{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:15:19Z","timestamp":1778710519281,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2060,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS048391"],"award-info":[{"award-number":["NS048391"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS060275"],"award-info":[{"award-number":["NS060275"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003925","name":"Lowe Syndrome Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000881","name":"Lowe Syndrome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.ydbio.2007.10.029","type":"journal-article","created":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T07:16:38Z","timestamp":1196234198000},"page":"384-397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults"],"prefix":"10.1016","volume":"313","author":[{"given":"David","family":"Weinkove","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bastiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara A.M.","family":"Chessa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Hauth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank T.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nullin","family":"Divecha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Schuske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2007.10.029_bib1","doi-asserted-by":"crossref","first-page":"37771","DOI":"10.1074\/jbc.M204145200","article-title":"Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2","volume":"277","author":"Benesch","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib2","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1074\/jbc.270.7.2881","article-title":"The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases","volume":"270","author":"Boronenkov","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib3","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1083\/jcb.200103107","article-title":"Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic","volume":"154","author":"Brown","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib4","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1074\/jbc.272.9.5861","article-title":"A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase","volume":"272","author":"Castellino","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib5","doi-asserted-by":"crossref","first-page":"34059","DOI":"10.1074\/jbc.M104917200","article-title":"G-protein-coupled receptor activation induces the membrane translocation and activation of phosphatidylinositol-4-phsophate 5-kinase I\u03b1 by a rac- and rho-dependent pathway","volume":"276","author":"Chatah","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib57","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1093\/genetics\/164.4.1355","article-title":"Identification of genes that regulate left-right asymmetric neuronal mingration in Caenorhabditis elegans","volume":"164","author":"Ch'ng","year":"2003","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2007.10.029_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0092-8674(94)90259-3","article-title":"The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells","volume":"79","author":"Chong","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2007.10.029_bib7","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/genetics\/137.4.987","article-title":"The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins","volume":"137","author":"Clark","year":"1994","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2007.10.029_bib8","doi-asserted-by":"crossref","first-page":"43849","DOI":"10.1074\/jbc.M209046200","article-title":"Inhibition of phosphatidylinositol-4-phosphate 5-kinase Ialpha impairs localized actin remodeling and suppresses phagocytosis","volume":"277","author":"Coppolino","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0092-8674(00)81649-9","article-title":"Essential role of phosphoinositide metabolism in synaptic vesicle recycling","volume":"99","author":"Cremona","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2007.10.029_bib10","doi-asserted-by":"crossref","first-page":"15787","DOI":"10.1074\/jbc.273.25.15787","article-title":"MSS4, a phosphatidylinositol-4-phosphate 5-kinase required for organization of the actin cytoskeleton in Saccharomyces cerevisiae","volume":"273","author":"Desrivieres","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib11","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature02896","article-title":"Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking","volume":"431","author":"Di Paolo","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2007.10.029_bib12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2005.09.026","article-title":"A slowed classical pathway rather than kiss-and-run mediates endocytosis at synapses lacking synaptojanin and endophilin","volume":"123","author":"Dickman","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2007.10.029_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/jcb.10100","article-title":"Overexpression of murine phosphatidylinositol 4-phosphate 5-kinase type Ibeta disrupts a phosphatidylinositol 4,5 bisphosphate regulated endosomal pathway","volume":"85","author":"Galiano","year":"2002","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1042\/bj20031394","article-title":"A novel neuronal-specific splice variant of type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma","volume":"379","author":"Giudici","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.ydbio.2007.10.029_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.1256405","article-title":"The role of the Rho GTPases in neuronal development","volume":"19","author":"Govek","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2007.10.029_bib16","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1002\/j.1460-2075.1992.tb05357.x","article-title":"The mec-7 beta-tubulin gene of Caenorhabditis elegans is expressed primarily in the touch receptor neurons","volume":"11","author":"Hamelin","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2007.10.029_bib17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1083\/jcb.150.3.589","article-title":"Mutations in synaptojanin disrupt synaptic vesicle recycling","volume":"150","author":"Harris","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0955-0674(91)90170-4","article-title":"Actin-binding proteins","volume":"3","author":"Hartwig","year":"1991","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib19","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1083\/jcb.150.6.1311","article-title":"Activation by Cdc42 and PIP(2) of Wiskott\u2013Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2\/3 complex","volume":"150","author":"Higgs","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib20","doi-asserted-by":"crossref","first-page":"728","DOI":"10.2144\/02324bm01","article-title":"PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegans","volume":"32","author":"Hobert","year":"2002","journal-title":"Biotechniques"},{"key":"10.1016\/j.ydbio.2007.10.029_bib21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(00)81540-8","article-title":"Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation","volume":"99","author":"Honda","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2007.10.029_bib22","doi-asserted-by":"crossref","first-page":"23611","DOI":"10.1074\/jbc.271.39.23611","article-title":"Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase","volume":"271","author":"Ishihara","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib23","doi-asserted-by":"crossref","first-page":"8741","DOI":"10.1074\/jbc.273.15.8741","article-title":"Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion\/substitution analysis of members of this novel lipid kinase family","volume":"273","author":"Ishihara","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib24","doi-asserted-by":"crossref","first-page":"20292","DOI":"10.1074\/jbc.273.32.20292","article-title":"A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals","volume":"273","author":"Itoh","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2007.08.036","article-title":"UNC-80 and the NCA Ion channels contribute to endocytosis defects in synaptojanin mutants","author":"Jospin","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib26","doi-asserted-by":"crossref","first-page":"30622","DOI":"10.1074\/jbc.M401443200","article-title":"Phosphatidylinositol 4,5-bisphosphate regulates adipocyte actin dynamics and GLUT4 vesicle recycling","volume":"279","author":"Kanzaki","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib27","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1242\/dev.126.20.4489","article-title":"Growth cones stall and collapse during axon outgrowth in Caenorhabditis elegans","volume":"126","author":"Knobel","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2007.10.029_bib28","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1074\/jbc.M110775200","article-title":"Stereo-specific substrate recognition by phosphatidylinositol phosphate kinases is swapped by changing a single amino acid residue","volume":"277","author":"Kunz","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib29","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1083\/jcb.149.7.1455","article-title":"GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism","volume":"149","author":"Laux","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib30","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.tcb.2006.03.007","article-title":"Movin' on up: the role of PtdIns(4,5)P(2) in cell migration","volume":"16","author":"Ling","year":"2006","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib31","doi-asserted-by":"crossref","first-page":"32937","DOI":"10.1074\/jbc.271.51.32937","article-title":"Type I phosphatidylinositol-4-phosphate 5-kinases are distinct members of this novel lipid kinase family","volume":"271","author":"Loijens","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib32","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1083\/jcb.138.6.1279","article-title":"Delayed retraction of filopodia in gelsolin null mice","volume":"138","author":"Lu","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib33","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1083\/jcb.140.5.1125","article-title":"Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts","volume":"140","author":"Ma","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib34","doi-asserted-by":"crossref","first-page":"33905","DOI":"10.1074\/jbc.274.48.33905","article-title":"Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases","volume":"274","author":"McEwen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib35","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/39908","article-title":"Identification and characterization of the vesicular GABA transporter","volume":"389","author":"McIntire","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2007.10.029_bib36","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1091\/mbc.e05-12-1120","article-title":"The phosphoinositide kinase PIKfyve\/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans","volume":"17","author":"Nicot","year":"2006","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2007.10.029_bib37","doi-asserted-by":"crossref","first-page":"8061","DOI":"10.1523\/JNEUROSCI.17-21-08061.1997","article-title":"Caenorhabditis elegans rab-3 mutant synapses exhibit impaired function and are partially depleted of vesicles","volume":"17","author":"Nonet","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ydbio.2007.10.029_bib38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/36621","article-title":"A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate","volume":"390","author":"Rameh","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2007.10.029_bib39","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)81560-3","article-title":"Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion","volume":"100","author":"Raucher","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2007.10.029_bib40","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1101\/gad.332305","article-title":"Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences","volume":"19","author":"Robert","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2007.10.029_bib41","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1083\/jcb.150.6.1299","article-title":"Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4,5-bisphosphate","volume":"150","author":"Rohatgi","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0960-9822(00)00384-5","article-title":"Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2\/3","volume":"10","author":"Rozelle","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib43","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1128\/MCB.17.7.3841","article-title":"Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments","volume":"17","author":"Sakisaka","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib44","doi-asserted-by":"crossref","first-page":"21589","DOI":"10.1074\/jbc.274.31.21589","article-title":"PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin","volume":"274","author":"Sbrissa","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib45","doi-asserted-by":"crossref","first-page":"47276","DOI":"10.1074\/jbc.M207576200","article-title":"Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells","volume":"277","author":"Sbrissa","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"Pt. 21","key":"10.1016\/j.ydbio.2007.10.029_bib46","first-page":"3685","article-title":"The actin cytoskeleton and plasma membrane connection: PtdIns(4,5)P(2) influences cytoskeletal protein activity at the plasma membrane","volume":"113","author":"Sechi","year":"2000","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.ydbio.2007.10.029_bib47","doi-asserted-by":"crossref","first-page":"7578","DOI":"10.1074\/jbc.272.12.7578","article-title":"Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo","volume":"272","author":"Shibasaki","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2007.10.029_bib48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/351033a0","article-title":"Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils","volume":"351","author":"Stephens","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2007.10.029_bib49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0076-6879(00)25443-8","article-title":"In vitro interaction of phosphoinositide-4-phosphate 5-kinases with Rac","volume":"325","author":"Tolias","year":"2000","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib50","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0960-9822(00)00315-8","article-title":"Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly","volume":"10","author":"Tolias","year":"2000","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib51","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/genetics\/158.1.221","article-title":"The G-protein beta-subunit GPB-2 in Caenorhabditis elegans regulates the G(o)alpha\u2013G(q)alpha signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16","volume":"158","author":"van der Linden","year":"2001","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2007.10.029_bib52","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0960-9822(01)00660-1","article-title":"Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling","volume":"12","author":"van Horck","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2007.10.029_bib53","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0896-6273(03)00644-5","article-title":"Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating","volume":"40","author":"Verstreken","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2007.10.029_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1741-7007-4-1","article-title":"Long-term starvation and ageing induce AGE-1\/PI 3-kinase-dependent translocation of DAF-16\/FOXO to the cytoplasm","volume":"4","author":"Weinkove","year":"2006","journal-title":"BMC Biol."},{"issue":"Pt. 3","key":"10.1016\/j.ydbio.2007.10.029_bib55","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1042\/bj3230597","article-title":"Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts","volume":"323","author":"Whiteford","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.ydbio.2007.10.029_bib56","doi-asserted-by":"crossref","first-page":"17226","DOI":"10.1074\/jbc.M109795200","article-title":"Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling","volume":"277","author":"Yamazaki","year":"2002","journal-title":"J. Biol. Chem."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160607014790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160607014790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T22:06:54Z","timestamp":1778710014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160607014790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0012160607014790"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2007.10.029","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overexpression of PPK-1, the Caenorhabditis elegans Type I PIP kinase, inhibits growth cone collapse in the developing nervous system and causes axonal degeneration in adults","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2007.10.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}