{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:00:41Z","timestamp":1791327641313,"version":"4.3.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2851,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.ydbio.2005.08.050","type":"journal-article","created":{"date-parts":[[2005,10,18]],"date-time":"2005-10-18T07:20:50Z","timestamp":1129620050000},"page":"378-389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":395,"title":["Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli"],"prefix":"10.1016","volume":"287","author":[{"given":"Scott R.","family":"May","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir M.","family":"Ashique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattias","family":"Karlen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiguo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostantinos","family":"Zarbalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Reiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Ericson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2005.08.050_bib1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0092-8674(00)80292-5","article-title":"Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor","volume":"89","author":"Aza-Blanc","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib2","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1242\/dev.129.20.4753","article-title":"Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway","volume":"129","author":"Bai","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.08.050_bib3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1534-5807(03)00394-0","article-title":"All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3","volume":"6","author":"Bai","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0092-8674(00)80853-3","article-title":"A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube","volume":"101","author":"Briscoe","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature02835","article-title":"Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound patched protein","volume":"431","author":"Casali","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.08.050_bib6","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1126\/science.1104135","article-title":"Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2","volume":"306","author":"Chen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2005.08.050_bib7","doi-asserted-by":"crossref","DOI":"10.1038\/nature04117","article-title":"Vertebrate Smoothened functions at the primary cilium","author":"Corbit","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.08.050_bib8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(00)00056-8","article-title":"Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened","volume":"102","author":"Denef","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0092-8674(00)80323-2","article-title":"Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling","volume":"90","author":"Ericson","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1101\/gad.10.3.301","article-title":"Conservation of the hedgehog\/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog","volume":"10","author":"Goodrich","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2005.08.050_bib11","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.cub.2003.08.034","article-title":"Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm","volume":"13","author":"Han","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib12","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1242\/dev.00594","article-title":"Smoothened translates Hedgehog levels into distinct responses","volume":"130","author":"Hooper","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.08.050_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02061","article-title":"Hedgehog signalling in the mouse requires intraflagellar transport proteins","volume":"426","author":"Huangfu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.08.050_bib14","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0960-9822(00)00755-7","article-title":"Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein","volume":"10","author":"Ingham","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib15","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1101\/gad.1136603","article-title":"Smoothened transduces Hedgehog signal by physically interacting with Costal2\/Fused complex through its C-terminal tail","volume":"17","author":"Jia","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2005.08.050_bib16","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature02962","article-title":"Hedgehog signalling in prostate regeneration, neoplasia and metastasis","volume":"431","author":"Karhadkar","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.08.050_bib17","doi-asserted-by":"crossref","first-page":"7548","DOI":"10.1073\/pnas.112212199","article-title":"Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly","volume":"99","author":"Lettice","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2005.08.050_bib18","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/79916","article-title":"Specification of ventral neuron types is mediated by an antagonistic interaction between Shh and Gli3","volume":"3","author":"Litingtung","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ydbio.2005.08.050_bib19","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nature01033","article-title":"Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity","volume":"418","author":"Litingtung","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.08.050_bib20","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1242\/dev.01894","article-title":"Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors","volume":"132","author":"Liu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.08.050_bib21","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1126\/science.1098020","article-title":"The Hedgehog response network: sensors, switches, and routers","volume":"304","author":"Lum","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2005.08.050_bib22","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S1097-2765(03)00426-X","article-title":"Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2","volume":"12","author":"Lum","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/384176a0","article-title":"Biochemical evidence that patched is the Hedgehog receptor","volume":"384","author":"Marigo","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.08.050_bib24","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0167-4889(00)00015-X","article-title":"Understanding the functions of kinesin-II","volume":"1496","author":"Marszalek","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ydbio.2005.08.050_bib25","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0960-9822(01)00178-6","article-title":"The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking","volume":"11","author":"Martin","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib26","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1242\/dev.125.15.2759","article-title":"Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system","volume":"125","author":"Matise","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.08.050_bib27","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/S0092-8674(00)80592-9","article-title":"Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus","volume":"96","author":"Methot","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0012-1606(03)00065-4","article-title":"The amino-terminal region of Gli3 antagonizes the Shh response and acts in dorsoventral fate specification in the developing spinal cord","volume":"257","author":"Meyer","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-213X-2-4","article-title":"Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2","volume":"2","author":"Monnier","year":"2002","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib30","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0012-1606(03)00159-3","article-title":"Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification","volume":"259","author":"Motoyama","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib31","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0896-6273(02)00689-X","article-title":"The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord","volume":"34","author":"Muller","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2005.08.050_bib32","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.mod.2004.04.015","article-title":"Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila","volume":"121","author":"Nakano","year":"2004","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2005.08.050_bib33","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ncb1118","article-title":"Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity","volume":"6","author":"Nishimura","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib34","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.cub.2003.10.004","article-title":"Identification of a functional interaction between the transmembrane protein Smoothened and the kinesin-related protein Costal2","volume":"13","author":"Ogden","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib35","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/25533","article-title":"Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator","volume":"396","author":"Ohlmeyer","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.08.050_bib36","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1242\/dev.127.8.1593","article-title":"Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation","volume":"127","author":"Park","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.08.050_bib37","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.144.3.473","article-title":"The DHC1b (DHC2) isoform of cytoplasmic dynein is required for flagellar assembly","volume":"144","author":"Pazour","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib38","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1101\/gad.243402","article-title":"Dorsal\u2013ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity","volume":"16","author":"Persson","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2005.08.050_bib39","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0092-8674(00)80802-8","article-title":"A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord","volume":"97","author":"Pierani","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib40","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1091\/mbc.10.3.693","article-title":"Cytoplasmic dynein heavy chain 1b is required for flagellar assembly in Chlamydomonas","volume":"10","author":"Porter","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib41","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1242\/dev.01389","article-title":"Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates","volume":"131","author":"Rana","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.08.050_bib42","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0092-8674(00)80331-1","article-title":"Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2","volume":"90","author":"Robbins","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib43","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrm952","article-title":"Intraflagellar transport","volume":"3","author":"Rosenbaum","year":"2002","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib44","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ncb1052","article-title":"Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog","volume":"5","author":"Ruel","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib45","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0304-3835(03)00451-8","article-title":"Hedgehog-Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer","volume":"204","author":"Ruiz i Altaba","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ydbio.2005.08.050_bib46","doi-asserted-by":"crossref","first-page":"12561","DOI":"10.1073\/pnas.0404956101","article-title":"Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling","volume":"101","author":"Sanchez","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2005.08.050_bib47","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.cub.2003.09.025","article-title":"Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails","volume":"13","author":"Sarpal","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib48","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1083\/jcb.147.3.519","article-title":"Role of a class DHC1b dynein in retrograde transport of IFT motors and IFT raft particles along cilia, but not dendrites, in chemosensory neurons of living Caenorhabditis elegans","volume":"147","author":"Signor","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib49","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0092-8674(00)80332-3","article-title":"Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway","volume":"90","author":"Sisson","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib50","doi-asserted-by":"crossref","first-page":"7064","DOI":"10.1074\/jbc.M311794200","article-title":"The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, Smoothened-independent manner","volume":"279","author":"Stegman","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2005.08.050_bib51","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0960-9822(01)00179-8","article-title":"Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation","volume":"11","author":"Strutt","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib52","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/nature00989","article-title":"Patched acts catalytically to suppress the activity of Smoothened","volume":"418","author":"Taipale","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.08.050_bib53","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1242\/dev.125.22.4417","article-title":"The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development","volume":"125","author":"Takahashi","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.08.050_bib54","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0092-8674(00)81783-3","article-title":"Specification of motor neuron identity by the MNR2 homeodomain protein","volume":"95","author":"Tanabe","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib55","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1242\/dev.01606","article-title":"A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo","volume":"132","author":"Tay","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.08.050_bib56","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1075620","article-title":"Progression of vertebrate limb development through SHH-mediated counteraction of GLI3","volume":"298","author":"te Welscher","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2005.08.050_bib57","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1242\/dev.127.20.4361","article-title":"Genetic control of dorsal\u2013ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2","volume":"127","author":"Toresson","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.08.050_bib58","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0896-6273(01)00412-3","article-title":"Different levels of repressor activity assign redundant and specific roles to Nkx6 genes in motor neuron and interneuron specification","volume":"31","author":"Vallstedt","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2005.08.050_bib59","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0092-8674(00)80678-9","article-title":"Hedgehog-regulated processing of Gli3 produces an anterior\/posterior repressor gradient in the developing vertebrate limb","volume":"100","author":"Wang","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.08.050_bib60","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1101\/gad.843900","article-title":"Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus","volume":"14","author":"Wang","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2005.08.050_bib61","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1242\/dev.125.16.3123","article-title":"Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling","volume":"125","author":"Yang","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.08.050_bib62","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1242\/dev.128.2.193","article-title":"Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon","volume":"128","author":"Yun","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.08.050_bib63","doi-asserted-by":"crossref","first-page":"E219","DOI":"10.1371\/journal.pbio.0020219","article-title":"A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development","volume":"2","author":"Zarbalis","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ydbio.2005.08.050_bib64","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1101\/gad.1080803","article-title":"Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction","volume":"17","author":"Zhu","year":"2003","journal-title":"Genes Dev."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160605006032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160605006032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:47:46Z","timestamp":1757908066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160605006032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0012160605006032"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2005.08.050","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1028677.342277","asserted-by":"object"}]},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2005.08.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}