{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:32:37Z","timestamp":1791822757028,"version":"4.3.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2846,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1016\/j.ydbio.2005.06.034","type":"journal-article","created":{"date-parts":[[2005,8,25]],"date-time":"2005-08-25T11:29:37Z","timestamp":1124969377000},"page":"16-30","source":"Crossref","is-referenced-by-count":27,"title":["Disruption of polycystin-1 function interferes with branching morphogenesis of the ureteric bud in developing mouse kidneys"],"prefix":"10.1016","volume":"286","author":[{"given":"Katalin","family":"Polgar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Burrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah P.","family":"Hyink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilda","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Luca","family":"Gusella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia D.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2005.06.034_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1139\/o99-064","article-title":"Roles of protein tyrosine phosphatases in cell migration and adhesion","volume":"77","author":"Angers-Loustau","year":"1999","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib2","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1074\/jbc.273.11.6013","article-title":"The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1","volume":"273","author":"Arnould","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2005.06.034_bib3","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF02620946","article-title":"Growth factor requirements of organogenesis in serum-free metanephric organ culture","volume":"21","author":"Avner","year":"1985","journal-title":"In Vitro Cell. Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib4","doi-asserted-by":"crossref","first-page":"9784","DOI":"10.1073\/pnas.171269898","article-title":"Nephrocystin interacts with Pyk2, p130 (Cas), and tensin and triggers phosphorylation of Pyk2","volume":"98","author":"Benzing","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2005.06.034_bib5","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S1097-2765(00)00123-4","article-title":"Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells","volume":"6","author":"Boletta","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2005.06.034_bib6","doi-asserted-by":"crossref","first-page":"12174","DOI":"10.1073\/pnas.211191098","article-title":"Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene","volume":"98","author":"Boulter","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2005.06.034_bib7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s004670050049","article-title":"Regulatory molecules in kidney development","volume":"14","author":"Burrow","year":"2000","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/emboj\/18.2.297","article-title":"The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease","volume":"18","author":"Bycroft","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2005.06.034_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000422098","article-title":"Tubular cell and matrix changes in renal cystic disease","volume":"101","author":"Carone","year":"1993","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.140.1.211","article-title":"Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration","volume":"140","author":"Cary","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib11","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1083\/jcb.149.1.111","article-title":"Compromised cytoarchitecture and polarized trafficking in autosomal dominant polycystic kidney disease cells","volume":"149","author":"Charron","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib12","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1100\/tsw.2002.854","article-title":"Morphogenesis of the metanephric kidney","volume":"2","author":"Davies","year":"2002","journal-title":"Scientific World J."},{"key":"10.1016\/j.ydbio.2005.06.034_bib13","first-page":"1","article-title":"Signal transduction by the c-Jun N-terminal kinase","volume":"64","author":"Davis","year":"1999","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/j.ydbio.2005.06.034_bib14","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1073\/pnas.80.9.2651","article-title":"Transferrin as a fetal growth factor: acquisition of responsiveness related to embryonic induction","volume":"80","author":"Ekblom","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2005.06.034_bib15","first-page":"F451","article-title":"Distribution and developmentally regulated expression of murine polycystin","volume":"272","author":"Geng","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0925-4439(00)00079-X","article-title":"Modification of the composition of polycystin-1 multiprotein complexes by calcium and tyrosine phosphorylation","volume":"1535","author":"Geng","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ydbio.2005.06.034_bib17","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1172\/JCI5111","article-title":"Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins","volume":"104","author":"Huan","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2005.06.034_bib18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/377539a0","article-title":"Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice","volume":"377","author":"Ilic","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.06.034_bib19","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1159\/000066650","article-title":"Towards understanding the polycystins","volume":"93","author":"Kaletta","year":"2003","journal-title":"Nephron, Exp. Nephrol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib20","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1074\/jbc.274.8.4947","article-title":"The polycystic kidney disease 1 gene product modulates Wnt signaling","volume":"274","author":"Kim","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2005.06.034_bib21","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1073\/pnas.040550097","article-title":"Polycystin 1 is required for the structural integrity of blood vessels","volume":"97","author":"Kim","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2005.06.034_bib22","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1083\/jcb.153.7.1427","article-title":"Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells","volume":"153","author":"Laukaitis","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib23","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1006\/bbrc.1999.0780","article-title":"Identification of phosphorylation sites in the PKD1-encoded protein C-terminal domain","volume":"259","author":"Li","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2005.06.034_bib24","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/bies.950161108","article-title":"Tensin: a potential link between the cytoskeleton and signal transduction","volume":"16","author":"Lo","year":"1994","journal-title":"BioEssays"},{"key":"10.1016\/j.ydbio.2005.06.034_bib25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ng1097-179","article-title":"Perinatal lethality with kidney and pancreas defects in mice with a targeted Pkd1 mutation","volume":"17","author":"Lu","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2005.06.034_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/jmg.35.1.13","article-title":"Prenatal diagnosis of autosomal dominant polycystic kidney disease (PKD1) presenting in utero and prognosis for very early onset disease","volume":"35","author":"MacDermot","year":"1998","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2005.06.034_bib27","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1681\/ASN.V13119","article-title":"Interaction of the leucine-rich repeats of polycystin-1 with extracellular matrix proteins: possible role in cell proliferation","volume":"13","author":"Malhas","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1126\/science.272.5259.263","article-title":"In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector","volume":"272","author":"Naldini","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2005.06.034_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2005.06.034_bib30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1172\/JCI0212867","article-title":"The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells","volume":"109","author":"Nickel","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2005.06.034_bib31","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1006\/dbio.2000.9618","article-title":"Reduced Pax2 gene dosage increases apoptosis and slows the progression of renal cystic disease","volume":"219","author":"Ostrom","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib32","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1006\/bbrc.1998.9514","article-title":"The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro","volume":"251","author":"Parnell","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2005.06.034_bib33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1046\/j.1432-0436.2002.700602.x","article-title":"The molecular control of renal branching morphogenesis: current knowledge and emerging insights","volume":"70","author":"Piscione","year":"2002","journal-title":"Differentiation"},{"key":"10.1016\/j.ydbio.2005.06.034_bib34","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ki.1995.324","article-title":"Renal proximal tubular epithelium from patients with nephropathic cystinosis: immortalized cell lines as in vitro model systems","volume":"48","author":"Racusen","year":"1995","journal-title":"Kidney Int."},{"key":"10.1016\/j.ydbio.2005.06.034_bib35","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/S0960-9822(01)00318-9","article-title":"Downregulation of Jun kinase signaling in the amnioserosa is essential for dorsal closure of the Drosophila embryo","volume":"11","author":"Reed","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib36","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/01.ASN.0000056481.66379.B2","article-title":"Na transport in autosomal recessive polycystic kidney disease (ARPKD) cyst lining epithelial cells","volume":"14","author":"Rohatgi","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib37","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1091\/mbc.e03-05-0296","article-title":"A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells","author":"Roitbak","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2005.06.034_bib38","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ki.1987.98","article-title":"Autosomal dominant polycystic kidney disease in childhood: a longitudinal study","volume":"31","author":"Sedman","year":"1987","journal-title":"Kidney Int."},{"key":"10.1016\/j.ydbio.2005.06.034_bib39","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/S0960-9822(01)00583-8","article-title":"Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity","volume":"11","author":"Timpson","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib40","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrg842","article-title":"Coordinating early kidney development: lessons from gene targeting","volume":"3","author":"Vainio","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ydbio.2005.06.034_bib41","first-page":"F602","article-title":"Polycystin expression is temporally and spatially regulated during renal development","volume":"272","author":"Van Adelsberg","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib42","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1006\/excr.1999.4416","article-title":"Overexpression of c-Src enhances cell\u2013matrix adhesion and cell migration in PDGF-stimulated NIH3T3 fibroblasts","volume":"248","author":"Verbeek","year":"1999","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ydbio.2005.06.034_bib43","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/ki.1996.208","article-title":"Metanephros organogenesis is highly stimulated by vitamin A derivatives in organ culture","volume":"49","author":"Vilar","year":"1996","journal-title":"Kidney Int."},{"key":"10.1016\/j.ydbio.2005.06.034_bib44","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1073\/pnas.93.4.1524","article-title":"Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney","volume":"93","author":"Ward","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2005.06.034_bib45","doi-asserted-by":"crossref","first-page":"E97","DOI":"10.1038\/ncb0402-e97","article-title":"Adhesion assembly, disassembly and turnover in migrating cells\u2014Over and over and over again","volume":"4","author":"Webb","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0925-4439(01)00046-1","article-title":"The polycystin-1 C-type lectin domain binds carbohydrate in a calcium-dependent manner, and interacts with extracellular matrix proteins in vitro","volume":"1536","author":"Weston","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ydbio.2005.06.034_bib47","series-title":"Polycystic Kidney Diseases","first-page":"125","article-title":"Pathogenesis of polycystic kidney disease: altered cellular function","author":"Wilson","year":"1996"},{"key":"10.1016\/j.ydbio.2005.06.034_bib48","first-page":"F434","article-title":"Epithelial cell polarity and disease","volume":"41","author":"Wilson","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib49","first-page":"317","article-title":"In vitro methods in renal research","volume":"vol. 5","author":"Wilson","year":"2004"},{"key":"10.1016\/j.ydbio.2005.06.034_bib50","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJMra022161","article-title":"Polycystic kidney disease","volume":"350","author":"Wilson","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ydbio.2005.06.034_bib51","first-page":"436","article-title":"Defined human renal tubular epithelia in culture: growth, characterization and hormonal response","volume":"248","author":"Wilson","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib52","first-page":"F420","article-title":"Reversed polarity of Na(+)-K(+)-ATPase: mislocation to apical plasma membranes in polycystic kidney disease epithelia","volume":"260","author":"Wilson","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib53","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/jcp.1041500220","article-title":"Abnormal extracellular matrix and excessive growth of human adult polycystic kidney disease epithelia","volume":"150","author":"Wilson","year":"1992","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib54","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000425085","article-title":"Abnormalities in extracellular matrix regulation in autosomal dominant polycystic kidney disease","volume":"118","author":"Wilson","year":"1996","journal-title":"Contrib. Nephrol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib55","first-page":"1311","article-title":"The PKD1 gene product, \u201cpolycystin-1,\u201d is a tyrosine\u2013phosphorylated protein that colocalizes with alpha2beta1-integrin in focal clusters in adherent renal epithelia","volume":"79","author":"Wilson","year":"1999","journal-title":"Lab. Invest."},{"key":"10.1016\/j.ydbio.2005.06.034_bib56","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0002-9440(10)64726-8","article-title":"Apical plasma membrane mispolarization of NaK-ATPase in polycystic kidney disease epithelia is associated with aberrant expression of the beta2 isoform","volume":"156","author":"Wilson","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ydbio.2005.06.034_bib57","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1097\/01.ASN.0000029587.47950.25","article-title":"The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia","volume":"13","author":"Yoder","year":"2002","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160605004549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160605004549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T18:23:49Z","timestamp":1626459829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160605004549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S0012160605004549"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2005.06.034","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}