{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:48:43Z","timestamp":1792802923420,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Nutrition Experimental"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.yclnex.2017.04.001","type":"journal-article","created":{"date-parts":[[2017,4,8]],"date-time":"2017-04-08T16:33:03Z","timestamp":1491669183000},"page":"1-11","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Arctigenin inhibits prostate tumor cell growth in\u00a0vitro and in\u00a0vivo"],"prefix":"10.1016","volume":"13","author":[{"given":"Piwen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Solorzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara E.","family":"Magyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne M.","family":"Henning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaydutt V.","family":"Vadgama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yclnex.2017.04.001_bib1","series-title":"Cancer facts & figures 2017","author":"American Cancer Society","year":"2017"},{"key":"10.1016\/j.yclnex.2017.04.001_bib2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/978-3-540-40901-4_4","article-title":"The prevention of prostate cancer","volume":"175","author":"Griffiths","year":"2007","journal-title":"Recent Results Cancer Res"},{"issue":"1","key":"10.1016\/j.yclnex.2017.04.001_bib3","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S1470-2045(00)00005-X","article-title":"Prostate cancer: to screen or not to screen?","volume":"1","author":"Neal","year":"2000","journal-title":"Lancet Oncol"},{"issue":"4","key":"10.1016\/j.yclnex.2017.04.001_bib4","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.canep.2013.03.014","article-title":"Life expectancy estimates as a key factor in over-treatment: the case of prostate cancer","volume":"37","author":"Delpierre","year":"2013","journal-title":"Cancer Epidemiol"},{"issue":"23","key":"10.1016\/j.yclnex.2017.04.001_bib5","doi-asserted-by":"publisher","first-page":"8715","DOI":"10.1158\/0008-5472.CAN-04-2840","article-title":"Oral consumption of green tea polyphenols inhibits insulin-like growth factor-I-induced signaling in an autochthonous mouse model of prostate cancer","volume":"64","author":"Adhami","year":"2004","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.yclnex.2017.04.001_bib6","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/mnfr.201000648","article-title":"Chemopreventive effects of tea in prostate cancer: green tea versus black tea","volume":"55","author":"Henning","year":"2011","journal-title":"Mol Nutr Food Res"},{"issue":"7","key":"10.1016\/j.yclnex.2017.04.001_bib7","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1080\/01635581.2010.509536","article-title":"Green tea and cancer prevention","volume":"62","author":"Yang","year":"2010","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.yclnex.2017.04.001_bib8","doi-asserted-by":"publisher","first-page":"632959","DOI":"10.1155\/2012\/632959","article-title":"Polyphenols: key issues involved in chemoprevention of prostate cancer","volume":"2012","author":"Cimino","year":"2012","journal-title":"Oxidative Med Cell Longev"},{"issue":"4","key":"10.1016\/j.yclnex.2017.04.001_bib9","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1007\/s10753-015-0115-3","article-title":"Arctigenin protects against lipopolysaccharide-induced pulmonary oxidative stress and inflammation in a mouse model via suppression of MAPK, HO-1, and iNOS signaling","volume":"38","author":"Zhang","year":"2015","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.yclnex.2017.04.001_bib10","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.intimp.2014.09.026","article-title":"Arctigenin but not arctiin acts as the major effective constituent of Arctium lappa L. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice","volume":"23","author":"Wu","year":"2014","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"10.1016\/j.yclnex.2017.04.001_bib11","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1055\/s-0031-1298433","article-title":"Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS","volume":"78","author":"He","year":"2012","journal-title":"Planta Medica"},{"issue":"3","key":"10.1016\/j.yclnex.2017.04.001_bib12","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1158\/0008-5472.CAN-05-3143","article-title":"Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation","volume":"66","author":"Awale","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.yclnex.2017.04.001_bib13","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.freeradbiomed.2013.10.004","article-title":"Arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ROS\/p38 MAPK pathway and epigenetic regulation","volume":"67","author":"Hsieh","year":"2014","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.yclnex.2017.04.001_bib14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/jbt.21533","article-title":"Arctigenin enhances chemosensitivity to cisplatin in human nonsmall lung cancer H460 cells through downregulation of survivin expression","volume":"28","author":"Wang","year":"2014","journal-title":"J\u00a0Biochem Mol Toxicol"},{"issue":"66","key":"10.1016\/j.yclnex.2017.04.001_bib15","doi-asserted-by":"publisher","first-page":"35242","DOI":"10.1039\/C4RA06616B","article-title":"Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells","volume":"4","author":"Wang","year":"2014","journal-title":"RSC Adv"},{"issue":"2","key":"10.1016\/j.yclnex.2017.04.001_bib16","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/mnfr.201400558","article-title":"Arctigenin in combination with quercetin synergistically enhances the antiproliferative effect in prostate cancer cells","volume":"59","author":"Wang","year":"2015","journal-title":"Mol Nutr Food Res"},{"issue":"19","key":"10.1016\/j.yclnex.2017.04.001_bib17","doi-asserted-by":"publisher","first-page":"7732","DOI":"10.1021\/jf071303g","article-title":"Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland","volume":"55","author":"Seeram","year":"2007","journal-title":"J\u00a0Agric Food Chem"},{"issue":"1","key":"10.1016\/j.yclnex.2017.04.001_bib18","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jnutbio.2013.09.005","article-title":"Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea","volume":"25","author":"Wang","year":"2014","journal-title":"J\u00a0Nutr Biochem"},{"issue":"6","key":"10.1016\/j.yclnex.2017.04.001_bib19","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1039\/c2fo10254d","article-title":"Quercetin increased bioavailability and decreased methylation of green tea polyphenols in\u00a0vitro and in\u00a0vivo","volume":"3","author":"Wang","year":"2012","journal-title":"Food & Funct"},{"issue":"10","key":"10.1016\/j.yclnex.2017.04.001_bib20","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nrg2634","article-title":"Causes and consequences of microRNA dysregulation in cancer","volume":"10","author":"Croce","year":"2009","journal-title":"Nat Rev Genet"},{"issue":"4","key":"10.1016\/j.yclnex.2017.04.001_bib21","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1080\/01635581.2012.661514","article-title":"Quercetin increased the antiproliferative activity of green tea polyphenol (-)-epigallocatechin gallate in prostate cancer cells","volume":"64","author":"Wang","year":"2012","journal-title":"Nutr Cancer"},{"issue":"1","key":"10.1016\/j.yclnex.2017.04.001_bib22","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","article-title":"Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice","volume":"46","author":"Prasad","year":"2014","journal-title":"Cancer Res Treat"},{"issue":"11","key":"10.1016\/j.yclnex.2017.04.001_bib23","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/j.jnutbio.2011.10.007","article-title":"Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis","volume":"23","author":"Henning","year":"2012","journal-title":"J\u00a0Nutr Biochem"},{"issue":"4","key":"10.1016\/j.yclnex.2017.04.001_bib24","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nm846","article-title":"A\u00a0novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2","volume":"9","author":"Qi","year":"2003","journal-title":"Nat Med"},{"issue":"16","key":"10.1016\/j.yclnex.2017.04.001_bib25","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1002\/pros.23056","article-title":"Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer","volume":"75","author":"Adissu","year":"2015","journal-title":"Prostate"},{"issue":"2","key":"10.1016\/j.yclnex.2017.04.001_bib26","doi-asserted-by":"publisher","first-page":"237","DOI":"10.2174\/156800909787580999","article-title":"Targeted therapy for advanced prostate cancer: inhibition of the PI3K\/Akt\/mTOR pathway","volume":"9","author":"Morgan","year":"2009","journal-title":"Curr Cancer Drug Targets"},{"issue":"6","key":"10.1016\/j.yclnex.2017.04.001_bib27","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.molonc.2012.09.006","article-title":"MicroRNA and cancer","volume":"6","author":"Jansson","year":"2012","journal-title":"Mol Oncol"},{"issue":"8","key":"10.1016\/j.yclnex.2017.04.001_bib28","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1111\/cas.12463","article-title":"MicroRNA-135a acts as a putative tumor suppressor by directly targeting very low density lipoprotein receptor in human gallbladder cancer","volume":"105","author":"Zhou","year":"2014","journal-title":"Cancer Sci"},{"issue":"6","key":"10.1016\/j.yclnex.2017.04.001_bib29","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1158\/0008-5472.CAN-08-2894","article-title":"miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon","volume":"69","author":"Gandellini","year":"2009","journal-title":"Cancer Res"},{"issue":"10","key":"10.1016\/j.yclnex.2017.04.001_bib30","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1093\/hmg\/dds031","article-title":"MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells","volume":"21","author":"Alvarez-Diaz","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"1","key":"10.1016\/j.yclnex.2017.04.001_bib31","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1349-7006.2009.01385.x","article-title":"Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas","volume":"101","author":"Hiroki","year":"2010","journal-title":"Cancer Sci"},{"issue":"4","key":"10.1016\/j.yclnex.2017.04.001_bib32","doi-asserted-by":"publisher","first-page":"6314","DOI":"10.3390\/ijms15046314","article-title":"GPC1 regulated by miR-96-5p, rather than miR-182-5p, in inhibition of pancreatic carcinoma cell proliferation","volume":"15","author":"Li","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.yclnex.2017.04.001_bib33","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.devcel.2008.07.002","article-title":"The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis","volume":"15","author":"Wang","year":"2008","journal-title":"Dev Cell"},{"issue":"2","key":"10.1016\/j.yclnex.2017.04.001_bib34","doi-asserted-by":"publisher","first-page":"e0149537","DOI":"10.1371\/journal.pone.0149537","article-title":"The angiogenic effect of microRNA-21 targeting TIMP3 through the regulation of MMP2 and MMP9","volume":"11","author":"Hu","year":"2016","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.yclnex.2017.04.001_bib35","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/sj.onc.1209769","article-title":"ZNF185, an actin-cytoskeleton-associated growth inhibitory LIM protein in prostate cancer","volume":"26","author":"Zhang","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.yclnex.2017.04.001_bib36","doi-asserted-by":"crossref","first-page":"e001","DOI":"10.1621\/nrs.06001","article-title":"AR, the cell cycle, and prostate cancer","volume":"6","author":"Balk","year":"2008","journal-title":"Nucl Recept Signal"},{"issue":"5","key":"10.1016\/j.yclnex.2017.04.001_bib37","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1002\/jcb.24020","article-title":"CaM kinase control of AKT and LNCaP cell survival","volume":"113","author":"Schmitt","year":"2012","journal-title":"J\u00a0Cell Biochem"},{"issue":"6","key":"10.1016\/j.yclnex.2017.04.001_bib38","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/onc.2013.7","article-title":"DLC1 induces expression of E-cadherin in prostate cancer cells through Rho pathway and suppresses invasion","volume":"33","author":"Tripathi","year":"2014","journal-title":"Oncogene"},{"issue":"5350","key":"10.1016\/j.yclnex.2017.04.001_bib39","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1126\/science.279.5350.563","article-title":"Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study","volume":"279","author":"Chan","year":"1998","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.yclnex.2017.04.001_bib40","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1023\/B:GLYC.0000025819.54723.a0","article-title":"Galectin-4 in normal tissues and cancer","volume":"20","author":"Huflejt","year":"2004","journal-title":"Glycoconj J"},{"issue":"44","key":"10.1016\/j.yclnex.2017.04.001_bib41","doi-asserted-by":"publisher","first-page":"32064","DOI":"10.1074\/jbc.M113.497644","article-title":"Protein phosphatase 2A isoforms utilizing Abeta scaffolds regulate differentiation through control of Akt protein","volume":"288","author":"Hwang","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.yclnex.2017.04.001_bib42","first-page":"3","article-title":"The cellular functions of RASSF1A and its inactivation in prostate cancer","volume":"11","author":"Amin","year":"2012","journal-title":"J\u00a0Carcinog"},{"issue":"3","key":"10.1016\/j.yclnex.2017.04.001_bib43","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/pros.21245","article-title":"Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior","volume":"71","author":"Pierconti","year":"2011","journal-title":"Prostate"},{"issue":"7","key":"10.1016\/j.yclnex.2017.04.001_bib44","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1055\/s-2007-991532","article-title":"The role of tissue factor pathway inhibitor-2 in cancer biology","volume":"33","author":"Sierko","year":"2007","journal-title":"Seminars Thrombosis Hemostasis"}],"container-title":["Clinical Nutrition Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235293931730009X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235293931730009X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T13:54:05Z","timestamp":1719150845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235293931730009X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":44,"alternative-id":["S235293931730009X"],"URL":"https:\/\/doi.org\/10.1016\/j.yclnex.2017.04.001","relation":{},"ISSN":["2352-9393"],"issn-type":[{"value":"2352-9393","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}