospital hypertonic saline resuscitation of patients with hypotension and severe traumatic brain injury: a randomized controlled trial","volume":"291","author":"Cooper","year":"2004","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.yasu.2012.03.001_bib75","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jcrc.2010.08.021","article-title":"The Toronto prehospital hypertonic resuscitation\u2013head injury and multiorgan dysfunction trial: feasibility study of a randomized controlled trial","volume":"26","author":"Morrison","year":"2011","journal-title":"J\u00a0Crit Care"},{"key":"10.1016\/j.yasu.2012.03.001_bib76","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1001\/archsurg.2007.41","article-title":"Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial","volume":"143","author":"Bulger","year":"2008","journal-title":"Arch Surg"},{"key":"10.1016\/j.yasu.2012.03.001_bib77","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/SLA.0b013e3181fcdb22","article-title":"Prehospital hypertonic resuscitation following traumatic hypovolemic shock: a randomized, placebo controlled trial","volume":"23","author":"Bulger","year":"2011","journal-title":"Ann Surg"},{"issue":"13","key":"10.1016\/j.yasu.2012.03.001_bib78","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/jama.2010.1405","article-title":"Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial","volume":"304","author":"Bulger","year":"2010","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.yasu.2012.03.001_bib79","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jamcollsurg.2007.07.020","article-title":"Hypertonic resuscitation: design and implementation of a prehospital intervention trial","volume":"206","author":"Brasel","year":"2008","journal-title":"J\u00a0Am Coll Surg"}],"container-title":["Advances in Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065341112000024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065341112000024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T05:44:21Z","timestamp":1687499061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065341112000024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0065341112000024"],"URL":"https:\/\/doi.org\/10.1016\/j.yasu.2012.03.001","relation":{},"ISSN":["0065-3411"],"issn-type":[{"value":"0065-3411","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}