{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:47:08Z","timestamp":1791254828971,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2420,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.ydbio.2006.09.001","type":"journal-article","created":{"date-parts":[[2006,9,10]],"date-time":"2006-09-10T11:09:41Z","timestamp":1157886581000},"page":"523-533","source":"Crossref","is-referenced-by-count":88,"title":["Hippi is essential for node cilia assembly and Sonic hedgehog signaling"],"prefix":"10.1016","volume":"300","author":[{"given":"Caroline","family":"Houde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin J.","family":"Dickinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky M.","family":"Houtzager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Cullum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Montpetit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Metzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A.","family":"Hoodless","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2006.09.001_bib1","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1242\/dev.126.14.3205","article-title":"Gli proteins encode context-dependent positive and negative functions: implications for development and disease","volume":"126","author":"Altaba","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0092-8674(94)90522-3","article-title":"HNF-3 beta is essential for node and notochord formation in mouse development","volume":"78","author":"Ang","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib3","doi-asserted-by":"crossref","first-page":"34211","DOI":"10.1074\/jbc.M300156200","article-title":"IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia","volume":"278","author":"Baker","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2006.09.001_bib4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/1096-8628(20010715)101:4<339::AID-AJMG1442>3.0.CO;2-P","article-title":"Cilia propel the embryo in the right direction","volume":"101","author":"Brueckner","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ydbio.2006.09.001_bib5","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/S0960-9822(02)01147-8","article-title":"Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling","volume":"12","author":"Caspary","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib6","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nature04117","article-title":"Vertebrate Smoothened functions at the primary cilium","volume":"437","author":"Corbit","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2006.09.001_bib7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/dbio.1996.0148","article-title":"Role of notochord in specification of cardiac left\u2013right orientation in zebrafish and Xenopus","volume":"177","author":"Danos","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib8","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1242\/dev.125.14.2533","article-title":"Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice","volume":"125","author":"Ding","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib9","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/0092-8674(93)90627-3","article-title":"Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity","volume":"75","author":"Echelard","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2005.09.022","article-title":"Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins","volume":"290","author":"Eggenschwiler","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0092-8674(95)90536-7","article-title":"Sonic hedgehog induces the differentiation of ventral forebrain neurons: a common signal for ventral patterning within the neural tube","volume":"81","author":"Ericson","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0092-8674(00)80323-2","article-title":"Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling","volume":"90","author":"Ericson","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib13","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s003359901099","article-title":"Revised nomenclature for strain 129 mice","volume":"10","author":"Festing","year":"1999","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.ydbio.2006.09.001_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncb735","article-title":"Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi","volume":"4","author":"Gervais","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1101\/gad.10.3.301","article-title":"Conservation of the hedgehog\/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog","volume":"10","author":"Goodrich","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2006.09.001_bib16","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1091\/mbc.01-08-0402","article-title":"Identification of a novel light intermediate chain (D2LIC) for mammalian cytoplasmic dynein 2","volume":"13","author":"Grissom","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0014-4827(02)00089-7","article-title":"Identification of CHE-13, a novel intraflagellar transport protein required for cilia formation","volume":"284","author":"Haycraft","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ydbio.2006.09.001_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cell.2006.03.002","article-title":"Nodal flow and the generation of left\u2013right asymmetry","volume":"125","author":"Hirokawa","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1601-183x.2004.00069.x","article-title":"The dark phase improves genetic discrimination for some high throughput mouse behavioral phenotyping","volume":"3","author":"Hossain","year":"2004","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.ydbio.2006.09.001_bib20","doi-asserted-by":"crossref","first-page":"9977","DOI":"10.1523\/JNEUROSCI.3356-04.2004","article-title":"Caspase-7 expanded function and intrinsic expression level underlies strain-specific brain phenotype of caspase-3-null mice","volume":"24","author":"Houde","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2006.09.001_bib21","doi-asserted-by":"crossref","first-page":"11325","DOI":"10.1073\/pnas.0505328102","article-title":"From the cover: cilia and hedgehog responsiveness in the mouse","volume":"102","author":"Huangfu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2006.09.001_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02061","article-title":"Hedgehog signalling in the mouse requires intraflagellar transport proteins","volume":"426","author":"Huangfu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2006.09.001_bib23","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: paradigms and principles","volume":"15","author":"Ingham","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2006.09.001_bib24","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0960-9822(02)00895-3","article-title":"Sonic hedgehog induces the segregation of patched and smoothened in endosomes","volume":"12","author":"Incardona","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib25","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1242\/dev.00590","article-title":"Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node","volume":"130","author":"Jeong","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0959-4388(00)00136-7","article-title":"Development. The decade of the developing brain","volume":"10","author":"Jessell","year":"2000","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/ng0597-44","article-title":"HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain","volume":"16","author":"Kalchman","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2006.09.001_bib28","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/S0092-8674(02)01200-X","article-title":"PKCgamma regulates syndecan-2 inside-out signaling during Xenopus left\u2013right development","volume":"111","author":"Kramer","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib29","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1242\/dev.01772","article-title":"Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis","volume":"132","author":"Kramer-Zucker","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib30","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0092-8674(95)90477-8","article-title":"A molecular pathway determining left\u2013right asymmetry in chick embryogenesis","volume":"82","author":"Levin","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1006\/dbio.1997.8662","article-title":"Left\/right patterning signals and the independent regulation of different aspects of situs in the chick embryo","volume":"189","author":"Levin","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0092-8674(02)00939-X","article-title":"Asymmetries in H+\/K+-ATPase and cell membrane potentials comprise a very early step in left\u2013right patterning","volume":"111","author":"Levin","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib33","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tig.2004.01.008","article-title":"Huntingtin\u2013protein interactions and the pathogenesis of Huntington's disease","volume":"20","author":"Li","year":"2004","journal-title":"Trends Genet."},{"key":"10.1016\/j.ydbio.2006.09.001_bib34","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1242\/dev.01894","article-title":"Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors","volume":"132","author":"Liu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib35","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1242\/dev.125.15.2759","article-title":"Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system","volume":"125","author":"Matise","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib36","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ydbio.2005.08.050","article-title":"Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli","volume":"287","author":"May","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib37","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0092-8674(00)81472-5","article-title":"Lefty-1 is required for left\u2013right determination as a regulator of lefty-2 and nodal","volume":"94","author":"Meno","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib38","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1523\/JNEUROSCI.17-15-05891.1997","article-title":"Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult In vitro","volume":"17","author":"Miao","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2006.09.001_bib39","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1242\/dev.126.20.4431","article-title":"Mouse patched1 controls body size determination and limb patterning","volume":"126","author":"Milenkovic","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib40","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1242\/dev.127.11.2347","article-title":"The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left\u2013right axis determination","volume":"127","author":"Murcia","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib41","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81705-5","article-title":"Randomization of left\u2013right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein","volume":"95","author":"Nonaka","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib42","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1242\/dev.01567","article-title":"Sonic hedgehog controls stem cell behavior in the postnatal and adult brain","volume":"132","author":"Palma","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib43","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1242\/dev.01389","article-title":"Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates","volume":"131","author":"Rana","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib44","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrg1830","article-title":"Left\u2013right asymmetry in the vertebrate embryo: from early information to higher-level integration","volume":"7","author":"Raya","year":"2006","journal-title":"Nat. Rev., Genet."},{"key":"10.1016\/j.ydbio.2006.09.001_bib45","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0092-8674(95)90397-6","article-title":"Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis","volume":"81","author":"Roelink","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib46","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1242\/dev.124.7.1313","article-title":"A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro","volume":"124","author":"Sasaki","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib47","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1242\/dev.126.17.3915","article-title":"Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling","volume":"126","author":"Sasaki","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib48","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev.cellbio.19.111401.091318","article-title":"Intraflagellar transport","volume":"19","author":"Scholey","year":"2003","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib49","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1242\/dev.02384","article-title":"The left\u2013right axis in the mouse: from origin to morphology","volume":"133","author":"Shiratori","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng0597-19","article-title":"Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice","volume":"16","author":"Simpson","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2006.09.001_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1053803","article-title":"A two-cilia model for vertebrate left\u2013right axis specification","volume":"17","author":"Tabin","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2006.09.001_bib52","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1083\/jcb.145.4.825","article-title":"Left\u2013right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A\u2212\/\u2212 mice analysis","volume":"145","author":"Takeda","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib53","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nature03494","article-title":"FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left\u2013right determination","volume":"435","author":"Tanaka","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2006.09.001_bib54","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1046\/j.1471-4159.1998.70031327.x","article-title":"Regional distribution of Sonic Hedgehog, patched, and smoothened mRNA in the adult rat brain","volume":"70","author":"Traiffort","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ydbio.2006.09.001_bib55","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1046\/j.0953-816x.2001.01708.x","article-title":"High expression and anterograde axonal transport of aminoterminal sonic hedgehog in the adult hamster brain","volume":"14","author":"Traiffort","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ydbio.2006.09.001_bib56","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/exnr.2001.7825","article-title":"Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease","volume":"173","author":"Tsuboi","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib57","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0896-6273(04)00268-5","article-title":"Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons","volume":"42","author":"Tsujikawa","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2006.09.001_bib58","doi-asserted-by":"crossref","first-page":"11376","DOI":"10.1073\/pnas.96.20.11376","article-title":"Multiple left\u2013right asymmetry defects in Shh(\u2212\/\u2212) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1","volume":"96","author":"Tsukui","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2006.09.001_bib59","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1083\/jcb.133.4.831","article-title":"Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles","volume":"133","author":"Vaisberg","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib60","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","article-title":"Neuropathological classification of Huntington's disease","volume":"44","author":"Vonsattel","year":"1985","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib61","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0092-8674(00)80678-9","article-title":"Hedgehog-regulated processing of Gli3 produces an anterior\/posterior repressor gradient in the developing vertebrate limb","volume":"100","author":"Wang","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib62","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/hmg\/6.3.487","article-title":"HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system","volume":"6","author":"Wanker","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2006.09.001_bib63","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0092-8674(94)90523-1","article-title":"The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo","volume":"78","author":"Weinstein","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib64","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1101\/gad.1025702","article-title":"A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord","volume":"16","author":"Wijgerde","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2006.09.001_bib65","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1083\/jcb.130.6.1387","article-title":"KIF3A\/B: a heterodimeric kinesin superfamily protein that works as a microtubule plus end-directed motor for membrane organelle transport","volume":"130","author":"Yamazaki","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2006.09.001_bib66","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1242\/dev.129.10.2507","article-title":"Sonic hedgehog and the molecular regulation of mouse neural tube closure","volume":"129","author":"Ybot-Gonzalez","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.001_bib67","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0166-4328(01)00413-2","article-title":"Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent","volume":"132","author":"Young","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ydbio.2006.09.001_bib68","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0092-8674(01)00385-3","article-title":"Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L\/R asymmetry by the mouse node","volume":"105","author":"Zhang","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.001_bib69","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1101\/gad.1080803","article-title":"Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction","volume":"17","author":"Zhu","year":"2003","journal-title":"Genes Dev."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160606011791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160606011791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T05:48:28Z","timestamp":1627796908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160606011791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0012160606011791"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2006.09.001","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}