{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:53:44Z","timestamp":1779911624798,"version":"3.53.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":1354,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.ydbio.2009.09.021","type":"journal-article","created":{"date-parts":[[2009,9,20]],"date-time":"2009-09-20T08:10:55Z","timestamp":1253434255000},"page":"407-417","source":"Crossref","is-referenced-by-count":45,"title":["The role of integrin \u03b18\u03b21 in fetal lung morphogenesis and injury"],"prefix":"10.1016","volume":"335","author":[{"given":"John T.","family":"Benjamin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Gaston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Halloran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M.","family":"Schnapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Zent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Prince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2009.09.021_bib1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1371\/journal.pgen.0010010","article-title":"Fog2 is required for normal diaphragm and lung development in mice and humans","volume":"1","author":"Ackerman","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ydbio.2009.09.021_bib2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1165\/rcmb.2006-0211RC","article-title":"Gata4 is necessary for normal pulmonary lobar development","volume":"36","author":"Ackerman","year":"2007","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib3","doi-asserted-by":"crossref","first-page":"L537","DOI":"10.1152\/ajplung.00050.2006","article-title":"Hyperoxia modulates TGF-beta\/BMP signaling in a mouse model of bronchopulmonary dysplasia","volume":"292","author":"Alejandre-Alcazar","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00019606-200603000-00009","article-title":"Validation of the 2-DeltaDeltaCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts","volume":"15","author":"Arocho","year":"2006","journal-title":"Diagn. Mol. Pathol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib5","doi-asserted-by":"crossref","first-page":"L550","DOI":"10.1152\/ajplung.00329.2006","article-title":"FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation","volume":"292","author":"Benjamin","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib6","doi-asserted-by":"crossref","first-page":"L1370","DOI":"10.1152\/ajplung.00367.2006","article-title":"Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease","volume":"292","author":"Bland","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib7","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1101\/gad.1026303","article-title":"Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung","volume":"17","author":"Chuang","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2009.09.021_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1084-2756(02)00193-8","article-title":"Pathology of new bronchopulmonary dysplasia","volume":"8","author":"Coalson","year":"2003","journal-title":"Semin. Neonatol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib9","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1177\/002215549804600703","article-title":"Distribution of integrins during human fetal lung development","volume":"46","author":"Coraux","year":"1998","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.ydbio.2009.09.021_bib10","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1242\/dev.126.17.3957","article-title":"Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse","volume":"126","author":"De Arcangelis","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.09.021_bib11","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ydbio.2004.09.023","article-title":"Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung","volume":"277","author":"De Langhe","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib12","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1203\/01.pdr.0000196371.85945.3a","article-title":"Hyperoxia and apoptosis in developing mouse lung mesenchyme","volume":"59","author":"Dieperink","year":"2006","journal-title":"Pediatr. Res."},{"issue":"147","key":"10.1016\/j.ydbio.2009.09.021_bib13","first-page":"e1","article-title":"Trends in neonatal morbidity and mortality for very low birthweight infants","volume":"196","author":"Fanaroff","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib14","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1097\/01.ASN.0000082999.46030.FE","article-title":"Glomerular and renal vascular structural changes in alpha8 integrin-deficient mice","volume":"14","author":"Haas","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib15","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0002-9440(10)64909-7","article-title":"The alpha8 integrin chain affords mechanical stability to the glomerular capillary tuft in hypertensive glomerular disease","volume":"160","author":"Hartner","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib16","article-title":"Prenatal inflammation and lung development","author":"Kramer","year":"2008","journal-title":"Semin. Fetal. Neonatal. Med."},{"key":"10.1016\/j.ydbio.2009.09.021_bib17","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1242\/dev.122.11.3537","article-title":"Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis","volume":"122","author":"Kreidberg","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.09.021_bib18","doi-asserted-by":"crossref","first-page":"L718","DOI":"10.1152\/ajplung.00084.2004","article-title":"Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood","volume":"287","author":"Le Cras","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib19","doi-asserted-by":"crossref","first-page":"L1012","DOI":"10.1152\/ajplung.00371.2001","article-title":"Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted allele","volume":"282","author":"Lim","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib20","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1242\/dev.005033","article-title":"The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression","volume":"134","author":"Linton","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2009.09.021_bib21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1152\/physrev.00028.2006","article-title":"Transcriptional control of lung morphogenesis","volume":"87","author":"Maeda","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ydbio.2009.09.021_bib22","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nature07005","article-title":"The branching programme of mouse lung development","volume":"453","author":"Metzger","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2009.09.021_bib23","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1164\/ajrccm.165.6.2108053","article-title":"Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry","volume":"165","author":"Moss","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ydbio.2009.09.021_bib24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/1711","article-title":"Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus","volume":"20","author":"Motoyama","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ydbio.2009.09.021_bib25","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0092-8674(00)81903-0","article-title":"Integrin alpha8beta1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis","volume":"88","author":"Muller","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2009.09.021_bib26","first-page":"441","article-title":"Potter's syndrome associated with renal agenesis or dysplasia. Morphological and biochemical study of the lung","volume":"109","author":"Nakamura","year":"1985","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.ydbio.2009.09.021_bib27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/dbio.2002.0658","article-title":"Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung","volume":"246","author":"Nguyen","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/adc.51.5.349","article-title":"Neonatal pulmonary hypoplasia after prolonged leakage of amniotic fluid","volume":"51","author":"Perlman","year":"1976","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ydbio.2009.09.021_bib29","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/dvdy.20362","article-title":"Toll-like receptor signaling inhibits structural development of the distal fetal mouse lung","volume":"233","author":"Prince","year":"2005","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2009.09.021_bib30","doi-asserted-by":"crossref","first-page":"L999","DOI":"10.1152\/ajplung.00111.2004","article-title":"Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB","volume":"287","author":"Prince","year":"2004","journal-title":"Am. J. Physiol. Lung. Cell. Mol. Physiol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3109\/01902149709074027","article-title":"Fibronectin and fibronectin receptors in lung development","volume":"23","author":"Roman","year":"1997","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.ydbio.2009.09.021_bib32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ppul.20252","article-title":"Similarities and dissimilarities of branching and septation during lung development","volume":"40","author":"Roth-Kleiner","year":"2005","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib33","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/nature01712","article-title":"Fibronectin requirement in branching morphogenesis","volume":"423","author":"Sakai","year":"2003","journal-title":"Nature"},{"issue":"Pt. 2","key":"10.1016\/j.ydbio.2009.09.021_bib34","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1242\/jcs.108.2.537","article-title":"Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells","volume":"108","author":"Schnapp","year":"1995","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.ydbio.2009.09.021_bib35","doi-asserted-by":"crossref","first-page":"23196","DOI":"10.1074\/jbc.270.39.23196","article-title":"The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin","volume":"270","author":"Schnapp","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2009.09.021_bib36","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s100249900068","article-title":"Fibronectin expression in bronchopulmonary dysplasia","volume":"1","author":"Sinkin","year":"1998","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1084-2756(02)00190-2","article-title":"Inflammation and bronchopulmonary dysplasia","volume":"8","author":"Speer","year":"2003","journal-title":"Semin. Neonatol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib38","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1542\/peds.111.4.766","article-title":"Collagen scaffolding during development and its deformation with chronic lung disease","volume":"111","author":"Thibeault","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.ydbio.2009.09.021_bib39","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/aja.1002040408","article-title":"Expression of the integrin subunit alpha 9 in the murine embryo","volume":"204","author":"Wang","year":"1995","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2009.09.021_bib40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0925-4773(99)00325-1","article-title":"The molecular basis of lung morphogenesis","volume":"92","author":"Warburton","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ydbio.2009.09.021_bib41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1083\/jcb.30.1.23","article-title":"Practical stereological methods for morphometric cytology","volume":"30","author":"Weibel","year":"1966","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib42","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1164\/ajrccm.163.6.2003098","article-title":"Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep","volume":"163","author":"Willet","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ydbio.2009.09.021_bib43","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/(SICI)1097-0177(199606)206:2<169::AID-AJA6>3.0.CO;2-G","article-title":"Differential expression of integrin alpha subunits supports distinct roles during lung branching morphogenesis","volume":"206","author":"Wu","year":"1996","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2009.09.021_bib44","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/sj.jp.7211297","article-title":"The association between early tracheal colonization and bronchopulmonary dysplasia","volume":"25","author":"Young","year":"2005","journal-title":"J. Perinatol."},{"key":"10.1016\/j.ydbio.2009.09.021_bib45","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1006\/dbio.1994.1057","article-title":"Tenascin-C in rat lung: distribution, ontogeny and role in branching morphogenesis","volume":"161","author":"Young","year":"1994","journal-title":"Dev. Biol."}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160609012068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160609012068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:46:21Z","timestamp":1633913181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160609012068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0012160609012068"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2009.09.021","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}