{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:26:52Z","timestamp":1791296812616,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":3150,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.ydbio.2004.08.024","type":"journal-article","created":{"date-parts":[[2004,9,21]],"date-time":"2004-09-21T14:24:21Z","timestamp":1095776661000},"page":"268-279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"title":["Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development"],"prefix":"10.1016","volume":"276","author":[{"given":"Jennifer","family":"Selever","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Fang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Behringer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2004.08.024_bib1","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1242\/dev.128.22.4449","article-title":"BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb","volume":"128","author":"Ahn","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.08.024_bib2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1101\/gad.1044903","article-title":"Ectodermal Wnt3\/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge","volume":"17","author":"Barrow","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2004.08.024_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.cellbio.17.1.87","article-title":"Patterning mechanisms controlling vertebrate limb development","volume":"17","author":"Capdevila","year":"2001","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2004.08.024_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s004410051267","article-title":"Dorsoventral patterning of the vertebrate limb: a process governed by multiple events","volume":"296","author":"Chen","year":"1999","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ydbio.2004.08.024_bib5","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/35079121","article-title":"The zebrafish Nodal signal Squint functions as a morphogen","volume":"411","author":"Chen","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2004.08.024_bib6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1126\/science.289.5478.438","article-title":"Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling","volume":"289","author":"Dahn","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2004.08.024_bib7","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1242\/dev.127.7.1337","article-title":"A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling","volume":"127","author":"Drossopoulou","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.08.024_bib8","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1101\/gad.9.22.2795","article-title":"A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye","volume":"9","author":"Dudley","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2004.08.024_bib9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nature00945","article-title":"A re-examination of proximodistal patterning during vertebrate limb development","volume":"418","author":"Dudley","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2004.08.024_bib10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ydbio.2003.08.012","article-title":"Fate map of mouse ventral limb ectoderm and the apical ectodermal ridge","volume":"264","author":"Guo","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2004.08.024_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/(SICI)1520-6408(1996)19:1<43::AID-DVG5>3.0.CO;2-0","article-title":"Analysis of limb patterning in BMP-7-deficient mice","volume":"19","author":"Hofmann","year":"1996","journal-title":"Dev. Genet."},{"key":"10.1016\/j.ydbio.2004.08.024_bib12","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0959-437X(96)80064-5","article-title":"Bone morphogenetic proteins in development","volume":"6","author":"Hogan","year":"1996","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ydbio.2004.08.024_bib13","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/sj.embor.7400184","article-title":"Restriction of BMP4 activity domains in the developing neural tube of the mouse embryo","volume":"5","author":"Hu","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ydbio.2004.08.024_bib14","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/(SICI)1520-6408(1998)22:4<340::AID-DVG4>3.0.CO;2-6","article-title":"Skeletal abnormalities in doubly heterozygous Bmp4 and Bmp7 mice","volume":"22","author":"Katagiri","year":"1998","journal-title":"Dev. Genet."},{"key":"10.1016\/j.ydbio.2004.08.024_bib15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0012-1606(76)90141-X","article-title":"Ultrastructural analysis of the apical ectodermal ridge during vertebrate limb morphogenesis: 1. The human forelimb with special reference to gap junctions","volume":"51","author":"Kelley","year":"1976","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2004.08.024_bib16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ng1178","article-title":"Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning","volume":"34","author":"Khokha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2004.08.024_bib17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1101\/gad.13.4.424","article-title":"Bmp4 is required for the generation of primordial germ cells in the mouse embryo","volume":"13","author":"Lawson","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2004.08.024_bib18","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nature01033","article-title":"Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity","volume":"418","author":"Litingtung","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2004.08.024_bib19","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1242\/dev.00354","article-title":"A role for the mesenchymal T-box gene Brachyury in AER formation during limb development","volume":"130","author":"Liu","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.08.024_bib20","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1073\/pnas.0308466101","article-title":"Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling","volume":"101","author":"Liu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2004.08.024_bib21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/gene.10092","article-title":"Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer","volume":"33","author":"Logan","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2004.08.024_bib22","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/382360a0","article-title":"The mouse Engrailed-1 gene and ventral limb patterning","volume":"382","author":"Loomis","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2004.08.024_bib23","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/45797","article-title":"Function of Rieger syndrome gene in left\u2013right asymmetry and craniofacial development","volume":"401","author":"Lu","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2004.08.024_bib24","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1101\/gad.9.22.2808","article-title":"BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning","volume":"9","author":"Luo","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2004.08.024_bib25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/(SICI)1526-968X(200004)26:4<225::AID-GENE10>3.0.CO;2-F","article-title":"Identification of a prx1 limb enhancer","volume":"26","author":"Martin","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2004.08.024_bib26","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1242\/dev.126.23.5515","article-title":"The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb","volume":"126","author":"Merino","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.08.024_bib27","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1242\/dev.124.8.1453","article-title":"The dorsoventral polarity of the presumptive limb is determined by signals produced by the somites and by the lateral somatopleure","volume":"124","author":"Michaud","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.08.024_bib28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrg1001","article-title":"Pattern formation: old models out on a limb","volume":"4","author":"Niswander","year":"2003","journal-title":"Nat. Rev., Genet."},{"key":"10.1016\/j.ydbio.2004.08.024_bib29","unstructured":"Ovchinnikov, D.A., Selever, J., Mishina, Y., Martin, J.F., Behringer, R.R., 2004. Signaling through the BMP receptor type I A in mouse limb bud mesenchyme regulates its development along all three of the cardinal axes. Submitted for publication."},{"key":"10.1016\/j.ydbio.2004.08.024_bib30","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1242\/dev.126.5.883","article-title":"BMPs negatively regulate structure and function of the limb apical ectodermal ridge","volume":"126","author":"Pizette","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.08.024_bib31","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1242\/dev.128.22.4463","article-title":"BMP controls proximodistal outgrowth, via induction of the apical ectodermal ridge, and dorsoventral patterning in the vertebrate limb","volume":"128","author":"Pizette","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.08.024_bib32","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1242\/dev.124.20.3999","article-title":"Polydactyly and ectopic ZPA formation in Alx-4 mutant mice","volume":"124","author":"Qu","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.08.024_bib33","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1242\/dev.125.14.2711","article-title":"Mutations in mouse Aristaless-like4 cause Strong's luxoid polydactyly","volume":"125","author":"Qu","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.08.024_bib34","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/j.cub.2003.09.040","article-title":"Fgf signaling controls the number of phalanges and tip formation in developing digits","volume":"13","author":"Sanz-Ezquerro","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2004.08.024_bib35","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1101\/gad.263003","article-title":"Genetic interaction between Wnt\/beta-catenin and BMP receptor signaling during formation of the AER and the dorsal\u2013ventral axis in the limb","volume":"17","author":"Soshnikova","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2004.08.024_bib36","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nature00902","article-title":"Functions of FGF signalling from the apical ectodermal ridge in limb development","volume":"418","author":"Sun","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2004.08.024_bib37","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1534-5807(03)00401-5","article-title":"Tbx genes specify posterior digit identity through Shh and BMP signaling","volume":"6","author":"Suzuki","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2004.08.024_bib38","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1242\/dev.125.22.4417","article-title":"The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development","volume":"125","author":"Takahashi","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.08.024_bib39","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1075620","article-title":"Progression of vertebrate limb development through SHH-mediated counteraction of GLI3","volume":"298","author":"te Welscher","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2004.08.024_bib40","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1534-5807(03)00095-9","article-title":"Patterning systems\u2014from one end of the limb to the other","volume":"4","author":"Tickle","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2004.08.024_bib41","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1101\/gad.13.23.3136","article-title":"Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch","volume":"13","author":"Trumpp","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2004.08.024_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.2001.0388","article-title":"Intracellular BMP signaling regulation in vertebrates: pathway or network?","volume":"239","author":"von Bubnoff","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2004.08.024_bib43","first-page":"339","article-title":"Cells of the apical ectodermal ridge in quail limb buds are coupled to one another but are isolated from subjacent mesoderm","author":"Wilcox","year":"1993","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.ydbio.2004.08.024_bib44","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1101\/gad.9.17.2105","article-title":"Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse","volume":"9","author":"Winnier","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2004.08.024_bib45","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1242\/dev.122.10.2977","article-title":"Mice deficient for BMP2 are nonviable and have defects in amnion\/chorion and cardiac development","volume":"122","author":"Zhang","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2004.08.024_bib46","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/44157","article-title":"Signal relay by BMP antagonism controls the SHH\/FGF4 feedback loop in vertebrate limb buds","volume":"401","author":"Zuniga","year":"1999","journal-title":"Nature"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160604005809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160604005809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:33:06Z","timestamp":1757907186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160604005809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0012160604005809"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2004.08.024","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2004.08.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}