{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:20:28Z","timestamp":1780456828983,"version":"3.54.1"},"reference-count":92,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2389,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1016\/j.ydbio.2006.09.050","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T08:27:35Z","timestamp":1160123255000},"page":"602-614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":145,"title":["Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects"],"prefix":"10.1016","volume":"301","author":[{"given":"Patrick Y.","family":"Jay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malgorzata","family":"Bielinska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Erlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Mannisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Heikinheimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2006.09.050_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1371\/journal.pgen.0010010","article-title":"Fog2 is required for normal diaphragm and lung development in mice and humans","volume":"1","author":"Ackerman","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2006.09.050_bib2","series-title":"Pediatric Academic Societies' Meeting, San Francisco","article-title":"Gata4 is necessary for normal pulmonary lobar development","author":"Ackerman","year":"2006"},{"key":"10.1016\/j.ydbio.2006.09.050_bib3","first-page":"2235","article-title":"Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermal derivatives and heart","volume":"13","author":"Arceci","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib4","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1073\/pnas.0401833101","article-title":"Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity","volume":"101","author":"Aries","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2006.09.050_bib5","first-page":"L1310","article-title":"Diaphragm defects occur in a CDH hernia model independently of myogenesis and lung formation","volume":"283","author":"Babiuk","year":"2002","journal-title":"Am. J. Physiol.: Lung. Cell Mol. Physiol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib6","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/sj.ejhg.5201475","article-title":"Duplications and copy number variants of 8p23.1 are cytogenetically indistinguishable but distinct at the molecular level","volume":"13","author":"Barber","year":"2005","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2006.09.050_bib7","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1210\/en.2004-1643","article-title":"Gonadotropin-induced adrenocortical neoplasia in NU\/J nude mice","volume":"146","author":"Bielinska","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.ydbio.2006.09.050_bib8","doi-asserted-by":"crossref","first-page":"84R","DOI":"10.1203\/01.pdr.0000203563.37626.77","article-title":"Developmental pathways and specification of intrapulmonary stem cells","volume":"59","author":"Borok","year":"2006","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ydbio.2006.09.050_bib9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10024-003-2133-7","article-title":"Congenital diaphragmatic hernia and chromosomal anomalies: autopsy study","volume":"7","author":"Borys","year":"2004","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib10","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1074\/jbc.M208173200","article-title":"Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2","volume":"278","author":"Clabby","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2006.09.050_bib11","doi-asserted-by":"crossref","first-page":"e356","DOI":"10.1542\/peds.2004-2845","article-title":"Outcomes of congenital diaphragmatic hernia: a population-based study in Western Australia","volume":"116","author":"Colvin","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.ydbio.2006.09.050_bib12","doi-asserted-by":"crossref","first-page":"15641","DOI":"10.1073\/pnas.95.26.15641","article-title":"Modeling stochastic gene expression: implications for haploinsufficiency","volume":"95","author":"Cook","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2006.09.050_bib13","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1101\/gad.875201","article-title":"Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors","volume":"15","author":"Crispino","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2006.09.050_bib14","doi-asserted-by":"crossref","first-page":"37178","DOI":"10.1074\/jbc.M103731200","article-title":"p300 functions as a coactivator of transcription factor GATA-4","volume":"276","author":"Dai","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2006.09.050_bib15","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1086\/302330","article-title":"Delineation of the critical deletion region for congenital heart defects, on chromosome 8p23.1","volume":"64","author":"Devriendt","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ydbio.2006.09.050_bib16","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/(SICI)1097-0223(1998100)18:10<1055::AID-PD405>3.0.CO;2-I","article-title":"Prenatal diagnosis of an 8p23.1 deletion in a fetus with a diaphragmatic hernia and review of the literature","volume":"18","author":"Faivre","year":"1998","journal-title":"Prenatal Diagn."},{"key":"10.1016\/j.ydbio.2006.09.050_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1742-4682-3-9","article-title":"Computer simulation analysis of normal and abnormal development of the mammalian diaphragm","volume":"3","author":"Fisher","year":"2006","journal-title":"Theor. Biol. Med. Model."},{"key":"10.1016\/j.ydbio.2006.09.050_bib18","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1101\/gad.5.9.1513","article-title":"Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice","volume":"5","author":"Friedrich","year":"1991","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2006.09.050_bib19","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/bdra.20151","article-title":"Congenital diaphragmatic hernia: a retinoid-signaling pathway disruption during lung development?","volume":"73","author":"Gallot","year":"2005","journal-title":"Birth Defects Res., A Clin. Mol. Teratol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nature01827","article-title":"GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5","volume":"424","author":"Garg","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2006.09.050_bib21","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1002\/dvdy.20836","article-title":"Bmp2 and Gata4 function additively to rescue heart tube development in the absence of retinoids","volume":"235","author":"Ghatpande","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2006.09.050_bib22","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jpedsurg.2005.03.025","article-title":"Cardiac anomalies in patients with congenital diaphragmatic hernia and their prognosis: a report from the Congenital Diaphragmatic Hernia Study Group","volume":"40","author":"Graziano","year":"2005","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2006.09.050_bib23","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/(SICI)1099-0496(200005)29:5<394::AID-PPUL9>3.0.CO;2-2","article-title":"Recent advances in understanding the pathogenesis of nitrofen-induced congenital diaphragmatic hernia","volume":"29","author":"Greer","year":"2000","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib24","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1152\/jappl.2000.89.6.2123","article-title":"Structure of the primordial diaphragm and defects associated with nitrofen-induced CDH","volume":"89","author":"Greer","year":"2000","journal-title":"J. Appl. Physiol"},{"key":"10.1016\/j.ydbio.2006.09.050_bib25","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1203\/01.PDR.0000062660.12769.E6","article-title":"Etiology of congenital diaphragmatic hernia: the retinoid hypothesis","volume":"53","author":"Greer","year":"2003","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ydbio.2006.09.050_bib26","doi-asserted-by":"crossref","first-page":"14387","DOI":"10.1074\/jbc.M210144200","article-title":"Lysyl oxidase is required for vascular and diaphragmatic development in mice","volume":"278","author":"Hornstra","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2006.09.050_bib27","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/(SICI)1097-0223(199611)16:11<1003::AID-PD995>3.0.CO;2-D","article-title":"Structural chromosome anomalies in congenital diaphragmatic hernia","volume":"16","author":"Howe","year":"1996","journal-title":"Prenatal Diagn."},{"key":"10.1016\/j.ydbio.2006.09.050_bib28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/dvdy.20552","article-title":"GATA-4:FOG interactions regulate gastric epithelial development in the mouse","volume":"234","author":"Jacobsen","year":"2005","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2006.09.050_bib29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jpedsurg.2005.11.021","article-title":"Small lungs and suspect smooth muscle: congenital diaphragmatic hernia and the smooth muscle hypothesis","volume":"41","author":"Jesudason","year":"2006","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2006.09.050_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1677\/joe.1.06750","article-title":"Gonadectomy in mice of the inbred strain CE\/J induces proliferation of sub-capsular adrenal cells expressing gonadal marker genes","volume":"190","author":"Johnsen","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib31","first-page":"L521","article-title":"Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development","volume":"286","author":"Kalinichenko","year":"2004","journal-title":"Am. J. Physiol.: Lung. Cell Mol. Physiol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib32","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0002-9440(10)65000-6","article-title":"Dual-hit hypothesis explains pulmonary hypoplasia in the nitrofen model of congenital diaphragmatic hernia","volume":"156","author":"Keijzer","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib33","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1242\/dev.128.4.503","article-title":"The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development","volume":"128","author":"Keijzer","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.050_bib34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/ajmg.a.30298","article-title":"46,XY sex-reversal (Swyer syndrome) and congenital diaphragmatic hernia","volume":"131","author":"Kent","year":"2004","journal-title":"Am. J. Med. Genet., A"},{"key":"10.1016\/j.ydbio.2006.09.050_bib35","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1530\/eje.0.1470397","article-title":"Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis","volume":"147","author":"Ketola","year":"2002","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib36","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00019605-200201000-00005","article-title":"Double vagina with sex reversal, congenital diaphragmatic hernia, pulmonary and cardiac malformations\u2014Another case of Meacham syndrome","volume":"11","author":"Killeen","year":"2002","journal-title":"Clin. Dysmorphol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib37","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1006\/dbio.1998.9139","article-title":"Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation","volume":"206","author":"Kostetskii","year":"1999","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib38","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0092-8674(93)90515-R","article-title":"WT-1 is required for early kidney development","volume":"74","author":"Kreidberg","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.050_bib39","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1101\/gad.11.8.1048","article-title":"GATA4 transcription factor is required for ventral morphogenesis and heart tube formation","volume":"11","author":"Kuo","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2006.09.050_bib40","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0925-4773(03)00161-8","article-title":"Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice","volume":"120","author":"Liu","year":"2003","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2006.09.050_bib41","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/pd.1468","article-title":"Prenatal diagnosis of de novo deletions of 8p23.1 or 15q26.1 in two fetuses with diaphragmatic hernia and congenital heart defects","volume":"26","author":"L\u00f3pez","year":"2006","journal-title":"Prenatal Diagn."},{"key":"10.1016\/j.ydbio.2006.09.050_bib42","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0022-3468(99)90152-5","article-title":"Cardiovascular malformations in experimental congenital diaphragmatic hernia","volume":"34","author":"Losty","year":"1999","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2006.09.050_bib43","first-page":"75","article-title":"Where to look for the genes related to diaphragmatic hernia?","volume":"14","author":"Lurie","year":"2003","journal-title":"Genet. Couns."},{"key":"10.1016\/j.ydbio.2006.09.050_bib44","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/ajmg.1320420503","article-title":"Phenotypically normal girl with male pseudohermaphroditism, hypoplastic left ventricle, lung aplasia, horseshoe kidney, and diaphragmatic hernia","volume":"42","author":"Maaswinkel-Mooij","year":"1992","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ydbio.2006.09.050_bib45","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1535-6108(03)00047-3","article-title":"Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation","volume":"3","author":"Magee","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ydbio.2006.09.050_bib46","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1242\/dev.128.12.2397","article-title":"Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations","volume":"128","author":"Mahlapuu","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.050_bib47","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1161\/01.CIR.0000038109.84500.1E","article-title":"Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice","volume":"106","author":"M\u00e4ki","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.ydbio.2006.09.050_bib48","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0002-9440(10)61183-2","article-title":"Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues","volume":"167","author":"M\u00e4ki","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib49","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/jmg.37.4.315","article-title":"Sex reversal and diaphragmatic hernia in phenotypically female sibs with normal XY chromosomes","volume":"37","author":"Manouvrier-Hanu","year":"2000","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2006.09.050_bib50","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1128\/MCB.26.5.1700-1709.2006","article-title":"Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice","volume":"26","author":"McLaughlin","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib51","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/ajmg.1320410420","article-title":"Double vagina, cardiac, pulmonary, and other genital malformations with 46, XY karyotype","volume":"41","author":"Meacham","year":"1991","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ydbio.2006.09.050_bib52","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/S0022-3468(99)90010-6","article-title":"Cardiovascular malformations in congenital diaphragmatic hernia: human and experimental studies","volume":"34","author":"Migliazza","year":"1999","journal-title":"J. Pediatr. Surg."},{"key":"10.1016\/j.ydbio.2006.09.050_bib53","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1101\/gad.11.8.1061","article-title":"Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis","volume":"11","author":"Molkentin","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2006.09.050_bib54","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00383-005-1571-x","article-title":"Retinoic acid rescues lung hypoplasia in nitrofen-induced hypoplastic foetal rat lung explants","volume":"22","author":"Montedonico","year":"2006","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.ydbio.2006.09.050_bib55","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1242\/dev.126.9.1845","article-title":"YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis","volume":"126","author":"Moore","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.050_bib56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0925-4773(98)00188-9","article-title":"YAC transgenic analysis reveals Wilms' tumour 1 gene activity in the proliferating coelomic epithelium, developing diaphragm and limb","volume":"79","author":"Moore","year":"1998","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2006.09.050_bib57","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1242\/dev.124.19.3755","article-title":"Cardiomyocyte differentiation by GATA-4 deficient embryonic stem cells","volume":"122","author":"Narita","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.050_bib58","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1006\/dbio.1997.8684","article-title":"Wild-type endoderm abrogates the ventral developmental defects associated with GATA-4 deficiency in the mouse","volume":"189","author":"Narita","year":"1997","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib59","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ydbio.2003.12.033","article-title":"Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis","volume":"268","author":"Natoli","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib60","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/humu.9410","article-title":"A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot","volume":"27","author":"Nemer","year":"2006","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ydbio.2006.09.050_bib61","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ydbio.2005.02.031","article-title":"Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung","volume":"282","author":"Nguyen","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib62","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1465-9921-7-28","article-title":"Lung development in laminin gamma2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation","volume":"7","author":"Nguyen","year":"2006","journal-title":"Respir. Res."},{"key":"10.1016\/j.ydbio.2006.09.050_bib63","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1136\/jmg.2004.018895","article-title":"A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family","volume":"41","author":"Okubo","year":"2004","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2006.09.050_bib64","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1399-0004.1990.tb04189.x","article-title":"Deficiency of distal 8p\u2212: report of two cases and review of the literature","volume":"38","author":"Pecile","year":"1990","journal-title":"Clinical Genetics"},{"key":"10.1016\/j.ydbio.2006.09.050_bib65","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1096-8628(19990319)83:3<201::AID-AJMG11>3.0.CO;2-V","article-title":"GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease","volume":"83","author":"Pehlivan","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.ydbio.2006.09.050_bib66","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ajmg.a.30904","article-title":"Infants with Bochdalek diaphragmatic hernia: sibling precurrence and monozygotic twin discordance in a hospital-based malformation surveillance program","volume":"138","author":"Pober","year":"2005","journal-title":"Am. J. Med. Genet., A"},{"key":"10.1016\/j.ydbio.2006.09.050_bib67","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ydbio.2004.08.008","article-title":"GATA4 is a dosage-sensitive regulator of cardiac morphogenesis","volume":"275","author":"Pu","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib68","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1172\/JCI119792","article-title":"Regulated overexpression of interleukin 11 in the lung. Use to dissociate development-dependent and -independent phenotypes","volume":"100","author":"Ray","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2006.09.050_bib69","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1146\/annurev.physiol.66.032102.135749","article-title":"Epithelial\u2013mesenchymal interactions in the developing lung","volume":"66","author":"Shannon","year":"2004","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib70","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1093\/emboj\/cdg502","article-title":"Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation","volume":"22","author":"Shikama","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2006.09.050_bib71","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/ajmg.a.30778","article-title":"Molecular characterization of del(8)(p23.1p23.1) in a case of congenital diaphragmatic hernia","volume":"136","author":"Shimokawa","year":"2005","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.ydbio.2006.09.050_bib72","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/adc.2003.045765","article-title":"Recent advances in congenital diaphragmatic hernia","volume":"90","author":"Smith","year":"2005","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ydbio.2006.09.050_bib73","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1242\/dev.121.11.3877","article-title":"Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro","volume":"121","author":"Soudais","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.050_bib74","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.lfs.2003.10.002","article-title":"Regulation of cardiac myocyte apoptosis by the GATA-4 transcription factor","volume":"74","author":"Suzuki","year":"2004","journal-title":"Life Sci."},{"key":"10.1016\/j.ydbio.2006.09.050_bib75","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/77146","article-title":"A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2","volume":"25","author":"Svensson","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2006.09.050_bib76","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1101\/sqb.2002.67.317","article-title":"A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx\/Nkx2.5","volume":"67","author":"Tanaka","year":"2002","journal-title":"Cold Spring Harbor Symp. Quant. Biol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib77","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1136\/jmg.31.9.735","article-title":"Diaphragmatic herniae and translocations involving 8q22 in two patients","volume":"31","author":"Temple","year":"1994","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ydbio.2006.09.050_bib78","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0092-8674(00)80885-5","article-title":"FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium","volume":"101","author":"Tevosian","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2006.09.050_bib79","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1242\/dev.129.19.4627","article-title":"Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2","volume":"129","author":"Tevosian","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.050_bib80","doi-asserted-by":"crossref","first-page":"12573","DOI":"10.1073\/pnas.0400752101","article-title":"GATA4 is essential for formation of the proepicardium and regulates cardiogenesis","volume":"101","author":"Watt","year":"2004","journal-title":"Proc. Natl. Acad. Sci U. S. A."},{"key":"10.1016\/j.ydbio.2006.09.050_bib81","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1165\/ajrcmb.23.3.3906","article-title":"Impaired distal airway development in mice lacking elastin","volume":"23","author":"Wendel","year":"2000","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib82","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1053\/j.semperi.2005.04.007","article-title":"Follow up of infants with congenital diaphragmatic hernia","volume":"29","author":"West","year":"2005","journal-title":"Semin. Perinatol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib83","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1242\/dev.02313","article-title":"FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains","volume":"133","author":"White","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.050_bib84","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1001\/archpedi.1983.02140310026006","article-title":"Interstitial deletion of 8q. Occurrence in a patient with multiple exostoses and unusual facies","volume":"137","author":"Wilson","year":"1983","journal-title":"Am. J. Dis. Child."},{"key":"10.1016\/j.ydbio.2006.09.050_bib85","doi-asserted-by":"crossref","first-page":"15062","DOI":"10.1073\/pnas.251407098","article-title":"Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1\/Robo1 gene","volume":"98","author":"Xian","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2006.09.050_bib86","doi-asserted-by":"crossref","first-page":"11189","DOI":"10.1073\/pnas.0604604103","article-title":"A threshold of GATA4 and GATA6 expression is required for cardiovascular development","volume":"103","author":"Xin","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2006.09.050_bib87","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/415168a","article-title":"Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo","volume":"415","author":"Yanagisawa","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2006.09.050_bib88","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1242\/dev.129.9.2233","article-title":"GATA6 regulates differentiation of distal lung epithelium","volume":"129","author":"Yang","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2006.09.050_bib89","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/bdra.20230","article-title":"Epidemiologic characteristics of congenital diaphragmatic hernia among 2.5 million California births, 1989\u20131997","volume":"76","author":"Yang","year":"2006","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.ydbio.2006.09.050_bib90","doi-asserted-by":"crossref","first-page":"16351","DOI":"10.1073\/pnas.0507832102","article-title":"Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia","volume":"102","author":"You","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2006.09.050_bib91","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1073\/pnas.0730709100","article-title":"A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3","volume":"100","author":"Yuan","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2006.09.050_bib92","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1172\/JCI23769","article-title":"Morphogenesis of the right ventricle requires myocardial expression of Gata4","volume":"115","author":"Zeisberg","year":"2005","journal-title":"J. Clin. Invest."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160606012668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160606012668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T03:57:05Z","timestamp":1757908625000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160606012668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":92,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["S0012160606012668"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2006.09.050","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2007,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2006.09.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}