{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:35:54Z","timestamp":1791221754983,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T00:00:00Z","timestamp":1291161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":995,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100006544","name":"Ministry of Health, State of Israel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Developmental Biology"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1016\/j.ydbio.2010.07.033","type":"journal-article","created":{"date-parts":[[2010,8,6]],"date-time":"2010-08-06T04:49:24Z","timestamp":1281070164000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["TMF\/ARA160: A key regulator of sperm development"],"prefix":"10.1016","volume":"348","author":[{"given":"Tal","family":"Lerer-Goldshtein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shai","family":"Bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Shpungin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erez","family":"Pery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny","family":"Motro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald S.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarit Itach","family":"Bar-Sheshet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Breitbart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Nir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ydbio.2010.07.033_bb0005","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/abbi.2000.1880","article-title":"Mammalian sperm acrosome: formation, contents, and function","volume":"379","author":"Abou-Haila","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0010","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ijc.24277","article-title":"TMF\/ARA160 downregulates proangiogenic genes and attenuates the progression of PC3 xenografts","volume":"125","author":"Abrham","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ydbio.2010.07.033_bb0015","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1093\/oxfordjournals.humrep.a137910","article-title":"Analysis of the ability of three probes targeting the outer acrosomal membrane or acrosomal contents to detect the acrosome reaction in human spermatozoa","volume":"8","author":"Aitken","year":"1993","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0020","series-title":"Cell and Molecular Biology of the Testis, Cell Biology of Mammalian Spermiogenesis","author":"Clermont","year":"1993"},{"key":"10.1016\/j.ydbio.2010.07.033_bb0025","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ydbio.2003.10.034","article-title":"Crosstalk between protein kinase A and C regulates phospholipase D and F-actin formation during sperm capacitation","volume":"267","author":"Cohen","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0030","first-page":"33","article-title":"The cellular biology of mammalian spermatids: a review","volume":"78","author":"Dadoune","year":"1994","journal-title":"Bull. Assoc. Anat. (Nancy)"},{"issue":"Suppl 1","key":"10.1016\/j.ydbio.2010.07.033_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/humrep\/13.suppl_1.1","article-title":"Spermatogenesis","volume":"13","author":"de Kretser","year":"1998","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0040","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0012-1606(75)90411-X","article-title":"The mammalian spermatozoon","volume":"44","author":"Fawcett","year":"1975","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0045","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2121-5-18","article-title":"TMF is a golgin that binds Rab6 and influences Golgi morphology","volume":"5","author":"Fridmann-Sirkis","year":"2004","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0050","doi-asserted-by":"crossref","first-page":"22373","DOI":"10.1074\/jbc.274.32.22373","article-title":"Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells","volume":"274","author":"Hsiao","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0055","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.1063665","article-title":"Lack of acrosome formation in Hrb-deficient mice","volume":"294","author":"Kang-Decker","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ydbio.2010.07.033_bb0060","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1091\/mbc.e03-04-0226","article-title":"Acroplaxome, an F-actin\u2013keratin-containing plate, anchors the acrosome to the nucleus during shaping of the spermatid head","volume":"14","author":"Kierszenbaum","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.ydbio.2010.07.033_bb0065","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1095\/biolreprod.103.025346","article-title":"The acroplaxome is the docking site of Golgi-derived myosin Va\/Rab27a\/b-containing proacrosomal vesicles in wild-type and Hrb mutant mouse spermatids","volume":"70","author":"Kierszenbaum","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0070","first-page":"33","article-title":"Molecular biology of sperm head shaping","volume":"65","author":"Kierszenbaum","year":"2007","journal-title":"Soc. Reprod. Fertil. Suppl."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0075","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1002\/dvdy.21789","article-title":"Expression of Fer testis (FerT) tyrosine kinase transcript variants and distribution sites of FerT during the development of the acrosome\u2013acroplaxome-manchette complex in rat spermatids","volume":"237","author":"Kierszenbaum","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0080","doi-asserted-by":"crossref","first-page":"C1113","DOI":"10.1152\/ajpcell.00238.2008","article-title":"Distinct phospho-forms of cortactin differentially regulate actin polymerization and focal adhesions","volume":"295","author":"Kruchten","year":"2008","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0085","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1023\/A:1008868325009","article-title":"Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase","volume":"7","author":"Lallemand","year":"1998","journal-title":"Transgenic Res."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0090","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.ydbio.2006.02.001","article-title":"Assembly of spermatid acrosome depends on microtubule organization during mammalian spermiogenesis","volume":"293","author":"Moreno","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-5793(02)02803-X","article-title":"A putative nuclear receptor coactivator (TMF\/ARA160) associates with hbrm\/hSNF2 alpha and BRG-1\/hSNF2 beta and localizes in the Golgi apparatus","volume":"520","author":"Mori","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0100","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/aja.1000990303","article-title":"A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal","volume":"99","author":"Oakberg","year":"1956","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0105","doi-asserted-by":"crossref","first-page":"8908","DOI":"10.1038\/sj.onc.1208149","article-title":"TMF\/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3","volume":"23","author":"Perry","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.ydbio.2010.07.033_bb0110","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1006\/dbio.2000.9745","article-title":"SNAREs in mammalian sperm: possible implications for fertilization","volume":"223","author":"Ramalho-Santos","year":"2000","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0115","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1095\/biolreprod67.4.1043","article-title":"Control of membrane fusion during spermiogenesis and the acrosome reaction","volume":"67","author":"Ramalho-Santos","year":"2002","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0120","series-title":"Histological and Histopathological Evaluation of the Testis","author":"Russell","year":"1990"},{"key":"10.1016\/j.ydbio.2010.07.033_bb0125","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1006\/dbio.1994.1256","article-title":"The centrosome and its mode of inheritance: the reduction of the centrosome during gametogenesis and its restoration during fertilization","volume":"165","author":"Schatten","year":"1994","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0130","first-page":"117","article-title":"On the cytomorphology of round-headed human spermatozoa","volume":"3","author":"Schirren","year":"1971","journal-title":"Andrologia"},{"key":"10.1016\/j.ydbio.2010.07.033_bb0135","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0014-5793(98)01003-5","article-title":"Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases","volume":"434","author":"Schwartz","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0140","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jemt.10319","article-title":"Ubiquitin-dependent proteolysis in mammalian spermatogenesis, fertilization, and sperm quality control: killing three birds with one stone","volume":"61","author":"Sutovsky","year":"2003","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0145","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1679\/aohc.67.361","article-title":"The coiled tail of the round-headed spermatozoa appears during epididymal passage in GOPC-deficient mice","volume":"67","author":"Suzuki-Toyota","year":"2004","journal-title":"Arch. Histol. Cytol."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0150","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1242\/dev.121.4.1129","article-title":"Capacitation of mouse spermatozoa. I. Correlation between the capacitation state and protein tyrosine phosphorylation","volume":"121","author":"Visconti","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.ydbio.2010.07.033_bb0155","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1089\/dna.2006.25.331","article-title":"TRNP: a conserved mammalian gene encoding a nuclear protein that accelerates cell-cycle progression","volume":"25","author":"Volpe","year":"2006","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0160","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1172\/JCI36230","article-title":"PICK1 deficiency causes male infertility in mice by disrupting acrosome formation","volume":"119","author":"Xiao","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0165","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1016\/j.yexcr.2007.07.010","article-title":"Functional involvement of TMF\/ARA160 in Rab6-dependent retrograde membrane traffic","volume":"313","author":"Yamane","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0170","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.mce.2009.03.003","article-title":"Male infertility caused by spermiogenic defects: lessons from gene knockouts","volume":"306","author":"Yan","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0175","doi-asserted-by":"crossref","first-page":"11211","DOI":"10.1073\/pnas.162027899","article-title":"Lack of acrosome formation in mice lacking a Golgi protein, GOPC","volume":"99","author":"Yao","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2010.07.033_bb0180","doi-asserted-by":"crossref","first-page":"13498","DOI":"10.1073\/pnas.212474399","article-title":"Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues","volume":"99","author":"Yeh","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"10.1016\/j.ydbio.2010.07.033_bb0185","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1172\/JCI29224","article-title":"Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility","volume":"116","author":"Yildiz","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ydbio.2010.07.033_bb0190","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.1073\/pnas.0701669104","article-title":"Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility","volume":"104","author":"Zheng","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"}],"container-title":["Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160610009784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0012160610009784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T22:47:04Z","timestamp":1762123624000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0012160610009784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0012160610009784"],"URL":"https:\/\/doi.org\/10.1016\/j.ydbio.2010.07.033","relation":{},"ISSN":["0012-1606"],"issn-type":[{"value":"0012-1606","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TMF\/ARA160: A key regulator of sperm development","name":"articletitle","label":"Article Title"},{"value":"Developmental Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ydbio.2010.07.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}