{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:32:55Z","timestamp":1790202775992,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2943,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.ydbio.2005.04.042","type":"journal-article","created":{"date-parts":[[2005,7,2]],"date-time":"2005-07-02T10:48:06Z","timestamp":1120301286000},"page":"157-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus"],"prefix":"10.1016","volume":"284","author":[{"given":"Wei-Yuan","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.W.","family":"Slack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2005.04.042_bib1","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1242\/dev.120.9.2369","article-title":"Programming gene expression in developing epidermis","volume":"120","author":"Byrne","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.04.042_bib2","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1083\/jcb.138.6.1379","article-title":"Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis","volume":"138","author":"Caulin","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1083\/jcb.149.1.17","article-title":"Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis","volume":"149","author":"Caulin","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib4","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ncb0804-699","article-title":"Cytoplasmic intermediate filaments revealed as dynamic and multipurpose scaffolds","volume":"6","author":"Coulombe","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib5","doi-asserted-by":"crossref","first-page":"C171","DOI":"10.1152\/ajpcell.00226.2003","article-title":"Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium","volume":"287","author":"Daniely","year":"2004","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib6","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0012-1606(85)90062-4","article-title":"Co-expression of specific acid and basic cytokeratins in teratocarcinoma-derived fibroblasts treated with 5-azacytidine","volume":"110","author":"Darmon","year":"1985","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib7","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/00000478-199103000-00010","article-title":"The normal esophagus","volume":"15","author":"DeNardi","year":"1991","journal-title":"Am. J. Surg. Pathol."},{"issue":"3","key":"10.1016\/j.ydbio.2005.04.042_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/scel.1995.0015","article-title":"Introduction: transdifferentiation","volume":"6","author":"Eguchi","year":"1995","journal-title":"Semin. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib9","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/0955-0674(93)90087-7","article-title":"Transdifferentiation","volume":"5","author":"Eguchi","year":"1993","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrg758","article-title":"Getting under the skin of epidermal morphogenesis","volume":"3","author":"Fuchs","year":"2002","journal-title":"Nat. Rev., Genet."},{"key":"10.1016\/j.ydbio.2005.04.042_bib11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1083\/jcb.149.2.431","article-title":"Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization","volume":"149","author":"Gilmore","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib12","doi-asserted-by":"crossref","first-page":"9856","DOI":"10.1073\/pnas.92.21.9856","article-title":"Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C\/EBP alpha","volume":"92","author":"Hu","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2005.04.042_bib13","first-page":"209","article-title":"The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labeling and lineage analysis","volume":"126","author":"Jenson","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.04.042_bib14","first-page":"431","article-title":"Developmental changes in the oesophageal epithelium in man","volume":"86","author":"Johns","year":"1952","journal-title":"J. Anat."},{"key":"10.1016\/j.ydbio.2005.04.042_bib15","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0092-8674(80)90237-8","article-title":"Cellular differentiation, cytidine analogs and DNA methylation","volume":"20","author":"Jones","year":"1980","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.04.042_bib16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1101\/gad.1165104","article-title":"p63 is the molecular switch for initiation of an epithelial stratification program","volume":"18","author":"Koster","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2005.04.042_bib17","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/BF02618445","article-title":"Effects of retinoic acid and other retinoids on the growth and differentiation of 3T3 supported human keratinocytes","volume":"17","author":"Kubilus","year":"1981","journal-title":"In Vitro"},{"key":"10.1016\/j.ydbio.2005.04.042_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/283249a0","article-title":"Intermediate filaments as mechanical integrators of cellular space","volume":"283","author":"Lazarides","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.04.042_bib19","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrg887","article-title":"Chromatin modification and epigenetic reprogramming in mammalian development","volume":"3","author":"Li","year":"2002","journal-title":"Nat. Rev., Genet."},{"key":"10.1016\/j.ydbio.2005.04.042_bib20","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/19531","article-title":"p63 is a p53 homologue required for limb and epidermal morphogenesis","volume":"398","author":"Mills","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.04.042_bib21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0092-8674(82)90400-7","article-title":"The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells","volume":"31","author":"Moll","year":"1982","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.04.042_bib22","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/bies.10316","article-title":"The quest for the function of simple epithelial keratins","volume":"25","author":"Owens","year":"2003","journal-title":"Bioessays"},{"key":"10.1016\/j.ydbio.2005.04.042_bib23","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1126\/science.270.5243.1818","article-title":"Evidence for developmentally programmed transdifferentiation in mouse esophageal muscle","volume":"270","author":"Patapoutian","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2005.04.042_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/excr.1998.4322","article-title":"Analysis of pancreatic development using a cell lineage label","volume":"247","author":"Percival","year":"1999","journal-title":"Exp. Cell Res."},{"issue":"5","key":"10.1016\/j.ydbio.2005.04.042_bib25","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0168-9525(03)00071-4","article-title":"Phenotypes, genotypes and their contribution to understanding keratin function","volume":"19","author":"Porter","year":"2003","journal-title":"Trends Genet."},{"key":"10.1016\/j.ydbio.2005.04.042_bib26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ar.1092300210","article-title":"Development of esophageal epithelium in the fetal and neonatal mouse","volume":"230","author":"Raymond","year":"1991","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ydbio.2005.04.042_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/gene.10198","article-title":"Skeletal myogenesis in the mouse esophagus does not occur through transdifferentiation","volume":"36","author":"Rishniw","year":"2003","journal-title":"Genesis"},{"key":"10.1016\/j.ydbio.2005.04.042_bib28","first-page":"173","article-title":"Some observations on the innervation of the striated muscle in the mouse oesophagus\u2014An electron microscopy study","volume":"112","author":"Samarasinghe","year":"1972","journal-title":"J. Anat."},{"key":"10.1016\/j.ydbio.2005.04.042_bib29","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0960-9822(00)00803-4","article-title":"Asymmetric stem-cell divisions define the architecture of human oesophageal epithelium","volume":"10","author":"Seery","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib30","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/35046522","article-title":"Molecular basis of transdifferentiation of pancreas to liver","volume":"2","author":"Shen","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib31","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0959-437X(00)00236-7","article-title":"Transdifferentiation and metaplasia-switching cell types","volume":"11","author":"Slack","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ydbio.2005.04.042_bib32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0378-1119(91)90247-9","article-title":"Sequence of EndoA gene encoding mouse cytokeratin and its methylation state in the CpG-rich region","volume":"104","author":"Tamai","year":"1991","journal-title":"Gene"},{"key":"10.1016\/j.ydbio.2005.04.042_bib33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1006\/dbio.1993.1326","article-title":"Embryonic expression of human keratin 18 and K18-beta-galactosidase fusion genes in transgenic mice","volume":"160","author":"Thorey","year":"1993","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nrm761","article-title":"How cells change their phenotype","volume":"3","author":"Tosh","year":"2002","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.04.042_bib35","doi-asserted-by":"crossref","first-page":"8551","DOI":"10.1073\/pnas.96.15.8551","article-title":"The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin","volume":"96","author":"Vasioukhin","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2005.04.042_bib36","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/ar.1091980407","article-title":"Indirect immunofluorescent staining of fibronectin associated with the floor of the foregut during formation and rupture of the oral membrane in the chick embryo","volume":"198","author":"Waterman","year":"1980","journal-title":"Anat. Rec."},{"key":"10.1016\/j.ydbio.2005.04.042_bib37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1242\/jcs.94.2.355","article-title":"Onset of expression of peanut lectin-binding glycoproteins is correlated with stratification of keratinocytes during human epidermal development in vivo and in vitro","volume":"94","author":"Watt","year":"1989","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ydbio.2005.04.042_bib38","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1073\/pnas.86.14.5434","article-title":"Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD","volume":"86","author":"Weintraub","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2005.04.042_bib39","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/19539","article-title":"p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development","volume":"398","author":"Yang","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.04.042_bib40","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0022-2836(02)00676-9","article-title":"Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases","volume":"321","author":"Zhou","year":"2002","journal-title":"J. Mol. Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160605003052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160605003052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:43:24Z","timestamp":1757907804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160605003052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0012160605003052"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2005.04.042","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2005.04.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}