{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:29:34Z","timestamp":1787984974879,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2389,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.ydbio.2006.08.068","type":"journal-article","created":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T09:10:08Z","timestamp":1157620208000},"page":"240-253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Pax2\/5\/8 gene egl-38 coordinates organogenesis of the C. elegansegg-laying system"],"prefix":"10.1016","volume":"301","author":[{"given":"Vandana","family":"Rajakumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Chamberlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2006.08.068_bib2","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1242\/dev.124.20.3919","article-title":"The PAX gene egl-38 mediates developmental patterning in Caenorhabditis elegans","volume":"124","author":"Chamberlin","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.08.068_bib1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/genetics\/153.2.731","article-title":"Characterization of seven genes affecting Caenorhabditis elegans hindgut development","volume":"153","author":"Chamberlin","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2006.08.068_bib3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0960-9822(99)80112-2","article-title":"Reciprocal EGF signaling back to the uterus from the induced C. elegans vulva coordinates morphogenesis of epithelia","volume":"9","author":"Chang","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2006.08.068_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0168-9525(01)02594-X","article-title":"Getting your Pax straight: Pax proteins in development and disease","volume":"18","author":"Chi","year":"2002","journal-title":"Trends Genet."},{"key":"10.1016\/j.ydbio.2006.08.068_bib5","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1093\/genetics\/165.3.1623","article-title":"The EGL-13 SOX domain transcription factor affects the uterine pi cell lineages in Caenorhabditis elegans","volume":"165","author":"Cinar","year":"2003","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2006.08.068_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1126\/science.1089163","article-title":"A Neurexin-related protein, BAM-2, terminates axonal branches in C. elegans","volume":"302","author":"Colavita","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2006.08.068_bib7","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/(SICI)1096-911X(199611)27:5<440::AID-MPO9>3.0.CO;2-M","article-title":"Pax-2, kidney development, and oncogenesis","volume":"27","author":"Dressler","year":"1996","journal-title":"Med. Pediatr. Oncol."},{"key":"10.1016\/j.ydbio.2006.08.068_bib8","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1242\/dev.109.4.787","article-title":"Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system","volume":"109","author":"Dressler","year":"1990","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.08.068_bib9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/362065a0","article-title":"Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities","volume":"362","author":"Dressler","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2006.08.068_bib10","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1101\/gr.2497604","article-title":"A first version of the Caenorhabditis elegans Promoterome","volume":"14","author":"Dupuy","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.ydbio.2006.08.068_bib11","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1371\/journal.pbio.0020334","article-title":"EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid","volume":"2","author":"Dutt","year":"2004","journal-title":"Plos Biol."},{"key":"10.1016\/j.ydbio.2006.08.068_bib12","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1101\/gad.11.16.2066","article-title":"The Pax2 homolog sparkling is required for development of cone and pigment cells in the Drosophila eye","volume":"11","author":"Fu","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2006.08.068_bib13","series-title":"C. elegans II","first-page":"519","article-title":"Development of the vulva","author":"Greenwald","year":"1997"},{"key":"10.1016\/j.ydbio.2006.08.068_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1242\/dev.02184","article-title":"Pax-2\/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney","volume":"133","author":"Grote","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.08.068_bib15","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1128\/MCB.18.8.4556","article-title":"Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction","volume":"18","author":"Gu","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2006.08.068_bib16","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1006\/dbio.2002.0688","article-title":"Tissue-specific regulation of the LIM homeobox gene lin-11 during development of the Caenorhabditis elegans egg-laying system","volume":"247","author":"Gupta","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.08.068_bib17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1242\/dev.126.1.169","article-title":"COG-2, a sox domain protein necessary for establishing a functional vulval\u2013uterine connection in Caenorhabditis elegans","volume":"126","author":"Hanna-Rose","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.08.068_bib18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1006\/dbio.2001.0514","article-title":"The Caenorhabditis elegans EGL-26 protein mediates vulval cell morphogenesis","volume":"241","author":"Hanna-Rose","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.08.068_bib19","unstructured":"Huang, L., Hanna-Rose, W., in press. EGF signaling overcomes a uterine cell death associated with temporal mis-coordination of organogenesis within the C. elegans egg-laying apparatus. Dev. Biol. (doi:10.1016\/j.ydbio.2006.08.024)."},{"key":"10.1016\/j.ydbio.2006.08.068_bib20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1242\/dev.00924","article-title":"A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development","volume":"131","author":"Hwang","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.08.068_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1567-133X(02)00055-8","article-title":"Gene expression markers for Caenorhabditis elegans vulval cells","volume":"2","author":"Inoue","year":"2002","journal-title":"Gene Expr. Patterns"},{"key":"10.1016\/j.ydbio.2006.08.068_bib22","doi-asserted-by":"crossref","first-page":"4972","DOI":"10.1073\/pnas.0408122102","article-title":"Transcriptional network underlying Caenorhabditis elegans vulval development","volume":"102","author":"Inoue","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2006.08.068_bib23","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0968-0004(98)01285-7","article-title":"Multiple sequence alignment with Clustal X","volume":"23","author":"Jeanmougin","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ydbio.2006.08.068_bib24","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1128\/MCB.16.2.529","article-title":"A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog","volume":"16","author":"Katz","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2006.08.068_bib25","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/ncb1101-983","article-title":"Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia","volume":"3","author":"Koppen","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2006.08.068_bib26","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1242\/dev.00520","article-title":"Wnt11 and Ret\/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development","volume":"130","author":"Majumdar","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.08.068_bib27","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences","volume":"10","author":"Mello","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2006.08.068_bib29","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1242\/dev.122.11.3617","article-title":"Morphogenesis of the C. elegans hermaphrodite uterus","volume":"122","author":"Newman","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.08.068_bib28","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.1242\/dev.126.23.5319","article-title":"The lin-11 LIM domain transcription factor is necessary for morphogenesis of C. elegans uterine cells","volume":"126","author":"Newman","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.08.068_bib30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/genetics\/135.2.385","article-title":"Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans","volume":"135","author":"Okkema","year":"1993","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2006.08.068_bib31","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1242\/dev.119.3.711","article-title":"Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development","volume":"119","author":"Rothenpieler","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.08.068_bib32","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0959-437X(00)00125-8","article-title":"Cross-talk in kidney development","volume":"10","author":"Schedl","year":"2000","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ydbio.2006.08.068_bib33","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1242\/dev.126.4.691","article-title":"Formation of the vulva in Caenorhabditis elegans: a paradigm for organogenesis","volume":"126","author":"Sharma-Kishore","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.08.068_bib34","series-title":"The Nematode Caenorhabditis elegans","first-page":"587","article-title":"Methods","author":"Sulston","year":"1988"},{"key":"10.1016\/j.ydbio.2006.08.068_bib35","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Post-embryonic cell lineages of the nematode Caenorhabditis elegans","volume":"56","author":"Sulston","year":"1977","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.08.068_bib36","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0012-1606(83)90201-4","article-title":"The embryonic cell lineage of the nematode Caenorhabditis elegans","volume":"100","author":"Sulston","year":"1983","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.08.068_bib37","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1073\/pnas.94.10.5156","article-title":"Evolution of paired domains: isolation and sequencing of jellyfish and hydra Pax genes related to Pax-5 and Pax-6","volume":"94","author":"Sun","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2006.08.068_bib38","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1242\/dev.121.12.4057","article-title":"Pax-2 controls multiple steps of urogenital development","volume":"121","author":"Torres","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.08.068_bib39","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/genetics\/104.4.619","article-title":"Egg-laying defective mutants of the nematode Caenorhabditis elegans","volume":"104","author":"Trent","year":"1983","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2006.08.068_bib40","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1525-142X.2004.04029.x","article-title":"Evolution of regulatory elements producing a conserved gene expression pattern in Caenorhabditis","volume":"6","author":"Wang","year":"2004","journal-title":"Evolut. Develop."},{"key":"10.1016\/j.ydbio.2006.08.068_bib41","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/genetics\/149.3.1323","article-title":"A new marker for mosaic analysis in Caenorhabditis elegans indicates a fusion between hyp6 and hyp7, two major components of the hypodermis","volume":"149","author":"Yochem","year":"1998","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2006.08.068_bib42","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/1096-9861(20000101)429:1<127::AID-CNE10>3.0.CO;2-H","article-title":"IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm","volume":"429","author":"Zahn","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.ydbio.2006.08.068_bib43","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.mod.2005.04.005","article-title":"Alteration of the DNA binding domain disrupts tissue-specific functions of the C. elegans Pax protein EGL-38","volume":"122","author":"Zhang","year":"2005","journal-title":"Mech. Dev."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160606011742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160606011742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:54:36Z","timestamp":1757908476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160606011742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0012160606011742"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2006.08.068","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Pax2\/5\/8 gene egl-38 coordinates organogenesis of the C. elegansegg-laying system","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2006.08.068","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}