{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:36:45Z","timestamp":1790685405543,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":2055,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.ydbio.2007.09.038","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T07:30:49Z","timestamp":1191310249000},"page":"217-230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"title":["Noggin is required for normal lobe patterning and ductal budding in the mouse prostate"],"prefix":"10.1016","volume":"312","author":[{"given":"Crist","family":"Cook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M.","family":"Vezina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Allgeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubie","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wade","family":"Bushman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2007.09.038_bib1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/path.1753","article-title":"Computer-based detection of neonatal changes to branching morphogenesis reveals different mechanisms of and predicts prostate enlargement in mice haplo-insufficient for bone morphogenetic protein 4","volume":"206","author":"Almahbobi","year":"2005","journal-title":"J. Pathol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0074-7696(01)03013-3","article-title":"Neural patterning in the vertebrate embryo","volume":"203","author":"Altmann","year":"2001","journal-title":"Int. Rev. Cytol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib3","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/dbio.2002.0779","article-title":"Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators","volume":"250","author":"Balemans","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ydbio.2003.11.018","article-title":"Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis","volume":"267","author":"Berman","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1126\/science.8392225","article-title":"Separable regulatory elements governing myogenin transcription in mouse embryogenesis","volume":"261","author":"Cheng","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2007.09.038_bib6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1210\/edrv-8-3-338","article-title":"The endocrinology and developmental biology of the prostate","volume":"8","author":"Cunha","year":"1987","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ydbio.2007.09.038_bib7","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/pros.20321","article-title":"Growth, morphogenesis, and differentiation during mouse prostate development in situ, in renal grafts, and in vitro","volume":"65","author":"Doles","year":"2005","journal-title":"Prostate"},{"key":"10.1016\/j.ydbio.2007.09.038_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ydbio.2005.12.002","article-title":"Functional compensation in Hedgehog signaling during mouse prostate development","volume":"295","author":"Doles","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0012-1606(03)00250-1","article-title":"FGF-10 plays an essential role in the growth of the fetal prostate","volume":"261","author":"Donjacour","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ydbio.2003.08.018","article-title":"Sonic hedgehog regulates prostatic growth and epithelial differentiation","volume":"264","author":"Freestone","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib11","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1242\/dev.01917","article-title":"Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation","volume":"132","author":"Gao","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2007.09.038_bib12","first-page":"17","article-title":"Detection of bromodeoxyuridine in paraffin-embedded tissue sections using microwave antigen retrieval is dependent on the mode of tissue fixation","volume":"1","author":"Garrett","year":"1998","journal-title":"Biochemica"},{"key":"10.1016\/j.ydbio.2007.09.038_bib13","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ydbio.2005.08.018","article-title":"BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling","volume":"288","author":"Grishina","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib14","first-page":"66","article-title":"Permissive and instructive induction of adult rodent prostatic epithelium by heterotypic urogenital sinus mesenchyme","volume":"2","author":"Hayashi","year":"1993","journal-title":"Epithel. Cell Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib15","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.ydbio.2004.11.020","article-title":"The role of Fgf10 signaling in branching morphogenesis and gene expression of the rat prostate gland: lobe-specific suppression by neonatal estrogens","volume":"278","author":"Huang","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bjps.2003.08.019","article-title":"The development of the male genitourinary system. I. The origin of the urorectal septum and the formation of the perineum","volume":"57","author":"Hynes","year":"2004","journal-title":"Br. J. Plast. Surg."},{"key":"10.1016\/j.ydbio.2007.09.038_bib17","first-page":"L370","article-title":"BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways","volume":"288","author":"Jeffery","year":"2005","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ng1178","article-title":"Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning","volume":"34","author":"Khokha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2007.09.038_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1126\/science.1085753","article-title":"Organizing axes in time and space; 25\u00a0years of colinear tinkering","volume":"301","author":"Kmita","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2007.09.038_bib20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/dbio.2001.0187","article-title":"Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate","volume":"232","author":"Lamm","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/dbio.2002.0774","article-title":"Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation","volume":"249","author":"Lamm","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/toxsci\/kfg218","article-title":"Region-specific inhibition of prostatic epithelial bud formation in the urogenital sinus of C57BL\/6 mice exposed in utero to 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"76","author":"Lin","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.ydbio.2007.09.038_bib23","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1101\/gad.12.10.1438","article-title":"Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite","volume":"12","author":"McMahon","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2007.09.038_bib24","doi-asserted-by":"crossref","first-page":"5515","DOI":"10.1242\/dev.126.23.5515","article-title":"The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb","volume":"126","author":"Merino","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2007.09.038_bib25","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0303-7207(87)90197-3","article-title":"Androgen-regulated expression of secretory protein synthesis in mouse ventral prostate","volume":"53","author":"Mills","year":"1987","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib26","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s00774-005-0624-5","article-title":"Expression profiles of BMP-related molecules induced by BMP-2 or -4 in muscle-derived primary culture cells","volume":"23","author":"Nakamura","year":"2005","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.ydbio.2007.09.038_bib27","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0022-5347(05)68999-9","article-title":"Hoxa-13 gene mutation results in abnormal seminal vesicle and prostate development","volume":"161","author":"Podlasek","year":"1999","journal-title":"J. Urol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0177(199901)214:1<1::AID-DVDY1>3.0.CO;2-2","article-title":"Hoxa-10 deficient male mice exhibit abnormal development of the accessory sex organs","volume":"214","author":"Podlasek","year":"1999","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2007.09.038_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ydbio.2004.06.002","article-title":"Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching","volume":"273","author":"Pu","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ydbio.2006.01.001","article-title":"BMP-signaling regulates the generation of hair-cells","volume":"292","author":"Pujades","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib31","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1432-0436.2006.00096.x","article-title":"Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps","volume":"74","author":"Que","year":"2006","journal-title":"Differentiation"},{"key":"10.1016\/j.ydbio.2007.09.038_bib32","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/pros.20357","article-title":"Isolation and characterization of an immortalized mouse urogenital sinus mesenchyme cell line","volume":"66","author":"Shaw","year":"2006","journal-title":"Prostate"},{"key":"10.1016\/j.ydbio.2007.09.038_bib34","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/S0002-9440(10)64814-6","article-title":"p63 is a prostate basal cell marker and is required for prostate development","volume":"157","author":"Signoretti","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib33","doi-asserted-by":"crossref","first-page":"11355","DOI":"10.1073\/pnas.0500165102","article-title":"p63 regulates commitment to the prostate cell lineage","volume":"102","author":"Signoretti","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2007.09.038_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0168-9525(98)01641-2","article-title":"TGF beta inhibitors. New and unexpected requirements in vertebrate development","volume":"15","author":"Smith","year":"1999","journal-title":"Trends Genet."},{"key":"10.1016\/j.ydbio.2007.09.038_bib36","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1046\/j.1432-0436.2003.7107004.x","article-title":"Mouse urogenital development: a practical approach","volume":"71","author":"Staack","year":"2003","journal-title":"Differentiation"},{"key":"10.1016\/j.ydbio.2007.09.038_bib37","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1006\/dbio.2001.0479","article-title":"The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth","volume":"240","author":"Stottmann","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1432-0436.2006.00115.x","article-title":"Markers of prostate region-specific epithelial identity define anatomical locations in the mouse prostate that are molecularly similar to human prostate cancers","volume":"75","author":"Thielen","year":"2007","journal-title":"Differentiation"},{"key":"10.1016\/j.ydbio.2007.09.038_bib39","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1530\/rep.0.1210187","article-title":"Role of androgens and fibroblast growth factors in prostatic development","volume":"121","author":"Thomson","year":"2001","journal-title":"Reproduction"},{"key":"10.1016\/j.ydbio.2007.09.038_bib40","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1242\/dev.126.16.3693","article-title":"Prostatic growth and development are regulated by FGF10","volume":"126","author":"Thomson","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2007.09.038_bib41","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1210\/en.2004-0526","article-title":"Differential effects of transforming growth factor-beta1 on cellular proliferation in the developing prostate","volume":"145","author":"Tomlinson","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.ydbio.2007.09.038_bib42","doi-asserted-by":"crossref","first-page":"24733","DOI":"10.1074\/jbc.M401602200","article-title":"Notch1-expressing cells are indispensable for prostatic branching morphogenesis during development and re-growth following castration and androgen replacement","volume":"279","author":"Wang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.09.038_bib43","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ydbio.2005.11.009","article-title":"Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation","volume":"290","author":"Wang","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib44","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1242\/dev.124.23.4781","article-title":"Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts","volume":"124","author":"Warot","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2007.09.038_bib45","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1242\/dev.127.12.2695","article-title":"Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis","volume":"127","author":"Weaver","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2007.09.038_bib46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0012-1606(03)00117-9","article-title":"Tissue interactions pattern the mesenchyme of the embryonic mouse lung","volume":"258","author":"Weaver","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib47","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ydbio.2005.07.016","article-title":"Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse","volume":"286","author":"Wijgerde","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2007.09.038_bib48","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0092-8674(00)80133-6","article-title":"The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4","volume":"86","author":"Zimmerman","year":"1996","journal-title":"Cell"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160607013814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160607013814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:03:51Z","timestamp":1757909031000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160607013814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0012160607013814"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2007.09.038","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Noggin is required for normal lobe patterning and ductal budding in the mouse prostate","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2007.09.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}