{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:51:41Z","timestamp":1791017501146,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,8,1]],"date-time":"2004-08-01T00:00:00Z","timestamp":1091318400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3272,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS40945"],"award-info":[{"award-number":["R01NS40945"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM37706"],"award-info":[{"award-number":["R01GM37706"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1016\/j.ydbio.2004.05.010","type":"journal-article","created":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T11:17:14Z","timestamp":1089112634000},"page":"389-402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["UNC-39, the C. elegans homolog of the human myotonic dystrophy-associated homeodomain protein Six5, regulates cell motility and differentiation"],"prefix":"10.1016","volume":"272","author":[{"given":"Judith L.","family":"Yanowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.Afaq","family":"Shakir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Hedgecock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Hutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Z.","family":"Fire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A.","family":"Lundquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2004.05.010_BIB1","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1093\/hmg\/8.8.1491","article-title":"Myotonic dystrophy is associated with a reduced level of RNA from the DMWD allele adjacent to the expanded repeat","volume":"8","author":"Alwazzan","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB2","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1093\/hmg\/4.10.1919","article-title":"A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat","volume":"4","author":"Boucher","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB4","first-page":"385","article-title":"Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3\u2032 end of a transcript encoding a protein kinase family member","volume":"69","author":"Brook","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB5","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1006\/geno.1993.1474","article-title":"Absence of myotonic dystrophy protein kinase (DMPK) mRNA as a result of a triplet repeat expansion in myotonic dystrophy","volume":"18","author":"Carango","year":"1993","journal-title":"Genomics"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB6","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0896-6273(94)90308-5","article-title":"The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system","volume":"12","author":"Cheyette","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/genetics\/148.1.187","article-title":"Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans","volume":"148","author":"Collet","year":"1998","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1006\/dbio.2001.0325","article-title":"The Caenorhabditis elegans Six\/sine oculis class homeobox gene ceh-32 is required for head morphogenesis","volume":"236","author":"Dozier","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB9","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(86)90004-8","article-title":"Genetic control of programmed cell death in the nematode C. elegans","volume":"44","author":"Ellis","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ng570","article-title":"CTCF-binding sites flank CTG\/CAG repeats and form a methylation-sensitive insulator at the DM1 locus","volume":"28","author":"Filippova","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB11","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/genetics\/148.1.151","article-title":"Identification of Caenorhabditis elegans genes required for neuronal differentiation and migration","volume":"148","author":"Forrester","year":"1998","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1126\/science.8469976","article-title":"Decreased expression of myotonin-protein kinase messenger RNA and protein in adult form of myotonic dystrophy","volume":"260","author":"Fu","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1006\/geno.1999.5916","article-title":"Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies","volume":"61","author":"Gallardo","year":"1999","journal-title":"Genomics"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB15","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1242\/dev.125.13.2479","article-title":"MyoD and the specification of muscle and non-muscle fates during postembryonic development of the C. elegans mesoderm","volume":"125","author":"Harfe","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB16","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1101\/gad.12.16.2623","article-title":"Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning","volume":"12","author":"Harfe","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB17","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/0140-6736(92)90729-M","article-title":"Unstable DNA sequence in myotonic dystrophy","volume":"339","author":"Harley","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB18","volume":"vol. 37","author":"Harper","year":"2001"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB19","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1101\/gad.13.24.3231","article-title":"Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation","volume":"13","author":"Heanue","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB20","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1242\/dev.100.3.365","article-title":"Genetics of cell and axon migrations in Caenorhabditis elegans","volume":"100","author":"Hedgecock","year":"1987","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0168-9525(99)01883-1","article-title":"Functions of LIM-homeobox genes","volume":"16","author":"Hobert","year":"2000","journal-title":"Trends Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB22","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/1521-1878(200007)22:7<616::AID-BIES4>3.0.CO;2-R","article-title":"Six family genes\u2014Structure and function as transcription factors and their roles in development","volume":"22","author":"Kawakami","year":"2000","journal-title":"BioEssays"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB23","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0012-1606(79)90035-6","article-title":"The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegans","volume":"70","author":"Kimble","year":"1979","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB24","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/S0960-9822(01)00319-0","article-title":"Drosophila homolog of the myotonic dystrophy-associated gene, SIX5, is required for muscle and gonad development","volume":"11","author":"Kirby","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/ng0897-402","article-title":"Trinucleotide repeat expansion at the myotonic dystrophy locus reduces expression of DMAHP","volume":"16","author":"Klesert","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/75490","article-title":"Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy","volume":"25","author":"Klesert","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB27","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1242\/dev.125.15.2973","article-title":"Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish","volume":"125","author":"Kobayashi","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB28","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1101\/gad.923102","article-title":"The T-box factor MLS-1 acts as a molecular switch during the specification of nonstriated muscle in C. elegans","volume":"16","author":"Kostas","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB29","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1242\/dev.00440","article-title":"Altered myogenesis in Six1-deficient mice","volume":"130","author":"Laclef","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB30","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/dvdy.1148","article-title":"Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos","volume":"221","author":"Lagutin","year":"2001","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB31","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1242\/dev.128.22.4475","article-title":"Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis","volume":"128","author":"Lundquist","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/dvg.1020110107","article-title":"Mutations affecting embryonic cell migrations in Caenorhabditis elegans","volume":"11","author":"Manser","year":"1990","journal-title":"Dev. Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/378078a0","article-title":"Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor","volume":"378","author":"Maricq","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0091-679X(08)61399-0","article-title":"DNA transformation","volume":"48","author":"Mello","year":"1995","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB35","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/oxfordjournals.hmg.a018923","article-title":"Skeletal muscle sodium channel gating in mice deficient in myotonic dystrophy protein kinase","volume":"9","author":"Mounsey","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB36","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1073\/pnas.92.12.5465","article-title":"Triplet repeat expansion in myotonic dystrophy alters the adjacent chromatin structure","volume":"92","author":"Otten","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB37","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/sj.ejhg.5200540","article-title":"A new mutation in the six-domain of SIX3 gene causes holoprosencephaly","volume":"8","author":"Pasquier","year":"2000","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB38","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1126\/science.280.5364.737","article-title":"Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy","volume":"280","author":"Philips","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB39","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/75500","article-title":"Heterozygous loss of Six5 in mice is sufficient to cause ocular cataracts","volume":"25","author":"Sarkar","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB40","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1242\/dev.127.9.1879","article-title":"The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism","volume":"127","author":"Seimiya","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB41","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/genetics\/138.4.1137","article-title":"Sine oculis is a homeobox gene required for Drosophila visual system development","volume":"138","author":"Serikaku","year":"1994","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB42","doi-asserted-by":"crossref","first-page":"14220","DOI":"10.1073\/pnas.95.24.14220","article-title":"Expression of myogenin during embryogenesis is controlled by Six\/sine oculis homeoproteins through a conserved MEF3 binding site","volume":"95","author":"Spitz","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB43","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Post-embryonic cell lineages of the nematode, Caenorhabditis elegans","volume":"56","author":"Sulston","year":"1977","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0012-1606(83)90201-4","article-title":"The embryonic cell lineage of the nematode Caenorhabditis elegans","volume":"100","author":"Sulston","year":"1983","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB45","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng0897-407","article-title":"Expansion of the myotonic dystrophy CTG repeat reduces expression of the flanking DMAHP gene","volume":"16","author":"Thornton","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB46","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1023\/A:1020881520353","article-title":"Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene","volume":"7","author":"Wakimoto","year":"2002","journal-title":"J. Interv. Card Electrophysiol."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB47","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/9718","article-title":"Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly","volume":"22","author":"Wallis","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2004.05.010_BIB48","first-page":"1","article-title":"The structure of the nervous system of the nematode Caenorhabditis elegans","volume":"314","author":"White","year":"1986","journal-title":"Philos. Trans. R. Soc. London"},{"key":"10.1016\/j.ydbio.2004.05.010_BIB49","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1093\/hmg\/8.3.481","article-title":"Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy","volume":"8","author":"Winchester","year":"1999","journal-title":"Hum. Mol. Genet."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160604003537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160604003537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:28:04Z","timestamp":1757906884000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160604003537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,8]]}},"alternative-id":["S0012160604003537"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2004.05.010","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"UNC-39, the C. elegans homolog of the human myotonic dystrophy-associated homeodomain protein Six5, regulates cell motility and differentiation","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2004.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}