{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T04:11:46Z","timestamp":1778127106545,"version":"3.51.4"},"reference-count":55,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2790,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.ydbio.2005.09.044","type":"journal-article","created":{"date-parts":[[2005,11,22]],"date-time":"2005-11-22T07:31:07Z","timestamp":1132644667000},"page":"30-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42"],"prefix":"10.1016","volume":"289","author":[{"given":"Jason M.","family":"Tennessen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather F.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy L.","family":"Volk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann E.","family":"Rougvie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2005.09.044_bib1","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/genetics\/149.3.1335","article-title":"Identification of heterochronic mutants in Caenorhabditis elegans: temporal misexpression of a collagen\u2237green fluorescent protein fusion gene","volume":"149","author":"Abrahante","year":"1998","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2005.09.044_bib55","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S1534-5807(03)00127-8","article-title":"The Caenorhabditis elegans hunchback-like gene lin-57\/hbl-1 controls developmental timing and is regulated by microRNAs","volume":"4","author":"Abrahante","year":"2003","journal-title":"Dev. Cell."},{"key":"10.1016\/j.ydbio.2005.09.044_bib2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/genetics\/137.2.483","article-title":"A screen for genetic loci required for body-wall muscle development during embryogenesis in Caenorhabditis elegans","volume":"137","author":"Ahnn","year":"1994","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2005.09.044_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.6494891","article-title":"Heterochronic mutants of the nematode Caenorhabditis elegans","volume":"226","author":"Ambros","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2005.09.044_bib4","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1101\/gad.1.4.398","article-title":"The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events","volume":"1","author":"Ambros","year":"1987","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2005.09.044_bib5","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1242\/dev.125.7.1191","article-title":"daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans","volume":"125","author":"Antebi","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.09.044_bib6","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1101\/gad.14.12.1512","article-title":"daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans","volume":"14","author":"Antebi","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2005.09.044_bib7","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1101\/gad.5.10.1825","article-title":"Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28","volume":"5","author":"Arasu","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2005.09.044_bib8","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1242\/dev.122.8.2517","article-title":"Stage-specific accumulation of the terminal differentiation factor LIN-29 during C. elegans development","volume":"122","author":"Bettinger","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.09.044_bib9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2005.09.044_bib10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0092-8674(81)90501-8","article-title":"Mutations that lead to reiterations in the cell lineages of C. elegans","volume":"24","author":"Chalfie","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.09.044_bib11","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0960-9822(03)00286-0","article-title":"A novel C-terminal domain of Drosophila PERIOD inhibits dCLOCK:CYCLE-mediated transcription","volume":"13","author":"Chang","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib12","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1093\/nar\/gkg500","article-title":"Multiple sequence alignment with the Clustal series of programs","volume":"31","author":"Chenna","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2005.09.044_bib13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/genetics\/95.2.317","article-title":"Genetic and phenotypic characterization of roller mutants of Caenorhabditis elegans","volume":"95","author":"Cox","year":"1980","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2005.09.044_bib14","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/j.cub.2003.10.022","article-title":"Light regulates the cell cycle in zebrafish","volume":"13","author":"Dekens","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/dbio.1998.9063","article-title":"The LIN-29 transcription factor is required for proper morphogenesis of the Caenorhabditis elegans male tail","volume":"206","author":"Euling","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1101\/gad.952302","article-title":"fzr-1 and lin-35\/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen","volume":"16","author":"Fay","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2005.09.044_bib17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/dbio.1999.9272","article-title":"The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans","volume":"210","author":"Feinbaum","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib18","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","article-title":"Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans","volume":"391","author":"Fire","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.09.044_bib19","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1083\/jcb.114.3.465","article-title":"Muscle cell attachment in Caenorhabditis elegans","volume":"114","author":"Francis","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0092-8674(02)00961-3","article-title":"The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo","volume":"111","author":"Fu","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.09.044_bib21","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ydbio.2003.10.014","article-title":"Expression and function of conserved nuclear receptor genes in Caenorhabditis elegans","volume":"266","author":"Gissendanner","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib22","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1242\/jcs.115.17.3369","article-title":"Central and peripheral circadian oscillator mechanisms in flies and mammals","volume":"115","author":"Glossop","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.ydbio.2005.09.044_bib23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/343536a0","article-title":"Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels","volume":"343","author":"Hardin","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.09.044_bib24","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1101\/gad.12.16.2623","article-title":"Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning","volume":"12","author":"Harfe","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2005.09.044_bib25","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0012-1606(85)90381-1","article-title":"Polyploid tissues in the nematode Caenorhabditis elegans","volume":"107","author":"Hedgecock","year":"1985","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib26","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/nar\/gkg174","article-title":"New role of zCRY and zPER2 as regulators of sub-cellular distributions of zCLOCK and zBMAL proteins","volume":"31","author":"Hirayama","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2005.09.044_bib27","doi-asserted-by":"crossref","first-page":"D134","DOI":"10.1093\/nar\/gkh044","article-title":"Recent improvements to the PROSITE database","volume":"32","author":"Hulo","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ydbio.2005.09.044_bib28","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1126\/science.286.5442.1141","article-title":"Similarity of the C. elegans developmental timing protein lin-42 to circadian rhythm proteins","volume":"286","author":"Jeon","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2005.09.044_bib29","first-page":"1","article-title":"Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans","volume":"2","author":"Kamath","year":"2001","journal-title":"Genome Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib30","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0012-1606(81)90284-0","article-title":"On the control of germ cell development in Caenorhabditis elegans","volume":"81","author":"Kimble","year":"1981","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib31","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.09.044_bib32","series-title":"Genetic Control of Stage-specific Developmental Events in C. elegans","author":"Liu","year":"1990"},{"key":"10.1016\/j.ydbio.2005.09.044_bib33","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1101\/gad.312604","article-title":"A novel nuclear receptor\/coregulator complex controls C. elegans lipid metabolism, larval development, and aging","volume":"18","author":"Ludewig","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2005.09.044_bib34","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences","volume":"10","author":"Mello","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2005.09.044_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/genetics\/97.1.65","article-title":"Suppression and function of X-linked lethal and sterile mutations in Caenorhabditis elegans","volume":"97","author":"Meneely","year":"1981","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2005.09.044_bib36","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0092-8674(00)81906-6","article-title":"The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA","volume":"88","author":"Moss","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.09.044_bib37","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1006\/dbio.1999.9523","article-title":"The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation","volume":"216","author":"Olsen","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib38","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1242\/dev.01098","article-title":"The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin","volume":"131","author":"Pepper","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.09.044_bib39","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1091\/mbc.9.12.3351","article-title":"The Chlamydomonas IDA7 locus encodes a 140-kDa dynein intermediate chain required to assemble the I1 inner arm complex","volume":"9","author":"Perrone","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2005.09.044_bib40","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.09.044_bib41","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0960-9822(01)00259-7","article-title":"Light-dependent interaction between Drosophila CRY and the clock protein PER mediated by the carboxy terminus of CRY","volume":"11","author":"Rosato","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib42","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1242\/dev.01972","article-title":"Intrinsic and extrinsic regulators of developmental timing: from miRNAs to nutritional cues","volume":"132","author":"Rougvie","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.09.044_bib43","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1242\/dev.121.8.2491","article-title":"The heterochronic gene lin-29 encodes a zinc finger protein that controls a terminal differentiation event in C. elegans","volume":"121","author":"Rougvie","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.09.044_bib44","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/338313a0","article-title":"The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch","volume":"338","author":"Ruvkun","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2005.09.044_bib45","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/dbio.2001.0563","article-title":"Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation","volume":"243","author":"Seggerson","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib46","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S1097-2765(00)80245-2","article-title":"The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor","volume":"5","author":"Slack","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2005.09.044_bib47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-1119(88)90005-4","article-title":"Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase","volume":"67","author":"Smith","year":"1988","journal-title":"Gene"},{"key":"10.1016\/j.ydbio.2005.09.044_bib48","doi-asserted-by":"crossref","first-page":"E45","DOI":"10.1371\/journal.pbio.0000045","article-title":"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics","volume":"1","author":"Stein","year":"2003","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib49","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1242\/dev.127.3.585","article-title":"Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans","volume":"127","author":"Su","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2005.09.044_bib50","series-title":"The Nematode Caenorhabditis elegans Methods","author":"Sulston","year":"1988"},{"key":"10.1016\/j.ydbio.2005.09.044_bib51","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Post-embryonic cell lineages of the nematode, Caenorhabditis elegans","volume":"56","author":"Sulston","year":"1977","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2005.09.044_bib52","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0092-8674(00)80399-2","article-title":"Reprogramming chemotaxis responses: sensory neurons define olfactory preferences in C. elegans","volume":"91","author":"Troemel","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.09.044_bib53","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","article-title":"Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans","volume":"75","author":"Wightman","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2005.09.044_bib54","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/genetics\/149.3.1323","article-title":"A new marker for mosaic analysis in Caenorhabditis elegans indicates a fusion between hyp6 and hyp7, two major components of the hypodermis","volume":"149","author":"Yochem","year":"1998","journal-title":"Genetics"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160605006810?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160605006810?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:47:49Z","timestamp":1757908069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160605006810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0012160605006810"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2005.09.044","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2005.09.044","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}