{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:02:58Z","timestamp":1791014578514,"version":"4.1.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1056,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000057","name":"NIH National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["R01 GM055297"],"award-info":[{"award-number":["R01 GM055297"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000057","name":"NIH National Institute of General Medical Sciences","doi-asserted-by":"crossref","award":["R01 GM074212"],"award-info":[{"award-number":["R01 GM074212"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Korean Research Foundation","award":["KRF-2008-357-C00125"],"award-info":[{"award-number":["KRF-2008-357-C00125"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.ydbio.2010.07.020","type":"journal-article","created":{"date-parts":[[2010,7,25]],"date-time":"2010-07-25T04:53:20Z","timestamp":1280033600000},"page":"113-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues"],"prefix":"10.1016","volume":"346","author":[{"given":"Dimple R.","family":"Bosu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoengwoo","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngjo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Wallenfang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward T.","family":"Kipreos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2010.07.020_bb0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1747-1028-3-7","article-title":"Cullin-RING ubiquitin ligases: global regulation and activation cycles","volume":"3","author":"Bosu","year":"2008","journal-title":"Cell Div."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0010","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1104\/pp.104.044495","article-title":"AtCAND1, a HEAT-repeat protein that participates in auxin signaling in Arabidopsis","volume":"135","author":"Cheng","year":"2004","journal-title":"Plant Physiol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0015","doi-asserted-by":"crossref","first-page":"17032","DOI":"10.1074\/jbc.M701153200","article-title":"Substrate-mediated regulation of cullin neddylation","volume":"282","author":"Chew","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0020","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.cellsig.2006.12.002","article-title":"Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells\u2014evidence for cullin dimerization","volume":"19","author":"Chew","year":"2007","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0025","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1105\/tpc.021923","article-title":"Arabidopsis ETA2, an apparent ortholog of the human cullin-interacting protein CAND1, is required for auxin responses mediated by the SCF(TIR1) ubiquitin ligase","volume":"16","author":"Chuang","year":"2004","journal-title":"Plant Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0030","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0092-8674(84)90300-3","article-title":"Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85","volume":"37","author":"Ciechanover","year":"1984","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0035","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0092-8674(03)00722-0","article-title":"COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases","volume":"114","author":"Cope","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2091-7-1","article-title":"Targeted silencing of Jab1\/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels","volume":"7","author":"Cope","year":"2006","journal-title":"BMC Biochem."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0045","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1126\/science.1075901","article-title":"Role of predicted metalloprotease motif of Jab1\/Csn5 in cleavage of Nedd8 from Cul1","volume":"298","author":"Cope","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0050","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S1534-5807(03)00121-7","article-title":"The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis","volume":"4","author":"Doronkin","year":"2003","journal-title":"Dev. Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0055","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neuron.2004.12.058","article-title":"LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans","volume":"46","author":"Dreier","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0060","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.cell.2008.07.022","article-title":"Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation","volume":"134","author":"Duda","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0065","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/70272","article-title":"CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans","volume":"1","author":"Feng","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0070","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1105\/tpc.021949","article-title":"Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin\/proteasome-mediated protein degradation","volume":"16","author":"Feng","year":"2004","journal-title":"Plant Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0075","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1006\/bbrc.2000.2260","article-title":"Characterization of mutations induced by ethyl methanesulfonate, UV, and trimethylpsoralen in the nematode Caenorhabditis elegans","volume":"269","author":"Gengyo-Ando","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0080","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1152\/physrev.00027.2001","article-title":"The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction","volume":"82","author":"Glickman","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0085","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2004.10.019","article-title":"Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases","volume":"119","author":"Goldenberg","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0090","doi-asserted-by":"crossref","first-page":"12036","DOI":"10.1074\/jbc.274.17.12036","article-title":"Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway","volume":"274","author":"Gong","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0095","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0092-8674(03)00316-7","article-title":"The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage","volume":"113","author":"Groisman","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0100","series-title":"Antibodies (A Laboratory Manual)","author":"Harlow","year":"1988"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0105","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1101\/gad.1322205","article-title":"The COP9 signalosome regulates the Neurospora circadian clock by controlling the stability of the SCFFWD-1 complex","volume":"19","author":"He","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0110","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/genetics\/144.4.1425","article-title":"Genomic libraries and a host strain designed for highly efficient two- hybrid selection in yeast","volume":"144","author":"James","year":"1996","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0115","series-title":"Current Protocols in Molecular Biology","year":"1995"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0120","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1006\/dbio.2000.9847","article-title":"The NED-8 conjugating system in Caenorhabditis elegans is required for embryogenesis and terminal differentiation of the hypodermis","volume":"226","author":"Jones","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0125","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1046-2023(03)00050-1","article-title":"Genome-wide RNAi screening in Caenorhabditis elegans","volume":"30","author":"Kamath","year":"2003","journal-title":"Methods"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0130","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature01278","article-title":"Systematic functional analysis of the Caenorhabditis elegans genome using RNAi","volume":"421","author":"Kamath","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0135","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1101\/gad.13.22.2928","article-title":"The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2","volume":"13","author":"Kamura","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0140","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1093\/emboj\/20.15.4003","article-title":"NEDD8 recruits E2-ubiquitin to SCF E3 ligase","volume":"20","author":"Kawakami","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0145","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1128\/MCB.00736-06","article-title":"The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4\/DDB-1 complex","volume":"27","author":"Kim","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0150","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.cub.2007.04.055","article-title":"C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway","volume":"17","author":"Kim","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0155","first-page":"1","article-title":"Ubiquitin-mediated pathways in C. elegans","author":"Kipreos","year":"2005","journal-title":"WormBook"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0160","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81267-2","article-title":"cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family","volume":"85","author":"Kipreos","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0165","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1242\/dev.127.23.5071","article-title":"The C. elegans F-box\/WD-repeat protein LIN-23 functions to limit cell division during development","volume":"127","author":"Kipreos","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0170","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1242\/dev.128.15.2867","article-title":"ELT-5 and ELT-6 are required continuously to regulate epidermal seam cell differentiation and cell fusion in C. elegans","volume":"128","author":"Koh","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0175","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1126\/science.1067765","article-title":"Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway","volume":"295","author":"Kurz","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0180","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molcel.2007.12.012","article-title":"Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation","volume":"29","author":"Kurz","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0185","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1101\/gad.12.7.914","article-title":"Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex","volume":"12","author":"Lammer","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0190","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1042\/bj20030755","article-title":"Saccharomyces cerevisiae ubiquitin-like protein Rub1 conjugates to cullin proteins Rtt101 and Cul3 in vivo","volume":"377","author":"Laplaza","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0195","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1093\/emboj\/17.8.2208","article-title":"A novel protein modification pathway related to the ubiquitin system","volume":"17","author":"Liakopoulos","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0200","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S1097-2765(02)00783-9","article-title":"NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases","volume":"10","author":"Liu","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0205","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1101\/gad.1090803","article-title":"Cop9\/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms","volume":"17","author":"Liu","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0210","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1242\/dev.01245","article-title":"CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans","volume":"131","author":"Liu","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0215","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1128\/MCB.26.4.1235-1244.2006","article-title":"CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1","volume":"26","author":"Lo","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0220","doi-asserted-by":"crossref","first-page":"4526","DOI":"10.1128\/MCB.01724-06","article-title":"CIF-1, a shared subunit of the COP9\/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo","volume":"27","author":"Luke-Glaser","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0225","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1126\/science.1059780","article-title":"Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome","volume":"292","author":"Lyapina","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0230","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1534\/genetics.166.3.1253","article-title":"A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23","volume":"166","author":"Mehta","year":"2004","journal-title":"Genetics"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0235","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ni1514","article-title":"COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence","volume":"8","author":"Menon","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0240","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0091-679X(08)61396-5","article-title":"Immunofluorescence microscopy","volume":"48","author":"Miller","year":"1995","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0245","doi-asserted-by":"crossref","first-page":"15905","DOI":"10.1074\/jbc.M213070200","article-title":"TIP120A associates with cullins and modulates ubiquitin ligase activity","volume":"278","author":"Min","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0250","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.bbrc.2005.06.188","article-title":"CAND1 enhances deneddylation of CUL1 by COP9 signalosome","volume":"334","author":"Min","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0255","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1006\/bbrc.2000.2576","article-title":"Modification of cullin-1 by ubiquitin-like protein Nedd8 enhances the activity of SCF(skp2) toward p27(kip1)","volume":"270","author":"Morimoto","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0260","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/embo-reports\/kvf028","article-title":"An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells","volume":"3","author":"Ohh","year":"2002","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0265","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1093\/emboj\/19.13.3475","article-title":"Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast","volume":"19","author":"Osaka","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0270","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0006-291X(03)00501-1","article-title":"Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1","volume":"303","author":"Oshikawa","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0275","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1101\/gad.1011402","article-title":"Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development","volume":"16","author":"Ou","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0280","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1535-6108(03)00243-5","article-title":"When protein destruction runs amok, malignancy is on the loose","volume":"4","author":"Pagano","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0285","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1038\/sj.onc.1207414","article-title":"Nedd8 on cullin: building an expressway to protein destruction","volume":"23","author":"Pan","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0290","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm1547","article-title":"Function and regulation of cullin-RING ubiquitin ligases","volume":"6","author":"Petroski","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0295","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cbpa.2004.09.009","article-title":"Polyubiquitin chains: polymeric protein signals","volume":"8","author":"Pickart","year":"2004","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0300","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0960-9822(03)00336-1","article-title":"Neddylation and deneddylation of CUL-3 is required to target MEI-1\/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans","volume":"13","author":"Pintard","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0305","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1073\/pnas.090465597","article-title":"A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination","volume":"97","author":"Podust","year":"2000","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0310","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1128\/MCB.20.7.2326-2333.2000","article-title":"Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha","volume":"20","author":"Read","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0315","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0092-8674(94)90462-6","article-title":"Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules","volume":"78","author":"Rock","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0320","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molcel.2008.08.021","article-title":"Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation","volume":"32","author":"Saha","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0325","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nsmb1191","article-title":"Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity","volume":"14","author":"Sakata","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0330","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/path.2223","article-title":"Altered pattern of Cul-1 protein expression and neddylation in human lung tumours: relationships with CAND1 and cyclin E protein levels","volume":"213","author":"Salon","year":"2007","journal-title":"J. Pathol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0335","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.molcel.2009.07.024","article-title":"F-box-directed CRL complex assembly and regulation by the CSN and CAND1","volume":"35","author":"Schmidt","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0340","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.1059776","article-title":"Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response","volume":"292","author":"Schwechheimer","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0345","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1074\/jbc.M611513200","article-title":"TBP-interacting protein 120B (TIP120B)\/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation","volume":"282","author":"Shiraishi","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0350","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1242\/dev.01244","article-title":"Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans","volume":"131","author":"Sonneville","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0355","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.devcel.2007.05.008","article-title":"A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination","volume":"13","author":"Starostina","year":"2007","journal-title":"Dev. Cell"},{"issue":"Pt 2","key":"10.1016\/j.ydbio.2010.07.020_bb0360","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1101\/SQB.1983.048.01.049","article-title":"Neuronal cell lineages in the nematode Caenorhabditis elegans","volume":"48","author":"Sulston","year":"1983","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0365","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0012-1606(77)90158-0","article-title":"Post-embryonic cell lineages of the nematode, Caenorhabditis elegans","volume":"56","author":"Sulston","year":"1977","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0370","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/sj.embor.7400895","article-title":"The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components","volume":"8","author":"Vasudevan","year":"2007","journal-title":"EMBO Rep."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0375","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ncb1241","article-title":"CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability","volume":"7","author":"Wee","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0380","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/ncb1203-1029","article-title":"The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?","volume":"5","author":"Wolf","year":"2003","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0385","doi-asserted-by":"crossref","first-page":"32317","DOI":"10.1074\/jbc.M004847200","article-title":"Conjugation of Nedd8 to CUL1 enhances the ability of the ROC1-CUL1 complex to promote ubiquitin polymerization","volume":"275","author":"Wu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0390","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ncb1301","article-title":"Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation","volume":"7","author":"Wu","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ydbio.2010.07.020_bb0395","doi-asserted-by":"crossref","first-page":"8470","DOI":"10.1073\/pnas.0804144105","article-title":"Genetic analysis of CAND1-CUL1 interactions in Arabidopsis supports a role for CAND1-mediated cycling of the SCFTIR1 complex","volume":"105","author":"Zhang","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0400","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/S1097-2765(02)00784-0","article-title":"CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex","volume":"10","author":"Zheng","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0405","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature01747","article-title":"CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing","volume":"423","author":"Zhong","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ydbio.2010.07.020_bb0410","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S1097-2765(03)00136-9","article-title":"Fission yeast COP9\/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p","volume":"11","author":"Zhou","year":"2003","journal-title":"Mol. Cell"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160610009516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160610009516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T04:20:06Z","timestamp":1757910006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160610009516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":82,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0012160610009516"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2010.07.020","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2010.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}