{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T18:48:50Z","timestamp":1725562130217},"reference-count":53,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1719,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.ydbio.2008.08.026","type":"journal-article","created":{"date-parts":[[2008,9,7]],"date-time":"2008-09-07T21:25:12Z","timestamp":1220822712000},"page":"166-176","source":"Crossref","is-referenced-by-count":13,"title":["Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3"],"prefix":"10.1016","volume":"323","author":[{"given":"Attila","family":"Stetak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Gutierrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Hajnal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2008.08.026_bib1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/348693a0","article-title":"The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily","volume":"348","author":"Aroian","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2008.08.026_bib2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0092-8674(93)80053-H","article-title":"Odorant-selective genes and neurons mediate olfaction in C. elegans","volume":"74","author":"Bargmann","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2008.08.026_bib3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/348503a0","article-title":"Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction","volume":"348","author":"Beitel","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2008.08.026_bib4","first-page":"47","article-title":"GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila","volume":"1603","author":"Bernards","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ydbio.2008.08.026_bib5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/08977190500130480","article-title":"GAPs in growth factor signalling","volume":"23","author":"Bernards","year":"2005","journal-title":"Growth Factors"},{"key":"10.1016\/j.ydbio.2008.08.026_bib6","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1126\/science.1055642","article-title":"Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development","volume":"291","author":"Berset","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2008.08.026_bib7","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1101\/gad.333505","article-title":"The C. elegans homolog of the mammalian tumor suppressor Dep-1\/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions","volume":"19","author":"Berset","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2008.08.026_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.gde.2005.03.004","article-title":"RASA1: variable phenotype with capillary and arteriovenous malformations","volume":"15","author":"Boon","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ydbio.2008.08.026_bib9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1091\/mbc.E02-05-0297","article-title":"Deregulation of the Egfr\/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap","volume":"14","author":"Botella","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2008.08.026_bib10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2008.08.026_bib11","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/sj.embor.7400574","article-title":"The Caenorhabditis elegans-oncogene ect-2 positively regulates RAS signalling during vulval development","volume":"6","author":"Canevascini","year":"2005","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ydbio.2008.08.026_bib12","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1242\/dev.120.10.2713","article-title":"The lin-3\/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans","volume":"120","author":"Chamberlin","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2008.08.026_bib13","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1093\/emboj\/19.13.3283","article-title":"Caenorhabditis elegans-1 is necessary for multiple RAS-mediated developmental signals","volume":"19","author":"Chang","year":"2000","journal-title":"Embo J."},{"key":"10.1016\/j.ydbio.2008.08.026_bib14","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1242\/dev.121.8.2525","article-title":"Three genes of the MAP kinase cascade, mek-2, mpk-1\/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans","volume":"121","author":"Church","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2008.08.026_bib15","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/356340a0","article-title":"C. elegans-signalling gene sem-5 encodes a protein with SH2 and SH3 domains","volume":"356","author":"Clark","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2008.08.026_bib16","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1038\/sj.onc.1210421","article-title":"MAP kinase signalling pathways in cancer","volume":"26","author":"Dhillon","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.ydbio.2008.08.026_bib17","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/genetics\/146.2.553","article-title":"Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 -sensitive, gain-of-function mutation","volume":"146","author":"Eisenmann","year":"1997","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2008.08.026_bib18","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/0092-8674(92)90073-L","article-title":"A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase","volume":"68","author":"Gaul","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2008.08.026_bib19","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1101\/gad.11.20.2715","article-title":"Inhibition of Caenorhabditis elegans vulval induction by GAP-1 and let-23 receptor tyrosine kinase","volume":"11","author":"Hajnal","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2008.08.026_bib20","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/genetics\/126.4.899","article-title":"The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans","volume":"126","author":"Han","year":"1990","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2008.08.026_bib21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/363133a0","article-title":"C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation","volume":"363","author":"Han","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2008.08.026_bib22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1365-2443.1998.00179.x","article-title":"Characterization of the C. elegans GAP-2 -GTPase activating protein and its possible role in larval development","volume":"3","author":"Hayashizaki","year":"1998","journal-title":"Genes Cells"},{"key":"10.1016\/j.ydbio.2008.08.026_bib23","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/377695a0","article-title":"Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein","volume":"377","author":"Henkemeyer","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2008.08.026_bib24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/35005101","article-title":"The Ras\u2013MAPK pathway is important for olfaction in Caenorhabditis elegans","volume":"404","author":"Hirotsu","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2008.08.026_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1097-2765(05)00001-8","article-title":"ARK-1 inhibits EGFR signaling in C. elegans","volume":"6","author":"Hopper","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2008.08.026_bib26","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng0794-353","article-title":"Tumour predisposition in mice heterozygous for a targeted mutation in Nf1","volume":"7","author":"Jacks","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2008.08.026_bib27","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1242\/dev.125.12.2337","article-title":"Interactions of EGF, Wnt and HOM-C genes specify the P12 neuroectoblast fate in C. elegans","volume":"125","author":"Jiang","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2008.08.026_bib28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1152\/physiolgenomics.00210.2005","article-title":"Comparative and evolutionary analysis of genes encoding small GTPases and their activating proteins in eukaryotic genomes","volume":"24","author":"Jiang","year":"2006","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.ydbio.2008.08.026_bib29","article-title":"Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans","volume":"2","author":"Kamath","year":"2001","journal-title":"Genome Biol."},{"key":"10.1016\/j.ydbio.2008.08.026_bib30","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0012-1606(81)90152-4","article-title":"Alterations in cell lineage following laser ablation of cells in the somatic gonad of Caenorhabditis elegans","volume":"87","author":"Kimble","year":"1981","journal-title":"Dev Biol."},{"key":"10.1016\/j.ydbio.2008.08.026_bib31","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1101\/gad.12.10.1425","article-title":"clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans","volume":"12","author":"Kokel","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2008.08.026_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0168-9525(97)01005-6","article-title":"Vulval development in Caenorhabditis elegans","volume":"13","author":"Kornfeld","year":"1997","journal-title":"Trends Genet."},{"key":"10.1016\/j.ydbio.2008.08.026_bib33","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1101\/gad.9.6.756","article-title":"The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK","volume":"9","author":"Kornfeld","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2008.08.026_bib34","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1101\/gad.8.2.160","article-title":"A MAP kinase homolog, mpk-1-mediated induction of vulval cell fates in Caenorhabditis elegans","volume":"8","author":"Lackner","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2008.08.026_bib35","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/genetics\/141.3.977","article-title":"Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system","volume":"141","author":"Maduro","year":"1995","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2008.08.026_bib36","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences","volume":"10","author":"Mello","year":"1991","journal-title":"Embo J."},{"key":"10.1016\/j.ydbio.2008.08.026_bib37","doi-asserted-by":"crossref","first-page":"12449","DOI":"10.1073\/pnas.192101699","article-title":"Serotonin mediates food-odor associative learning in the nematode Caenorhabditis elegans","volume":"99","author":"Nuttley","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2008.08.026_bib38","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/j.1460-2075.1996.tb00448.x","article-title":"Determinants of Ras proteins specifying the sensitivity to yeast Ira2p and human p120-GAP","volume":"15","author":"Parrini","year":"1996","journal-title":"Embo J."},{"key":"10.1016\/j.ydbio.2008.08.026_bib39","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.bbamcr.2007.01.012","article-title":"Ras oncogenes and their downstream targets","volume":"1773","author":"Rajalingam","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ydbio.2008.08.026_bib40","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1073\/pnas.83.13.4725","article-title":"Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21","volume":"83","author":"Sigal","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ydbio.2008.08.026_bib41","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0960-9822(02)01041-2","article-title":"Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi","volume":"12","author":"Simmer","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2008.08.026_bib42","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0092-8674(86)90842-1","article-title":"Pattern formation during vulval development in C. elegans","volume":"44","author":"Sternberg","year":"1986","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2008.08.026_bib43","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Post-embryonic cell lineages of the nematode, Caenorhabditis elegans","volume":"56","author":"Sulston","year":"1977","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2008.08.026_bib44","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1242\/dev.122.9.2823","article-title":"A Ras-mediated signal transduction pathway is involved in the control of sex myoblast migration in Caenorhabditis elegans","volume":"122","author":"Sundaram","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2008.08.026_bib45","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1126\/science.276.5313.791","article-title":"Rescue of a Drosophila NF1 mutant phenotype by protein kinase A","volume":"276","author":"The","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2008.08.026_bib46","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1126\/science.2821624","article-title":"A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants","volume":"238","author":"Trahey","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2008.08.026_bib47","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1101\/gad.1466806","article-title":"Reduced growth of Drosophila-cell-autonomous requirement for GTPase-activating protein activity in larval neurons","volume":"20","author":"Walker","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2008.08.026_bib48","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1126\/science.1063097","article-title":"A circadian output in Drosophila-1 and Ras\/MAPK","volume":"293","author":"Williams","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2008.08.026_bib49","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1101\/gad.8.2.147","article-title":"Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans-1 MAP kinase in vulval differentiation","volume":"8","author":"Wu","year":"1994","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2008.08.026_bib50","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1101\/gad.9.6.742","article-title":"MEK-2, a Caenorhabditis elegans-mediated vulval induction and other developmental events","volume":"9","author":"Wu","year":"1995","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2008.08.026_bib51","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1128\/MCB.17.5.2716","article-title":"Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans","volume":"17","author":"Yochem","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2008.08.026_bib52","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1126\/science.1091639","article-title":"Crosstalk between the EGFR and LIN-12\/Notch pathways in C. elegans vulval development","volume":"303","author":"Yoo","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2008.08.026_bib53","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1126\/science.7652556","article-title":"Similarity of sli-1, a regulator of vulval development in C. elegans-oncogene c-cbl","volume":"269","author":"Yoon","year":"1995","journal-title":"Science"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160608011603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160608011603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T03:32:10Z","timestamp":1631763130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160608011603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0012160608011603"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2008.08.026","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}