{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:31:02Z","timestamp":1790044262272,"version":"4.0.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1568,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.ydbio.2009.02.017","type":"journal-article","created":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T04:55:47Z","timestamp":1235537747000},"page":"506-516","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud"],"prefix":"10.1016","volume":"328","author":[{"given":"Patrick","family":"Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"G\u00f6tz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"R\u00fcther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2009.02.017_bib1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cell.2004.07.023","article-title":"Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning","volume":"118","author":"Ahn","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2009.02.017_bib2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0168-9525(99)01869-7","article-title":"Ci: a complex transducer of the hedgehog signal","volume":"15","author":"Aza-Blanc","year":"1999","journal-title":"Trends Genet."},{"key":"10.1016\/j.ydbio.2009.02.017_bib3","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0092-8674(00)80292-5","article-title":"Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor","volume":"89","author":"Aza-Blanc","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2009.02.017_bib4","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1242\/dev.129.20.4753","article-title":"GLI2, but not GLI1, is required for initial SHH signaling and ectopic activation of the SHH pathway","volume":"129","author":"Bai","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.02.017_bib5","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ng1197-259","article-title":"Strike three for GLI3","volume":"17","author":"Biesecker","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2009.02.017_bib6","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/hmg\/11.9.1129","article-title":"Pallister\u2013Hall syndrome phenotype in mice mutant for GLI3","volume":"11","author":"B\u00f6se","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2009.02.017_bib7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.ydbio.2004.06.012","article-title":"The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth","volume":"273","author":"Boulet","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2009.02.017_bib8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/(SICI)1097-0177(199801)211:1<88::AID-AJA8>3.0.CO;2-3","article-title":"Expression profile of Gli family members and Shh in normal and mutant mouse limb development","volume":"211","author":"B\u00fcscher","year":"1998","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2009.02.017_bib9","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1007\/s003359900845","article-title":"The Xt allele generates a GLI3 fusion transcript","volume":"9","author":"B\u00fcscher","year":"1998","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.ydbio.2009.02.017_bib10","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1242\/dev.127.11.2461","article-title":"The bHLH transcription factor dHAND controls sonic hedgehog expression and establishment of the zone of polarizing activity during limb development","volume":"127","author":"Charit\u00e9","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.02.017_bib11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1006\/dbio.2001.0346","article-title":"Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function","volume":"236","author":"Chiang","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2009.02.017_bib12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/ajmg.a.20495","article-title":"The hedgehog signaling network","volume":"123A","author":"Cohen","year":"2003","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.ydbio.2009.02.017_bib13","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1074\/jbc.274.12.8143","article-title":"Sonic hedgehog-induced activation of the GLI1 promoter is mediated by GLI3","volume":"274","author":"Dai","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2009.02.017_bib14","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1242\/dev.120.8.2187","article-title":"Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11","volume":"120","author":"Davis","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.02.017_bib15","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1242\/dev.127.10.2133","article-title":"Role of dHAND in the anterior\u2013posterior polarization of the limb bud: implications for the sonic hedgehog pathway","volume":"127","author":"Fernandez-Teran","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.02.017_bib16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0925-4773(99)00194-X","article-title":"Expression pattern of Dkk-1 during mouse limb development","volume":"89","author":"Grotewold","year":"1999","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2009.02.017_bib17","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/hmg\/ddm156","article-title":"The molecular basis of Pallister\u2013Hall associated polydactyly","volume":"16","author":"Hill","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2009.02.017_bib18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng0393-241","article-title":"A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the GLI3 gene","volume":"3","author":"Hui","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2009.02.017_bib19","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: paradigms and principles","volume":"15","author":"Ingham","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2009.02.017_bib20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ejca.2005.08.039","article-title":"GLI transcription factors: mediators of oncogenic hedgehog signalling","volume":"42","author":"Kasper","year":"2006","journal-title":"EJC"},{"key":"10.1016\/j.ydbio.2009.02.017_bib21","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ng0397-266","article-title":"GLI3 frameshift mutations cause autosomal dominant Pallister\u2013Hall syndrome","volume":"15","author":"Kang","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2009.02.017_bib22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ng1178","article-title":"Gremlin is the BMP antagonist required for maintenance of SHH and Fgf signals during limb patterning","volume":"34","author":"Khokha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2009.02.017_bib23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nature01189","article-title":"Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs","volume":"420","author":"Kmita","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2009.02.017_bib24","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/82609","article-title":"Fgf8 signalling from the AER is essential for normal limb development","volume":"26","author":"Lewandoski","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2009.02.017_bib25","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nature01033","article-title":"SHH and GLI3 are dispensable for limb skeleton formation but regulate digit number and identity","volume":"418","author":"Litingtung","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2009.02.017_bib26","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1242\/dev.00956","article-title":"Finger or toe: the molecular basis of limb identity","volume":"130","author":"Logan","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.02.017_bib27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/dbio.1996.0300","article-title":"Sonic hedgehog differentially regulates expression of Gli and Gli3 during limb development","volume":"180","author":"Marigo","year":"1996","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2009.02.017_bib28","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.mod.2005.06.012","article-title":"Pax9 and Jagged1 act downstream of GLI3 in vertebrate limb development","volume":"122","author":"McGlinn","year":"2005","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2009.02.017_bib29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0012-1606(03)00159-3","article-title":"Differential requirement for GLI2 and GLI3 in ventral neural cell fate specification","volume":"259","author":"Motoyama","year":"2003","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2009.02.017_bib30","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1006\/dbio.1995.1248","article-title":"Characterization and developmental expression of Pax9, a paired-box-containing gene related to Pax1","volume":"170","author":"Neub\u00fcser","year":"1995","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2009.02.017_bib31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1399-0004.2004.00360.x","article-title":"Hedgehog signaling and congenital malformations","volume":"67","author":"Nieuwenhuis","year":"2005","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ydbio.2009.02.017_bib32","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/25533","article-title":"Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator","volume":"396","author":"Ohlmeyer","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2009.02.017_bib33","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1242\/dev.127.8.1593","article-title":"Mouse GLI1 mutants are viable but have defects in SHH signaling in combination with a GLI2 mutation","volume":"127","author":"Park","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.02.017_bib34","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1101\/gad.12.17.2735","article-title":"Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities","volume":"12","author":"Peters","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2009.02.017_bib35","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1242\/dev.124.20.3999","article-title":"Polydactyly and ectopic ZPA formation in Alx-4 mutant mice","volume":"124","author":"Qu","year":"1997","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.02.017_bib36","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/0092-8674(93)90626-2","article-title":"Sonic hedgehog mediates the polarizing activity of the ZPA","volume":"75","author":"Riddle","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2009.02.017_bib37","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/j.cub.2003.09.040","article-title":"Fgf signaling controls the number of phalanges and tip formation in developing digits","volume":"13","author":"Sanz-Ezquerro","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2009.02.017_bib38","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1242\/dev.126.17.3915","article-title":"Regulation of GLI2 and GLI3 activities by an amino-terminal repression domain: implication of GLI2 and GLI3 as primary mediators of SHH signaling","volume":"126","author":"Sasaki","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.02.017_bib39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0925-4773(00)00458-5","article-title":"Similar expression and regulation of Gli2 and Gli3 in the chicken limb bud","volume":"98","author":"Schweitzer","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2009.02.017_bib40","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/nature00902","article-title":"Functions of FGF signalling from the apical ectodermal ridge in limb development","volume":"418","author":"Sun","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2009.02.017_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1534-5807(03)00401-5","article-title":"Tbx genes specify posterior digit identity through SHH and BMP signaling","volume":"6","author":"Suzuki","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2009.02.017_bib42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1399-0004.2005.00404.x","article-title":"The developing limb and the control of the number of digits","volume":"67","author":"Talamillo","year":"2005","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ydbio.2009.02.017_bib43","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1101\/gad.219202","article-title":"Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling","volume":"16","author":"te Welscher","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2009.02.017_bib44","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1126\/science.1075620","article-title":"Progression of vertebrate limb development through SHH-mediated counteraction of GLI3","volume":"298","author":"te Welscher","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2009.02.017_bib45","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s003359900973","article-title":"The mouse mutation Pdn (Polydactyly Nagoya) is caused by the integration of a retrotransposon into the GLI3 gene","volume":"10","author":"Thien","year":"1999","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.ydbio.2009.02.017_bib46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1741-4520.2003.00005.x","article-title":"Sonic hedgehog expression in GLI3 depressed mouse embryo, Pdn\/Pdn","volume":"44","author":"Ueta","year":"2004","journal-title":"Congenit. Anom."},{"key":"10.1016\/j.ydbio.2009.02.017_bib47","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/352539a0","article-title":"GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families","volume":"352","author":"Vortkamp","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2009.02.017_bib48","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1242\/dev.126.22.5097","article-title":"The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels","volume":"126","author":"Wang","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.02.017_bib49","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0092-8674(00)80678-9","article-title":"Hedgehog-regulated processing of GLI3 produces an anterior\/posterior repressor gradient in the developing vertebrate limb","volume":"100","author":"Wang","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2009.02.017_bib50","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.ydbio.2007.02.029","article-title":"The Shh-independent activator function of the full-length GLI3 protein and its role in vertebrate limb digit patterning","volume":"305","author":"Wang","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2009.02.017_bib51","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/hmg\/6.11.1979","article-title":"Point mutations in human GLI3 cause Greig syndrome","volume":"6","author":"Wild","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ydbio.2009.02.017_bib52","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s004410051262","article-title":"Hox genes in digit development and evolution","volume":"296","author":"Zakany","year":"1999","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ydbio.2009.02.017_bib53","doi-asserted-by":"crossref","first-page":"13695","DOI":"10.1073\/pnas.94.25.13695","article-title":"Regulation of number and size of digits by posterior Hox genes: a dose-dependent mechanisms with potential evolutionary implications","volume":"94","author":"Zakany","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2009.02.017_bib54","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.1096049","article-title":"A dual role for Hox genes in limb anterior\u2013posterior asymmetry","volume":"304","author":"Zakany","year":"2004","journal-title":"Science"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216060900133X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S001216060900133X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:17:13Z","timestamp":1757909833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S001216060900133X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S001216060900133X"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2009.02.017","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2009.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}